- Hand blink reflex in virtual reality: the role of vision and proprioception in modulating defensive responsesAbstract Our research focused on the role of vision and proprioception in modulating a defensive reflex (Hand‐Blink Reflex, HBR) whose magnitude is enhanced when the threatened hand is inside the peripersonal space of the face. We capitalized on virtual reality, which allows dissociating vision and proprioception by presenting a virtual limb in congruent/incongruent positions with respect to the participants’ limb. In experiment 1, participants
- Modified synaptic dynamics predict neural activity patterns in an auditory field within the frontal cortexAbstract Frontal areas of the mammalian cortex are thought to be important for cognitive control and complex behaviour. These areas have been studied mostly in humans, non‐human primates and rodents. In this article, we present a quantitative characterization of response properties of a frontal auditory area responsive to sound in the brain of Carollia perspicillata, the frontal auditory field (FAF). Bats are highly vocal animals and they consti
- Editorial BoardPublication date: 1 December 2019Source: Journal of Neuroscience Methods, Volume 328Author(s):
- Doing the locomotion: Insights and potential pitfalls associated with using locomotor activity as a readout of the circadian rhythm in larval zebrafishPublication date: Available online 18 October 2019Source: Journal of Neuroscience MethodsAuthor(s): Matthew E. Wolter, Kurt R. SvobodaAbstractBackgroundZebrafish have been used as a model to study circadian rhythms (CRs) for over 20 years by analyzing various endpoints including locomotor activity. Such studies often utilize high-throughput analysis monitoring activity of larvae placed in well plates numbering >48 wells per plate. Although the CR
- Editorial overview: Computational neurosciencePublication date: Available online 19 October 2019Source: Current Opinion in NeurobiologyAuthor(s): Brent Doiron, Máté Lengyel
- Wounds in the Head from <em>Kitāb al-Dhakhīra fī ʿIlm al-Ṭibb</em> by Thābit b. Qurra in the Ninth CenturyPublication date: December 2019Source: World Neurosurgery, Volume 132Author(s): Ahmet AcidumanObjectiveKitāb al-Dhakhīra fī ʿIlm al-Ṭibb is one of Thābit b. Qurra’s most noteworthy books on medicine in Arabic in the ninth century. This study aims to present and discuss the section subtitled “wounds in the head” in the 24th chapter of Kitāb al-Dhakhīra considering the information in the literature.Materials and MethodsThis study is primarily based
- A Brain Morphometric and Functional MRI Study on Patients with Visual Field Defects Resulting from Suprasellar Tumors: Preoperative and Postoperative AssessmentPublication date: Available online 18 October 2019Source: World NeurosurgeryAuthor(s): Jianyou Ying, Taoyang Yuan, Lu Jin, Chuzhong Li, Songbai Gui, Rui Wang, Zhentao Zuo, Yazhuo ZhangAbstractObjectiveThe aim of this study was to investigate the structural and functional changes in the visual cortex in the suprasellar tumors of patients with recovery of visual field defects at different times before and after surgical decompression of the optic n
- Effectiveness of low-dose intravenous fentanyl for postoperative headache management after neck clipping of ruptured intracranial aneurysms: Fentanyl for post-subarachnoid hemorrhage headachePublication date: Available online 18 October 2019Source: World NeurosurgeryAuthor(s): Toshitsugu Terakado, Yasunobu Nakai, Go Ikeda, Kazuya Uemura, Yuji Matsumaru, Eiichi Ishikawa, Akira MatsumuraAbstractBackgroundAfter subarachnoid hemorrhage, headache management is often difficult owing to the need to use multiple analgesic drugs. Fentanyl is an opioid we can use after surgery, and it can decrease pain after subarachnoid hemorrhage. The aim of
- Investigating risk factors and predicting complications in deep brain stimulation surgery with machine learning algorithmsPublication date: Available online 18 October 2019Source: World NeurosurgeryAuthor(s): Farrokh Farrokhi, Quinlan D. Buchlak, Matt Sikora, Nazanin Esmaili, Maria Marsans, Pamela McLeod, Jamie Mark, Emily Cox, Christine Bennett, Jonathan CarlsonAbstractBackgroundDeep brain stimulation (DBS) surgery is an option for patients experiencing medically resistant neurological symptoms. DBS complications are rare; finding significant predictors requires a
- Vertebral Artery Sacrifice: A Novel Strategy in the Treatment of Vertebral Artery Loop: Treatment in Vertebral Artery SacrificePublication date: Available online 18 October 2019Source: World NeurosurgeryAuthor(s): Mahammed Zia Khansuheb, Alexander Drofa, Michael Manchak, Qasim Durrani, Evgueni KouznetsovAbstractBackgroundTo report a case of cervical radiculopathy caused by an anomalous vertebral artery (VA) and the efficacy of endovascular vertebral artery sacrifice.Case DescriptionA 62-year-old woman is referred to neurosurgery because of an 8-9-year history of progress
