Osthole inhibits the progression of human gallbladder cancer cells through JAK/STAT3 signal pathway both in vitro and in vivoOsthole is an antitumor compound, which effect on Gallbladder cancer (GBC) has been not elucidated. This study focused on its anti-GBC effect and mechanism both in vitro and in vivo. The antiproliferation effect on cell lines NOZ and SGC-996 were measured by cell counting kit-8 (CCK-8) and colony formation assay. The effects on cell apoptosis and cell cycle were investigated by flow cytometry assay. The migration effect was checked by transwell a- Ruxolitinib as monotherapy in a patient with anaplastic lymphoma kinase positive lung adenocarcinomaWe present unusual treatment outcome in a 59-year-old male diagnosed with metastatic lung adenocarcinoma with a very good response to ruxolitinib as monotherapy. In June 2017, this patient was diagnosed with myeloproliferative neoplasm – Janus-associated kinases 2 positive – and in December 2017 ruxolitinib therapy was started. At the same time, patient was diagnosed with lung adenocarcinoma in the left lower lobe with positive anaplastic lymphom
- The signaling axis of Rac1-TFEB regulates autophagy and tumorigenesisMacroautophagy (hereafter referred to as autophagy) plays essential roles in cellular and organismal homeostasis. Transcription factor EB (TFEB) is a master regulator of autophagy and lysosome biogenesis. It is not fully understood how the function of TFEB in autophagy pathway is regulated. Here, we show that Rac1 GTPase is a negative modulator of autophagy by targeting TFEB. Mechanistically, Rac1 reduces autophagy flux by repressing the expressi
- Hyperprogression after first dose of immunotherapy in a patient with radioresistant metastasis from nonsmall cell lung cancerImmune checkpoint inhibitors (ICIs) represent a new standard of care for patients with advanced nonsmall cell lung cancer, improving overall survival compared with standard chemotherapy. However, a new pattern of response to ICIs characterized by accelerated tumor growth has been recently described, termed hyperprogressive disease (HPD). We report the case of a 73-year-old patient with advanced lung adenocarcinoma who developed HPD following trea
- Phase I Study of IGF-Methotrexate Conjugate in the Treatment of Advanced Tumors Expressing IGF-1RObjectives: Insulin-like growth factor-methotrexate (IGF-MTX) is a conjugate of methotrexate and 765IGF, a variant of IGF-1 with high affinity for insulin-like growth factor type 1 receptor. The study aim was to determine the maximum tolerated dose of IGF-MTX in refractory solid organ and hematologic malignancies expressing insulin-like growth factor type 1 receptor. Materials and Methods: This phase I trial used a modified toxicity proba
- Disparities in the Use of Adjuvant External Beam Radiation Therapy in Node-positive Cervical Cancer Patients Following HysterectomyObjective: The objective of this study was to investigate the use of adjuvant external beam radiation therapy (EBRT) among patients with early-stage cervical carcinoma metastatic to regional lymph nodes (LNs). Materials and Methods: The National Cancer Database was accessed and patients with early-stage cervical carcinoma diagnosed between 2004 and 2015 were identified. Those with regional LN metastases who had a hysterectomy were selecte
- Prognostic Nomogram for Hepatitis B Virus–related Hepatocellular Carcinoma With Adjuvant Transarterial Chemoembolization After Radical ResectionObjectives: The objective of this study was to establish a reliable and effective nomogram for predicting prognosis of hepatitis B virus (HBV)–related hepatocellular carcinoma (HCC) with postoperative adjuvant transarterial chemoembolization (TACE). Patients and Methods: A derivation cohort of 370 HCC patients treated with postoperative TACE in the Eastern Hepatobiliary Surgery Hospital from January 2009 to December 2012 were retrospectiv
