Aim. The aim of the study was to determine the frequency of pathologies which can mimic normal-tension glaucoma (NTG), observed in neuroimaging of NTG patients, and to evaluate the frequency of pathologies in determined additional indications for neuroimaging. Material and Methods. The studied group consisted of 126 NTG patients who met at least one of the following criteria: unilateral NTG, damage in the visual field (VF) inconsistent with optic disc appearance, fast VF progression, worsening of...
Tue Aug 18, 2020 16:05
Aim. To explore the clinicopathological and prognostic role of PIK3CA gene mutation and expression in non-small-cell lung cancer (NSCLC) patients. Methods. A systematic and comprehensive literature search was conducted through EMBASE (via OVID), Web of Science, and PubMed. Relative risks (RRs) and hazard ratios (HRs) with 95% confidence intervals (CIs) were combined to evaluate the relationship of the PIK3CA gene with clinicopathological parameters and the survival of NSCLC patients, respectively....
Tue Aug 18, 2020 13:50
Circular RNAs (circRNAs) are endogenous RNAs with a covalently closed continuous loop, generated through various backsplicing events of pre-mRNA. An accumulating number of studies have shown that circRNAs are potential biomarkers for major human diseases such as cancer and Alzheimer’s disease. Thus, identification and prediction of human disease-associated circRNAs are of significant importance. To this end, a computational analysis-assisted strategy is indispensable to detect, verify, and quantify...
Tue Aug 18, 2020 13:35
Despite several available methodologies for Chagas disease (CD) serological screening, the main limitation of chronic CD diagnosis is the lack of effective tools for large-scale screening and point-of-care diagnosis to be used in different CD epidemiological scenarios. Taking into account that developing such a diagnostic tool will significantly improve the ability to identify CD carriers, we aimed at performing a proof-of-concept study (phase I study) to assess the use of these proteins in a point-of-care...
Tue Aug 18, 2020 13:20
The purpose of this study was to evaluate the long-term effects of half-time photodynamic therapy (PDT) on the retinal sensitivity in eyes with chronic central serous chorioretinopathy (CSC). Twenty-two eyes of 22 patients with chronic CSC were studied. PDT was applied with full-dose verteporfin and half-time laser duration. The best-corrected visual acuity (BCVA) and retinal sensitivity in the central 2 and 10 degrees were evaluated at the baseline, and at 12 and 24 months after the half-time PDT....
Tue Aug 18, 2020 13:20
Background. COVID-19 first broke out in China and spread rapidly over the world. Objectives. To describe the CT features of COVID-19 pneumonia and to share our experience at initial diagnoses. Patients and Methods. Data from 53 patients (31 men, 22 women; mean age, 53 years; age range, 16-83 years) with confirmed COVID-19 pneumonia were collected. Their complete clinical data was reviewed, and their CT features were recorded and analyzed. Results. The average time between onset of illness and the...
Tue Aug 18, 2020 12:20
Emerging data suggest that the gut microbiome is related to the pathophysiology of obesity. This study is aimed at characterizing the gut microbiota composition between obese and normal-weight Korean children aged 5-13. We collected fecal samples from 22 obese and 24 normal-weight children and performed 16S rRNA gene sequencing using the Illumina MiSeq platform. The relative abundance of the phylum Bacteroidetes was lower in the obese group than in the normal-weight group and showed a significant...
Tue Aug 18, 2020 12:05
A critical stage of shotgun proteomics is database search, a process which attempts to match the experimental spectra to the theoretical one. Given the considerable time and effort spent in analysis, it is self-evident for a researcher to aspire for rigorous computational analysis and a more confident and accurate peptide/protein identification. Mass spectrometry (MS) has been applied across several clinical disciplines. The pathophysiology of Stress Urinary Incontinence (SUI), caused by a damaged...
Tue Aug 18, 2020 12:05
Finding an optimal set of discriminative features is still a crucial but challenging task in biomedical science. The complexity of the task is intensified when any of the two scenarios arise: a highly dimensioned dataset and a small sample-sized dataset. The first scenario poses a big challenge to existing machine learning approaches since the search space for identifying the most relevant feature subset is so diverse to be explored quickly while utilizing minimal computational resources. On the...
Tue Aug 18, 2020 12:05
According to a new study published in the Journal of Studies on Alcohol and Drugs, your smartphone can tell you if you’re drunk. While this may seem like common sense to those who have witnessed the unsteady walk and unsavory speech from a friend who likely had a few too many drinks, a smartphone could be a proactive, real-time tool to complement a breathalyzer, help prevent drunk driving, and even reduce alcohol consumption for those trying to come clean. The premise is simple: in...
Tue Aug 18, 2020 21:16
Researchers in Brazil have developed a wearable sweat sensor made from microbial nanocellulose. The natural polymer provides a breathable interface with the underlying skin and allows sweat to travel through for electrochemical analysis using printed electrodes. The system can measure a wide variety of metabolites and biomarkers present in sweat, and could be useful for monitoring conditions such as diabetes. Wearable sensors are developing apace, and hold significant promise in monitoring...
Tue Aug 18, 2020 18:01
Diabetes is one of the world’s top causes of disease and death, affecting more than 450 million people worldwide. While technology has come a long way in helping to detect and manage diabetes, it still typically involves blood draws and clinical tools. Moreover, around half of all people with diabetes aren’t even aware that they have the disease. Researchers at UC San Francisco have now come up with a promising method of detecting diabetes using a smartphone camera and some deep learning,...
Tue Aug 18, 2020 16:48
Background Cancer classification is of great importance to understanding its pathogenesis, making diagnosis and developing treatment. The accumulation of extensive omics data of abundant cancer cell line provide basis for large scale classification of cancer with low cost. However, the reliability of cell lines as in vitro models of cancer has been controversial. Methods In this study, we explore the classification on...