- Stepwise local anesthesia for percutaneous endoscopic interlaminar discectomy: technique strategy and clinical outcomesPublication date: Available online 18 October 2019Source: World NeurosurgeryAuthor(s): Kai Wu, Yuwei Zhao, Zhiyun Feng, Xiaojian Hu, Zhong Chen, Yue WangAbstractBackgroundDue to suboptimal pain control under conventional local anesthesia, percutaneous interlaminar endoscopic discectomy is typically performed under general anesthesia. The purpose of this study is to develop a stepwise approach of local anesthesia for interlaminar endoscopic discec
- The correlation between postoperative cervical sagittal alignment and spine sagittal alignment in adolescent idiopathic scoliosis: a meta-analysisPublication date: Available online 18 October 2019Source: World NeurosurgeryAuthor(s): Yonggang Fan, Jie Wang, Mandi Cai, Xudong Wang, Lei XiaAbstractPurposeTo perform a meta-analysis exploring the correlation between the cervical lordosis (CL) and sagittal spine alignment in adolescent idiopathic scoliosis (AIS) patients after surgery for determining a surgical strategy.MethodsWe searched three electronic databases for studies discussing the cor
- Dorsal hippocampus cholinergic and nitrergic neurotransmission modulate the cardiac baroreflex function in ratsAbstract Hippocampus is a limbic structure involved in the baroreflex and chemoreflex control that receives extensive cholinergic input from basal forebrain. Hippocampal muscarinic receptors activation by acetylcholine might evoke nitric oxide synthesis, which is an important neuromodulator of cardiovascular responses. Thus, we hypothesize that cholinergic and nitrergic neurotransmission within the DH modulates the baroreflex and chemoreflex fun
- Pre-operative Halo-gravity traction in severe neurofibromatosis type 1 and congenital scoliosis with thoracic rotatory subluxationPublication date: Available online 19 October 2019Source: Clinical Neurology and NeurosurgeryAuthor(s): Benlong Shi, Liang Xu, Yang Li, Zhen Liu, Xu Sun, Zezhang Zhu, Yong QiuAbstractObjectivesTo evaluate the efficacy and safety of pre-operative Halo-gravity traction in the treatment of severe neurofibromatosis type 1 and congenital scoliosis patients with thoracic rotatory subluxation.Patients and MethodsPatients with neurofibromatosis type 1 an
- Early 18F-FDG PET/CT response predicts survival in Relapsed/Refractory Hodgkin Lymphoma treated with NivolumabAnti-PD-1 monoclonal antibodies (anti PD-1 mAbs) such as nivolumab and pembrolizumab are associated with high response rates in patients with relapsed or refractory (R/R) classical Hodgkin lymphoma (HL). To date, no prognostic factor for overall survival (OS) has been established with these agents in HL. We examined whether the first early response assessment evaluated using 18F-Fluorodeoxyglucose PET/CT (ePET1), may be associated with OS in this
- Image quality and activity optimization in oncological 18F-FDG PET using the digital Biograph Vision PET/CTThe first Siemens Biograph Vision PET/CT system (Siemens Healthineers, Knoxville, USA) was installed at the University Medical Center Groningen. Improved performance of this system could allow for a reduction in activity administration and/or scan duration. This study evaluates the effects of reduced scan duration in oncological 18F-FDG PET imaging on quantitative and subjective imaging parameters and its influence on clinical image reading. M
- Prospective Evaluation in an Academic Center of 18F-DCFPyL PET/CT in Biochemically Recurrent Prostate Cancer: A Focus on Localizing Disease and Changes in Management18F-DCFPyL is a promising PET radiopharmaceutical targeting prostate specific membrane antigen (PSMA). We present our experience in this single academic center prospective study evaluating the positivity rate of 18F-DCFPyL PET/CT in patients with biochemical recurrence (BCR) of prostate cancer (PC). Methods: We prospectively enrolled 72 men (52-91 years old, mean±SD: 71.5±7.2) with BCR after primary definitive treatment with prostatectomy
- Human Radiation Dosimetry of Orally or Intravenously Administered 18F-FluorodeoxyglucosePurpose: Intravenous access is difficult in some patients referred for 18F-fluorodeoxyglucose positron emission tomography (18F-FDG PET) imaging. Extravasation at the injection site and accumulation in central catheters can lead to limited tumor 18F-FDG uptake, erroneous quantitation, and significant image artifacts. In this study, we compare the human biodistribution and dosimetry of 18F-FDG for oral and intravenous administrations sequentially
- Back-table fluorescence-guided imaging for circumferential resection margin evaluation in locally advanced rectal cancer patients using bevacizumab-800CWRationale: Negative circumferential resection margins (CRM) are the cornerstone for curative treatment of locally advanced rectal cancer (LARC). However, in up to 18.6% of patients tumor-positive resection margins are detected upon histopathology. In this proof-of-concept study, we investigated the feasibility of optical molecular imaging as a tool to evaluate the CRM directly after surgical resection in order to improve tumor-negative CRM rates.