- Development and usability testing of the e‐EXCELS tool to guide cancer survivorship follow‐up careAbstract Objective The aim of this study is to describe a user‐centered (e.g., cancer survivors and clinicians) development process of an eHealth tool designed to facilitate self‐management of cancer survivorship follow‐up care. Methods Guided by Cognitive‐Social Health Information Processing (C‐SHIP) model and informed by core self‐management skills, we engaged in a user‐centered design process. In phase I, we conducted in‐depth interv
- Antisense targeting of CD47 enhances human cytotoxic T-cell activity and increases survival of mice bearing B16 melanoma when combined with anti-CTLA4 and tumor irradiationAbstract Antibodies targeting the T-cell immune checkpoint cytotoxic T-lymphocyte antigen-4 (CTLA4) enhance the effectiveness of radiotherapy for melanoma patients, but many remain resistant. To further improve response rates, we explored combining anti-CTLA4 blockade with antisense suppression of CD47, an inhibitory receptor on T cells that limit T-cell receptor signaling and killing of irradiated target cells. Human melanoma
- Monocytes reprogrammed with lentiviral vectors co-expressing GM-CSF, IFN-α2 and antigens for personalized immune therapy of acute leukemia pre- or post-stem cell transplantationAbstract Acute myeloid leukemia (AML) is the most common acute leukemia in adults and overall survival remains poor. Chemotherapy is the standard of care for intensive induction therapy. Patients who achieve a complete remission require post-remission therapies to prevent relapse. There is no standard of care for patients with minimal residual disease (MRD), and stem cell transplantation is a salvage therapy. Considering the AM
- Models and tools for those living with and beyond cancerPublication date: Available online 17 October 2019Source: Critical Reviews in Oncology/HematologyAuthor(s): Dipesh P Gopal
- Immunotherapy of brain metastases: breaking a “dogma”Until very few years ago, the oncology community dogmatically excluded any clinical potential for immunotherapy in controlling brain metastases. Therefore, despite the significant therapeutic efficacy of monoc...
- LINC00673 is activated by YY1 and promotes the proliferation of breast cancer cells via the miR-515-5p/MARK4/Hippo signaling pathwayAn increasing number of studies have shown that long noncoding RNAs (lncRNAs) play essential roles in tumor initiation and progression. LncRNAs act as tumor promoters or suppressors by targeting specific genes...
- MEIS2C and MEIS2D promote tumor progression via Wnt/β-catenin and hippo/YAP signaling in hepatocellular carcinomaMEIS2 has been identified as one of the key transcription factors in the gene regulatory network in the development and pathogenesis of human cancers. Our study aims to identify the regulatory mechanisms of ME...
- Effect of modern high-dose versus standard-dose radiation in definitive concurrent chemo-radiotherapy on outcome of esophageal squamous cell cancer: a meta-analysisRadiation Therapy Oncology Group (RTOG) 94–05 has demonstrated that higher dose radiation didn’t improve outcome of patients with esophageal cancer (EC). However, several retrospective studies showed that a hi...
- Assessing the financial toxicity of radiation oncology patients using the validated Comprehensive Score for Financial Toxicity (COST) as a patient-reported outcome: Measuring financial toxicity in radiation oncologyPublication date: Available online 18 October 2019Source: Practical Radiation OncologyAuthor(s): Kevin A. D'Rummo, Leah Miller, Mindi J. TenNapel, Xinglei ShenAbstractPurposeThe financial burden of cancer care may significantly impact patient quality of life and clinical outcomes. However, the financial impact of radiotherapy on patients remains difficult to characterize, due in part to the lack of standardized methods to measure patient distress
