The Journal of Physiology
- Corticospinal excitability modulation by pairing peripheral nerve stimulation with cortical states of movement initiationKey points We compare the effects on corticospinal excitability of repeatedly delivering peripheral nerve stimulation at three time points (−30 ms, 0 ms, +50 ms) relative to muscle onset in a cue‐guided task. Plastic changes in excitability are only observed when stimuli are delivered immediately before the time when muscles activate, while stimuli delivered at muscle onset or shortly later (0, +50 ms) have no effect. Plastic effects are abo
Anthropology-News
- Witnessing Puerto Rico, Recognition, and Feeling in the Wake of Hurricane MariaAs the plane descended to land in San Juan’s Airport in August 2018, almost a year after Hurricane Maria jolted Puerto Ricans on the island and elsewhere, I looked out the window. As my ears began to pop, I pushed the window shade and looked out. I saw water and greenery as I searched for imprints of Maria from up high. But, instead my eyes noticed large areas of blue. These blue blurs were not water. I decided almost instantly they must be solar
Radiology
- Scleroderma CXR: eQ Series on eMedicozHere is brief video discussing integrated question on CXR findings of scleroderma, discussed by Dr Sumer Sethi. Many such teaching videos available on eMedicoz app. Download it by clicking on links below:Android : http://bit.ly/emedicozandroidiOS: http://bit.ly/emedicozIOSFamous Radiology Blog http://www.sumerdoc.blogspot.com TeleRad Providers at www.teleradproviders.com Mail us at sales@teleradproviders.com
Medical Image Analysis
- IDRiD: Diabetic Retinopathy – Segmentation and Grading ChallengePublication date: Available online 3 October 2019Source: Medical Image AnalysisAuthor(s): Prasanna Porwal, Samiksha Pachade, Manesh Kokare, Girish Deshmukh, Jaemin Son, Woong Bae, Lihong Liu, Jianzong Wang, Xinhui Liu, Liangxin Gao, TianBo Wu, Jing Xiao, Fengyan Wang, Baocai Yin, Yunzhi Wang, Gopichandh Danala, Linsheng He, Yoon Ho Choi, Yeong Chan Lee, Sang Hyuk JungAbstractDiabetic Retinopathy (DR) is the most common cause of avoidable vision l
Annals of Intensive Care - Latest Articles
- Direct admission to the intensive care unit from the emergency department and mortality in critically ill hematology patientsThe aim of this study was to assess the benefit of direct ICU admission from the emergency department (ED) compared to admission from wards, in patients with hematological malignancies requiring critical care.
- Inflammatory macrophages switch to CCL17‐expressing phenotype and promote peritoneal fibrosisAbstract Peritoneal fibrosis remains a problem in kidney failure patients treated with peritoneal dialysis. Severe peritoneal fibrosis with encapsulation or encapsulating peritoneal sclerosis is devastating and life‐threatening. Although submesothelial fibroblasts as the major precursor of scar‐producing myofibroblasts in animal models and M2 macrophage (Mϕ)‐derived chemokines in peritoneal effluents of patients before diagnosis of encapsulating
- Genetic or pharmacologic blockade of enhancer of zeste homolog 2 inhibits the progression of peritoneal fibrosisAbstract Dysregulation of histone methyltransferase enhancer of zeste homolog 2 (EZH2) has been implicated in the pathogenesis of many cancers. However, the role of EZH2 in peritoneal fibrosis remains unknown. We investigated EZH2 expression in peritoneal dialysis (PD) patients and assessed its role in peritoneal fibrosis in cultured human peritoneal mesothelial cells (HPMCs) and murine models of peritoneal fibrosis induced by chlorhexidine gluc
- Molecular mechanisms in chaperonopathies: clues to understanding the histopathological abnormalities and developing novel therapiesABSTRACT Molecular chaperones, many of which are heat shock proteins (Hsp), are components of the chaperoning system and when defective can cause disease, the chaperonopathies. Chaperone‐gene variants cause genetic chaperonopathies, whereas in the acquired chaperonopathies the genes are normal, but their protein products are not, due to aberrant post‐transcriptional mechanisms, e.g., post‐translational modifications (PTM). Since the chaperoning
- Dysregulation of AMPA receptor subunit expression in sporadic ALS post‐mortem brainABSTRACT Amyotrophic lateral sclerosis (ALS) is characterised by progressive motor neuron degeneration. Although there are over 40 genes associated with causal monogenetic mutations, the majority of ALS patients are not genetically determined. Causal ALS mutations are being increasingly mechanistically studied, though how these mechanisms converge and diverge between the multiple known familial causes of ALS (fALS) and sporadic forms of ALS (sAL
