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Πέμπτη 6 Αυγούστου 2020

 


A Comprehensive, Flexible Collection of SARS-CoV-2 Coding Regions
The world is facing a global pandemic of COVID-19 caused by the SARS-CoV-2 coronavirus. Here we describe a collection of codon-optimized coding sequences for SARS-CoV-2 cloned into Gateway-compatible entry vectors, which enable rapid transfer into a variety of expression and tagging vectors. The collection is freely available. We hope that widespread availability of this SARS-CoV-2 resource will enable many subsequent molecular studies to better understand the viral life cycle and how to block it.
G3: .Genes, Genomes, Genetics Mission - Online First Articles
00:58
Mutator Foci Are Regulated by Developmental Stage, RNA, and the Germline Cell Cycle in Caenorhabditis elegans
RNA interference is a crucial gene regulatory mechanism in Caenorhabditis elegans. Phase-separated perinuclear germline compartments called Mutator foci are a key element of RNAi, ensuring robust gene silencing and transgenerational epigenetic inheritance. Despite their importance, Mutator foci regulation is not well understood, and observations of Mutator foci have been largely limited to adult hermaphrodite germlines. Here we reveal that punctate Mutator foci arise in the progenitor germ cells...
G3: .Genes, Genomes, Genetics Mission - Online First Articles
00:58
On the Distribution of Tract Lengths During Adaptive Introgression
Admixture is increasingly being recognized as an important factor in evolutionary genetics. The distribution of genomic admixture tracts, and the resulting effects on admixture linkage disequilibrium, can be used to date the timing of admixture between species or populations. However, the theory used for such prediction assumes selective neutrality despite the fact that many famous examples of admixture involve natural selection acting for or against admixture. In this paper, we investigate the effects...
G3: .Genes, Genomes, Genetics Mission - Online First Articles
00:58
Global Analysis of Cereal microProteins Suggests Diverse Roles in Crop Development and Environmental Adaptation
MicroProteins are class of small single-domain proteins that post-translationally regulate larger multidomain proteins from which they evolved or to which they relate. They disrupt the normal function of their targets by forming microProtein-target heterodimers through compatible protein-protein interaction (PPI) domains. Recent studies confirm the significance of microProteins in the fine-tuning of plant developmental processes such as shoot apical meristem maintenance and flowering time regulation....
G3: .Genes, Genomes, Genetics Mission - Online First Articles
00:58

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