- Prospective Peer Review in Radiotherapy Treatment Planning: Long-term Results from a Longitudinal StudyPublication date: Available online 18 October 2019Source: Practical Radiation OncologyAuthor(s): Brett W. Cox, Sewit Teckie, Ajay Kapur, Henry Chou, Louis PottersAbstractPurposeTo present the longitudinal results of a prospective peer review evaluation system (PES) prior to treatment planning.Methods and MaterialsAll cases undergoing radiation therapy at a high-volume, academic institution were graded in a daily prospective multidisciplinary cont
- Associations of early Medicaid expansion with insurance status and stage at diagnosis among cancer patients receiving radiation therapyPublication date: Available online 18 October 2019Source: Practical Radiation OncologyAuthor(s): Justin M. Barnes, Amar J. Srivastava, Prashant Gabani, Stephanie M. PerkinsAbstractPurposeMedicaid expansion in 2014 is associated with improved insurance coverage and stage at diagnosis in cancer patients. However, little is known about the impact of early Medicaid expansions in 2010-2011 on outcomes in radiotherapy recipients. The objective of this
- Advanced practice providers in radiation oncologyPublication date: Available online 17 October 2019Source: Practical Radiation OncologyAuthor(s): Kate L. Martin, Betty Krechmer, Richard N. Boyajian, Mary Carr Reynolds, Daniel N. Cagney, Neil MartinAbstractPurposeHighlight utilization of advanced practice providers (APPs) in an academic radiation oncology center and how their role benefits patient care and departmental workflow.Methods and MaterialsA self-reported workflow analysis of department
- A Dose-Effect Analysis of Early Changes in Orbital Bone Morphology following Radiotherapy for RhabdomyosarcomaPublication date: Available online 16 October 2019Source: Practical Radiation OncologyAuthor(s): Marinka L.F. Hol, Daniel J. Indelicato, Ronny L. Rotondo, Raymond B. Mailhot Vega, Haruka Uezono, Natalie A. Lockney, Eric Sandler, Julie A. BradleyAbstractIntroductionIn survivors of orbital embryonal rhabdomyosarcoma (ERMS), late effects include facial deformation and asymmetry. We sought to quantify orbital asymmetry in ERMS survivors and character
- Haematological immune-related adverse events with immune checkpoint inhibitors, how to manage?Publication date: November 2019Source: European Journal of Cancer, Volume 122Author(s): J.M. Michot, J. Lazarovici, A. Tieu, S. Champiat, A.L. Voisin, M. Ebbo, B. Godeau, M. Michel, V. Ribrag, O. LambotteAbstractImmune checkpoint inhibitors (ICIs) are changing the treatments of many patients with cancer. These immunotherapies are generally better tolerated than chemotherapy, and their adverse events are immune-related mimicking autoimmune or infl
- Outcome of adolescent patients with acute lymphoblastic leukaemia aged 10–14 years as compared with those aged 15–17 years: Long-term results of 1094 patients of the AIEOP-BFM ALL 2000 studyPublication date: November 2019Source: European Journal of Cancer, Volume 122Author(s): Anna Maria Testi, Andishe Attarbaschi, Maria Grazia Valsecchi, Anja Möricke, Gunnar Cario, Felix Niggli, Daniela Silvestri, Peter Bader, Michaela Kuhlen, Rosanna Parasole, Maria Caterina Putti, Peter Lang, Christian Flotho, Georg Mann, Carmelo Rizzari, Elena Barisone, Franco Locatelli, Christin Linderkamp, Melchior Lauten, Meinolf SuttorpAbstractBackgroundAdol
- Nivolumab-related mucous membrane pemphigoidPublication date: November 2019Source: European Journal of Cancer, Volume 121Author(s): Vincent Sibaud, Emmanuelle Vigarios, Aurore Siegfried, Chloe Bost, Nicolas Meyer, Cecile Pages-Laurent
- BRAF exon 11 mutant melanoma and sensitivity to BRAF/MEK inhibition: Two case reportsPublication date: November 2019Source: European Journal of Cancer, Volume 121Author(s): Audrey Melin, Emilie Routier, Hubert Tissot, Etienne Rouleau, Caroline Robert
- Effective anti-programmed cell death 1 treatment for chemoresistant gestational trophoblastic neoplasiaPublication date: November 2019Source: European Journal of Cancer, Volume 121Author(s): Min Chul Choi, Jisu Oh, Chan Lee
