• Pinocembrin inhibits the proliferation and migration and promotes the apoptosis of ovarian cancer cells through down-regulating the mRNA levels of N-cadherin and GABAB receptor

  Publication date: December 2019Source: Biomedicine & Pharmacotherapy, Volume 120Author(s): Jun Gao, Shixin Lin, Yao Gao, Xia Zou, Jun Zhu, Man Chen, Hong Wan, Hong ZhuAbstractThere is no previous study on the effect of pinocembrin on ovarian cancer to the best of our knowledge. Moreover, the effects of pinocembrin on the expression of GABAB1 and GABAB2 genes are not studied before. Therefore, this study aimed to investigate effects of pinocembrin

  Biomedicine & Pharmacotherapy

  Sat Oct 19, 2019 08:21
• Clinical and biological significances of heat shock protein 90 (Hsp90) in human nasopharyngeal carcinoma cells and anti-cancer effects of Hsp90 inhibitor

  Publication date: December 2019Source: Biomedicine & Pharmacotherapy, Volume 120Author(s): Fangxian Liu, Liangliang Wang, Shijiang Yi, Qianghe Liu, Xiaoxiao Xu, Min SuAbstractNasopharyngeal carcinoma (NPC) is a malignant tumor in South China, characterized with high death rate. If untreated, NPC cells will be invasiveness and then spread to other tissues. In clinical practice, however, lack of early effective screening to prevent the NPC developm

  Biomedicine & Pharmacotherapy

  Sat Oct 19, 2019 08:21
• The protective effects of hydrogen sulfide on the myocardial ischemia via regulating Bmal1

  Publication date: December 2019Source: Biomedicine & Pharmacotherapy, Volume 120Author(s): Jiaqin Hu, Yan Xue, Kai Tang, Jing Fan, Junxi Du, Wenfu Li, Siyu Chen, Chang Liu, Wenjin Ji, Jiexian Liang, Jian Zhuang, Kun ChenAbstractBackgroundTo investigate the effect of hydrogen peroxide (H2S) on myocardial clock gene Bmal1 in ischemic cardiomyocytes.Materials & methodsQuantitative PCR (qPCR) was used to detect the expression of Bmal1 at the mRNA lev

  Biomedicine & Pharmacotherapy

  Sat Oct 19, 2019 08:21
• High glucose inhibits myogenesis and induces insulin resistance by down-regulating AKT signaling

  Publication date: December 2019Source: Biomedicine & Pharmacotherapy, Volume 120Author(s): Wei Luo, Lei Ai, Bo-fa Wang, Yue ZhouAbstractBackgroundA high glucose level is usually considered to be the factor that induces tissue and cell dysfunction and damage, commonly known as “glucose toxicity”.ObjectiveThis study aimed to explore the effects and the potential molecular mechanisms of high glucose on myoblast differentiation and insulin sensitivit

  Biomedicine & Pharmacotherapy

  Sat Oct 19, 2019 08:21
• Regulation of CD39 expression in ATP-P2Y2R-mediated alcoholic liver steatosis and inflammation

  Publication date: December 2019Source: International Immunopharmacology, Volume 77Author(s): Zhen-ni Liu, Wen-qian Jia, Tao Jiang, Jing-wen Dai, Chen Shuai, Xiong-wen LvAbstractInflammation plays a central role in the progression of alcoholic liver disease. ATP-P2Y2R signaling and CD39 play an important role in various diseases, but little is known about their role in alcoholic liver steatosis and inflammation. As a transmembrane hydrolase, CD39

  ScienceDirect Publication: International Immunopharmacology

  Sat Oct 19, 2019 05:26
• Therapeutic treatment of a novel selective JAK3/JAK1/TBK1 inhibitor, CS12192, in rat and mouse models of rheumatoid arthritis

