Abstract Functional endoscopic sinus surgery (FESS) has become one of the most common surgical techniques performed by otolaryngologists with significant data demonstrating its efficacy in managing patients with chronic rhinosinusitis (CRS). However, despite this initial success, patients may continue to present with recurrent symptoms and approximately 10–15% of them will require revision surgery. Failure of FESS may have many different causes which include inappropriate patient...
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Local plans tailored to different parts of the UK rather than a centralised and one-size-fits-all approach are needed to mitigate the covid-19 epidemic and get the country out of lockdown, public...
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The UK’s Office for National Statistics has published new figures showing deaths involving covid-19 by local areas and deprivation. The data, which cover the period between 1 March and 17 April 2020,...
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Commercial agreements between the UK government and manufacturers of covid-19 antibody tests are allowing the latter to control whether evaluation results of their products are made publicly...
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The most concerning complication of SARS-CoV-2 infection (covid-19) is acute hypoxaemic respiratory failure requiring mechanical ventilation. Numerous mechanisms have been suggested for the...
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Local plans tailored to different parts of the UK rather than a centralised and one-size-fits-all approach are needed to mitigate the covid-19 epidemic and get the country out of lockdown, public...
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The UK’s Office for National Statistics has published new figures showing deaths involving covid-19 by local areas and deprivation. The data, which cover the period between 1 March and 17 April 2020,...
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Commercial agreements between the UK government and manufacturers of covid-19 antibody tests are allowing the latter to control whether evaluation results of their products are made publicly...
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Doctors and researchers are noticing some curious and unexpectedly positive side effects of the abrupt shifts in human behaviour in response to the covid-19 pandemic. Skies are bluer, fewer cars are...
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Greenberg and colleagues rightly state that the development of psychological injury is “influenced by the way [staff] are supported before, during, and after a challenging incident.”1 But...
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An extra zero crept into the number of deaths from covid-19 in this feature by Bhavya Dore (BMJ 2020;369:m1711; doi:10.1136/bmj.m1711). The number of deaths in India should be over 1000 not 10 000....
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Covid-19: Coroners needn’t investigate PPE policy failures in deaths of NHS staff, new guidance says
Coroners have been issued with new guidance on covid-19 deaths steering them away from investigating policy failures in the provision of protective equipment in the workplace.1The guidance from Mark...
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Key messagesCompartmental modelling studies on covid-19 should not be relied on as the only approach for monitoring the pandemic or assessing the effectiveness of infection control measuresSimple and...
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Last month the Royal College of Obstetricians and Gynaecologists introduced new guidance1 on covid-19 and occupational health, asserting that for pregnant healthcare workers after 28 weeks’ gestation...
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Most UK medical schools have postponed clinical teaching because of the covid-19 pandemic, leaving students, who would usually be busy with exam preparations and clinical commitments, with time off....
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In this analysis (BMJ 2020;369:m1107, doi:10.1136/bmj.m1107, published 29 April 2020), one of the five serious risks of SGLT2 inhibitors was omitted—acute kidney injury. The full list is diabetic...
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The most concerning complication of SARS-CoV-2 infection (covid-19) is acute hypoxaemic respiratory failure requiring mechanical ventilation. Numerous mechanisms have been suggested for the...
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Expression of the DNA/RNA helicase schlafen family member 11 (SLFN11) has been identified as a sensitizer of tumor cells to DNA-damaging agents including platinum chemotherapy. We assessed the impact of SLFN11 expression on response to platinum chemotherapy and outcomes in patients with metastatic castration-resistant prostate cancer (CRPC). Tumor expression of SLFN11 was assessed in 41 patients with CRPC treated with platinum chemotherapy by RNA sequencing (RNA-seq) of metastatic biopsy tissue (n...
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Physical and chemical DNA-damaging agents are used widely in the treatment of cancer. Double-strand break (DSB) lesions in DNA are the most deleterious form of damage and, if left unrepaired, can effectively kill cancer cells. DNA-dependent protein kinase (DNA-PK) is a critical component of nonhomologous end joining (NHEJ), one of the two major pathways for DSB repair. Although DNA-PK has been considered an attractive target for cancer therapy, the development of pharmacologic DNA-PK inhibitors for...
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Long noncoding RNAs (lncRNA) have been found to play critical roles in tumorigenesis and the development of various cancers, including hepatocellular carcinoma (HCC). Metastasis associated with lung adenocarcinoma transcript-1 (MALAT1) has been identified as an oncogene and prognostic biomarker in HCC. Here, we demonstrated that MALAT1 expression was obviously high in sorafenib-resistant HCC cells. Furthermore, knockdown of MALAT1 increased sorafenib sensitivity in nonresponsive HCC cells, whereas...
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2-fluorofucose (2FF) inhibits protein and cellular fucosylation. Afucosylation of IgG antibodies enhances antibody-dependent cell-mediated cytotoxicity by modulating antibody affinity for FcRIIIa, which can impact secondary T-cell activation. Immune responses toward most common solid tumors are dominated by a humoral immune response rather than the presence of tumor-infiltrating cytotoxic T cells. IgG antibodies directed against numerous tumor-associated proteins are found in the sera of both patients...
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Gastrointestinal stromal tumor (GIST), the most common sarcoma, is characterized by KIT protein overexpression, and tumors are frequently driven by oncogenic KIT mutations. Targeted inhibition of KIT revolutionized GIST therapy and ushered in the era of precision medicine for the treatment of solid malignancies. Here, we present the first use of a KIT-specific DNA aptamer for targeted labeling of GIST. We found that an anti-KIT DNA aptamer bound cells in a KIT-dependent manner and was highly specific...