- Immune gene expression in head and neck squamous cell carcinoma patientsPublication date: November 2019Source: European Journal of Cancer, Volume 121Author(s): Charlotte Lecerf, Maud Kamal, Sophie Vacher, Walid Chemlali, Anne Schnitzler, Claire Morel, Coraline Dubot, Emmanuelle Jeannot, Didier Meseure, Jerzy Klijanienko, Odette Mariani, Edith Borcoman, Valentin Calugaru, Nathalie Badois, Anne Chilles, Maria Lesnik, Samar Krhili, Olivier Choussy, Caroline Hoffmann, Eliane PiaggioAbstractBackgroundNivolumab and pembrol
- Older and younger patients treated with immune checkpoint inhibitors have similar outcomes in real-life settingPublication date: November 2019Source: European Journal of Cancer, Volume 121Author(s): Pauline Corbaux, Denis Maillet, Amélie Boespflug, Myriam Locatelli-Sanchez, Marie Perier-Muzet, Michaël Duruisseaux, Lize Kiakouama-Maleka, Stéphane Dalle, Claire Falandry, Julien PéronAbstractBackgroundAge-related immune dysfunction might impair the efficacy of immune checkpoint inhibitors (ICIs) in older patients. We aimed to evaluate the impact of age on cl
- Efficacy of molecularly targeted agents given in the randomised trial SHIVA01 according to the ESMO Scale for Clinical Actionability of molecular TargetsPublication date: November 2019Source: European Journal of Cancer, Volume 121Author(s): A. Moreira, J. Masliah-Planchon, C. Callens, S. Vacher, C. Lecerf, M. Frelaut, E. Borcoman, N. Torossian, F. Ricci, S. Hescot, M.P. Sablin, P. Tresca, D. Loirat, S. Melaabi, O. Trabelsi-Grati, G. Pierron, D. Gentien, V. Bernard, A. Vincent Salomon, N. ServantAbstractBackgroundA randomised trial SHIVA01 compared the efficacy of matched molecularly targeted ther
- Metabolic crosstalk in the breast cancer microenvironmentPublication date: November 2019Source: European Journal of Cancer, Volume 121Author(s): Ana S. Dias, Catarina R. Almeida, Luisa A. Helguero, Iola F. DuarteAbstractDuring tumorigenesis, breast tumour cells undergo metabolic reprogramming, which generally includes enhanced glycolysis, tricarboxylic acid cycle activity, glutaminolysis and fatty acid biosynthesis. However, the extension and functional importance of these metabolic alterations may div
- Finnish sauna bathing does not increase or decrease the risk of cancer in men: A prospective cohort studyPublication date: November 2019Source: European Journal of Cancer, Volume 121Author(s): Jari A. Laukkanen, Timo H. Mäkikallio, Hassan Khan, Tanjaniina Laukkanen, Jussi Kauhanen, Setor K. KunutsorAbstractIntroductionEvidence suggests that heat therapy can be used to prevent and treat cancer; anecdotal reports suggest passive heat therapies may increase cancer risk. Finnish sauna bathing has been linked to a reduced risk of chronic diseases, but it
- Analysis of 105.000 patients with cancer: have they been discussed in oncologic multidisciplinary team meetings? A nationwide population-based study in the NetherlandsPublication date: November 2019Source: European Journal of Cancer, Volume 121Author(s): J.E.W. Walraven, I.M.E. Desar, J.J.M. Hoeven van der, K.K.H. Aben, R. Hillegersberg van, C.R.N. Rasch, V.E.P.P. Lemmens, R.H.A. VerhoevenAbstractIntroductionFor optimal oncological care, it is recommended to discuss every patient with cancer in a multidisciplinary team meeting (MDTM). This is a time consuming and expensive practice, leading to a growing demand
- Phase II trial of the glycoprotein non-metastatic B-targeted antibody–drug conjugate, glembatumumab vedotin (CDX-011), in recurrent osteosarcoma AOST1521: A report from the Children's Oncology GroupPublication date: November 2019Source: European Journal of Cancer, Volume 121Author(s): Lisa M. Kopp, Suman Malempati, Mark Krailo, Yun Gao, Allen Buxton, Brenda J. Weigel, Thomas Hawthorne, Elizabeth Crowley, Jeffrey A. Moscow, Joel M. Reid, Victor Villalobos, R. Lor Randall, Richard Gorlick, Katherine A. JanewayAbstractBackgroundThe prognosis is poor for children and adolescents with recurrent osteosarcoma (OS). Glycoprotein non-metastatic B (g
