Journal of Adolescent and Young Adult Oncology, Ahead of Print.
Wed Oct 30, 2019 09:00
Future Oncology, Ahead of Print.
Wed Oct 30, 2019 07:29
Future Oncology, Ahead of Print.
Wed Oct 30, 2019 07:06
Future Oncology, Ahead of Print.
Wed Oct 30, 2019 06:35
Future Oncology, Ahead of Print.
Wed Oct 30, 2019 06:03
Future Oncology, Ahead of Print.
Wed Oct 30, 2019 05:11
British Journal of Cancer, Published online: 31 October 2019; doi:10.1038/s41416-019-0616-1Patient-derived organoids as a potential model to predict response to PD-1/PD-L1 checkpoint inhibitors
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British Journal of Cancer, Published online: 31 October 2019; doi:10.1038/s41416-019-0603-6Circulating biomarkers in patients with glioblastoma
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Purpose: The clinical utility of plasma cell-free DNA (cfDNA) has not been assessed prospectively in patients with glioblastoma (GBM). We aimed to determine the prognostic impact of plasma cfDNA in GBM, as well as its role as a surrogate of tumor burden and substrate for next-generation sequencing (NGS). Experimental Design: We conducted a prospective cohort study of 42 patients with newly diagnosed GBM. Plasma cfDNA was quantified at baseline prior to initial tumor resection and longitudinally during...
Wed Oct 30, 2019 15:25
Cancer patients who have exhausted standard treatments often seek access to investigational drugs. Often, however, such access is unavailable, due to either the unavailability of a trial, lack of an open recruiting spot on the trial, even when the trial itself is open, or the inability of the patient to meet one or more trial eligibility criteria. In such settings patients often seek access to investigational agents outside of a trial. The federal "Right to Try" legislation was passed to create...
Wed Oct 30, 2019 15:25
Wed Oct 30, 2019 14:28
Two large randomized controlled trials (NLST, NELSON) revealed a significant decrease in lung cancer mortality with LD CT screening but its implementation is still debatable.The aims of our prospective multicentre study were to assess the implementation of a lung cancer screening program in a real-life setting.Our study demonstrates the feasibility of this screening program in the general population.
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Allergan has agreed to pay $750m (£580m ;€680m) to settle claims from a group of US direct purchasers that it used anti-competitive practices to block them from buying cheaper generic alternatives...
Wed Oct 30, 2019 19:11
Nearly 900 children under 12 are among 1112 cases of HIV infection now confirmed in an outbreak linked to a paediatrician in Ratodero, Pakistan, who reused syringes and IV drips.Authorities fear that...
Wed Oct 30, 2019 18:26
Van Hove and Leng say that metered dose inhalers are a similar price to dry powder inhalers.1 This might be true for some inhalers, but because of the far greater use of plain metered dose inhalers...
Wed Oct 30, 2019 16:21
Van Hove and Leng, of the National Institute for Health and Care Excellence (NICE), are right to call for a more sustainable NHS, but wrong about a system-wide approach being needed to move us...
Wed Oct 30, 2019 14:50
The government has announced that 78 NHS trusts in England will receive funding over the next two years to replace, refurbish, or upgrade computed tomography (CT) machines, magnetic resonance imaging...
Wed Oct 30, 2019 14:31
Nominations have opened for the 2020 BMJ Awards, which will once again celebrate outstanding achievements in medicine.Doctors have until Friday 17 January 2020 to submit entries on behalf of...
Wed Oct 30, 2019 13:41
This study aims to explore whether E545K, the most common hot-spot mutation of PIK3CA in cervical cancer, confers radioresistance to cervical cancer cells, to demonstrate the underling mechanism and to develop the effective targets. SiHa and MS751 cells with PIK3CA-WT and PIK3CA-E545K were established by lentiviral transfection. The radiosensitivity was assessed by colony formation, cell cycle, cell apoptosis, DNA damage and repair assay. The growth and immunohistochemistry assay of xenograft tumor,...
Wed Oct 30, 2019 16:08
Publication date: November–December 2019Source: Reports of Practical Oncology & Radiotherapy, Volume 24, Issue 6Author(s): Ivica Ratosa, Maja Ivanetic PantarAbstractAimTo explore available recent literature related to cardiotoxicity following mediastinal radiation.BackgroundRadiotherapy-related heart injury is well documented, with no apparent safety threshold dose. The number of long-term cancer survivors exposed to mediastinal radiotherapy at some point of their treatment is increasing. Heart...
