A recent Danish study showed pregnancy loss was not associated with later cancer development among women with various cancer types. (Source: CancerNetwork)
Wed Oct 30, 2019 05:00
A new inhibitor may help patients with a certain subset of head and neck squamous cell carcinoma. (Source: CancerNetwork)
Wed Oct 30, 2019 05:00
Abstract Genetic studies provide valuable information to assess if the effect of genetic variants varies by the nongenetic “environmental” variables, what is traditionally defined to be gene–environment interaction (GxE). A common complication is that multiple disease states present with the same set of symptoms, and hence share the clinical diagnosis. Because (a) disease states might have distinct genetic bases; and (b) frequencies of the disease states within the clinical diagnosis vary by the...
Wed Oct 30, 2019 20:19
Advances in HIV-1 therapy have transformed the once fatal infection into a manageable, chronic condition, yet the search for a widely applicable approach to cure remains elusive. The ineffectiveness of antiretroviral therapy (ART) in reducing the size of the HIV-1 latent reservoir has prompted investigation into the mechanisms of HIV-1 latency and immune escape. One of the major regulators of apoptosis, the BCL-2 protein, alongside its homologous family members, is a major target of HIV-1-induced...
Wed Oct 30, 2019 14:30
Abstract Background Free flap failure or vascular compromise remains a dreadful complication of microvascular free tissue transfer. Near‐infrared spectroscopy (NIRS) is a novel technique for free flap monitoring that has the propensity for early detection of vascular compromise when compared to the current gold standard, clinical monitoring (CM). The objective of this review is to evaluate the efficacy of a NIRS system in the postoperative monitoring of free flaps and its effect on flap salvage....
Wed Oct 30, 2019 16:54
Abstract Since 1964 the author has seen and experienced the progress of nuclear medicine in Japan. The purpose of this review article is to trace the application of radiopharmaceuticals and instruments for the diagnosis of tumors and treatment of cancers in the past 55 years. The application of various radiopharmaceuticals for the detection of tumors and therapy of cancers are historically reviewed based on the author’s personal clinical experience and research work. Nuclear medicine...
Wed Oct 30, 2019 02:00
Abstract Astrocytes are the key homeostatic cells in the central nervous system; initiation of reactive astrogliosis contributes to neuroinflammation. Pro-inflammatory cytokine interferon γ (IFNγ) induces the expression of the major histocompatibility complex class II (MHCII) molecules, involved in antigen presentation in reactive astrocytes. The pathway for MHCII delivery to the astrocyte plasma membrane, where MHCII present antigens, is unknown. Rat astrocytes in culture and...
Wed Oct 30, 2019 02:00
Abstract Accumulation of misfolded and aggregated forms of tau protein in the brain is a neuropathological hallmark of tauopathies, such as Alzheimer’s disease and frontotemporal lobar degeneration. Tau aggregates have the ability to transfer from one cell to another and to induce templated misfolding and aggregation of healthy tau molecules in previously healthy cells, thereby propagating tau pathology across different brain areas in a prion-like manner. The molecular mechanisms...
Wed Oct 30, 2019 02:00
Abstract Intrinsically disordered proteins (IDPs) do not have a well-defined structure under physiological conditions, but they have key roles in cell signaling and regulation, and they are frequently related to the development of diseases, such as cancer and other malignancies. This has converted IDPs in attractive therapeutic targets; however, targeting IDPs is challenging because of their dynamic nature. In the last years, different experimental and computational approaches,...
Wed Oct 30, 2019 02:00
Background: The objective of this study was to evaluate the diagnostic value of serological markers Krebs von den Lungen-6 (KL-6), surfactant protein-A (SP-A), SP-D, chemokine ligand 2 (CCL2), and chemokine 13 (CXCL13) in idiopathic interstitial pneumonia (IIP). Methods: Patients with IIP aged 18–80 years from the First Affiliated Hospital of Guangzhou Medical University were enrolled in this retrospective case-control study. Data on the general patient characteristics, laboratory test results, chest...
Wed Oct 30, 2019 16:18
Background: Chronic obstructive pulmonary disease (COPD) is a leading cause of mortality, therefore the prediction of mortality in COPD patients is crucial. In the current study, the abilities of different categorization systems to predict mortality in stable COPD patients from a prospective cohort were compared. Methods: The ability to predict mortality was compared in terms of discrimination by Harrell’s C (HC) index and calibration using graphical comparison among the GOLD (Global Initiative for...