  Publication date: December 2019Source: International Immunopharmacology, Volume 77Author(s): Song Shan, You Zhou, Jindi Yu, Qianjiao Yang, Desi Pan, Yanan Wang, Lingjie Li, Jingzhong Zhu, Yu Zhang, Shengjian Huang, Zhibin Li, Zhiqiang Ning, Lijun Xin, Xianping LuAbstractRheumatoid arthritis (RA) is a representative autoimmune disease characterized by chronic inflammation and joint destruction. Although biological inhibitors such as TNF-α and IL-6

  ScienceDirect Publication: International Immunopharmacology

  Sat Oct 19, 2019 05:26
• The tiliroside derivative, 3-<em>O</em>-[(<em>E</em>)-(2-oxo-4-(p-tolyl) but–3–en–1–yl] kaempferol produced inhibition of neuroinflammation and activation of AMPK and Nrf2/HO-1 pathways in BV-2 microglia

  Publication date: December 2019Source: International Immunopharmacology, Volume 77Author(s): Ravikanth Velagapudi, Faisal Jamshaid, Izabela Lepiarz, Folashade O. Katola, Karl Hemming, Olumayokun A. OlajideAbstractNeuroinflammation is now widely accepted as an important pathophysiological mechanism in neurodegenerative disorders, thus providing a critical target for novel compounds. In this study, 3-O-[(E)-(2-oxo-4-(p-tolyl)but-3-en-1-yl] kaempfer

  ScienceDirect Publication: International Immunopharmacology

  Sat Oct 19, 2019 05:26
• 1-Methylnicotinamide attenuates lipopolysaccharide-induced cognitive deficits via targeting neuroinflammation and neuronal apoptosis

  Publication date: December 2019Source: International Immunopharmacology, Volume 77Author(s): Rong-hao Mu, Yuan-zhi Tan, Li-li Fu, Mohammad Nazmul Islam, Mei Hu, Hao Hong, Su-su TangAbstractAlzheimer’s disease (AD) is a neurodegenerative disease that affects cognition and behavior. The neuroinflammatory response in the brain is an important pathological characteristic in AD. In this study, we investigated the neuroprotective effects of 1-Methylnic

  ScienceDirect Publication: International Immunopharmacology

  Sat Oct 19, 2019 05:26
• Neutrophil to lymphocyte ratio and platelet to lymphocyte ratio in patients with systemic lupus erythematosus and their correlation with activity: A meta-analysis

  Publication date: November 2019Source: International Immunopharmacology, Volume 76Author(s): Lisha Ma, Aiping Zeng, Binxuan Chen, Ying Chen, Renfang ZhouAbstractObjectiveThe neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) have been suggested to be potential biomarkers for systemic lupus erythematosus (SLE). We thus performed this meta-analysis to investigate the relationship between NLR and PLR and SLE.MethodsA literat

  ScienceDirect Publication: International Immunopharmacology

  Sat Oct 19, 2019 05:26
• Riluzole Oral Suspension: Bioavailability Following Percutaneous Gastrostomy Tube-modeled Administration Versus Direct Oral Administration

  Publication date: Available online 18 October 2019Source: Clinical TherapeuticsAuthor(s): Benjamin Rix Brooks, Paolo Bettica, Sara CazzanigaAbstractPurposeDuring amyotrophic lateral sclerosis progression, up to 85% of patients develop dysphagia. Riluzole oral suspension 50 mg/10 mL is bioequivalent to riluzole 50-mg film-coated tablets administered orally under fasting conditions. Here, we compare the bioavailability of a single 50-mg dose of ril

  Clinical Therapeutics

  Sat Oct 19, 2019 05:05
• The role of palliative interventional radiotherapy (brachytherapy) in esophageal cancer: An AIRO (Italian Association of Radiotherapy and Clinical Oncology) systematic review focused on dysphagia-free survival

  Publication date: Available online 18 October 2019Source: BrachytherapyAuthor(s): Valentina Lancellotta, Francesco Cellini, Bruno Fionda, Vitaliana De Sanctis, Cristiana Vidali, Vincenzo Fusco, Fernando Barbera, Maria Antonietta Gambacorta, Renzo Corvò, Stefano Maria Magrini, Luca TagliaferriAbstractPurposeThe aim of this review was to examine efficacy of palliative interventional radiotherapy (IRT) in esophageal cancer compared with other treatm