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Dysregulation of DNA methylation is an established feature of breast cancers. DNA demethylating therapies like decitabine are proposed for the treatment of triple-negative breast cancers (TNBC) and indicators of response need to be identified. For this purpose, we characterized the effects of decitabine in a panel of 10 breast cancer cell lines and observed a range of sensitivity to decitabine that was not subtype specific. Knockdown of potential key effectors demonstrated the requirement of deoxycytidine...
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TNF-related apoptosis-inducing ligand (TRAIL) and an agonistic antibody against the death-inducing TRAIL receptor 5, DR5, are thought to selectively induce tumor cell death and therefore, have gained attention as potential therapeutics currently under investigation in several clinical trials. However, some tumor cells are resistant to TRAIL/DR5–induced cell death, even though they express DR5. Previously, we reported that DR5 is transported into the nucleus by importin β1, and knockdown of importin...
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Overexpression of transcription factor 3 in alveolar soft part sarcoma(ASPS) results in upregulation of cell proliferation pathways. No standard treatment algorithm exists for ASPS; multikinase inhibitors[tyrosine kinase inhibitor (TKI)] and immune checkpoint inhibitors (ICI) have shown clinical benefit. To date, no studies have reported on management strategies or sequencing of therapy. We evaluated ASPS treatment patterns and responses in an experimental therapeutics clinic. Genomic and morphoproteomic...
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The development of efficacious therapies targeting metastatic spread of breast cancer to the brain represents an unmet clinical need. Accordingly, an improved understanding of the molecular underpinnings of central nervous system spread and progression of breast cancer brain metastases (BCBM) is required. In this study, the clinical burden of disease in BCBM was investigated, as well as the role of aldehyde dehydrogenase 1A3 (ALDH1A3) in the metastatic cascade leading to BCBM development. Initial...
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There is a need to develop novel approaches to improve the balance between efficacy and toxicity for transcription factor–targeted therapies. In this study, we exploit context-dependent differences in RNA polymerase II processivity as an approach to improve the activity and limit the toxicity of the EWS-FLI1–targeted small molecule, mithramycin, for Ewing sarcoma. The clinical activity of mithramycin for Ewing sarcoma is limited by off-target liver toxicity that restricts the serum concentration...
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KRAS mutation is a negative predictive biomarker of anti-EGFR agents in patients with metastatic colorectal cancer (mCRC), and remains an elusive target. Pelareorep, a double-stranded RNA virus selectively replicates in KRAS-mutated cells, and is synergistic with irinotecan. A dose escalation trial of FOLFIRI/bevacizumab [irinotecan (150–180 mg/m2) and pelareorep (1 x 1010 TCID50–3 x 1010 TCID50)] was implemented in adult patients with oxaliplatin refractory/intolerant, KRAS-mutant mCRC. Pelareorep...
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This first-in-human phase I study evaluated the pharmacokinetics, safety, and preliminary efficacy of telisotuzumab, formerly called ABT-700, an antagonistic antibody directed against c-Met. For dose escalation (3+3 design), 3 to 6 patients with advanced solid tumors were enrolled into four dose cohorts (5–25 mg/kg). In the dose-expansion phase, a subset of patients was prospectively selected for MET amplification (FISH screening). Patients received telisotuzumab intravenously on day 1 every 21 days....
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Publication date: Available online 4 May 2020Source: Biochimica et Biophysica Acta (BBA) - Proteins and ProteomicsAuthor(s): Stephanny Miranda Alves de Souza, Tácio Vinício Amorim Fernandes, Dário Eluan Kalume, Luís Maurício Trambaioli da Rocha e Lima, Pedro Geraldo Pascutti, Theo Luiz Ferraz de Souza
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Publication date: Available online 3 May 2020Source: Biochimica et Biophysica Acta (BBA) - Proteins and ProteomicsAuthor(s): Masumi Katane, Hisashi Kuwabara, Kazuki Nakayama, Yasuaki Saitoh, Tetsuya Miyamoto, Masae Sekine, Hiroshi Homma
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37 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: quality of care These pubmed results were generated on 2020/05/04PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
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A weightlifting guru, author and podcaster calls the U.S. response to the pandemic an “exercise in hysteria" that might do more harm than good. -- Read more on ScientificAmerican.com
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The potential dangers of this technology are great enough that we need to be very careful about how powerful we allow it to be -- Read more on ScientificAmerican.com
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Related ArticlesExploring the conceptualisation and study of freebirthing as a historical and social phenomenon: a meta-narrative review of diverse research traditions. Med Humanit. 2020 May 02;: Authors: McKenzie G, Robert G, Montgomery E Abstract Freebirthing is a clandestine practice whereby women intentionally give birth without healthcare professionals (HCPs) present in countries where there are medical facilities available to assist them. Women...
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Publication date: Available online 4 May 2020Source: Biochimica et Biophysica Acta (BBA) - General SubjectsAuthor(s): Yun Bai, Jia Liu, Lijuan Yang, Liangwei Zhong
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ACS NanoDOI: 10.1021/acsnano.9b08726
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Related ArticlesHPV driven squamous cell head and neck cancer of unknown primary is likely to be HPV driven squamous cell oropharyngeal cancer. Oral Oncol. 2020 Apr 30;107:104721 Authors: Schroeder L, Pring M, Ingarfield K, Pawlita M, Leary SD, Thomas SJ, Waylen A, Waterboer T, Ness AR Abstract OBJECTIVES: To compare risk factors and survival in people with oropharyngeal cancer (OPC) and cancer unknown primary (CUP). MATERIALS AND METHODS: We...
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