Wed Oct 30, 2019 13:50
Abstract Liver cancer stem cells (LCSCs) are responsible for the carcinogenesis, recurrence, metastasis and chemoresistance of hepatocellular carcinoma (HCC). This study aimed to explore the role of CCND1 (Cyclin D1), an oncogene in HCC, in regulating LCSC differentiation and to elucidate whether autophagy was involved in this process. The CCND1 mRNA level was examined by qRT-PCR. The protein levels of autophagy markers (Becin-1 and LC3II) were examined by western blot to evaluate...
Wed Oct 30, 2019 02:00
Abstract Long non-coding RNA (lncRNA), a member of non-coding RNA family with over 200 nucleotides in length, typically serves as an oncogene or tumor suppressor in tumor progression, such as cancer cell proliferation, apoptosis and glycolysis. Recent studies manifested lncRNA LINC00857 was involved in cell cycle regulation of lung cancer. Due to complicated networks in tumorigenesis, the potential roles of LINC00857 underlying lung cancer progression still need further investigation....
Wed Oct 30, 2019 02:00
Abstract Osteosarcoma is a highly malignant tumor. The molecular mechanism of its occurrence and development has not yet been clarified. Current studies have found that noncoding RNAs, such as circular RNAs (circRNAs) and microRNAs (miRNAs), play important regulatory roles in the progression of diseases. Our previous studies have shown that miR-19b is an oncogene in osteosarcoma. Further studies have shown that circ_ANKIB1 has binding sites for miR-19b, and both molecules were...
Wed Oct 30, 2019 02:00
Abstract Computing the permanent of a (0, 1)-square matrix is a \(\# P\) -complete problem, whereas the determinant and rank are solved in polynomial time. A simple graph is called a bi-block graph if each block in it is a complete bipartite graph. In this paper, we consider the (0, 1)-adjacency matrix of a bi-block to find its permanent, determinant, and rank. These numbers are known for...
Wed Oct 30, 2019 02:00
Related ArticlesNovel lncRNA PSMG3‑AS1 functions as a miR‑143‑3p sponge to increase the proliferation and migration of breast cancer cells. Oncol Rep. 2019 Oct 25;: Authors: Cui Y, Fan Y, Zhao G, Zhang Q, Bao Y, Cui Y, Ye Z, Chen G, Piao X, Guo F, Wang J, Bai Y, Yu D Abstract Long non‑coding RNAs (lncRNAs) are considered to be important regulators in breast cancer. In the present study, the potential mechanisms and functional roles of lncRNA PSMG3‑antisense...
Wed Oct 30, 2019 15:53
Related ArticlesΟlive tree blossom polyphenolic extracts exert antioxidant and antimutagenic activities in vitro and in various cell lines. Oncol Rep. 2019 Oct 23;: Authors: Kouka P, Tekos F, Valta K, Mavros P, Veskoukis AS, Angelis A, Skaltsounis AL, Kouretas D Abstract Olive oil has held a prominent place in the Mediterranean diet since ancient times due to its beneficial effects on human health thus, becoming the subject of great scientific interest....
Wed Oct 30, 2019 15:53
Related ArticlesIdentification of TPD52 and DNAJB1 as two novel bile biomarkers for cholangiocarcinoma by iTRAQ‑based quantitative proteomics analysis. Oncol Rep. 2019 Oct 23;: Authors: Ren H, Luo M, Chen J, Zhou Y, Li X, Zhan Y, Shen D, Chen B Abstract Cholangiocarcinoma (CCA) represents a type of epithelial cancer with a late diagnosis and poor outcome. However, the molecular mechanisms responsible for the development of CCA have not yet been fully...
Wed Oct 30, 2019 15:53
Related ArticlesCrosstalk between histone modification and DNA methylation orchestrates the epigenetic regulation of the costimulatory factors, Tim‑3 and galectin‑9, in cervical cancer. Oncol Rep. 2019 Oct 24;: Authors: Zhang L, Tian S, Pei M, Zhao M, Wang L, Jiang Y, Yang T, Zhao J, Song L, Yang X Abstract Persistent infection with high‑risk human papillomavirus is known to cause cervical cancer. The binding of the costimulatory factors, Tim‑3 and galectin‑9,...