  Brachytherapy

  Sat Oct 19, 2019 04:21
• Radiotherapy can increase the risk of ischemic cerebrovascular disease in head and neck cancer patients: A Korean population-based cohort study

  Publication date: Available online 17 October 2019Source: Radiotherapy and OncologyAuthor(s): Jin Yong Lee, Young Ae Kim, Ho Seob Kim, Joung Hwan Back, Young Ho Jung, Duk-Hyoung Lee, Suzy KimAbstractBackground and purposeSeveral reports suggested that radiotherapy (RT) was related to an increased risk of cerebrovascular disease (CVD) in head and neck cancer (HNC) patients, but other risk factors of CVD were not properly considered in estimating t

  Radiotherapy and Oncology

  Fri Oct 18, 2019 11:45
• Cross-modality applicability of rectal normal tissue complication probability models from photon- to proton-based radiotherapy

  Publication date: Available online 17 October 2019Source: Radiotherapy and OncologyAuthor(s): Jesper Pedersen, Stella Flampouri, Curtis Bryant, Xiaoying Liang, Nancy Mendenhall, Zuofeng Li, Mitchell Liu, Ludvig P MurenAbstractBackground and purposeProton therapy (PT) is currently being studied to improve normal tissue (NT) sparing beyond what can be achieved with conventional photon-based therapy. Compared to photons, PT dose distributions have a

  Radiotherapy and Oncology

  Fri Oct 18, 2019 11:45
• Long-term survival and complications following bladder-preserving brachytherapy in patients with cT1-T2 bladder cancer

  Publication date: Available online 17 October 2019Source: Radiotherapy and OncologyAuthor(s): Charlotte S. Voskuilen, Judith Bosschieter, Erik van Werkhoven, Kees Hendricksen, André N. Vis, Thelma Witteveen, Bradley R. Pieters, Max Burger, Axel Bex, Henk G. van der Poel, Luc M. Moonen, Simon Horenblas, Jakko A. Nieuwenhuijzen, Bas W.G. van RhijnAbstractBackground and purposeRadical cystectomy (RC) is considered standard treatment for muscle-invas

  Radiotherapy and Oncology

  Fri Oct 18, 2019 11:45
• NTCP model for postoperative complications and one-year mortality after trimodality treatment in oesophageal cancer

  Publication date: Available online 17 October 2019Source: Radiotherapy and OncologyAuthor(s): Melissa Thomas, Gilles Defraene, Maarten Lambrecht, Wei Deng, Johnny Moons, Philippe Nafteux, Steven H. Lin, Karin HaustermansAbstractPurpose/ObjectivesTo develop normal tissue complication probability (NTCP) models for postoperative pulmonary and cardiac complications and one-year mortality after preoperative chemoradiotherapy and surgery in oesophageal

  Radiotherapy and Oncology

  Fri Oct 18, 2019 11:45
• Synthetic MRI-aided multi-organ segmentation on male pelvic CT using cycle consistent deep attention network

  Publication date: Available online 17 October 2019Source: Radiotherapy and OncologyAuthor(s): Xue Dong, Yang Lei, Sibo Tian, Tonghe Wang, Pretesh Patel, Walter J. Curran, Ashesh B. Jani, Tian Liu, Xiaofeng YangAbstractBackground and purposeManual contouring is labor intensive, and subject to variations in operator knowledge, experience and technique. This work aims to develop an automated computed tomography (CT) multi-organ segmentation method f

  Radiotherapy and Oncology

  Fri Oct 18, 2019 11:45
• Critical review and quality-assessment of cost analyses in radiotherapy: How reliable are the data?

