The Shining and the Psychological Fear of the World of Stephen King The Mary Sue
Wed Oct 30, 2019 21:17
Abstract Background To demonstrate the use of a 4 K 3‐dimensional microvideoscope (VITOM 3D) system for free flap head and neck reconstruction. Methods Clinical human study of free flap harvesting and microvascular anastomosis in patients undergoing reconstruction after ablative surgery for head and neck carcinoma. The video shows the harvesting of a chimeric myofascial/fascio‐cutaneous anterolateral thigh free flap and microvascular anastomosis using different techniques. Results...
Wed Oct 30, 2019 11:31
Related ArticlesInsights into the Structural Aspects of the mGlu Receptor Orthosteric Binding Site. Curr Top Med Chem. 2019 Oct 10;: Authors: Hao J, Chen Q Abstract The amino terminal domain (ATD) of the metabotropic glutamate (mGlu) receptors contains the orthosteric glutamate recognition site, which is highly conserved across the eight mGlu receptor subtypes. In total, 29 X-ray crystal structures of the mGlu ATD proteins have been reported to date....
Wed Oct 30, 2019 14:06
Related ArticlesDeveloping Insulin and BDNF Mimetics for Diabetes Therapy. Curr Top Med Chem. 2019 Oct 10;: Authors: Chan CB, Ahuja P, Ye K Abstract Diabetes is a global public health concern nowadays. The majority of diabetes mellitus (DM) patients belong to type 2 diabetes mellitus (T2DM), which is highly associated with obesity. The general principle of current therapeutic strategies for patients with T2DM mainly focuses on restoring cellular insulin...
Wed Oct 30, 2019 14:06
Related ArticlesThe Use of Conformational Restriction in Medicinal Chemistry. Curr Top Med Chem. 2019;19(19):1712-1733 Authors: de Sena M Pinheiro P, Rodrigues DA, do Couto Maia R, Thota S, Fraga CAM Abstract During the early preclinical phase, from hit identification and optimization to a lead compound, several medicinal chemistry strategies can be used to improve potency and/or selectivity. The conformational restriction is one of these approaches....
Wed Oct 30, 2019 14:06
Related ArticlesStrategies and Tactics in Medicinal Chemistry. Curr Top Med Chem. 2019;19(19):1677-1678 Authors: Manssour Fraga CA AbstractPMID: 31659943 [PubMed - in process]
Wed Oct 30, 2019 14:06
Related ArticlesPrognostic relevance of the Golgi mannosidase MAN1A1 in ovarian cancer: impact of N-glycosylation on tumour cell aggregation. Br J Cancer. 2019 Oct 29;: Authors: Hamester F, Legler K, Wichert B, Kelle N, Eylmann K, Rossberg M, Ding Y, Kürti S, Schmalfeldt B, Milde-Langosch K, Oliveira-Ferrer L Abstract BACKGROUND: Maturation of complex N-glycans involves the action of Golgi mannosidases and plays a major role in cancer progression. We...
Wed Oct 30, 2019 12:03
Risk of Mortality between Untreated and Treated Papillary Thyroid Cancer: A Matched Cohort Analysis.
Related ArticlesRisk of Mortality between Untreated and Treated Papillary Thyroid Cancer: A Matched Cohort Analysis. Ann Otol Rhinol Laryngol. 2019 Oct 28;:3489419885403 Authors: Lin JK, Sakoda LC, Darbinian J, Socarras M, Chiao W, Calixto N, Quesenberry C, Gurushanthaiah D, Wang KH, Durr M Abstract OBJECTIVES: To examine the association between treatment status and mortality risk among patients with papillary thyroid cancer (PTC). METHODS:...
Wed Oct 30, 2019 12:02
Related ArticlesNeck Surgery with Hypnosis: An Evaluation Based Upon Patient's Self Assessment. Ann Otol Rhinol Laryngol. 2019 Oct 28;:3489419882445 Authors: Jaouen M, Parent V, Codet M, Gerard V, Chatellier-Miras A, Chaize C, De Crouy Chanel O, Jegoux F Abstract BACKGROUND: Surgery with hypnosis avoids the use of general anesthesia (GA). It also shortens hospitalization and promotes outpatient surgery. The objective of this study has been to assess...