Wed Oct 30, 2019 15:53
Related Articles[Corrigendum] A 19‑miRNA Support Vector Machine classifier and a 6‑miRNA risk score system designed for ovarian cancer patients. Oncol Rep. 2019 Oct 23;: Authors: Dong J, Xu M Abstract Subsequently to the publication of this paper, the authors have realized that the affilitation address omitted the name of the university at which this research was conducted (Capital Medical University). Therefore, the author affiliations for this paper...
Wed Oct 30, 2019 15:53
Related ArticlesAssociation of iRhom1 and iRhom2 expression with prognosis in patients with cervical cancer and possible signaling pathways. Oncol Rep. 2019 Oct 25;: Authors: Xu Q, Chen C, Liu B, Lin Y, Zheng P, Zhou D, Xie Y, Lin Y, Guo C, Liu J, Li L Abstract Several proteins in the iRhom family function as oncogenic regulators in certain cancers. However, the function of these proteins in cervical cancer (CC) is unknown. The relationship of iRhom1...
Wed Oct 30, 2019 15:53
Related ArticlesTranscriptome analysis of dog oral melanoma and its oncogenic analogy with human melanoma. Oncol Rep. 2019 Oct 25;: Authors: Rahman MM, Lai YC, Husna AA, Chen HW, Tanaka Y, Kawaguchi H, Hatai H, Miyoshi N, Nakagawa T, Fukushima R, Miura N Abstract Dogs have been considered as an excellent immunocompetent model for human melanoma due to the same tumor location and the common clinical and pathological features with human melanoma. However,...
Wed Oct 30, 2019 15:53
Background: Cochlear implantation (CI) is an effective treatment option for patients with severe-to-profound hearing loss. When CI first started, it was recommended to wait until at least 4 weeks after the CI surgery for the initial activation because of possible complications. Advances in the surgical techniques and experiences in fitting have made initial activation possible within 24 h. Objectives: To compare the complaints and complications after early activation between behind-the-ear (BTE)...
Wed Oct 30, 2019 15:33
Background: Vestibular schwannoma (VS) is a benign intracranial neoplasm originating in the Schwann cells of the vestibular nerve. Despite its origin, the most common symptom is sensorineural hearing loss which is presented in more than 90% of patients. The underlying pathophysiology of this hearing loss has not been fully understood. Objective: To assess the in vivo function of cochlear inner hair cells and spiral ganglion neurons in VS, cochlear dead regions (DRs) were evaluated via the threshold-equalizing...
Wed Oct 30, 2019 15:33
Publication date: December 2019Source: International Immunopharmacology, Volume 77Author(s): Ying Hou, Depeng Yang, Rongwu Xiang, Huiyang Wang, Xianshi Wang, Haotian Zhang, Pengwei Wang, Zhen Zhang, Xiaohang Che, Yinglu Liu, Yongfeng Gao, Xiangnan Yu, Xiaoyun Gao, Wen Zhang, Jingyu Yang, Chunfu WuAbstractNeutrophils have been traditionally considered as the major mediators of harmful inflammatory responses in ischemic stroke, whereas accumulating evidence indicates that neutrophils can be polarized...
Wed Oct 30, 2019 15:35
Publication date: December 2019Source: International Immunopharmacology, Volume 77Author(s): Kunal Singh, Amit K. Singh, Siva R. Uppalapati, Joseph J. Kingston, Manmohan ParidaAbstractBurkholderia lethal factor 1 (BLF1), a glutamine deamidase, is a key virulence factor that plays significant role in B. pseudomallei pathogenesis. To elucidate the BLF1 immunological responses, two truncated BLF1 structural units, BLF1-C (90–211 amino acids) with structural similarity to T. maritima Chemoreceptor glutamine...
Wed Oct 30, 2019 15:35
Related ArticlesDexmedetomidine improves cardiac function and protects against maladaptive remodeling following myocardial infarction. Mol Med Rep. 2019 Oct 29;: Authors: Han H, Dai D, Hu J, Zhu J, Lu L, Tao G, Zhang R Abstract Dexmedetomidine (DEX), a highly specific and selective α2 adrenergic receptor agonist, has been demonstrated to possess potential cardioprotective effects. However, the mechanisms underlying this process remain to be fully illuminated....
