(From top to bottom) American chestnut, black cherry, tigerwood, and snakewood. (Jonathon Kambouris/)Experienced artisans can fashion almost anything from wood—as long as they have the right material. These four options offer them increasing levels of hardness.American chestnutCarpenters once used this hardwood for everything from construction to furniture. That changed in the early 1900s, when a fungus decimated the native population—but you can still find choice boards that have been reclaimed...
Sat May 02, 2020 18:00
Many moms would be delighted to receive a wine rack like this. (Jose Mendoza/)Mother’s Day is coming up, and you’re probably looking for a way to show Mom how much you appreciate her. Homemade gifts go a long way in that department, but if you’re older than seven, you’re going to have to do better than a macaroni “painting” of your family.Each of these five projects can come together easily in a weekend, leaving you enough time to pick a lovely wildflower bouquet or bake a cake in time for the holiday.Bath...
Sat May 02, 2020 12:00
Controllers, head phones, and more. (Screen Post via Unsplash/)The insidious nature of mobile gaming means that once you’ve found an app that suits your fancy you’re probably well beyond hooked. Sure, you could do the noble thing and try to find a more “productive” hobby, but sometimes you just need to relax. For those times, we suggest a few pieces of gear that make playing on your cell phone a more wholesome experience. Give your touchscreen a break with a controller. Hook up headphones so your...
Sat May 02, 2020 03:57
Cabin fever is a real problem. But it's one you can solve. (John Hafner/)This story originally featured on Outdoor Life.These days there’s enough fear and uncertainty to go around for everyone. Most folks are simply doing their best to hang tough and help keep themselves and others safe the best way they can. Many of us now find ourselves on lockdown, mandated to stay home. Some are lucky to have exceptions, and easy access to the outdoors, but some aren’t. There are a lot of folks out there who...
Sat May 02, 2020 01:00
Apple or onion? You decide. (PopSci/)We know you are bored at home right now—we are too. Here are some puzzles and brainteasers to challenge your family and friends with, either in person or over video chat.Our five senses—taste, touch, smell, hearing, and sight—don’t function in vacuums. They work together in intricate ways. Consider this: With our eyes covered and our nose plugged, we probably can’t distinguish an apple from an onion.Without our eyes to see, an apple is an apple and an onion an...
Fri May 01, 2020 21:31
We're lucky the sun isn't causing more of a ruckus. (NASA/SDO/)Boring. Humdrum. Monotonous. Those aren’t words most of us would usually associate with the miasma of incandescent plasma that makes life as we know it possible, but a recent study suggests that, as far as sun-like stars go, our own sun is a bit of a layabout.In a study published this week in the journal Science, researchers compared our sun to 369 stars deemed similar to the one at the center of our own solar system—ones that take between...
Fri May 01, 2020 19:42
Shoot hoops without leaving your house. (Brandi Redd via Unsplash/)Do you find yourself calling your shot when throwing your napkin into the trash, or bouncing ping pong balls idly off your ceiling? Maybe it’s time to add some follow-through to meet your athletic and entertainment goals. Whether you live in a small apartment or want to practice your three-pointers on the driveway, there’s a place for some basketball gear in your life. Here are our favorite picks.A home-office slam dunk. (Amazon/)Instead...
Fri May 01, 2020 19:09
Few things are better than ice cream you've made yourself. (John Kennedy/)Welcome to PopSci’s at-home science projects series. On weekdays at noon, we’ll be posting new projects that use ingredients you can buy at the grocery store. Show us how it went by tagging your project on social media using #popsciprojects.This is where we usually tell you why a project is fun, educational, or useful as justification for why you should make it yourself. But come on, we’re making ice cream. It’s a timeless...
Fri May 01, 2020 19:00
The Raspberry Pi camera has a big enough sensor to capture higher-quality images. (Raspberry Pi/)Even if you don’t fancy yourself a coder or maker, Raspberry Pi’s tiny, dirt cheap computers offer a great entry point into that world. Just $35 will get you the essential guts for a fully working computer (you supply the mouse, keyboard, monitor, and power supply). Now, the company has announced a high-quality camera module that works with its pint-sized computers. It has a 12-megapixel resolution, a...
Fri May 01, 2020 17:15
A place off the floor. (Amazon/)Having an infant is wonderful in many ways, but sometimes you need to put them down. It’s not that you don’t love holding them close, but we all need a moment to drink our coffee. You’ll be a better mom once you wake up, after all. The right play mat or gym will put your mind at ease. Your little one will be by your side, stimulated and comfortable, while you do the crossword. Here are four of our favorite baby mats and gyms that you will surely recommend to all your...
Fri May 01, 2020 15:44
This scanning electron microscope image shows SARS-CoV-2 (orange) isolated from a patient in the U.S., emerging from the surface of cells (green) cultured in the lab. (NIAID/)Follow all of PopSci’s COVID-19 coverage here, including tips on cleaning groceries, ways to tell if your symptoms are just allergies, and a tutorial on making your own mask.The hunt for pharmaceutical weapons to help beat the COVID-19 pandemic has already produced a few disappointments (and a few nonsensical suggestions regarding...