- Predictive Value of 18F-Florbetapir and 18F-FDG PET for Conversion from Mild Cognitive Impairment to Alzheimer DementiaThe present study examines the predictive values of amyloid PET, 18F-fluorodeoxyglucose (FDG) PET and non-imaging predictors (alone and in combination) for development of Alzheimer dementia (AD) in a large population of patients with mild cognitive impairment (MCI). Methods: 319 patients with MCI from the Alzheimer’s disease neuroimaging initiative database were included. In a derivation dataset (n = 159), the following Cox proportional hazard
- Intraindividual comparison of 18F-PSMA-1007 with renally excreted PSMA ligands for PSMA-PET imaging in patients with relapsed prostate cancer18F-Prostate-specific membrane antigen (PSMA)-1007 is mainly excreted through the liver. We benchmarked the performance of 18F-PSMA-1007 against three renally excreted PSMA-tracers. Methods: Among 668 patients we selected 27 patients in whom the PET/CT with 68Ga-PSMA-11, 18F-DCFPyL, or 18F-JK-PSMA-7 was interpreted as equivocal or negative or as oligometastatic disease (PET-1). Within <3 weeks, a second PET scan with 18F-PSMA-1007 was perform
- Bilateral Scalp Necrosis in Giant Cell ArteritisAbstract: Giant cell arteritis (GCA) is a medium-to-large vessel vasculitis of the elderly. Common constitutional clinical features include headache, scalp tenderness, and jaw claudication. Severe unilateral or bilateral visual loss is the most feared ophthalmic complication of GCA. Scalp necrosis is a known ischemic complication of GCA with approximately 100 cases reported in the literature to date. We report a case of scalp pain and an eryth
- Origins of Cerebral Edema: Implications for Spaceflight-Associated Neuro-Ocular SyndromeBackground: Spaceflight-associated neuro-ocular syndrome (SANS) was first described in 2011 and is associated with structural ocular changes found to occur in astronauts after long-duration missions. Despite multiple insufficient potential terrestrial models, an understanding of the etiology has yet to be described. Evidence Acquisition: A systematic review was conducted on literature published about the pathophysiology of cerebral edema.
- Escalating low‐dose Δ9‐tetrahydrocannabinol exposure during adolescence induces differential behavioral and neurochemical effects in male and female adult ratsAbstract Cannabinoid administration during adolescence affects various physiological processes, such as motor and affective response, cognitive‐related functions, and modulates neurotransmitter activity. Literature remains scant concerning the parallel examination of the effects of adolescent escalating low‐dose Δ9‐tetrahydrocannabinol (Δ9‐THC) on the behavioral and plasticity profile of adult rats in both sexes. Herein, we investigated the long
- Learning and transfer of complex motor skills in virtual reality: a perspective reviewThe development of more effective rehabilitative interventions requires a better understanding of how humans learn and transfer motor skills in real-world contexts. Presently, clinicians design interventions t...
- A novel wearable device to deliver unconstrained, unpredictable slip perturbations during gaitTask-specific perturbation training is a widely studied means of fall prevention, utilizing techniques that induce slips or slip-like perturbations during gait. Though effective, these methods only simulate na...
- Modifying ankle foot orthosis stiffness in patients with calf muscle weakness: gait responses on group and individual levelTo improve gait, persons with calf muscle weakness can be provided with a dorsal leaf spring ankle foot orthosis (DLS-AFO). These AFOs can store energy during stance and return this energy during push-off, whi...
- Advantages of using 3D virtual reality based training in persons with Parkinson’s disease: a parallel studyParkinson’s disease (PD) is a slowly progressive neurodegenerative disease. There are mixed reports on success of physiotherapy in patients with PD. Our objective was to investigate the functional improvements...
