Detecting cancer at its early stages remains a major challenge in oncology. Even monitoring the progression of cancer is difficult, but researchers at the University of Michigan have come up with a tiny implantable device that can draw cancer cells toward itself for gene expression analysis. The microscopic device is a biomaterial scaffold that is designed to allow new cells to settle within. Circulating tumor cells, being the most opportunistic at finding fresh nooks to make home, are quickly...
Wed Oct 30, 2019 21:56
INVO Bioscience, a Florida company, has just won European regulatory approval for its INVOcell culture and retention device. The product is part of the INVO Solution, which involves introducing sperm to an egg within the INVOcell device and then placing the device within the vaginal cavity of the woman seeking to become pregnant. After three days of incubation within the woman, the device is removed and the resulting embryos can be analyzed in a lab. The optimal candidates are chosen and...
Wed Oct 30, 2019 17:33
Earlier this month, Tampa General Hospital (TGH) became the first deployment site for a new telemedicine station developed by health technology company OnMed. Available as part of the TGH staff health program, the OnMed Station connects patients with doctors, nurses, and pharmacists for real-time consultations via high definition audio and video. Available 24/7, doctors available through OnMed are board certified or board eligible in the state where the OnMed station is located. ...
Wed Oct 30, 2019 15:35
The timing of exposure to ligands may impact their developmental consequences. Here we show how to image release of a Drosophila bone morphogenetic protein (BMP) called Dpp from cells of the wing disc.
Wed Oct 30, 2019 21:03
A cryogenic pulverization method to process murine paws using a liquid nitrogen freezer mill was developed to improve the yield and quality of RNA or protein extracted from the tissues and enable the analysis of molecular profiles associated with inflammatory responses.
Wed Oct 30, 2019 20:04
Proliferation is a critical part of cellular function, and a common readout used to assess potential toxicity of new drugs. Measuring proliferation is, therefore, a frequently used assay in cell biology. Here we present a simple, versatile method of measuring proliferation that can be used in adherent and non-adherent cells.
Wed Oct 30, 2019 19:04
Publication date: Available online 29 October 2019Source: Trends in ImmunologyAuthor(s): Yansong Xue, Daniel Enosi Tuipulotu, Wei Hong Tan, Callum Kay, Si Ming ManThe inflammasome is a cytosolic immune signaling complex that induces inflammation and pyroptosis. Inflammasome complexes respond to a variety of pathogens, as well as danger or homeostasis-altering signals; they can play critical roles in the development of autoinflammatory conditions and cancer. Studies have now provided additional insights...
Wed Oct 30, 2019 20:42
Cells, Vol. 8, Pages 1359: Peripheral Delivery of Neural Precursor Cells Ameliorates Parkinson’s Disease-Associated Pathology Cells doi: 10.3390/cells8111359 Authors: Edwards III Gamez Armijo Kramm Morales Taylor-Presse Schulz Soto Moreno-Gonzalez : Parkinson’s disease (PD) is a progressive neurodegenerative disorder characterized by loss of motor control due to a wide loss of dopaminergic neurons along the nigro-striatal pathway. Some of the...
Wed Oct 30, 2019 02:00
Cells, Vol. 8, Pages 1357: The Oncogene AF1Q is Associated with WNT and STAT Signaling and Offers a Novel Independent Prognostic Marker in Patients with Resectable Esophageal Cancer Cells doi: 10.3390/cells8111357 Authors: Gruber Oberhuber Birner Schlederer Kenn Schreiner Jomrich Schoppmann Gnant Tse Kenner : AF1q impairs survival in hematologic and solid malignancies. AF1q expression is associated with tumor progression, migration, and chemoresistance,...