Fri May 01, 2020 17:23
Diaries can be an important time capsule to disease-fighting practices. (Kvkrillow/Deposit Photos/)Ute Lotz-Heumann is an associate professor and director of the Division for Late Medieval and Reformation Studies at the University of Arizona. This story originally featured on The Conversation.In early April, writer Jen Miller urged New York Times readers to start a coronavirus diary.“Who knows,” she wrote, “maybe one day your diary will provide a valuable window into this period.”During a different...
Fri May 01, 2020 03:00
A mortuary at Dover Air Force Base (William M. Plate Jr./)Follow all of PopSci’s COVID-19 coverage here, including tips on cleaning groceries, ways to tell if your symptoms are just allergies, and a tutorial on making your own mask.In the fight against disease, the dead are rarely thought of as an active part of war. But especially when it comes to an emerging virus like SARS-CoV-2, decedents are a crucial part of figuring out what exactly is going on inside infected people’s bodies. And that’s made...
Fri May 01, 2020 17:19
Your Canon DSLR will outshine your webcam's picture quality. (Canon /)Social distancing suddenly made webcams extremely important. People are flocking to video-chatting services and big tech companies like Facebook, Google, and Microsoft are providing users with an ever-increasing arsenal of options when it comes to face-to-face calling. Chances are, the webcam on your computer wasn’t ready for its new place in the spotlight. Many built-in computer webcams are still relatively low-resolution with...
Thu Apr 30, 2020 22:05
First steps to first steps. (Amazon/)When your little ones start pulling up on the couch, you know it is only a matter of time before they launch off and take their first steps. Perhaps your baby is perfectly happy scooching around on all fours, and you’d like to give them some encouragement to get upright. You can take a break from holding their hands all the time by setting them up with a baby walker. Some walkers even double as high chairs for those of you who don’t want extra clutter. It’s time...
Thu Apr 30, 2020 19:26
Fatty (but warm) hands. (Purbita Saha/)Welcome to PopSci’s at-home science projects series. On weekdays at noon, we’ll be posting new projects that use ingredients you can buy at the grocery store. Show us how it went by tagging your project on social media using #popsciprojects.When a gray whale swims from Alaska to Mexico in December to start a family, it doesn’t stop for a single meal or snack. Instead, it survives off the foot-thick layer of fat it gains after eating oily krill all summer long....
Thu Apr 30, 2020 19:28
Hear what you're working with. (ConvertKit via Unsplash/)When you’re editing audio or video, a proper set of headphones designed specifically for the task is essential for doing it right. The most common headphones produced for consumer use often accentuate different elements of the sonic spectrum to enhance the user’s listening experience, editing headphones are typically designed to be as accurate, un-enhanced and true-to-source as possible to help creatives make critical editing decisions. In...
Thu Apr 30, 2020 18:29
Huge predatory dinosaurs—like the abelisaur, a short-snouted predatory dinosaur and the pterosaur, both pictured here—once roamed regions of what is now the Sahara Desert. (Artwork by Davide Bonadonna, under the scientific supervision of Simone Maganuco and Nizar Ibrahim/)During these times of quarantine, last month feels like 100 million years ago. But if you were to actually go back to that period of time and make your way to the western Sahara, you’d likely run into a whole new set of problems...
Thu Apr 30, 2020 18:00
Convert browns, greens, and water into rich compost. (Markus Spiske via Unsplash/)Anyone can compost outdoors by making a pile surrounded by wood or wire, using a composter, or starting a worm farm to feast on your food scraps. Over a period of months to years, cultivate a mix of browns from your yard (like dead leaves and twigs), water, and greens (like food waste and coffee grounds). You’ll lower your carbon footprint, and create organic fertilizer that helps plants thrive. Here are our top picks...
Thu Apr 30, 2020 15:40
Early astronomers noticed this star detonate in 1572. While any dust it expelled hasn’t had nearly enough time to reach the moon, early explosions could have punched holes in lunar rocks. ( X-ray: NASA/CXC/RIKEN & GSFC/T. Sato et al; Optical: DSS/)Astronomers usually mine starlight for information. Flickers in the light that reaches earth regularly unveil new vignettes of distant systems—such as a muggy alien atmosphere, a pulsating stellar bulge, and a dead star snacking on an ice world.But...
Thu Apr 30, 2020 13:00
Summary Tivantinib has been described as a selective inhibitor of c-Met and is being studied in various types of cancer. In this study, we evaluated the effects of tivantinib on the suppression of gastric cancer (GC) cell migration and apoptosis. We also examined the mechanism of action of tivantinib by oncogenic pathway analysis. We applied an RNA-sequencing approach in 34 GC patients to identify oncogenes that are differentially expressed in GC tissues. To examine the inhibitory...