- Treatment-related mortality in children with cancer: Prevalence and risk factorsPublication date: November 2019Source: European Journal of Cancer, Volume 121Author(s): Erik A.H. Loeffen, Rutger R.G. Knops, Joren Boerhof, E.A.M. (Lieke) Feijen, Johannes H.M. Merks, Ardine M.J. Reedijk, Jan A. Lieverst, Rob Pieters, H. Marike Boezen, Leontien C.M. Kremer, Wim J.E. TissingAbstractAimIntensive treatment regimens have contributed to a marked increase in childhood cancer survival rates. Death due to treatment-related adverse effec
- Safety and efficacy of nivolumab in challenging subgroups with advanced melanoma who progressed on or after ipilimumab treatment: A single-arm, open-label, phase II study (CheckMate 172)Publication date: November 2019Source: European Journal of Cancer, Volume 121Author(s): Dirk Schadendorf, Paolo A. Ascierto, John Haanen, Enrique Espinosa, Lev Demidov, Claus Garbe, Michele Guida, Paul Lorigan, Vanna Chiarion-Sileni, Helen Gogas, Michele Maio, Maria Teresa Fierro, Christoph Hoeller, Patrick Terheyden, Ralf Gutzmer, Tormod K. Guren, Dimitrios Bafaloukos, Piotr Rutkowski, Ruth Plummer, Ashita WaterstonAbstractBackgroundLimited data
- Measured and genetically predicted plasma YKL-40 levels and melanoma mortalityPublication date: November 2019Source: European Journal of Cancer, Volume 121Author(s): Hafsa Ismail, Jens Helby, Lisbet R. Hölmich, Annette H. Chakera, Lars Bastholt, Helle Klyver, Pia Sjøgren, Henrik Schmidt, Liv Schöllhammer, Julia S. Johansen, Børge G. Nordestgaard, Stig E. BojesenAbstractPurposeHigh plasma levels of YKL-40 might be associated with mortality in patients with melanoma, and it is unknown if YKL-40 is causally related to mortali
- Response to salvage chemotherapy after progression on immune checkpoint inhibitors in patients with recurrent and/or metastatic squamous cell carcinoma of the head and neckPublication date: November 2019Source: European Journal of Cancer, Volume 121Author(s): Khalil Saleh, Amaury Daste, Nicolas Martin, Elvire Pons-Tostivint, Anne Auperin, Ruth Gabriela Herrera-Gomez, Neus Baste-Rotllan, Francois Bidault, Joel Guigay, Christophe Le Tourneau, Esma Saada-Bouzid, Caroline EvenAbstractBackgroundImmune checkpoint inhibitors (ICI) are active in patients with recurrent/metastatic squamous cell carcinoma of the head and nec
- Pooled Analysis of external-beam RADiotherapy parameters in phase II and phase III trials in radiochemotherapy in Anal Cancer (PARADAC)Publication date: November 2019Source: European Journal of Cancer, Volume 121Author(s): Eleonor Rivin del Campo, Oscar Matzinger, Karin Haustermans, Didier Peiffert, Robert Glynne-Jones, Kathryn A. Winter, Andre A. Konski, Jaffer A. Ajani, Jean-François Bosset, Jean-Michel Hannoun-Levi, Marc Puyraveau, A. Bapsi Chakravarthy, Helen Meadows, John Northover, Laurence Collette, Melissa Christiaens, Philippe MaingonAbstractPurposeConcomitant external-
- EGFR-TKIs plus bevacizumab demonstrated survival benefit than EGFR-TKIs alone in patients with EGFR-mutant NSCLC and multiple brain metastasesPublication date: November 2019Source: European Journal of Cancer, Volume 121Author(s): Tao Jiang, Yongchang Zhang, Xuefei Li, Chao Zhao, Xiaoxia Chen, Chunxia Su, Shengxiang Ren, Nong Yang, Caicun ZhouAbstractIntroductionPrevious studies suggested that epidermal growth factor receptor (EGFR)–tyrosine kinase inhibitor (TKIs) plus bevacizumab could significantly prolong progression-free survival (PFS) than EGFR-TKI alone as first-line setting for
- Variability of predictive markers (hormone receptors, Her2, Ki67) and intrinsic subtypes of breast cancer in four consecutive years 2015–2018Abstract Purpose Accurate monitoring of predictive markers is of utmost importance as oncological treatment decisions almost entirely depend on these factors. In this study, we conducted a quality control assessment on hormone receptors, Her2 status, Ki67 Labelling Index (LI) and histological grading in breast cancer over 4 years (2015–2018).