- Voice and Lifestyle Behaviors of Speech-Language Pathology Students: Impact of History Gathering Method on Self-Reported DataPublication date: Available online 2 October 2019Source: Journal of VoiceAuthor(s): Jeff Searl, Troy DarginAbstractObjectivesThis study described voice use and lifestyle information from student speech-language pathologists (SLP) and assessed the impact of history gathering method on the acquired data.MethodsOne hundred sixty-two SLP students completed a detailed history form and estimated voice and life style parameters at study intake and subse
- Sensitivity, Specificity, and Reproducibility of the Brazilian Portuguese Version of the Reflux Symptom IndexPublication date: Available online 2 October 2019Source: Journal of VoiceAuthor(s): Claudia A. Eckley, Rodrigo TangerinaSummaryIntroductionThe diagnosis of laryngopharyngeal reflux is controversial. There is currently no gold standard, so it relies mainly on suspicious clinical symptoms and videolaryngoscopic findings. Unfortunately these signs and symptoms are common to other causes of chronic laryngitis. Scoring systems have been proposed to re
Molecular Cancer Therapeutics Online First Articles
- The novel ATR inhibitor BAY 1895344 is efficacious as monotherapy and combined with DNA damage-inducing or repair-compromising therapies in preclinical cancer modelsThe DNA damage response (DDR) secures the integrity of the genome of eukaryotic cells. DDR deficiencies can promote tumorigenesis but concurrently may increase dependence on alternative repair pathways. The ataxia telangiectasia and Rad3-related (ATR) kinase plays a central role in the DDR by activating essential signaling pathways of DNA damage repair. Here, we studied the effect of the novel selective ATR kinase inhibitor BAY 1895344 on tumor c
- Minicircle DNA-Engineered CAR T Cells Suppressed Tumor Growth in MiceViral-based CAR T cell manufacturing has potential safety risks and relatively high costs. The non-viral minicircle DNA (mcDNA) is safer for patients, cheaper to produce, and may be a more suitable technique to generate CAR T cells. In this study, we produced mcDNA-based CAR T cells specifically targeting PSCA (mcDNA-PSCA-CAR T cells). Our results showed that mcDNA-PSCA-CAR T cells persisted in mouse peripheral blood as long as 28 days and demons
- Dual inhibition of angiopoietin-TIE2 and MET alters the tumor microenvironment and prolongs survival in a metastatic model of renal cell carcinomaReceptor tyrosine kinase inhibitors have shown clinical benefit in clear cell renal cell carcinoma (ccRCC) but novel therapeutic strategies are needed. The angiopoietin/Tie2 and MET pathways have been implicated in tumor angiogenesis, metastases, and macrophage infiltration. In our study, we used trebananib, an angiopoietin 1/2 inhibitor and a novel small molecule MET kinase inhibitor in patient derived xenograft (PDX) models of ccRCC. Our goal w
- Ibrutinib potentiates anti-hepatocarcinogenic efficacy of sorafenib by targeting EGFR in tumor cells and BTK in immune cells in the stromaHepatocellular carcinoma (HCC), the most prevalent primary liver cancer, is a leading cause of cancer-related death worldwide because of rising incidence and limited therapy. Although treatment with sorafenib or lenvatinib is the standard of care in advanced-stage HCC patients, the survival benefit from sorafenib is limited due to low response rate and drug resistance. Ibrutinib, an irreversible tyrosine kinase inhibitor (TKI) of TEC (e.g. BTK) a
- A multi-functional therapy approach for cancer: targeting Raf1- mediated inhibition of cell motility, growth and interaction with the microenvironmentProstate cancer (PCa) cells move from their primary site of origin, interact with a distant microenvironment, grow and thereby cause death. It had heretofore not been possible to selectively inhibit cancer cell motility. Our group has recently shown that inhibition of intracellular activation of Raf1 with the small molecule therapeutic, KBU2046, permits for the first time selective inhibition of cell motility. We hypothesized that simultaneous di
Mucosal Immunology - Issue - nature.com science feeds
- Fine tuning of the DNAM-1/TIGIT/ligand axis in mucosal T cells and its dysregulation in pediatric inflammatory bowel diseases (IBD)Mucosal Immunology, Published online: 03 October 2019; doi:10.1038/s41385-019-0208-7Fine tuning of the DNAM-1/TIGIT/ligand axis in mucosal T cells and its dysregulation in pediatric inflammatory bowel diseases (IBD)
Evolutionary Biology News -- ScienceDaily
- Ant-plant partnerships may play unexpected role in ant evolutionPartnerships between ant and plant species appear to arise from -- but not drive -- rapid diversification of ants into new species.