Sat May 02, 2020 03:00
Summary A new drug, Caba-780, was synthesized by chemical coupling of the heptamethyl phthalocyanine near-infrared fluorescent (NIRF) dye IR-780 and the paclitaxel-based chemotherapeutic drug cabazitaxel. Then, the potential value of Caba-780 in the diagnosis and treatment of castration-resistant prostate cancer (CRPC) was evaluated. The CRPC cell lines DU145 and PC-3, as well as the normal human prostate stromal cell line WPMY-1, were used to evaluate the uptake of Caba-780 and...
Sat May 02, 2020 03:00
We introduce a protocol for measuring real-time drug response in organotypic tumor tissue slices. The experimental strategy outlined here provides a platform to carry out medium-high throughput drug screens on tissue slices derived from clinical or mouse tumors in ex vivo conditions.
Sat May 02, 2020 21:33
This protocol describes the use of macromolecular crowding to create an in vitro human hypertrophic scar tissue model that resembles in vivo conditions. When cultivated in a crowded macromolecular environment, human skin fibroblasts exhibit phenotypes, biochemistry, physiology, and functional characteristics resembling scar tissue.
Fri May 01, 2020 22:25
This protocol describes an effective in situ hybridization approach to detect the mRNA expression levels and spatial patterns of target genes in Sipunculus nudus coelomic fluid.
Fri May 01, 2020 22:00
This research sets out a proposed protocol for the identification of dyslexia. The protocol is based on diagnostic and response to intervention models. The proposal involves using structured interviews and standardized tests for the assessment of reading and writing performance and determinant factors.
Fri May 01, 2020 21:00
Repeat-associated non-ATG-dependent translational products are emerging pathogenic features of several repeat expansion-based diseases. The goal of the protocol described is to evaluate toxicity caused by these peptides using behavioral and cellular assays in the model system C. elegans.
Thu Apr 30, 2020 22:20
We describe the creation of a rat model of pressure overload induced moderate remodeling and early systolic dysfunction where signal transduction pathways involved in the initiation of the remodeling process are activated. This animal model will aid in identifying molecular targets for applying early therapeutic anti-remodeling strategies for heart failure.
Thu Apr 30, 2020 22:00
We describe a tuberculosis molecular bacterial load assay test performed after heat inactivation of sputum. Heat inactivation renders sputum samples noninfectious and obviates the need for containment level 3 laboratories for tuberculosis molecular tests.
Thu Apr 30, 2020 20:20
Publication date: June 2020Source: Brain Research Bulletin, Volume 159Author(s):
Sat May 02, 2020 20:45
Publication date: Available online 30 April 2020Source: Brain Research BulletinAuthor(s): Ying Chen, Jiabing Shen, Chengxiao Ma, Maosheng Cao, Jianan Yan, Jingjing Liang, Kaifu Ke, Maohong Cao, Gu Xiaosu
Thu Apr 30, 2020 14:59
Abstract Chlorpyrifos, an organophosphate (OP) pesticide, possess broad-spectrum insecticidal activity against Lepidoptera, Diptera, Homoptera, Coleoptera, Orthoptera, Hymenoptera, and Hemiptera. Organophosphate pesticides have acute neurotoxicity because they suppress acetylcholine esterase (AChE) which regulates the enzyme of neurotransmitters by reducing acetylcholine concentration at synaptic junctions. On exposure to OP, AChE is inactivated and leads to accumulation of acetylcholine...
Sat May 02, 2020 03:00
Abstract Hot springs are fascinating extreme environments for the isolation of polyextremophilic microorganisms with extraordinary characteristics. Since polyextremophilic bacterial growth are not as high as routine bacteria, the objective of this study was to investigate the effect of some environmental factors on biomass and metabolites productions in the newly isolated strain, from Larijan hot spring in Iran. The strain was identified as Aeribacillus pallidus Lhs-10 and deposited...
Sat May 02, 2020 03:00
Publication date: June 2020Source: Journal of Human Evolution, Volume 143Author(s): Reuven Yeshurun, Dan Malkinson, Kathryn M. Crater Gershtein, Yossi Zaidner, Mina Weinstein-Evron
Sat May 02, 2020 19:28
Publication date: June 2020Source: Journal of Human Evolution, Volume 143Author(s): Iulia Bădescu, Pascale Sicotte, Aaron A. Sandel, Kelly J. Desruelle, Cassandra Curteanu, David P. Watts, Daniel W. Sellen
Fri May 01, 2020 18:49
Publication date: June 2020Source: Journal of Human Evolution, Volume 143Author(s): Ron Shimelmitz, Steven L. Kuhn, Mina Weinstein-Evron
Thu Apr 30, 2020 18:07
Publication date: June 2020Source: Journal of Human Evolution, Volume 143Author(s): Biren A. Patel, Caley M. Orr, Tea Jashashvili
Thu Apr 30, 2020 18:07
Publication date: June 2020Source: Journal of Human Evolution, Volume 143Author(s): Peter Andrews
Thu Apr 30, 2020 18:07
Publication date: Available online 1 May 2020Source: Medical HypothesesAuthor(s): Emilia Siemińska, Przemysław Sobczak, Natalia Skibińska, Joanna Sikora
Sat May 02, 2020 19:10
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