Abstract Immune checkpoint inhibitors (ICI) improve the ability of the immune system to target cancer cells by blocking signaling through either the cytotoxic T‐lymphocyte‐associated antigen 4 (CTLA‐4), programmed cell death (PD‐1) receptor, or its ligand (PD‐L1). They have been found to cause a variety of immune‐related adverse events (irAEs) including a form of nonscarring alopecia that resembles alopecia areata (AA) in presentation and histology. Clinical features of ICI‐induced AA are poorly...
Abstract Surgical treatment of vitiligo lesions over the fingers has poor outcome. Three variations were used in treatment of finger vitiligo lesions: minipuch grafting, melanocytes keratinocyte transplantation procedure (MKTP) preceded by cryoblebbing or full CO2 laser resurfacing of the recipient site. An intra‐patient comparative study including 12 patients with stable non‐ segmental vitiligo (NSV) affecting the middle 3 fingers of one hand. Liquid nitrogen was used to create blebs in one finger...
Abstract There is a need for adjuvant imaging techniques that would allow reducing the number of slow Mohs stages. This study aimed to evaluate the use of dermoscopy in the demarcation of basal cell carcinoma (BCC) surgical margins for slow Mohs surgery. This was a retrospective study over 3 years (2016‐2019), including patients with BCC excised using slow Mohs surgery. On the basis of the treatment received, the patients were divided into 2 groups: group 1 (28 BCC) and group 2 (26 BCC). In group...
Abstract BACKGROUND Oral oxybutynin (OOx) is an effective and safe treatment for the treatment of hyperhidrosis (HH). However, in some patients a loss of efficacy during prolonged treatment has been observed. Analysis of these cases could enable us to identify patients susceptible to OOx tolerance. An alternative treatment might then be considered. OBJECTIVES To assess tolerance to OOx in the treatment of HH. Secondarily, to assess epidemiological data and the duration of efficacy, together...
Abstract Calcium hydroxylapatite (CaHA) is a biostimulatory filler with long lasting efficacy after a single injection. Data con the effect of repeated injections, however, are sparse. This is a single‐center observational study. Forty Caucasian females of Fitzpatrick skin type I to III, aged between 50 and 95 years (mean age 63 ± 13.4 years), and seeking non‐surgical improvement of facial aging were included. Patients with previous face lifts, threads or other surgical treatments were excluded....
Raynaud phenomenon is a vasospastic disorder clinically characterized by cold or stress‐induced discoloration of the skin, pain and ulcers of the fingers or toes. Although this phenomenon might be self‐limiting, there is a subgroup of patients requiring a therapeutic approach. The majority of patients do well on conservative measures, however, there is also a subgroup requiring systemic treatment. The efficacy of these systemic treatments is currently not thoroughly investigated. Furthermore, no...
The medical community in the past months has seen a flourishing of information related to the SARS‐CoV‐2 virus responsible for the COVID‐19 pandemic. From the early days of the pandemic, the SARS‐CoV‐2 virus has been linked to multiple different types of skin involvement. To the best of our knowledge, we are the first to report on a case of familial clustering of a maculopapular COVID‐19 rash. 8 persons presented COVID‐19 symptoms, 6 were confirmed via SAR‐CoV‐2 chemoluminescent immunoassays, and...
Abstract Mycobacterium caprae (M. caprae), a member of the Mycobacterium tuberculosis complex (MTC) causes tuberculosis in man and animals, but the incidence in humans is very low worldwide. Direct contact with animals and with unpasteurized dairy products is the most frequent source of contagion. Cutaneous tuberculosis (CT) supposes a diagnostic challenge due to its variety of clinical manifestations and the difficulty in demonstrating resistant acid‐alcohol bacilli in histological samples. In...
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