  Publication date: Available online 17 October 2019Source: Radiotherapy and OncologyAuthor(s): Defourny Noémie, Monten Chris, Grau Cai, Lievens Yolande, Perrier LionelAbstractPurpose/objectiveHealth economic evaluations (HEE) are increasingly having an impact on policymakers, although the results greatly depend on the quality of the methodology used and on transparent reporting. The two main objectives of this study were to evaluate the quality of

  Radiotherapy and Oncology

  Fri Oct 18, 2019 11:45
• Intraoperative radiotherapy for glioblastoma: an international pooled analysis

  Publication date: Available online 16 October 2019Source: Radiotherapy and OncologyAuthor(s): Gustavo R. Sarria, Elena Sperk, Xiaodi Han, Gustavo J. Sarria, Frederik Wenz, Stefanie Brehmer, Bing Fu, Siming Min, Hongjun Zhang, Shusen Qin, Xiaoguang Qiu, Daniel Hänggi, Yasser Abo-Madyan, David Martinez, Carla Cabrera, Frank A. GiordanoAbstractPurposeTo report the results of the first international pooled analysis of patients with glioblastoma treat

  Radiotherapy and Oncology

  Fri Oct 18, 2019 11:45
• Inhaled corticosteroids and risk of pneumonia in patients with chronic obstructive pulmonary disease: A meta-analysis of randomized controlled trials

  Publication date: December 2019Source: International Immunopharmacology, Volume 77Author(s): Mingjin Yang, Yuejun Du, Hong Chen, Depeng Jiang, Zhibo XuAbstractObjectiveInhaled corticosteroids (ICS) are generally used to treat patients with chronic obstructive pulmonary disease (COPD) who suffer from repeated exacerbations. Recently, it was reported that ICS treatment increased the risk of pneumonia in COPD patients. But it is controversial. The o

  ScienceDirect Publication: International Immunopharmacology

  Fri Oct 18, 2019 08:55
• Tobacco smoking aggravates airway inflammation by upregulating endothelin-2 and activating the c-Jun amino terminal kinase pathway in asthma

  Publication date: December 2019Source: International Immunopharmacology, Volume 77Author(s): Maoqing Guo, Yanan Liu, Xiao Han, Fangfang Han, Jiechen Zhu, Shuyang Zhu, Bi ChenAbstractBackgroundAsthma is closely associated with tobacco smoking (TS) and is more difficult to effectively treat after exposure to TS.ObjectiveTo observe the effects of TS on the expression of endothelin-2 (ET-2) and airway inflammation in asthmatic rats and to explore the

  ScienceDirect Publication: International Immunopharmacology

  Fri Oct 18, 2019 08:55
• Subcutaneous administration of α-GalCer activates iNKT10 cells to promote M2 macrophage polarization and ameliorates chronic inflammation of obese adipose tissue

  Publication date: December 2019Source: International Immunopharmacology, Volume 77Author(s): Dongzhi Chen, Huijuan Zhao, Xiang Gao, Shengde Chen, Huifang Liu, Jingnan Zhang, Jinku Zhang, Ming MengAbstractObjectiveThe role of iNKT cells was investigated in chronic adipose tissue inflammation in obese mice after administration of α-GalCer in different pathways.MethodsC57BL/6J mice were fed high-fat diet (HFD) for 12 weeks to establish the obese mou

  ScienceDirect Publication: International Immunopharmacology

  Fri Oct 18, 2019 08:55
• Serum and sputum levels of IL-17, IL-21, TNFα and mRNA expression of IL-17 in sulfur mustard lung tissue with long term pulmonary complications (28 years after sulfur mustard exposure)

  Publication date: November 2019Source: International Immunopharmacology, Volume 76Author(s): Ali Mohammad Mohseni Majd, Soghrat Faghihzadeh, Shahryar Pourfarzam, Marzieh Eghtedardoost, Davoud Jamali, Ensie Sadat Mirsharif, Razieh Dilmaghanian, Tooba GhazanfariAbstractBackgroundIranian veterans who had exposed to Sulfur Mustard (SM) suffer from long term complications such as Chronic Obstructive Pulmonary Disease (COPD) and bronchiolitis obliterat