- Decentralized distribution-sampled classification models with application to brain imagingPublication date: 1 January 2020Source: Journal of Neuroscience Methods, Volume 329Author(s): Noah Lewis, Harshvardhan Gazula, Sergey M. Plis, Vince D. CalhounAbstractBackgroundIn this age of big data, certain models require very large data stores in order to be informative and accurate. In many cases however, the data are stored in separate locations requiring data transfer between local sites which can cause various practical hurdles, such as p
- A likelihood ratio approach for functional localization in fMRIPublication date: Available online 16 October 2019Source: Journal of Neuroscience MethodsAuthor(s): Jasper Degryse, Beatrijs MoerkerkeAbstractBackgroundTo increase power when analyzing fMRI data, researchers often define functional regions of interest (fROIs). It is crucial that this fROI is defined with an optimal balance between both false positives and false negatives to ensure maximal spatial accuracy and to avoid potentially biased results i
- Rapid, label-free detection of cerebral ischemia in rats using hyperspectral imagingPublication date: Available online 16 October 2019Source: Journal of Neuroscience MethodsAuthor(s): Chuhua Fu, Kang Ma, Zhao Li, Haifeng Wang, Tunan Chen, Dayong Zhang, Shi Wang, Ning Mu, Chuanyan Yang, Lu Zhao, Sheng Gong, Hua Feng, Fei LiAbstractBackgroundStroke is the third most common cause of disability and the second most common cause of death worldwide. Ischemia, one of the two broad categories of stroke, is characterized by a lack of suff
- Autophagy and synaptic plasticity: epigenetic regulationPublication date: December 2019Source: Current Opinion in Neurobiology, Volume 59Author(s): Jee-Yeon Hwang, Jingqi Yan, Ruth Suzanne ZukinIn neurons, autophagy is crucial to proper axon guidance, vesicular release, dendritic spine architecture, spine pruning and synaptic plasticity and, when dysregulated, is associated with brain disorders, including autism spectrum disorders, and neurodegenerative diseases such as Parkinson’s and Alzheimer’s dis
- Transgenerational epigenetic inheritance: from phenomena to molecular mechanismsPublication date: December 2019Source: Current Opinion in Neurobiology, Volume 59Author(s): Noa Liberman, Simon Yuan Wang, Eric Lieberman GreerInherited information not encoded in the DNA sequence can regulate a variety of complex phenotypes. However, how this epigenetic information escapes the typical epigenetic erasure that occurs upon fertilization and how it regulates behavior is still unclear. Here we review recent examples of brain related
- Outcome of endoscopic endonasal surgery in pediatric craniopharyngiomasPublication date: Available online 17 October 2019Source: World NeurosurgeryAuthor(s): Diego Mazzatenta, Matteo Zoli, Federica Guaraldi, Francesca Ambrosi, Marco Faustini Fustini, Ernesto Pasquini, Sofia Asioli, Mino ZucchelliAbstractIntroductionIn the last years, few reports have demonstrated the feasibility of the endoscopic endonasal approach (EEA) for craniopharyngiomas of pediatric age. For these tumors recent studies have suggested to prefe
- Two internal carotid aneurysms after a car accident in a young man – case reportPublication date: Available online 17 October 2019Source: World NeurosurgeryAuthor(s): Yang Chen, Fan Chen, Du Yin, Qiang Shao, Fei Hu, Jun Chen, Yubo XiongAbstractBackgroundPosttraumatic internal carotid aneurysms are rare. Two posttraumatic aneurysms occurring at the same time are even more rare. Two pseudoaneurysms located in different segments of the ipsilateral internal carotid artery have not been found in the literature. We provide the res
- Optic nerve sheath measurements by computed tomography to predict intracranial pressure and guide surgery in patients with traumatic brain injuryPublication date: Available online 17 October 2019Source: World NeurosurgeryAuthor(s): Meng liu, Zhi-Kun Yang, Yu-Feng Yan, Xiao Shen, Hui-Bin Yao, Li Fei, Er-Song WangAbstractBackgroundResearch has shown that the optic nerve sheath diameter (ONSD) is a good predictor of intracranial pressure (ICP) and may predict the need for surgery in the patients with head injury.ObjectiveTo test the value of ONSD in predicting the requirement for surgery in
- Cerebellar arteriovenous malformation rupture despite apparent angiographic obliteration: a case reportPublication date: Available online 17 October 2019Source: World NeurosurgeryAuthor(s): Gustavo Chagoya, Andrew A. Hardigan, Brandon M. Fox, Nicholas M.B. Laskay, Arsalaan A. Salehani, Lauren E. Rotman, Galal A. Elsayed, Joshua D. Bernstock, Nidal B. Omar, B. Ethan Tabibian, Adeel Ilyas, James Hackney, Winfield S. FisherAbstractBackgroundArteriovenous malformations (AVMs) can occur in all regions of the brain and spinal cord with clinical conseque