Tue Aug 18, 2020 03:00
Background European brown hares (Lepus europaeus) and European rabbits (Oryctolagus cuniculus) are invasive pest species in Australia, with rabbits having a substantially larger environmental impact than hares. As their spatial distribution in Australia partially overlaps, we conducted a comparative microbiome study to determine how the composition of gastrointestinal microbiota varies between these species, since this may indicate species differences in diet, physiology, and other internal and...
Tue Aug 18, 2020 03:00
The Somali Sengi or Somali Elephant-shrew (‘Elephantulus’ revoilii, Macroscelidea, Mammalia) has been considered a “lost species” and is primarily known from about 39 museum specimens, with no new vouchered occurrence records since the early 1970s. The scientific literature contains no data concerning living Somali Sengi individuals and the species’ current Data Deficient conservation status is attributable to an absence of modern information. Almost everything that has been published about the species...
Tue Aug 18, 2020 03:00
Development of female flowers is an important process that directly affects the yield of Cucubits. Little information is available on the sex determination and development of female flowers in pumpkin, a typical monoecious plant. In the present study, we used aborted and normal pistils of pumpkin for RNA-Seq analysis and determined the differentially expressed genes (DEGs) to gain insights into the molecular mechanism underlying pistil development in pumpkin. A total of 3,817 DEGs were identified,...
Tue Aug 18, 2020 03:00
The Proboscideans, an order of mammals including elephants, are the largest of the Earth lands animals. One probable consequence of the rapid increase of their body size is the development of the trunk, a multitask highly sensitive organ used in a large repertoire of behaviours. The absence of bones in the trunk allows a substantial degree of freedom for movement in all directions, and this ability could underlie individual-level strategies. We hypothesised a stronger behavioural variability in simple...
Tue Aug 18, 2020 03:00
Background Reproductive biology and the evolutionary constraints acting on dispersal stages are poorly understood in many stony coral species. A key piece of missing information is egg and sperm gene expression. This is critical for broadcast spawning corals, such as our model, the Hawaiian species Montipora capitata, because eggs and sperm are exposed to environmental stressors during dispersal. Furthermore, parental effects such as transcriptome investment may provide a means for...
Tue Aug 18, 2020 03:00
Accurate characterization of the vaginal microbiome remains a fundamental goal of the Human Microbiome project (HMP). For over a decade, this goal has been made possible deploying high-throughput next generation sequencing technologies (NGS), which indeed has revolutionized medical research and enabled large-scale genomic studies. The 16S rRNA marker-gene survey is the most commonly explored approach for vaginal microbial community studies. With this approach, prior studies have elucidated substantial...
Tue Aug 18, 2020 03:00
The Indonesian archipelago is one of the most diverse regions in the marine World. Many contributions on polychaete worms have been published since the Dutch Siboga Expedition to the Indonesian archipelago at the end of the 19th century. In this study, we examined specimens of Sabellidae Latreille, 1825 collected during the Snellius II Expedition (1984) to Indonesia, carried out by the Dutch Research Vessel (RV) “Tyro” and the Indonesian RV “Samudera”. The results include reports of Acromegalomma...
Tue Aug 18, 2020 03:00
Background Lipid metabolism factors may play an important role in the progression of nonalcoholic fatty liver disease (NAFLD) and its related cardiovascular dysfunctions. The study aims to assess whether Apolipoprotein A-1 (ApoA1) was associated with vascular stiffness in NAFLD patients. Methods From 2012 to 2013, we included 2,295 non-alcohol users with fatty liver disease (1,306 male patients) and completely excluded subjects who drank any alcohol ever to eliminate the effect of alcohol...
Tue Aug 18, 2020 03:00
Objective Pelvic organ prolapse (POP) refers to the decline of pelvic organ position and dysfunction caused by weak pelvic floor support. The aim of the present study was to screen the hub genes and immune cell infiltration related to POP disease. Methods Microarray data of 34 POP tissues in the GSE12852 gene expression dataset were used as research objects. Weighted gene co-expression network analysis (WGCNA) was performed to elucidate the hub module and hub genes related to POP occurrence....
Tue Aug 18, 2020 03:00
Publication date: 1 September 2020Source: International Journal of Radiation Oncology*Biology*Physics, Volume 108, Issue 1Author(s):
Tue Aug 18, 2020 23:59
Publication date: 1 September 2020Source: International Journal of Radiation Oncology*Biology*Physics, Volume 108, Issue 1Author(s): Sanjay A. Joseph, Srinivasan Vijayakumar
Tue Aug 18, 2020 23:59
Publication date: 1 September 2020Source: International Journal of Radiation Oncology*Biology*Physics, Volume 108, Issue 1Author(s): Stanley I. Gutiontov, Sean P. Pitroda, Steven J. Chmura, Ainhoa Arina, Ralph R. Weichselbaum
Tue Aug 18, 2020 23:59
Publication date: 1 September 2020Source: International Journal of Radiation Oncology*Biology*Physics, Volume 108, Issue 1Author(s): Silvia C. Formenti, Sandra Demaria
Tue Aug 18, 2020 23:59
Publication date: 1 September 2020Source: International Journal of Radiation Oncology*Biology*Physics, Volume 108, Issue 1Author(s): Anthony L. Zietman, Sue S. Yom
Tue Aug 18, 2020 23:59
Publication date: 1 September 2020Source: International Journal of Radiation Oncology*Biology*Physics, Volume 108, Issue 1Author(s):
Tue Aug 18, 2020 23:59
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