  ScienceDirect Publication: International Immunopharmacology

  Fri Oct 18, 2019 08:55
• Corrigendum to “Effect of chlorogenic acid on mast cell-dependent anaphylactic reaction” [Int. Immunopharmacol. 10 (2010) 1135–1141]

  Publication date: Available online 28 August 2019Source: International ImmunopharmacologyAuthor(s): Hui-Di Qin, Yan-Qiu Shi, Zhao-Hua Liu, Zhong-Gang Li, Huai-Shan Wang, Hong Wang, Zhao-Ping Liu

  ScienceDirect Publication: International Immunopharmacology

  Fri Oct 18, 2019 08:55
• Ferulic acid, a natural polyphenol, protects against osteoporosis by activating SIRT1 and NF-κB in neonatal rats with glucocorticoid-induced osteoporosis

  Publication date: December 2019Source: Biomedicine & Pharmacotherapy, Volume 120Author(s): Tingting Hou, Lirong Zhang, Xiaohong YangAbstractOsteoporosis is a chronic disease whose symptoms include a reduction in bone strength, osteopenia, and damage to the bone microstructure. Ferulic acids are natural polyphenols present in various fruits that suppress the fusion and apoptosis of mature osteoclasts. Rats were divided into sham, control (osteopor

  Biomedicine & Pharmacotherapy

  Fri Oct 18, 2019 08:48
• Tambulin from <em>Zanthoxylum armatum</em> acutely potentiates the glucose-induced insulin secretion via K_ATP-independent Ca²⁺-dependent amplifying pathway

  Publication date: December 2019Source: Biomedicine & Pharmacotherapy, Volume 120Author(s): Abdul Hameed, Sayed Ali Raza, M. Israr Khan, Janaki Baral, Achyut Adhikari, Mohammad Nur-e-Alam, Sarfaraz Ahmed, Adnan J. Al-Rehaily, Sajda Ashraf, Zaheer Ul-Haq, Rahman M. HafizurAbstractTambulin, a flavonol isolated from Zanthoxylum armatum, showed potent insulin secretory activity in our preliminary anti-diabetic screening. Here, we explored the insulin

  Biomedicine & Pharmacotherapy

  Fri Oct 18, 2019 08:48
• Tongguan capsule derived-herb ameliorates remodeling at infarcted border zone and reduces ventricular arrhythmias in rats after myocardial infarction

  Publication date: December 2019Source: Biomedicine & Pharmacotherapy, Volume 120Author(s): Shiyu Ma, Jin Ma, Yuanshen Zhou, Liheng Guo, Junqi Bai, Minzhou ZhangAbstractObjectiveTongguan Capsule, a traditional Chinese medicine, is safe to use and is efficient in treating ischemic heart diseases. The present study aimed to investigate whether Tongguan capsule derived-herb (TGD) can mitigate left ventricular remodeling and dysfunction in post myocar

  Biomedicine & Pharmacotherapy

  Fri Oct 18, 2019 08:48
• HPLC-ESI- MS/MS analysis of beet (<em>Beta vulgaris)</em> leaves and its beneficial properties in type 1 diabetic rats

  Publication date: December 2019Source: Biomedicine & Pharmacotherapy, Volume 120Author(s): Eman A. Abd El-Ghffar, Nesrine M. Hegazi, Hamada H. Saad, Mohamed M. Soliman, Mohamed A. El-Raey, Safia M. Shehata, Alaa Barakat, Aziz Yasri, Mansour SobehAbstractThe phenolic profile of the leaves of Beta vulgaris subspecies vulgaris variety rubra was investigated by high-performance liquid chromatography (HPLC) coupled to electrospray ionization high reso

  Biomedicine & Pharmacotherapy

  Fri Oct 18, 2019 08:48
• Aberrant DNA methylation of PAX1, SOX1 and ZNF582 genes as potential biomarkers for esophageal squamous cell carcinoma