- How the influenza virus achieves efficient viral RNA replicationResearchers offer new insights on how subunits of the influenza virus polymerase co-evolve to ensure efficient viral RNA replication.
- How the Texas puma saved the Florida pantherScientists have pieced together the first complete picture of the Florida panther genome -- work that could serve to protect that endangered population and other endangered species going forward.
- Genomes of parasitic mites harming the world's bees sequencedResearchers sequenced the genomes of the two Varroa mite species that parasitize the honey bee. They found that each species of mite used its own distinct strategy to survive in its bee host, potentially overwhelming the bees' defenses. In addition to pointing to how scientists might vanquish these deadly intruders, the findings also shed light on how parasites and hosts evolve in response to one another.
Clinical Cancer Research Online First Articles
- HER2-overexpressing/amplified breast cancer as a testing ground for antibody-drug conjugate drug development in solid tumorsEfficacy data from the KATHERINE clinical trial comparing ado-trastuzumab emtansine (T-DM1) to trastuzumab in patients with early-stage human epidermal growth factor receptor 2 (HER2)-overexpressing breast cancer with residual disease after neoadjuvant therapy (hazard ratio for invasive disease or death, 0.50; P<0.001). This establishes foundational precedent for antibody drug conjugates (ADCs) as effective therapy for treatment of subclinical mi
- The outcome of TGF{beta} antagonism in metastatic breast cancer models in vivo reflects a complex balance between tumor-suppressive and pro-progression activities of TGF{beta}Purpose: Transforming growth factor-βs (TGF-βs) are overexpressed in many advanced cancers and promote cancer progression through mechanisms that include suppression of immunosurveillance. Multiple strategies to antagonize the TGF-β pathway are in early phase oncology trials. However, TGF-βs also have tumor suppressive activities early in tumorigenesis, and the extent to which these might be retained in advanced disease has not been fully explo
- ctDNA in gastric and gastroesophageal cancer: prognostic, predictive or preliminary?In gastric and gastroesophageal adenocarcinoma, ctDNA identifies molecular drivers missed using routine tumor biopsy, can refine patient selection for targeted therapy, and may be prognostic following surgical resection. However, lack of standardisation could impede adoption of this technology as a clinically useful tool; prospective validation in clinical trials is required.
- Molecular imaging of extracellular tumor pH to reveal effects of loco-regional therapy on liver cancer microenvironmentPurpose: To establish MR-based molecular imaging paradigms for the non-invasive monitoring of extracellular pH (pHe) as a functional surrogate biomarker for metabolic changes induced by loco-regional therapy of liver cancer. Experimental Design: Thirty-two VX2 tumor-bearing New Zealand White rabbits underwent longitudinal imaging on clinical 3T-MRI and CT scanners before and up to 2 weeks after complete conventional transarterial chemoembolizati
- Intratumoral delivery of plasmid interleukin-12 via electroporation leads to regression of injected and non-injected tumors in Merkel cell carcinomaPurpose: Interleukin-12 (IL-12) promotes adaptive type-1 immunity and has demonstrated anti-tumor efficacy, but systemic administration leads to severe adverse events (AEs), including death. This pilot trial investigated safety, efficacy, and immunologic activity of intratumoral delivery of IL-12 plasmid DNA (tavo) via in vivo electroporation (i.t.-tavo-EP) in patients with Merkel cell carcinoma (MCC), an aggressive virus-associated skin cancer.