Wed Oct 30, 2019 02:00
Cells, Vol. 8, Pages 1356: Natural Sulfur-Containing Compounds: An Alternative Therapeutic Strategy against Liver Fibrosis Cells doi: 10.3390/cells8111356 Authors: Milito Brancaccio D’Argenio Castellano Liver fibrosis is a pathophysiologic process involving the accumulation of extracellular matrix proteins as collagen deposition. Advanced liver fibrosis can evolve in cirrhosis, portal hypertension and often requires liver transplantation. At the cellular level, hepatic fibrosis...
Wed Oct 30, 2019 02:00
Cells, Vol. 8, Pages 1358: Why Bile Acids Are So Important in Non-Alcoholic Fatty Liver Disease (NAFLD) Progression Cells doi: 10.3390/cells8111358 Authors: Aline Gottlieb Ali Canbay Non-alcoholic fatty liver disease (NAFLD) is a complex disease, affecting not just the liver, but also all other organs in the body. Despite an increasing amount of people worldwide developing NAFLD and having it progress to non-alcoholic steatohepatitis (NASH) and potentially cirrhosis, there is still...
Wed Oct 30, 2019 02:00
Cells, Vol. 8, Pages 1354: Improved Motor Nerve Regeneration by SIRT1/Hif1a-Mediated Autophagy Cells doi: 10.3390/cells8111354 Authors: David Romeo-Guitart Tatiana Leiva-Rodriguez Joaquim Forés Caty Casas Complete restoring of functional connectivity between neurons or target tissue after traumatic lesions is still an unmet medical need. Using models of nerve axotomy and compression, we investigated the effect of autophagy induction by genetic and pharmacological manipulation...
Wed Oct 30, 2019 02:00
Cells, Vol. 8, Pages 1355: Mitofusin 2-Deficiency Suppresses Mycobacterium tuberculosis Survival in Macrophages Cells doi: 10.3390/cells8111355 Authors: Junghwan Lee Ji-Ae Choi Soo-Na Cho Sang-Hun Son Chang-Hwa Song Apoptosis is an important host defense mechanism against mycobacterial infection. However, the molecular mechanisms regulating apoptosis during mycobacterial infection are not well known. Recent reports suggest that bacterial infection regulates mitochondrial...
Wed Oct 30, 2019 02:00
Cells, Vol. 8, Pages 1350: BAP31 Inhibits Cell Adaptation to ER Stress Conditions, Negatively Regulating Autophagy Induction by Interaction with STX17 Cells doi: 10.3390/cells8111350 Authors: Kayo Machihara Takushi Namba Cancer cells modulate their metabolism to proliferate and survive under the metabolic stress condition, which is known as endoplasmic reticulum (ER) stress. Therefore, cancer cells should suppress ER stress-mediated cell death and induce autophagy—which...
Wed Oct 30, 2019 02:00
Cells, Vol. 8, Pages 1353: Adenosine Depletion as A New Strategy to Decrease Glioblastoma Stem-Like Cells Aggressiveness Cells doi: 10.3390/cells8111353 Authors: Ignacio Niechi Atenea Uribe-Ojeda José Ignacio Erices Ángelo Torres Daniel Uribe José Dellis Rocha Pamela Silva Hans G. Richter Rody San Martín Claudia Quezada Glioblastoma is the brain tumor with the worst prognosis. This is mainly due to a cell subpopulation with an extremely aggressive potential,...
Wed Oct 30, 2019 02:00
Cells, Vol. 8, Pages 1351: A Matricryptic Conformation of the Integrin-Binding Domain of Fibronectin Regulates Platelet-Derived Growth Factor-Induced Intracellular Calcium Release Cells doi: 10.3390/cells8111351 Authors: Christopher S. Farrar Geoffrey T. Rouin Benjamin L. Miller Carol H. Raeman Nancie A. Mooney Denise C. Hocking Platelet-derived growth factor (PDGF) signaling is dysregulated in a wide variety of diseases, making PDGF an attractive therapeutic target. However,...