Wed Oct 30, 2019 12:02
Related ArticlesA multicenter analysis of genomic profiles and PD-L1 expression of primary lymphoepithelioma-like carcinoma of the lung. Mod Pathol. 2019 Oct 28;: Authors: Xie Z, Liu L, Lin X, Xie X, Gu Y, Liu M, Zhang J, Ouyang M, Lizaso A, Zhang H, Feng W, Li B, Han-Zhang H, Chen S, Li S, Zhong N, Liu H, Zhou C, Qin Y Abstract To understand the molecular mechanism of tumorigenesis of pulmonary lymphoepithelioma-like carcinoma and explore potential...
Wed Oct 30, 2019 12:01
Related ArticlesNew and evolving concepts of melanocytic nevi and melanocytomas. Mod Pathol. 2019 Oct 28;: Authors: Yeh I Abstract In daily clinical practice melanocytic nevi are commonly encountered. Traditionally, both benign and malignant melanocytic tumors have been sub-classified by their histopathologic characteristics with differing criteria for malignancy applied to each group. Recently, many of the mutations that initiate nevus formation have...
Wed Oct 30, 2019 12:01
Related ArticlesPathologic separation of idiopathic pulmonary fibrosis from fibrotic hypersensitivity pneumonitis. Mod Pathol. 2019 Oct 28;: Authors: Wright JL, Churg A, Hague CJ, Wong A, Ryerson CJ Abstract Accurate separation of idiopathic pulmonary fibrosis from fibrotic (chronic) hypersensitivity pneumonitis is crucial to patient management, but is frequently a difficult problem. Our objective was to identify pathologic variables that help make this...
Wed Oct 30, 2019 12:01
Pradip Kumar PrajapatiIndian Journal of Rheumatology 2019 14(3):244-246 Spondyloarthritis is an inflammatory disorder of the axial skeleton, while inflammatory myositis is an inflammatory disease affecting the striated muscles. There is no usual association of spondyloarthritis and inflammatory myositis. A 35-year-old female patient presented with proximal muscle weakness and lower back pain with a history of knee synovitis and was diagnosed to have axial spondyloarthritis with inflammatory myositis....
Wed Oct 30, 2019 00:00
Rohini HandaIndian Journal of Rheumatology 2019 14(3):172-173
Wed Oct 30, 2019 00:00
Durga Prasanna Misra, G SRSN K Naidu, Aman SharmaIndian Journal of Rheumatology 2019 14(3):218-228 The prognosis of antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) has remarkably improved from an almost uniformly fatal disease about three decades back, to a chronic manageable disease with survival rates in excess of 80%. Induction of remission largely relies on cyclophosphamide or rituximab-based regimens, although emerging data suggest some potential role of mycophenolate...
Wed Oct 30, 2019 00:00
Sharad Lakhanpal, Akshai LakhanpalIndian Journal of Rheumatology 2019 14(3):174-176
Wed Oct 30, 2019 00:00
Juan Antonio Becerra-GarcíaIndian Journal of Rheumatology 2019 14(3):254-256
Wed Oct 30, 2019 00:00
Sakir AhmedIndian Journal of Rheumatology 2019 14(3):177-179
Wed Oct 30, 2019 00:00
Zakiya Saleh Al Mosawi, Hiba Omar Abduljawad, Maryam Yusuf Busehail, Barrak Mahmood Al MoosawiIndian Journal of Rheumatology 2019 14(3):236-240 Deficiency of Adenosine deaminase 2 (DADA2) syndrome is a chronic, systemic, and inflammatory disorder, characterized by early-onset recurrent strokes, fever, livedo reticularis, and immunodeficiency. We report the case of a 4-year-old child, a product of consanguineous marriage, who presented with three episodes of hemiparesis within 1 year. She also manifested...