Wed Oct 30, 2019 18:08
Publication date: November–December 2019Source: Reports of Practical Oncology & Radiotherapy, Volume 24, Issue 6Author(s): Haruka Oi, Satoshi Yamamoto, Yoshiharu Kono, Yukiyoshi MasakiAbstractLymphoepithelioma-like carcinoma (LELC) is histologically similar in form to nasopharyngeal carcinoma (NPC) and is an epithelial tumor that is suggested to be involved in infection with Epstein-Barr virus (EBV), but it is rare to occur in the colon. A 35-year-old woman was found to have a rectal wall thickening...
Wed Oct 30, 2019 18:08
The association between statins therapy and prostate cancer is extensively studied [1,2]. Recently, one cohort study conducted by Van Rompay et al. published in European Journal of Cancer demonstrated that statins use was associated with a lower mortality of prostate cancer than non-use (hazard ratio 0.73, 95% confidence interval 0.66–0.81) [3]. This result was compatible with another cohort study in Finland showing that statins use after prostate cancer diagnosis was associated with 20% reduced...
Wed Oct 30, 2019 02:00
The Health Foundation recently published a report on emergency hospital admissions from care homes.1 The analysis, coproduced with NHS England, found that 41% were for “potentially avoidable...
Wed Oct 30, 2019 13:11
Van Hove and Leng raise some very valuable points on how the healthcare sector could reduce the environmental impact of metered dose inhaler propellants and anaesthetic gases.1When buying lightbulbs,...
Wed Oct 30, 2019 13:01
Cancers, Vol. 11, Pages 1691: Automated Workflow for Somatic and Germline Next Generation Sequencing Analysis in Routine Clinical Cancer Diagnostics Cancers doi: 10.3390/cancers11111691 Authors: Muscarella Fabrizio De Bonis Mancini Balsamo Graziano Centra Sparaneo Trombetta Bonfitto Scagliusi Larizza Capoluongo Fazio Thanks to personalized medicine trends and collaborations between industry, clinical research groups and regulatory...
Wed Oct 30, 2019 02:00
Publication date: December 2019Source: European Journal of Cancer, Volume 123Author(s): Alexander TJ. Lee, Paul H. Huang, Robin L. Jones
Wed Oct 30, 2019 17:08
Wed Oct 30, 2019 02:00
Wed Oct 30, 2019 02:00
Abstract Purpose Age-related factors including oxidative stress play an important role in prostate carcinogenesis. We hypothesize that germline single-nucleotide polymorphisms (SNPs) in oxidative stress pathway are associated with prostate cancer (PCa) risk. In this study, we aim to examine which of these SNPs is associated with PCa. Methods Participants...
Wed Oct 30, 2019 02:00
Publication date: Available online 29 October 2019Source: Surgical Oncology Clinics of North AmericaAuthor(s): Ian Greenwalt, Norah Zaza, Shibandri Das, Benjamin D. Li
Wed Oct 30, 2019 14:37
Publication date: Available online 29 October 2019Source: Surgical Oncology Clinics of North AmericaAuthor(s): Deborah B. Doroshow, James H. Doroshow
Wed Oct 30, 2019 14:37
Publication date: Available online 29 October 2019Source: Surgical Oncology Clinics of North AmericaAuthor(s): Kieuhoa T. Vo, D. Williams Parsons, Nita L. Seibel
Wed Oct 30, 2019 14:37
Abstract Cancer-specific defects in DNA repair pathways create the opportunity to employ synthetic lethality approach. Recently, GEMA (gene expression and mutation analysis) approach detected insufficient expression of BRCA or NHEJ (non-homologous end joining) to predict PARP inhibitors response. We evaluated a possible role of DNA repair pathways using gene expression of single-strand break (XPA, XPC, XPG/ERCC5, CSA/ERCC8, and CSB/ERCC6) and double-strand...
Wed Oct 30, 2019 02:00
Abstract Purpose To describe patterns of opioid use in cancer survivors. Methods In a cohort study of colon cancer patients diagnosed during 1995–2014 and enrolled at two Kaiser Permanente regions, we constructed quarterly measures of opioid use from 1 year before cancer diagnosis through 5 years after diagnosis to examine changes in use. Measures included...