- Cancers, Vol. 11, Pages 1590: EP4 and Class III β-Tubulin Expression in Uterine Smooth Muscle Tumors: Implications for Prognosis and TreatmentCancers, Vol. 11, Pages 1590: EP4 and Class III β-Tubulin Expression in Uterine Smooth Muscle Tumors: Implications for Prognosis and Treatment Cancers doi: 10.3390/cancers11101590 Authors: Jocelyn Reader Amy K. Harper Teklu Legesse Paul N. Staats Olga Goloubeva Gautam G. Rao Amy Fulton Dana M. Roque The microtubule-stabilizing agent docetaxel in combination with gemcitabine represents one of the most effective re
- Cancers, Vol. 11, Pages 1592: Targeting Programmed Fusobacterium nucleatum Fap2 for Colorectal Cancer TherapyCancers, Vol. 11, Pages 1592: Targeting Programmed Fusobacterium nucleatum Fap2 for Colorectal Cancer Therapy Cancers doi: 10.3390/cancers11101592 Authors: Kumar Ganesan Songhe Guo Sundaz Fayyaz Ge Zhang Baojun Xu Colorectal patients generally have the maximum counts of Fusobacterium nucleatum (F. nucleatum) in tumors and elevate colorectal adenomas and carcinomas, which show the lowest rate of human survival. Hence, F. n
- Cancers, Vol. 11, Pages 1591: Acute Promyelocytic Leukemia: Update on the Mechanisms of Leukemogenesis, Resistance and on Innovative Treatment StrategiesCancers, Vol. 11, Pages 1591: Acute Promyelocytic Leukemia: Update on the Mechanisms of Leukemogenesis, Resistance and on Innovative Treatment Strategies Cancers doi: 10.3390/cancers11101591 Authors: N. I. Noguera G. Catalano C. Banella M. Divona I. Faraoni T. Ottone W. Arcese M. T. Voso This review highlights new findings that have deepened our understanding of the mechanisms of leukemogenesis, therapy and resis
- Cancers, Vol. 11, Pages 1593: Apalutamide Sensitizes Prostate Cancer to Ionizing Radiation via Inhibition of Non-Homologous End-Joining DNA RepairCancers, Vol. 11, Pages 1593: Apalutamide Sensitizes Prostate Cancer to Ionizing Radiation via Inhibition of Non-Homologous End-Joining DNA Repair Cancers doi: 10.3390/cancers11101593 Authors: Wenhao Zhang Chen-Yi Liao Hajar Chtatou Luca Incrocci Dik C. van Gent Wytske M. van Weerden Julie Nonnekens Androgen-deprivation therapy was shown to improve treatment outcome of external beam radiation therapy (EBRT) for loca
- Comparison of patient-specific intensity modulated radiation therapy quality assurance for the prostate across multiple institutionsPublication date: November–December 2019Source: Reports of Practical Oncology & Radiotherapy, Volume 24, Issue 6Author(s): Kazuki Kubo, Hajime Monzen, Kohei Shimomura, Kenji Matsumoto, Tomoharu Sato, Mikoto Tamura, Kiyoshi Nakamatsu, Kentaro Ishii, Ryu KawamoritaAbstractAimTo evaluate the success of a patient-specific intensity modulated radiation therapy (IMRT) quality assurance (QA) practice for prostate cancer patients across multiple institut
- Skin barrier function in patients under radiation therapy due to the head and neck cancers - Preliminary studyPublication date: November–December 2019Source: Reports of Practical Oncology & Radiotherapy, Volume 24, Issue 6Author(s): Jakub Pazdrowski, Adriana Polaſska, Joanna Kaźmierska, Wojciech Barczak, Mateusz Szewczyk, Zygmunt Adamski, Ryszard Żaba, Paweſ Golusiſski, Wojciech Golusiſski, Aleksandra Daſczak-PazdrowskaAbstractAimTo present the possibility of non-invasive monitoring of the skin after radiotherapy in regards of epidermal barrier function.