Wed Oct 30, 2019 00:00
Pandiarajan Vignesh, Surjit SinghIndian Journal of Rheumatology 2019 14(3):180-181
Wed Oct 30, 2019 00:00
VR JoshiIndian Journal of Rheumatology 2019 14(3):250-250
Wed Oct 30, 2019 00:00
Naresh Kumar, K Anu Punnen, Sukesh Chandran Nair, Visalakshi Jayaseelan, T Sathish KumarIndian Journal of Rheumatology 2019 14(3):182-186 Background: Platelet-derived microparticles (PMPs) are small vesicles that are released from the plasma membrane upon platelet activation, which are then involved in haemostasis, vascular health, and have recently been shown to be intimately involved in immune responses. Aims and Objectives: We aimed to evaluate the level of plasma Platelet-derived micro particles...
Wed Oct 30, 2019 00:00
Shivani Garg, Ram Raj SinghIndian Journal of Rheumatology 2019 14(3):167-171
Wed Oct 30, 2019 00:00
Suad Mohammed, Lydia Say Lee Pok, Ying Chew Tee, Fariz YahyaIndian Journal of Rheumatology 2019 14(3):187-193 Aims: The aim of the study was to evaluate the treatment patterns of conventional synthetic disease-modifying antirheumatic drugs (csDMARDs), drug survival, and the factors in initiating biologic DMARDs based on race and ethnicity in rheumatoid arthritis (RA) patients. Materials and Methods: Data on RA patients, including race/ethnicity, who were attending University Malaya Medical Centre,...
Wed Oct 30, 2019 00:00
Praveen Pratap Jadhav, Saourabh Rajesh Desai, Janhavee Praveen Jadhav, Lata Sunil BichileIndian Journal of Rheumatology 2019 14(3):229-235 Acute pancreatitis is seen in many rheumatological disorders, of which, systemic lupus erythematosus (SLE) is the most common. SLE is a multisystemic disease, affecting the gastrointestinal system in about half of the patients. Acute pancreatitis is a rare but life-threatening complication of SLE. Here, we report three intriguing cases of SLE wherein patients...
Wed Oct 30, 2019 00:00
Zohreh Karimiankakolaki, Maryam Khadibi, Sakineh Gerayllo, Bahareh Motaghi, Fatemeh HeidariIndian Journal of Rheumatology 2019 14(3):194-199 Introduction: Osteoporosis is the most common metabolic bone disease. Therefore, the present study was conducted to determine the effect of training through the Telegram network on increasing the knowledge and perceptions of women in preventing osteoporosis. Methods: This study was an educational intervention, pretest and posttest type with randomized control...
Wed Oct 30, 2019 00:00
Shruti Bajad, Rohit Bajaj, Dhaval Tanna, Muzaffar Bindroo, Kanchan Kaur, Rajiva GuptaIndian Journal of Rheumatology 2019 14(3):241-243 We report a rare case of eosinophilic mastitis in a young asthmatic female who presented with a breast lump and was managed conservatively with a successful outcome. Eosinophilic mastitis, characterized by eosinophilic infiltration of mammary glands, is one such entity which is frequently given a miss, and is diagnosed based on histopathological analysis. The identification...
Wed Oct 30, 2019 00:00
Vinod Narayan, Vasanthi Pallinti, Nalini GanesanIndian Journal of Rheumatology 2019 14(3):200-205 Background: This study was aimed to measure the serum levels of YKL-40 among early and late rheumatoid arthritis (RA) patients along with other disease activity measures in RA patients. Materials and Methods: It was a cross-sectional study involving 152 RA patients based on the 1987 American College of Rheumatology criteria for the diagnosis of RA and 68 age- and sex-matched healthy controls. The...
Wed Oct 30, 2019 00:00
Anshul Goel, Arun GognaIndian Journal of Rheumatology 2019 14(3):247-249 Relapsing polychondritis (RP) is a multisystem inflammatory disease affecting all types of cartilage and proteoglycan-rich tissues with recurrent bouts of inflammation resulting in tissue damage. The pleomorphic nature, the wide spectrum of clinical features and insidious onset of the disease makes the diagnosis of RP a challenge for clinicians. Eyelid edema is a recognized manifestation of this disease frequently in association...