Wed Oct 30, 2019 02:00
Cells, Vol. 8, Pages 1352: MicroRNAs in Inflammatory Heart Diseases and Sepsis-Induced Cardiac Dysfunction: A Potential Scope for the Future? Cells doi: 10.3390/cells8111352 Authors: Moritz Mirna Vera Paar Richard Rezar Albert Topf Miriam Eber Uta C. Hoppe Michael Lichtenauer Christian Jung Background: MicroRNAs (miRNAs) are small, single-stranded RNA sequences that regulate gene expression on a post-transcriptional level. In the last few decades, various trials...
Wed Oct 30, 2019 02:00
Cells, Vol. 8, Pages 1349: Functions and Implications of Autophagy in Colon Cancer Cells doi: 10.3390/cells8111349 Authors: Samantha N Devenport Yatrik M Shah Autophagy is an essential function to breakdown cellular proteins and organelles to recycle for new nutrient building blocks. In colorectal cancer, the importance of autophagy is becoming widely recognized as it demonstrates both pro- and anti-tumorigenic functions. In colon cancer, cell autonomous and non-autonomous roles for...
Wed Oct 30, 2019 02:00
Cells, Vol. 8, Pages 1348: Glycobiology of Human Fungal Pathogens: New Avenues for Drug Development Cells doi: 10.3390/cells8111348 Authors: Danielle J. Lee Holly O’Donnell Françoise H. Routier Joe Tiralongo Thomas Haselhorst Invasive fungal infections (IFI) are an increasing threat to the developing world, with fungal spores being ubiquitous and inhaled every day. Some fungal species are commensal organisms that are part of the normal human microbiota, and, as such, do not...
Wed Oct 30, 2019 02:00
Journal Name: Clinical Chemistry and Laboratory Medicine (CCLM)Issue: Ahead of print
Wed Oct 30, 2019 19:35
Abstract Autologous stem cell transplantation (ASCT) combined with novel agents is the standard treatment for transplant-eligible, newly diagnosed myeloma (NDMM) patients. Lenalidomide is approved for maintenance after ASCT until progression, although the optimal duration of maintenance is unknown. In this trial, 80 patients with NDMM received three cycles of lenalidomide, bortezomib, and dexamethasone followed by ASCT and lenalidomide maintenance until progression or toxicity....
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Journal Name: Clinical Chemistry and Laboratory Medicine (CCLM)Issue: Ahead of print
Wed Oct 30, 2019 19:35
Journal Name: Clinical Chemistry and Laboratory Medicine (CCLM)Issue: Ahead of print
Wed Oct 30, 2019 19:35
Journal Name: Clinical Chemistry and Laboratory Medicine (CCLM)Issue: Ahead of print
Wed Oct 30, 2019 19:35
Journal Name: Clinical Chemistry and Laboratory Medicine (CCLM)Issue: Ahead of print
Wed Oct 30, 2019 19:35
Journal Name: Clinical Chemistry and Laboratory Medicine (CCLM)Issue: Ahead of print
Wed Oct 30, 2019 19:35
Journal Name: Clinical Chemistry and Laboratory Medicine (CCLM)Issue: Ahead of print
Wed Oct 30, 2019 19:35
Journal Name: Clinical Chemistry and Laboratory Medicine (CCLM)Issue: Ahead of print
Wed Oct 30, 2019 19:35
Journal Name: Clinical Chemistry and Laboratory Medicine (CCLM)Issue: Ahead of print
Wed Oct 30, 2019 19:35
Journal Name: Clinical Chemistry and Laboratory Medicine (CCLM)Issue: Ahead of print
Wed Oct 30, 2019 19:35
Journal Name: Journal of Pediatric Endocrinology and MetabolismIssue: Ahead of print
Wed Oct 30, 2019 18:37
Genes, Vol. 10, Pages 868: Type II DNA Topoisomerases Cause Spontaneous Double-Strand Breaks in Genomic DNA Genes doi: 10.3390/genes10110868 Authors: Morimoto Tsuda Bunch Sasanuma Austin Takeda Type II DNA topoisomerase enzymes (TOP2) catalyze topological changes by strand passage reactions. They involve passing one intact double stranded DNA duplex through a transient enzyme-bridged break in another (gated helix) followed by ligation of the break by TOP2. A TOP2...