  Publication date: December 2019Source: Biomedicine & Pharmacotherapy, Volume 120Author(s): Li Tang, Yu-Ligh Liou, Zi-Rui Wan, Jie Tang, Yuan Zhou, Wei Zhuang, Guo WangAbstractBackgroundEsophageal squamous cell carcinoma (ESCC) is a highly invasive malignant tumor and the majority of patients have advanced stage of ESCC at diagnosis with poor outcome. Identification of sensitive and specific biomarkers for early screening of ESCC is critical for i

  Biomedicine & Pharmacotherapy

  Fri Oct 18, 2019 08:48
• CTRP3 acts as a novel regulator in depressive-like behavior associated inflammation and apoptosis by meditating p38 and JNK MAPK signaling

  Publication date: December 2019Source: Biomedicine & Pharmacotherapy, Volume 120Author(s): Jing Meng, Dong-Ming Wang, Li-Ling LuoAbstractDepression is a complicated etiological pattern, and its pathology and effective treatments are highly limited.C1q-tumor necrosis factor-related protein-3 (CTRP3) is an adipokine, playing crucial roles in metabolic regulatory properties. However, the effects of CTRP3 on depression are largely unknown. In the pre

  Biomedicine & Pharmacotherapy

  Fri Oct 18, 2019 08:48
• Karyopherin β1 deletion suppresses tumor growth and metastasis in colorectal cancer (CRC) by reducing MET expression

  Publication date: December 2019Source: Biomedicine & Pharmacotherapy, Volume 120Author(s): Yi Zhang, Ke-Feng LiAbstractColorectal cancer (CRC) has become the third most common type of cancer worldwide, and CRC liver metastasis (CRLM) is associated with poor survival rates. However, the molecular mechanisms driving this phenomenon remain unclear. Karyopherin β1 (KPNB1) is an adaptor protein that transports several proteins to the nuclear, and has

  Biomedicine & Pharmacotherapy

  Fri Oct 18, 2019 08:48
• XIAOPI formula promotes breast cancer chemosensitivity <em>via</em> inhibiting CXCL1/HMGB1-mediated autophagy

  Publication date: December 2019Source: Biomedicine & Pharmacotherapy, Volume 120Author(s): Neng Wang, Bowen Yang, Gulizeba Muhetaer, Shengqi Wang, Yifeng Zheng, Jiahong Lu, Min Li, Fengxue Zhang, Honglin Situ, Yi Lin, Zhiyu WangAbstractXIAOPI formula is a national approved drug prescribed to patients with high breast cancer risk. Previously we demonstrated that XIAOPI formula could inhibit breast cancer metastasis via suppressing CXCL1 expression

  Biomedicine & Pharmacotherapy

  Fri Oct 18, 2019 08:48
• AGEs impair Kv channel-mediated vasodilation of coronary arteries by activating the NF-κB signaling pathway in ZDF rats

  Publication date: December 2019Source: Biomedicine & Pharmacotherapy, Volume 120Author(s): Qingbo Liu, Bing Hua, Wen Su, Beibing Di, Shandong Yu, Side Gao, Huirong Liu, Xueqiao Zhao, Weiping Li, Hongwei LiAbstractExcessive formation of advanced glycation end products (AGEs) impairs voltage-gated potassium (Kv) channels in rat coronary artery smooth muscle cells (CSMCs), resulting in weakened Kv-mediated coronary vasodilation. We hypothesized that

  Biomedicine & Pharmacotherapy

  Fri Oct 18, 2019 08:48
• Prevalence and sensitivity of trigger points in lumbo-pelvic-hip muscles in patients with patellofemoral pain syndrome

  Publication date: Available online 15 October 2019Source: Journal of Bodywork and Movement TherapiesAuthor(s): Mahbobeh Samani, Farahnaz Ghaffarinejad, Sara Abolahrari-Shirazi, Tahereh Khodadadi, Fatemeh RoshanAbstractObjectivesChanges in the activity of the lumbo-pelvic-hip muscles have been established as a major cause of patellofemoral pain syndrome (PFPS), a common orthopedic problem. The present study aimed to compare the prevalence and sens