- Back Cover: Diaphragm‐based optical fiber sensor for pulse wave monitoring and cardiovascular diseases diagnosis (J. Biophotonics 10/2019)A wearable device based on fiber optic biosensor for high‐precision radial pulse wave monitoring and diagnosis is proposed and demonstrated in this article. Owing to the high sensitivity of the tiny fiber tip with aluminum diaphragm assembled in the sportswristband, weak acoustic signal induced by arterial pulse can be high‐fidelity recovered and then quantitatively analyzed for clinical diagnosis, which is promising in early cardiovascular disea
- Front Cover: Capsule optoacoustic endoscopy for esophageal imaging (J. Biophotonics 10/2019)A novel capsule optoacoustic endoscopy (COE) system is built which provides high‐quality 360‐degree images of the entire lumen, specifically designed for typical dimensions of human esophagus. The pill‐shaped encapsulated probe consists of a novel and highly sensitive ultrasound transducer fitted with an integrated miniature pre‐amplifier. For the first time, ex vivo volumetric vascular network images to a depth of 2 mm in swine esophageal lining
- Risk of CIN2 or more severe lesions after negative HPV‐mRNA E6/E7 overexpression assay and after negative HPV‐DNA test: concurrent cohorts with a 5‐year follow upAim of this study was to compare the 5‐year risk of CIN2+ / CIN3+ and the performance parameters at 3‐year re‐screening of a negative E6/E7 mRNA‐Human Papillomavirus (HPV) test with those of a HPV‐DNA negative test. We studied a cohort of HPV‐negative women tested with the Aptima HPV mRNA Assay (“HPV‐mRNA cohort”) versus a cohort of HPV‐negatives tested with the Hybrid Capture 2 DNA test living in neighboring areas. Both cohorts were re‐screened
- Chronic Oral Anticoagluation and Risk of Prostate Cancer: Evidence of Detection BiasWarfarin treatment has been associated with lower risks of prostate cancer, without a specified biological mechanism. This study tested the hypothesis that reluctance to perform prostate biopsies in men who are anticoagulated results in lower rates of diagnosed prostate cancer, leading to an apparent protective effect. Rates of prostate biopsies have decreased from 2000 to 2015, allowing calendar time to be used as the intervention. In a national
- Sex‐specificity in lung cancer riskSmoking is indisputably linked to lung cancer, yet only a small fraction of smokers develops this disease. While previously tobacco derived carcinogens and enzyme polymorphisms have been identified to increase the risk for smokers, recent epidemiological data suggest even sex‐specificity as a new and additional factor. Obviously, women have a higher risk to develop lung cancer upon smoking than men. Overall, the odds ratio to develop lung cancer
- Racial differences in characteristics and prognoses between Asian and white patients with non‐small cell lung cancer receiving atezolizumab: an ancillary analysis of the POPLAR and OAK studiesThis study aimed to compare the differences in characteristics and prognoses between Asian and white patients receiving immunotherapy for non‐small cell lung cancer (NSCLC). We studied 390 patients who received atezolizumab as part of the POPLAR or OAK trial, and analyzed the differences in baseline characteristics, outcomes, and genetic mutations in blood samples between Asian and white patients. Overall survival (OS) was longer in Asian compare
- The impact of current treatment modalities on the outcomes of patients with melanoma brain metastases: a systematic reviewPatients with melanoma brain metastases (MBM) still have a very poor prognosis. Several treatment modalities have been investigated in an attempt to improve the management of MBM. This review aimed to evaluate the impact of current treatments for MBM on patient‐ and tumor‐related outcomes, and to provide treatment recommendations for this patient population. A literature search in the databases PubMed, Embase, Web of Science and Cochrane was cond
- Inflammatory serum markers and risk and severity of prostate cancer. The PROCA‐life StudyWhether chronic inflammation mirrored by high levels of systemic inflammatory markers such as high sensitive‐CRP (hs‐CRP) and white blood cell count (WBC) are associated with prostate cancer development remains unclear. In the Prostate Cancer Study throughout Life (PROCA‐life), a prospective population‐based cohort study, 7,356 men were included. Pre‐diagnostic WBC and hs‐CRP were assessed from blood collected at study entry; 2,210 participants a