- Intraoperative breast radiotherapy: survival, local control and risk factors for recurrencePublication date: November–December 2019Source: Reports of Practical Oncology & Radiotherapy, Volume 24, Issue 6Author(s): Guilherme Rocha Melo Gondim, Fabiana Baroni Alves Makdissi, Ricardo Cesar Fogaroli, Juan Bautista Donoso Collins, Hirofumi Iyeyasu, Douglas Guedes de Castro, Maria Letícia Gobo Silva, Michael Jenwei Chen, Tharcisio Machado Coelho, Henderson Ramos, Antônio Cássio Assis PellizzonAbstractBackgroundWhole breast irradiation reduce
- Patient preferences for attributes of tyrosine kinase inhibitor treatments for EGFR mutation-positive non-small-cell lung cancer.Related ArticlesPatient preferences for attributes of tyrosine kinase inhibitor treatments for EGFR mutation-positive non-small-cell lung cancer. Future Oncol. 2019 Oct 17;: Authors: Bridges JF, la Cruz M, Pavilack M, Flood E, Janssen EM, Chehab N, Fernandes AW Abstract Aim: EGFR-tyrosine kinase inhibitors (TKIs) vary in efficacy, side effects (SEs) and dosing regimen. We explored EGFR-TKI treatment
- Cancers, Vol. 11, Pages 1588: Calcium Regulates HCC Proliferation as well as EGFR Recycling/Degradation and Could Be a New Therapeutic Target in HCCCancers, Vol. 11, Pages 1588: Calcium Regulates HCC Proliferation as well as EGFR Recycling/Degradation and Could Be a New Therapeutic Target in HCC Cancers doi: 10.3390/cancers11101588 Authors: Teresa Maria Elisa Modica Francesco Dituri Serena Mancarella Claudio Pisano Isabel Fabregat Gianluigi Giannelli Calcium is the most abundant element in the human body. Its role is essential in physiological and biochemical proc
- Cancers, Vol. 11, Pages 1589: Salivary Gland FNA Diagnostics in a Real-Life Setting: One-Year-Experiences of the Implementation of the Milan System in a Tertiary Care CenterCancers, Vol. 11, Pages 1589: Salivary Gland FNA Diagnostics in a Real-Life Setting: One-Year-Experiences of the Implementation of the Milan System in a Tertiary Care Center Cancers doi: 10.3390/cancers11101589 Authors: Erkka Tommola Satu Tommola Sinikka Porre Ivana Kholová The Milan System for Reporting Salivary Gland Cytopathology (MSRSGC) was introduced in 2018 following other organ specific cytopathological reporting sys
- Cancers, Vol. 11, Pages 1587: Histone Deacetylase Expressions in Hepatocellular Carcinoma and Functional Effects of Histone Deacetylase Inhibitors on Liver Cancer Cells In VitroCancers, Vol. 11, Pages 1587: Histone Deacetylase Expressions in Hepatocellular Carcinoma and Functional Effects of Histone Deacetylase Inhibitors on Liver Cancer Cells In Vitro Cancers doi: 10.3390/cancers11101587 Authors: Kim Freese Tatjana Seitz Peter Dietrich Serene M.L. Lee Wolfgang E. Thasler Anja Bosserhoff Claus Hellerbrand Hepatocellular carcinoma (HCC) is a leading cause for deaths worldwide. Histone deace
ΩτοΡινοΛαρυγγολόγος Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,
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