  ScienceDirect Publication: Journal of Bodywork and Movement Therapies

  Fri Oct 18, 2019 07:59
• Athletic Development - Part 2: The Foundational Stage of Development

  Publication date: Available online 15 October 2019Source: Journal of Bodywork and Movement TherapiesAuthor(s): Nicole Rodriguez, Fred Duncan, Craig Liebenson

  ScienceDirect Publication: Journal of Bodywork and Movement Therapies

  Fri Oct 18, 2019 07:59
• THE EFFECT OF TREATMENT REGIMENS ON SALIVARY CORTISOL LEVELS IN PATIENTS WITH CHRONIC MUSCULOSKELETAL DISORDERS

  Publication date: Available online 15 October 2019Source: Journal of Bodywork and Movement TherapiesAuthor(s): Maria Papandreou, Anastassios Philippou, Orjona Taso, Michael Koutsilieris, Alexandra KaperdaAbstractBackgroundIncreased levels of circulating cortisol have been associated with pain severity in patients with chronic musculoskeletal disorders (CMD). Little is known about the potential association between pain management and salivary cort

  ScienceDirect Publication: Journal of Bodywork and Movement Therapies

  Fri Oct 18, 2019 07:59
• Multimodal imaging of a choroidal granuloma as a first sign of tuberculosis

  Publication date: Available online 17 October 2019Source: Photodiagnosis and Photodynamic TherapyAuthor(s): Funda Ebru Aksoy, Cigdem Altan, Berna BasarirAbstractChoroidal granuloma is rarely seen as the first sign of tuberculosis(TB). Here we report a case of a 34-year old male with a choroidal mass which was associated with serous retinal detachment on EDI-OCT and the “contact sign” between the neurosensory retina and the retinal pigment epithel

  ScienceDirect Publication: Photodiagnosis and Photodynamic Therapy

  Fri Oct 18, 2019 07:48
• Impact of l -carnitine on imatinib-related muscle cramps in patients with gastrointestinal stromal tumor

  Summary Introduction Muscle cramps constitute one of the leading adverse events of imatinib, the standard first-line treatment for advanced gastrointestinal stromal tumor (GIST). This study aims to assess the impact of l-carnitine on relieving cramps in patients with GIST taking imatinib. Materials and methods We reviewed our prospective database for patients with GIST who took l-carnitine (500-mg tablet, 2–3 times daily) for m

  Latest Results for Investigational New Drugs

  Thu Oct 17, 2019 17:00
• Reduction in Hospital Readmission Rates Among Medicare Beneficiaries With Chronic Obstructive Pulmonary Disease: A Real-world Outcomes Study of Nebulized Bronchodilators

  Publication date: Available online 17 October 2019Source: Clinical TherapeuticsAuthor(s): Allison Keshishian, Lin Xie, Carole Dembek, Huseyin YuceAbstractPurposeChronic obstructive pulmonary disease (COPD) is a common condition responsible for substantial morbidity, mortality, and costs in the United States. The economic burden of COPD is driven primarily by hospitalizations, with 1 in 5 hospitalized patients experiencing a 30-day readmission. Br

  Clinical Therapeutics

  Fri Oct 18, 2019 04:05
• Cost-effectiveness of Molecular Profile Patient Selection for First-line Treatment of Recurrent/Metastatic Head and Neck Cancer

  Publication date: Available online 17 October 2019Source: Clinical TherapeuticsAuthor(s): Carla Rognoni, Silvana Quaglini, Jan Baptist Vermorken, Loris De Cecco, Lisa Licitra, Paolo BossiAbstractPurposePatients with recurrent and/or metastatic head and neck squamous cell cancer are offered platinum-based chemotherapy plus cetuximab; however, this strategy is not cost-effective. We evaluated the cost-effectiveness of a hypothetical predictive mole

  Clinical Therapeutics

  Fri Oct 18, 2019 04:05