Wed Oct 30, 2019 02:00
Abstract The pathologist is frequently called “the doctor’s doctor.” However, there are many uncertainties about the role of a pathologist among patients and policymakers and even among other medical specialties. The aim of the current study is to analyze the misconceptions of who a pathologist is among inpatients and Internet users, to find where the lack of understanding is originating from, and to confirm the need to educate the general public about pathologists. The survey...
Wed Oct 30, 2019 02:00
Cancers, Vol. 11, Pages 1690: Successful Targeting of the Warburg Effect in Prostate Cancer by Glucose-Conjugated 1,4-Naphthoquinones Cancers doi: 10.3390/cancers11111690 Authors: Sergey A. Dyshlovoy Dmitry N. Pelageev Jessica Hauschild Ksenia L. Borisova Moritz Kaune Christoph Krisp Simone Venz Yurii E. Sabutskii Ekaterina A. Khmelevskaya Tobias Busenbender Vladimir A. Denisenko Natalia D. Pokhilo Lyubov N. Atopkina Markus Graefen Hartmut Schlüter...
Wed Oct 30, 2019 02:00
Dolly Sen from Norfolk remembers being an inpatient in a bay on a mental health ward and men coming in to ask for sex. She had stayed in mixed sex hospital accommodation many times, and on this...
Wed Oct 30, 2019 12:56
bmj;367/oct29_10/l6261/FAF1faPeter Oliver Behan was from a humble background in Athy, County Kildare, Ireland. He was educated by the Christian Brothers and qualified from Leeds medical school in...
Tue Oct 29, 2019 14:06
Related ArticlesObservational study of clinical outcomes of eribulin mesylate in metastatic breast cancer after cyclin-dependent kinase 4/6 inhibitor therapy. Future Oncol. 2019 Oct 29;: Authors: Mougalian SS, Feinberg BA, Wang E, Alexis K, Chatterjee D, Knoth RL, Nero D, Miller T, Liassou D, Kish JK Abstract Aim: To examine the effectiveness of eribulin mesylate for metastatic breast cancer post cyclin-dependent kinase inhibitor (CDKi) 4/6 therapy....
Wed Oct 30, 2019 15:02
Related ArticlesJournal retractions in oncology: a bibliometric study. Future Oncol. 2019 Oct 29;: Authors: Pantziarka P, Meheus L Abstract Aim: To investigate secular trends in article retractions in the oncology literature, particularly relating to cancer treatments and data available to patients. Methods: A bibliometric analysis of article retractions from PubMed in the period 2000-2018. Results: Analysis shows that article lifetime - that is the...
Wed Oct 30, 2019 15:02
Wed Oct 30, 2019 12:02
Abstract Purpose Stereotactic radiosurgery (SRS) is a well-established treatment option for brain metastases (BM). Repeat SRS for progressive BM is an increasingly used paradigm, although little data is available to support this practice. The goal of this study was to assess the safety and efficacy of a second SRS procedure on a previously treated BM. Methods ...
Wed Oct 30, 2019 02:00
Abstract Purpose Recently, the potential value of isocitrate dehydrogenase (IDH) mutation as a prognostic marker in glioblastomas has been established. Glioblastomas are classified by their IDH mutation status under the 2016 WHO classification system. However, noninvasive diagnostic methods for the mutation status in glioblastoma patients have not been established so far. The purpose of this study was to evaluate the difference of acetate...
Wed Oct 30, 2019 02:00
Abstract Chemoradiotherapy (CRT) is the standard neoadjuvant therapy for locally advanced rectal cancer (RC). However, neoadjuvant chemotherapy (NAC) also shows favorable outcomes. Although the immunological environment of RC has been thoroughly discussed, the effect of NAC on it is less clear. Here, we investigated the immunological microenvironment, including T‐cell infiltration, activation, and topological distribution, of resected RC tissue after neoadjuvant therapies and evaluated the correlation...
Tue Oct 29, 2019 11:56
Abstract Objective To assess the cross‐sectional and prospective associations between depressive symptoms, neuroticism and participation in breast and cervical screening in the UK. Methods Women in the UK Biobank cohort with complete data who were eligible for breast cancer screening (aged 50‐70 years, N=143 461) and/or cervical screening (<65 years, N=141 753) at baseline recruitment (2006‐10) and those with follow‐up data (2014‐19) were identified (N=11 050 and N=9 780 for breast and...