Wed Oct 30, 2019 00:00
Viraj Panchal, Puja Srivastava, Dhaiwat Shukla, Devang Rana, Supriya Malhotra, Sapan PandyaIndian Journal of Rheumatology 2019 14(3):206-210 Background: Most patients coming to government hospital are from lower socioeconomic class and do not always get investigations done like ESR or CRP. A purely clinical index like CDAI would be a useful measure in such resource poor settings. Also there is scarce data on patterns of DMARD use from our country. Objectives: To compare Disease Activity Score...
Wed Oct 30, 2019 00:00
Amee D Pandya, Dhaiwat Shukla, Supriya D Malhotra, Pankaj Patel, Sapan PandyaIndian Journal of Rheumatology 2019 14(3):251-253
Wed Oct 30, 2019 00:00
Joseph Sushil Rao, Vineeta Shobha, Tinku Thomas, Usha KiniIndian Journal of Rheumatology 2019 14(3):211-217 Background: Systemic Lupus Erythematosus (SLE), a systemic autoimmune disease, is diagnosed by correlating clinical features with a positive Antinuclear Antibody (ANA) test. Detection of ANA by Indirect Immunofluorescence (IIF) is used for screening SLE and is dependent on initial dilution titers which require population-specific standardization. With lack of exclusive commercial kits for...
Wed Oct 30, 2019 00:00
Yeow Leng Tan, Jun Yin LeeIndian Journal of Rheumatology 2019 14(3):257-258
Wed Oct 30, 2019 00:00
Abstract MX2 protein is a dynamin‐like GTPase2 that has recently been identified as an interferon‐induced restriction factor of HIV‐1 and other primate lentiviruses. A single nucleotide polymorphism (SNP), rs45430, in an intron of the MX2 gene, was previously reported as a novel melanoma susceptibility locus in genome wide association studies. Functionally, however, it is still unclear if and how MX2 contributes to melanoma susceptibility and tumorigenesis. Here we show that MX2 is differentially...
Tue Oct 29, 2019 11:54
Abstract Autophagy regulates cellular turnover by disassembling unnecessary or dysfunctional constituents. Recent studies demonstrated that autophagy and its regulators play a wide variety of roles in melanocyte biology. Activation of autophagy is known to induce melanogenesis and regulate melanosome biogenesis in melanocytes. Also, autophagy induction was reported to regulate physiologic skin color via melanosome degradation, although the downstream effectors are not yet clarified. To determine...
Mon Oct 28, 2019 20:13
Background The problem of access to medical information, particularly in low-income countries, has been under discussion for many years. Although a number of developments have occurred in the last decade (e.g., the open access (OA) movement and the website Sci-Hub), everyone agrees that these difficulties still persist very widely, mainly due to the fact that paywalls still limit access to approximately 75% of scholarly documents. In this study, we compare the accessibility of recent full text...
Wed Oct 30, 2019 02:00
An 81-year-old, functionally independent woman with a history of bypass surgery and a previous vein graft intervention presented to us with significant angina refractory to medical management. An urgent angiogram revealed severe in-stent restenosis (ISR) in the proximal stent of the right coronary artery graft. At the same time, multiple trials to predilate the tight ISR using various-sized non-compliant and cutting balloons were unsuccessful. During the second attempt the next day, rotational atherectomy...
Wed Oct 30, 2019 11:04
Rupture of a non-parasitic splenic cyst is a rare but possibly dangerous complication with 21 cases described so far. We present a 46-year-old woman who presented with acute abdominal pain and was diagnosed with a spontaneous ruptured splenic cyst that was successfully treated by laparoscopic splenectomy. Histological examination showed characteristics corresponding with a non-parasitic congenital cyst that had lost its epithelial lining. Several treatment options can be considered for splenic cysts,...
Wed Oct 30, 2019 11:04
Transcobalamin (TC) deficiency is a rare autosomal recessive inborn error of cobalamin transport which clinically manifests in early infancy. We describe a child with TC deficiency who presented with classical clinical and lab stigmata of inborn error of vitamin B12 metabolism except normal serum B12 levels. He was started on empirical parenteral cobalamin supplements at 2 months of age; however, the definitive diagnosis could only be established at 6 years of age when a genetic evaluation revealed...
Wed Oct 30, 2019 11:04
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