- Oral Human Papillomavirus Prevalence and Type Distribution by Country (Brazil, Mexico and the United States) and Age among HPV Infection in Men (HIM) Study ParticipantsIncidence of human papillomavirus (HPV) attributable oropharyngeal cancers (OPCs) has been increasing globally, especially among men in high income countries. There is a lack of studies comparing oral HPV prevalence by age and country among healthy men. The purpose of this study was to assess oral HPV prevalence by country and age. Participants of the HPV Infection in Men study (HIM), a cohort of 3,098 healthy men from São Paulo, Brazil, Cuernava
- Unique and redundant roles of SOX2 and SOX17 in regulating the germ cell tumour fateEmbryonal carcinomas (ECs) and seminomas are testicular germ cell tumours. ECs display expression of SOX2, while seminomas display expression of SOX17. In somatic differentiation, SOX17 drives endodermal cell fate. However, seminomas lack expression of endoderm markers, but show features of pluripotency. Here, we use ChIP‐sequencing to report and compare the binding pattern of SOX17 in seminoma‐like TCam‐2 cells to SOX17 in somatic cells and SOX2
- Endoscopy for gastroesophageal reflux disease and survival in esophageal adenocarcinomaGastroesophageal reflux disease (GERD) is a risk factor of esophageal adenocarcinoma (EAC) and the most common indication for upper gastrointestinal endoscopy. Yet, whether GERD or endoscopy practice influence survival in EAC is largely unknown and was assessed in this study. This nationwide cohort study included all Swedish residents diagnosed with EAC in 1997‐2013 with follow‐up to 2018. Exposures were history of GERD and endoscopies prior to
- Comparison of the 7th and 8th edition AJCC classification system in oral cavity squamous cell cancersThe aim of our study was to evaluate the predictive ability of the AJCC 8th edition staging system for oral cavity cancers and validate these changes rendering the hypothesis of improving prognostication. We conducted a retrospective study including all OCSCC patients visiting our tertiary centre from 2012 to 2015, staged as per the 7th and 8th edition AJCC systems. Stage‐specific disease‐free survival (DFS) and Overall survival (OS) was calcula
- Epidemiological Evidence that Common HPV Types May Be Common Because of Their Ability to Evade Immune Surveillance: Results from the Women's Interagency HIV StudyInfection by human papillomavirus (HPV) type 16, the most oncogenic HPV type, was found to be the least affected by HIV‐status and CD4 count of any of the approximately 13 oncogenic HPV types. This relative independence from host immune status has been interpreted as evidence that HPV16 may have an innate ability to avoid the effects of immunosurveillance. However, the impact of immune status on other individual HPV types has not been carefully a
- Genetic Alterations of Epithelial Polarity Genes are Associated with Loss of Polarity in Invasive Breast CancerBreast cancer remains a leading cause of cancer‐related death for women. The stepwise development of breast cancer through pre‐invasive to invasive disease is associated with progressive disruption of cellular and tissue organization. Apical‐basal polarity is thought to be a barrier to breast cancer development, but the extent and potential mechanisms that contribute to disrupted polarity are incompletely understood. To investigate the cell polar
- Genome‐wide association study of INDELs identified four novel susceptibility loci associated with lung cancer riskGenome‐wide association studies (GWAS) have identified 45 susceptibility loci associated with lung cancer. Only less than SNPs, small insertions and deletions (INDELs) are the second most abundant genetic polymorphisms in the human genome. INDELs are highly associated with multiple human diseases, including lung cancer. However, limited studies with large‐scale samples have been available to systematically evaluate the effects of INDELs on lung c
- Long Noncoding RNA TC0101441 induces epithelial‐mesenchymal transition in epithelial ovarian cancer metastasis by downregulating KiSS1Peritoneal metastasis is a critical feature and clinical challenge in epithelial ovarian cancer (EOC). We previously identified a novel long noncoding RNA (lncRNA, TC0101441) in epithelial ovarian cancer (EOC) using microarrays. However, the impact of TC0101441 on EOC metastasis and prognosis remains unclear. TC0101441 expression in EOC tissues and its correlation with clinicopathological factors and prognosis were examined. A series of in vitro
ΩτοΡινοΛαρυγγολόγος Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,
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00302841026182,
00306932607174,
alsfakia@gmail.com,
Anapafseos 5 Agios Nikolaos 72100 Crete Greece,
Medicine by Alexandros G. Sfakianakis
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