Wed Oct 30, 2019 11:40
Abstract OBJECTIVE To evaluate current evidence for the effectiveness of distance‐based interventions to support smoking cessation (SC) or alcohol use moderation (AM) among cancer survivors. Secondary, differences in effectiveness are explored regarding multi‐behaviour interventions versus single‐behaviour interventions targeting SC or AM only. METHODS A systematic search of PubMed, PsycINFO, Web of Science, EMBASE, CINAHL and Cochrane Central Register of Controlled Trials was conducted....
Wed Oct 30, 2019 11:40
Abstract Objective This longitudinal study mapped distinct trajectories of Fear of cancer recurrence (FCR) over 12 months among patients with breast (BC) or colorectal (CRC) cancer, and examined if metacognition, indirectly via attentional bias, intrusive thoughts and avoidance (hallmarks of cognitive attentional syndrome; CAS) predicted FCR trajectory membership. Methods 270 BC (n=163) or CRC (n=107) patients were assessed at 8‐weeks, 3‐months, 6‐months, and 12‐months post‐surgery on a...
Tue Oct 29, 2019 20:40
Abstract OBJECTIVE Even when medical treatments are limited, supporting patients’ coping strategies could improve their quality of life. Greater understanding of patients’ coping strategies, and influencing factors, can aid developing such support. We examined the prevalence of coping strategies and associated variables. METHODS We used sociodemographic and baseline data from the ACTION trial, including measures of Denial, Acceptance and Problem‐focused coping (COPE; Brief COPE inventory),...
Tue Oct 29, 2019 20:39
Abstract Objective Understanding the unmet supportive care needs of men on active surveillance for prostate cancer may enable researchers and health professionals to better support men and prevent discontinuation when there is no evidence of disease progression. This review aimed to identify the specific unmet supportive care needs of men on active surveillance. Methods A systematic review following PRISMA guidelines was conducted. Databases (Pubmed, Embase, PsycINFO, and CINAHL) were searched...
Tue Oct 29, 2019 15:23
Abstract Objective The primary objective of this research was to examine patterns of parent‐child relationship functioning among pediatric cancer survivors and their caregivers across a variety of relationship indicators (i.e., Involvement, Attachment, Communication, Parenting Confidence, and Relational Frustration), and evaluate how these factors relate to psychosocial outcomes in survivors. Methods Young survivors aged 10‐18 and their caregivers (N=165) completed measures related to posttraumatic...
Tue Oct 29, 2019 13:09
Cancers, Vol. 11, Pages 1688: Secondary Somatic Mutations in G-Protein-Related Pathways and Mutation Signatures in Uveal Melanoma Cancers doi: 10.3390/cancers11111688 Authors: Francesca Piaggio Veronica Tozzo Cinzia Bernardi Michela Croce Roberto Puzone Silvia Viaggi Serena Patrone Annalisa Barla Domenico Coviello Martine J. Jager Pieter A. van der Velden Michael Zeschnigk Davide Cangelosi Alessandra Eva Ulrich Pfeffer Adriana Amaro Background:...
Wed Oct 30, 2019 02:00
Cancers, Vol. 11, Pages 1689: Overview of Immune Checkpoint Inhibitors Therapy for Hepatocellular Carcinoma, and The ITA.LI.CA Cohort Derived Estimate of Amenability Rate to Immune Checkpoint Inhibitors in Clinical Practice Cancers doi: 10.3390/cancers11111689 Authors: Edoardo Giannini Andrea Aglitti Mauro Borzio Martina Gambato Maria Guarino Massimo Iavarone Quirino Lai Giovanni Levi Sandri Fabio Melandro Filomena Morisco Francesca Ponziani Maria Rendina Francesco...
Wed Oct 30, 2019 02:00
Cancers, Vol. 11, Pages 1687: Fibroblasts in Nodular Sclerosing Classical Hodgkin Lymphoma Are Defined by a Specific Phenotype and Protect Tumor Cells from Brentuximab-Vedotin Induced Injury Cancers doi: 10.3390/cancers11111687 Authors: Katrin Bankov Claudia Döring Adam Ustaszewski Maciej Giefing Marco Herling Chiara Cencioni Francesco Spallotta Carlo Gaetano Ralf Küppers Martin-Leo Hansmann Sylvia Hartmann Classical Hodgkin lymphoma (cHL) is one of the...
Wed Oct 30, 2019 02:00
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