Wed Oct 30, 2019 02:00
Genes, Vol. 10, Pages 869: Nuclear–Cytoplasmic Coevolution Analysis of RuBisCO in Synthesized Cucumis Allopolyploid Genes doi: 10.3390/genes10110869 Authors: Yufei Zhai Xiaqing Yu Zaobing Zhu Panqiao Wang Ya Meng Qinzheng Zhao Ji Li Jinfeng Chen Allopolyploids are often faced with the challenge of maintaining well-coordination between nuclear and cytoplasmic genes inherited from different species. The synthetic allotetraploid Cucumis × hytivus is a useful...
Wed Oct 30, 2019 02:00
Genes, Vol. 10, Pages 866: To Repeat or Not to Repeat: Repetitive Sequences Regulate Genome Stability in Candida albicans Genes doi: 10.3390/genes10110866 Authors: Dunn Anderson Genome instability often leads to cell death but can also give rise to innovative genotypic and phenotypic variation through mutation and structural rearrangements. Repetitive sequences and chromatin architecture in particular are critical modulators of recombination and mutability. In Candida albicans,...
Wed Oct 30, 2019 02:00
Genes, Vol. 10, Pages 865: The Many Faces of Gene Regulation in Cancer: A Computational Oncogenomics Outlook Genes doi: 10.3390/genes10110865 Authors: Enrique Hernández-Lemus Helena Reyes-Gopar Jesús Espinal-Enríquez Soledad Ochoa Cancer is a complex disease at many different levels. The molecular phenomenology of cancer is also quite rich. The mutational and genomic origins of cancer and their downstream effects on processes such as the reprogramming of the gene regulatory...
Wed Oct 30, 2019 02:00
Genes, Vol. 10, Pages 867: Molecular Cloning and Characterization of SYCP3 and TSEG2 Genes in the Testicles of Sexually Mature and Immature Yak Genes doi: 10.3390/genes10110867 Authors: Kalwar Chu Ahmad Ma Zhang Ma Xie Ding Wu Bao Yan Testis-specific genes play an essential part in the centromere union during meiosis in male germ cells, spermatogenesis, and in fertility. Previously, there was no research report available on the expression pattern...
Wed Oct 30, 2019 02:00
Genes, Vol. 10, Pages 862: HiCNN2: Enhancing the Resolution of Hi-C Data Using an Ensemble of Convolutional Neural Networks Genes doi: 10.3390/genes10110862 Authors: Tong Liu Zheng Wang We present a deep-learning package named HiCNN2 to learn the mapping between low-resolution and high-resolution Hi-C (a technique for capturing genome-wide chromatin interactions) data, which can enhance the resolution of Hi-C interaction matrices. The HiCNN2 package includes three methods each with...
Wed Oct 30, 2019 02:00
Genes, Vol. 10, Pages 863: Evidence for Adaptive Selection in the Mitogenome of a Mesoparasitic Monogenean Flatworm Enterogyrus malmbergi Genes doi: 10.3390/genes10110863 Authors: Dong Zhang Hong Zou Shan G. Wu Ming Li Ivan Jakovlić Jin Zhang Rong Chen Wen X. Li Gui T. Wang Whereas a majority of monogenean flatworms are ectoparasitic, i.e., parasitize on external surfaces (mainly gills) of their fish hosts, Enterogyrus species (subfamily Ancyrocephalinae) are...
Wed Oct 30, 2019 02:00
Genes, Vol. 10, Pages 864: Meta-Analysis of Polymyositis and Dermatomyositis Microarray Data Reveals Novel Genetic Biomarkers Genes doi: 10.3390/genes10110864 Authors: Jaeseung Song Daeun Kim Juyeon Hong Go Woon Kim Junghyun Jung Sejin Park Hee Jung Park Jong Wha J. Joo Wonhee Jang Polymyositis (PM) and dermatomyositis (DM) are both classified as idiopathic inflammatory myopathies. They share a few common characteristics such as inflammation and muscle weakness....
