New Findings What is the central question of this study? What is the impact of airway cholinergic history on airway mucus secretion properties in a cystic fibrosis‐like environment? What is the main finding and its importance? Prior cholinergic challenge mildly modifies mucus secretion characteristics to second cholinergic challenge in a diminished bicarbonate and chloride transport environment. Such modifications may lead to retention of mucus on the airway surface, thereby potentiating...
Fri Jul 31, 2020 16:34
Abstract Tetramerized single-chain variable fragment (ScFv) of anti-cyclic citrullinated peptide (TeAb-CCP) is a constructed tetramerized ScFv of anti-cyclic citrullinated peptide (CCP) antibodies with p53 tetrameric domain, aim to investigate its effect on fibroblast-like synoviocytes (FLSs) proliferation, migration, invasion, and production of inflammatory mediators in the in vitro co-culture system of peripheral mononuclear cells...
Sat Aug 01, 2020 03:00
Abstract The analysis of the similarity of the brain response of different individuals using intersubject correlation (ISC) can be used to uncover the neural mechanisms behind the processing of complex audiovisual stimuli, and to understand how the brain works in real‐life situations. Previous research on ISC reported anecdotal evidence of larger ISC during emotional scenes compared to neutral ones, but this effect has not been systematically investigated using standardized emotional movies. Moreover,...
Fri Jul 31, 2020 20:15
Key points Motor units, comprising a motor neuron and the muscle fibre it innervates, are activated in an orderly fashion to provide varying amounts of force. A unilateral C2 spinal hemisection (C2SH) disrupts predominant excitatory input from medulla, causing cessation of inspiratory‐related diaphragm muscle activity, whereas higher force, non‐ventilatory diaphragm activity persists. In this study, we evidence a disproportionately larger loss of excitatory glutamatergic innervation to small...
Fri Jul 31, 2020 16:34
Key points β‐NAD is a key inhibitory neurotransmitter in the colon. The neuroeffector junction in the gut consists of enteric motor neurons and SIP syncytium, including smooth muscle cells (SMCs), interstitial cells of Cajal (ICC), and cells expressing platelet‐derived growth factor receptor α (PDGFRα+ cells). Measuring metabolism of 1,N 6‐etheno‐NAD (eNAD) in colonic tunica muscularis and in SMCs, ICC, and PDGFRα+ cells with HPLC‐FLD, we report that 1) in tissues, eNAD is degraded to eADP‐ribose,...
Fri Jul 31, 2020 16:34
Key points Ketone bodies are proposed to represent an alternative fuel source driving energy production, particularly during exercise. Biologically, the extent to which mitochondria utilize ketone bodies compared to other substrates remains unknown. We demonstrate in vitro that maximal mitochondrial respiration supported by ketone bodies is low when compared to carbohydrate‐derived substrates in the left ventricle and red gastrocnemius muscle from rodents, and in human skeletal muscle. When...
Fri Jul 31, 2020 16:33
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