Wed Oct 30, 2019 15:28
Related ArticlesmiR‑760 regulates skeletal muscle proliferation in rheumatoid arthritis by targeting Myo18b. Mol Med Rep. 2019 Oct 29;: Authors: Tang X, Wang J, Zhou S, Zhou J, Jia G, Wang H, Xin C, Fu G, Zhang J Abstract MicroRNAs serve an important role in the development of several diseases. Numerous genes regulate the skeletal muscle differentiation of C2C12 myoblasts. The role of miR‑760 in rheumatoid arthritis (RA) has not been reported, to the...
Wed Oct 30, 2019 15:28
Related ArticlesmiR‑593 inhibits proliferation and invasion and promotes apoptosis in non‑small cell lung cancer cells by targeting SLUG‑associated signaling pathways. Mol Med Rep. 2019 Oct 29;: Authors: Wei F, Wang M, Li Z, Wang Y, Zhou Y Abstract Increasing evidence suggests that microRNAs (miRNAs or miRs) serve a critical role in tumor development. However, the role of miRNAs in non‑small cell lung cancer (NSCLC) progression remains largely unknown....
Wed Oct 30, 2019 15:28
Related ArticlesOxyntomodulin attenuates TNF‑α induced neuropathic pain by inhibiting the activation of the NF‑κB pathway. Mol Med Rep. 2019 Oct 25;: Authors: Zhang Y, Yuan L, Chen Y, Lin C, Ye G Abstract Neuropathic pain is rarely diagnosed. Oxyntomodulin is peripherally and centrally distributed; however, the potential mechanisms underlying the effects of oxyntomodulin in attenuating nociception remain unclear; thus, we aimed to explore them in the...
Wed Oct 30, 2019 15:28
Related ArticlesGene targets of sulforaphane in head and neck squamous cell carcinoma. Mol Med Rep. 2019 Oct 23;: Authors: Hu L, Li H, Lee ED, Grandis JR, Bauman JE, Johnson DE Abstract Patients who have undergone curative‑intent therapy for head and neck squamous cell carcinoma (HNSCC) exhibit a high rate of development of second primary tumors (SPTs), which are frequently lethal. A chemoprevention strategy that prevents SPTs would have a major impact...
Wed Oct 30, 2019 15:28
Related ArticlesExendin‑4 promotes osteogenic differentiation of adipose‑derived stem cells and facilitates bone repair. Mol Med Rep. 2019 Oct 23;: Authors: Deng B, Zhu W, Duan Y, Hu Y, Chen X, Song S, Yi Z, Song Y Abstract Inflammation‑related bone defects pose a heavy burden on patients and orthopedic surgeons. Although stem‑cell‑based bone repair has developed rapidly, it is of great significance to characterize bio‑active molecules that facilitate...
Wed Oct 30, 2019 15:28
Related ArticlesCP-25 exerts anti-angiogenic effects on a rat model of adjuvant-induced arthritis by promoting GRK2-induced downregulation of CXCR4-ERK1/2 signaling in endothelial cells. Mol Med Rep. 2019 Oct 23;: Authors: Zhang M, Gao M, Chen J, Song L, Wei W Abstract Angiogenesis can produce an invasive and destructive front, also named a pannus, comprised of inflammatory vascular tissue that covers and erodes articular cartilage, subchondral bone...
Wed Oct 30, 2019 15:28
Related ArticlesGallotannin attenuates 2‑deoxy‑D‑glucose‑induced dedifferentiation and endoplasmic reticulum stress through inhibition of inositol‑requiring enzyme 1 downstream p38 kinase pathway in chondrocytes. Mol Med Rep. 2019 Oct 25;: Authors: Kim SM, Han Y, Yu SM, Kim SJ Abstract Gallotannin (GT) is a class of polyphenols with antioxidant, anticancer, and antiviral activities. 2‑Deoxy‑D‑glucose (2DG), a glucose‑derived molecule, can inhibit glucose...