Wed Oct 30, 2019 02:00
Genes, Vol. 10, Pages 861: ZW Sex Chromosomes in Australian Dragon Lizards (Agamidae) Originated from a Combination of Duplication and Translocation in the Nucleolar Organising Region Genes doi: 10.3390/genes10110861 Authors: Kazumi Matsubara Denis O’Meally Stephen D. Sarre Arthur Georges Kornsorn Srikulnath Tariq Ezaz Sex chromosomes in some reptiles share synteny with distantly related amniotes in regions orthologous to squamate chromosome 2. The latter finding suggests...
Wed Oct 30, 2019 02:00
Genes, Vol. 10, Pages 860: Transcriptional Structure of Petunia Clock in Leaves and Petals Genes doi: 10.3390/genes10110860 Authors: Marta I. Terry Marta Carrera-Alesina Julia Weiss Marcos Egea-Cortines The plant circadian clock coordinates environmental signals with internal processes including secondary metabolism, growth, flowering, and volatile emission. Plant tissues are specialized in different functions, and petals conceal the sexual organs while attracting pollinators....
Wed Oct 30, 2019 02:00
ACS Infectious DiseasesDOI: 10.1021/acsinfecdis.9b00286
Wed Oct 30, 2019 06:00
ACS Infectious DiseasesDOI: 10.1021/acsinfecdis.9b00186
Wed Oct 30, 2019 06:00
Antioxidants, Vol. 8, Pages 522: Syntaxin-17-Dependent Mitochondrial Dynamics is Essential for Protection Against Oxidative-Stress-Induced Apoptosis Antioxidants doi: 10.3390/antiox8110522 Authors: Wang Xiao Huang Liu In this study, cell death induced by the oxidant tert-butylhydroperoxide (tBH) was observed in U2OS cells; this phenotype was rescued by Syntaxin 17 (STX17) knockout (KO) but the mechanism is unknown. STX17 plays dual roles in autophagosome–lysosome...
Wed Oct 30, 2019 02:00
Antioxidants, Vol. 8, Pages 521: Sideritis Perfoliata (Subsp. Perfoliata) Nutritive Value and Its Potential Medicinal Properties Antioxidants doi: 10.3390/antiox8110521 Authors: Namrita Lall Antonios Chrysargyris Isa Lambrechts Bianca Fibrich Analike Blom Van Staden Danielle Twilley Marco Nuno de Canha Carel Basson Oosthuizen Dikonketso Bodiba Nikolaos Tzortzakis Sideritis perfoliata L. subsp. perfoliata is an endemic species of the Eastern Mediterranean region...
Wed Oct 30, 2019 02:00
Antioxidants, Vol. 8, Pages 520: Influence of the Physical State of Spray-Dried Flavonoid-Inulin Microparticles on Oxidative Stability of Lipid Matrices Antioxidants doi: 10.3390/antiox8110520 Authors: Guibeth Morelo Begoña Giménez Gloria Márquez-Ruiz Francisca Holgado Patricio Romero-Hasler Eduardo Soto-Bustamante Paz Robert The effect of the physical state of flavonoid-inulin microparticles (semi-crystalline/amorphous) on the oxidative stability of lipid matrices...