- Expression and clinical significance of immune checkpoint regulator B7-H3 (CD276) in human meningiomaPublication date: Available online 16 October 2019Source: World NeurosurgeryAuthor(s): Jiaojiao Deng, Mengyin Ma, Daijun Wang, Hongda Zhu, Lingyang Hua, Shuchen Sun, Hong Chen, Haixia Cheng, Zhi Rong Qian, Qing Xie, Tao Zhang, Ye GongAbstractPurposeThe high expression across multiple tumor types and restricted expression in normal tissues make B7-H3 an attractive target for immunotherapy. So far, little is known about the clinical significance of
- Subarachnoid hemorrhage attributable to bilateral aplastic or twig-like middle cerebral artery: Bilateral aplastic middle cerebral arteryPublication date: Available online 16 October 2019Source: World NeurosurgeryAuthor(s): Kazutaka Shirokane, Tomonori Tamaki, Kyongsong Kim, Akio MoritaAbstractBackgroundAplastic or twig-like MCA, a congenital anomaly related to the abnormal development of the MCA, is rare. It is usually unilateral; bilateral lesions are extremely rare. An aplastic or twig-like MCA may lead to cerebral ischemic stroke, intracranial hemorrhage, and SAH. In patients
- Choroid plexus carcinoma in adults: literature review and first report of a location into the third ventriclePublication date: Available online 16 October 2019Source: World NeurosurgeryAuthor(s): Antonio Crea, Andrea Bianco, Christian Cossandi, Sara Forgnone, Riccardo Fornaro, Emanuela Crobeddu, Daniele Marino, Giorgia Piras, Gianluca Scalia, Chiara Saglietti, Renato Boldorini, Renato Galzio, Gabriele PanzarasaAbstractIntroductionChoroid plexus carcinoma (CPC) is a rare intraventricular neoplasm originating from choroid plexus. CPC is the most aggressiv
- Endovascular revascularization of non-acute symptomatic proximal extracranial vertebral artery occlusionPublication date: Available online 16 October 2019Source: World NeurosurgeryAuthor(s): Lizhang Chen, Yi Jiang, Fayun Hu, Li He, Hongbo Zheng
- Rare cervicothoracic intramedullary and extramedullary lipomaPublication date: Available online 16 October 2019Source: World NeurosurgeryAuthor(s): Chao-Yuan Ge, Ding-Jun Hao, Wen-Yuan WeiAbstractWe report a rare case of cervicothoracic intramedullary and extramedullary lipoma. Complete resection of the extramedullary lipoma and almost complete resection of the intramedullary lipoma was performed using a microscope, followed by posterior fusion and internal fixation from C4-T2 to maintain the stability of
- Relationship of Grit and Resilience to Burnout Among US Neurosurgery ResidentsPublication date: Available online 16 October 2019Source: World NeurosurgeryAuthor(s): Hakeem J. Shakir, Justin M. Cappuzzo, Hussain Shallwani, Amanda Kwasnicki, Carli Bullis, Jiefei Wang, Ryan M. Hess, Elad I. LevyAbstractIntroductionStudies have begun investigating grit (continued fortitude in the face of hardship) and resilience (ability to recover from a setback) and their relationship to burnout (emotional exhaustion (EE) due to prolonged st
- Cranial melioidosis presenting as osteomyelitis and/or extra-axial abscess: Literature reviewPublication date: Available online 16 October 2019Source: World NeurosurgeryAuthor(s): G Lakshmi PrasadAbstractBackgroundCentral nervous system (CNS) melioidosis is rare. Clinical presentations depend on the region of endemicity. Despite treatment, neurologic disease has relatively high mortality rates. Less than 80 cases of CNS involvement have been reported.Materials and methodsLiterature review was performed by searching online databases for m
- Prognosis of hardware-related problems in anterior cervical discectomy and fusion with cage and plate constructsPublication date: Available online 16 October 2019Source: World NeurosurgeryAuthor(s): Kyung-Jin Song, Byung-Wan Choi, Dong Hun Ham, Hyeong Jik KimAbstractBackground/ObjectivesThe purpose of this study was to analyze hardware-related problems and their prognoses after anterior cervical discectomy and fusion (ACDF) using cages and plates for degenerative and traumatic cervical disc diseases.MethodsEight-hundred-and-eight patients who underwent ACD
ΩτοΡινοΛαρυγγολόγος Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,
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alsfakia@gmail.com,
Anapafseos 5 Agios Nikolaos 72100 Crete Greece,
Medicine by Alexandros G. Sfakianakis,
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