Wed Oct 30, 2019 15:28
Related ArticlesmiR‑486 acts as an oncogene and potential prognostic biomarker in renal cell carcinoma. Mol Med Rep. 2019 Oct 25;: Authors: Sun C, Sun C, Zhou Y, Yang G, Li G, Xiang C, Ding X, Sun J Abstract MicroRNAs (miRNAs) are well established key players in tumorigenesis. Their emergence as potential diagnostic and prognostic biomarkers for cancer has demonstrated the importance of miRNAs in cancer biology. Although miR‑486 is implicated in many...
Wed Oct 30, 2019 15:28
Related ArticlesClinical and molecular characterization of four patients with NTCP deficiency from two unrelated families harboring the novel SLC10A1 variant c.595A>C (p.Ser199Arg). Mol Med Rep. 2019 Oct 23;: Authors: Li H, Deng M, Guo L, Qiu JW, Lin GZ, Long XL, Xiao XM, Song YZ Abstract Sodium taurocholate cotransporting polypeptide (NTCP), a carrier protein encoded by solute carrier family 10 member 1 (SLC10A1), is expressed in the basolateral...
Wed Oct 30, 2019 15:28
Related ArticlesPrognostic implications of aberrantly expressed methylation‑driven genes in hepatocellular carcinoma: A study based on The Cancer Genome Atlas. Mol Med Rep. 2019 Oct 25;: Authors: Li J, Chen N, Gong X Abstract RNA‑Sequencing and methylation data for hepatocellular carcinoma (HCC) were downloaded from The Cancer Genome Atlas (TCGA). The aberrantly expressed methylation‑driven genes in HCC and normal tissues were identified using the Limma...
Wed Oct 30, 2019 15:28
Related ArticlesLong noncoding RNA MIAT: A potential role in the diagnosis and mediation of acute myocardial infarction. Mol Med Rep. 2019 Oct 23;: Authors: Azat M, Huojiahemaiti X, Gao R, Peng P Abstract The long noncoding RNA myocardial infarction associated transcript (MIAT) has been shown to be a risk allele for myocardial infarction in a previous study. However, there is still controversy about whether MIAT can be used as a biomarker for acute myocardial...
Wed Oct 30, 2019 15:28
Related ArticlesCannabinoid receptor 2‑selective agonist JWH015 attenuates bone cancer pain through the amelioration of impaired autophagy flux induced by inflammatory mediators in the spinal cord. Mol Med Rep. 2019 Oct 25;: Authors: Mao Y, Huang Y, Zhang Y, Wang C, Wu H, Tian X, Liu Y, Hou B, Liang Y, Rong H, Gu X, Ma Z Abstract Bone cancer pain (BCP) is a severe complication of advanced bone cancer. Although cannabinoid receptor 2 (CB2) agonists may...
Wed Oct 30, 2019 15:28
Related ArticlesA simple, efficient and economical method for isolating and culturing human umbilical cord blood‑derived mesenchymal stromal cells. Mol Med Rep. 2019 Oct 23;: Authors: Zhang J, Zhao J, Mao Q, Xia H Abstract Mesenchymal stromal cells (MSCs) hold broad therapeutic potential in various diseases, however, it is difficult to produce sufficient numbers of MSCs for clinical application, therefore, improved culture systems are required. The present...
Wed Oct 30, 2019 15:28
Related ArticlesIdentification of dysregulated serum miR-508-3p and miR-885-5p as potential diagnostic biomarkers of clear cell renal carcinoma. Mol Med Rep. 2019 Oct 22;: Authors: Liu S, Deng X, Zhang J Abstract Clear cell renal cell carcinoma (ccRCC), the most common subtype, accounts for approximately 80% of all RCC cases. ccRCC patients typically present with an advanced stage at the time of diagnosis resulting in a poor patient prognosis. The present...
Wed Oct 30, 2019 15:28
Related ArticlesFroggy mouth: a new myofunctional approach to atypical swallowing. Eur J Paediatr Dent. 2019 Mar;20(1):33-37 Authors: Di Vecchio S, Manzini P, Candida E, Gargari M Abstract INTRODUCTION: Atypical swallowing has a high incidence in adult and child populations. The treatment of the latter is generally achieved by the adoption of orthodontic appliances in conjunction with speech therapy. The aim of this article is to describe the clinical...
Wed Oct 30, 2019 15:21
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