Wed Oct 30, 2019 02:00
Environmental Science & TechnologyDOI: 10.1021/acs.est.9b05250
Wed Oct 30, 2019 06:00
Environmental Science & TechnologyDOI: 10.1021/acs.est.9b05000
Wed Oct 30, 2019 06:00
Publication date: November 2019Source: Annals of Allergy, Asthma & Immunology, Volume 123, Issue 5Author(s):
Wed Oct 30, 2019 18:03
Publication date: November 2019Source: Annals of Allergy, Asthma & Immunology, Volume 123, Issue 5Author(s): Carolina S. Aranda, Luis Felipe Ensina, Marcia C. Mallozi, Vicente Odone Filho, Dirceu Solé
Wed Oct 30, 2019 18:03
Publication date: November 2019Source: Annals of Allergy, Asthma & Immunology, Volume 123, Issue 5Author(s): Jay Adam Lieberman
Wed Oct 30, 2019 18:03
Publication date: November 2019Source: Annals of Allergy, Asthma & Immunology, Volume 123, Issue 5Author(s): Terry Harville
Wed Oct 30, 2019 18:03
Publication date: November 2019Source: Annals of Allergy, Asthma & Immunology, Volume 123, Issue 5Author(s): Richard L. Wasserman
Wed Oct 30, 2019 18:03
Publication date: November 2019Source: Annals of Allergy, Asthma & Immunology, Volume 123, Issue 5Author(s):
Wed Oct 30, 2019 18:03
Publication date: November 2019Source: Annals of Allergy, Asthma & Immunology, Volume 123, Issue 5Author(s):
Wed Oct 30, 2019 18:03
Publication date: November 2019Source: Annals of Allergy, Asthma & Immunology, Volume 123, Issue 5Author(s):
Wed Oct 30, 2019 18:03
Publication date: November 2019Source: Annals of Allergy, Asthma & Immunology, Volume 123, Issue 5Author(s):
Wed Oct 30, 2019 18:03
Publication date: November 2019Source: Annals of Allergy, Asthma & Immunology, Volume 123, Issue 5Author(s): Chitra Dinakar, Vivian Hernandez-Trujillo, Gerald B. Lee, Stanley M. FinemanA new Annals feature in 2018, “From the Pages of AllergyWatch” is devoted to publishing synopses of Allergy and Asthma literature relevant to a topic of emphasis. These unbiased synopses and comments by our Editors have been previously printed in the AllergyWatch bimonthly newsletter, and it is our hope that presenting...
Wed Oct 30, 2019 18:03
In this review, we present a comprehensive discussion of matters related to the problem of blood culture contamination. Issues addressed include the scope and magnitude of the problem, the bacteria most often recognized as contaminants, the impact of blood culture contamination on clinical microbiology laboratory function, the economic and clinical ramifications of contamination, and, perhaps most importantly, a systematic discussion of solutions to the problem. We conclude by providing a series...
Wed Oct 30, 2019 14:30
Tuberculosis (TB) is the leading killer among all infectious diseases worldwide despite extensive use of the Mycobacterium bovis bacille Calmette-Guérin (BCG) vaccine. A safer and more effective vaccine than BCG is urgently required. More than a dozen TB vaccine candidates are under active evaluation in clinical trials aimed to prevent infection, disease, and recurrence. After decades of extensive research, renewed promise of an effective vaccine against this ancient airborne disease has recently...
Wed Oct 30, 2019 14:30
Advances in HIV-1 therapy have transformed the once fatal infection into a manageable, chronic condition, yet the search for a widely applicable approach to cure remains elusive. The ineffectiveness of antiretroviral therapy (ART) in reducing the size of the HIV-1 latent reservoir has prompted investigation into the mechanisms of HIV-1 latency and immune escape. One of the major regulators of apoptosis, the BCL-2 protein, alongside its homologous family members, is a major target of HIV-1-induced...
Wed Oct 30, 2019 14:30
Abstract Enhanced tolerance to wilt disease (Fusarium oxysporum f.sp. cubense) was achieved in banana variety Rasthali (AAB) by the transformation of embryogenic cells with two antimicrobial genes viz., Ace-AMP1 and pflp using Agrobacterium mediated transformation. The transgene copy numbers in stable transformants were confirmed by Southern analysis. The expression of stacked genes in the transgenic lines was validated by RT-PCR as well as Northern analysis. Bioassay using Foc...
Wed Oct 30, 2019 02:00
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