In conclusion, this meta-analysis indicated that MTRR rs1801394 was significantly associated with LC in smokers, and MTHFR rs1801133 polymorphisms was also significantly associated with LC in smokers and East Asians. These results suggested that these two polymorphisms could be used to identify individuals at high risk of developing LC in certain populations. PMID: 31661627 [PubMed - as supplied by publisher] (Source: Nutrition and Cancer)
Tue Oct 29, 2019 00:00
Twin-to-twin transfusion syndrome (TTTS) is a serious complication typical of monochorionic pregnancies. Cases in dichorionic pregnancies have been described. The authors present a case report of a presumed TTTS in a dichorionic pregnancy followed at our institution in which the patient presented to the emergency department at 31 4/7 weeks’ gestation complaining of lack of fetal movements. Both fetuses did not show any cardiac activity. On the first twin, an oligohydramnios was present and his bladder...
Wed Oct 30, 2019 11:04
A 65-year-old woman presented to the emergency department with an acute onset of left-sided hemiparesis and slurred speech for 6 hours. Physical examination was notable for clubbing and peripheral cyanosis. Brain MRI showed an acute infarct involving the right gangliocapsular region. Investigations showed an elevated haemoglobin level, a haematocrit level of >65% and thrombocytopaenia. Transthoracic echocardiography revealed tricuspid atresia, ventricular septal defect and atrial septal defect....
Wed Oct 30, 2019 11:04
A 63-year-old woman with a prior history of chronic lower extremity lymphedema came to the hospital for evaluation of new-onset left leg pain and swelling associated with haemorrhagic blisters and foul-smelling discharge. Relevant history included a recent trip to a Hudson River Valley beach in New York 1 week prior to hospitalisation. Laboratory evaluation revealed significant leukocytosis and lactic acidosis. She was found to have sepsis and bacteremia secondary to Vibrio cholerae (serotype non-O1,...
Wed Oct 30, 2019 11:04
A 1-day-old child was brought to the clinic for evaluation of enlarged right eye (OD). On examination, OD showed buphthalmos with diffuse scleral melanocytosis, fleshy blackish-brown extrascleral mass with corneal extension, and secondary glaucoma. Anterior segment evaluation revealed darkly pigmented iris and fundus evaluation OD revealed a darkly pigmented choroidal lesion. The left eye was within normal limits. A clinical diagnosis of choroidal melanocytoma with ocular melanocytosis was made....
Wed Oct 30, 2019 11:04
We report the case of a 59-year-old man with a history of type 2 diabetes, hypertension and chronic kidney disease who presented with symptomatic severe hypercalcaemia (calcium 15.8 mg/dL) and acute kidney injury. Evaluation revealed that the hypercalcaemia was not mediated by parathyroid hormone (PTH), PTH-related peptide or 1,25-hydroxyvitamin D. Adrenal insufficiency was subsequently diagnosed and was initially thought to be the aetiology of the hypercalcaemia. He was treated with intravenous...
Wed Oct 30, 2019 11:04
A previously healthy 8-year-old girl presented to the hospital with right periorbital and forehead swelling in the setting of a 1-week history of upper respiratory symptoms. Contrast-enhanced CT revealed pansinusitis with orbital and frontal abscesses and thrombosis of the anterior portion of the superior sagittal sinus. She was treated with surgical drainage, antibiotics and anticoagulants. After 2 days she developed cranial nerve (CN) VI palsy. Contrast-enhanced MRI revealed small epidural abscess,...
Wed Oct 30, 2019 11:04
BackgroundInappropriate visits to emergency departments (EDs) could represent from 20% to 40% of all visits. Inappropriate use is a burden on healthcare costs and increases the risk of ED overcrowding. The aim of this study was to explore socioeconomic and geographical determinants of inappropriate ED use in France.MethodThe French Emergency Survey was a nationwide cross-sectional survey conducted on June 11 2013, simultaneously in all EDs in France and covered characteristics of patients, EDs and...
Wed Oct 30, 2019 11:00
Publication date: Available online 29 October 2019Source: American Journal of Infection ControlAuthor(s): Víctor Daniel Rosenthal, Ider Bat-Erdene, Debkishore Gupta, Souad Belkebir, Prasad Rajhans, Farid Zand, Sheila Nainan Myatra, Majeda Afeef, Vito L Tanzi, S. Muralidharan, Vaidotas Gurskis, Hail M. Al-Abdely, Amani El-Kholy, Safa A. Aziz AlKhawaja, Suha Sen, Yatin Mehta, Vineya Rai, Nguyen Viet Hung, Amani F. Sayed, Fausto Marcos Guerrero-ToapantaBackgroundWe report the results of International...
Wed Oct 30, 2019 11:26
Publication date: Available online 29 October 2019Source: American Journal of Infection ControlAuthor(s): Amanda M. Wilson, Kelly A. Reynolds, Lee-Ann Jaykus, Blanca Escudero-Abarca, Charles P. GerbaBackgroundThe purpose of this study was to relate experimentally measured log10 human norovirus reductions for a nonresidual (60% ethanol) and a residual (quaternary ammonium-based) hand sanitizer to infection risk reductions.MethodsHuman norovirus log10 reductions on hands for both sanitizers were experimentally...
Wed Oct 30, 2019 11:26
Attention deficit hyperactivity disorder (ADHD) is a behavioural disorder characterised by the core symptoms of hyperactivity, impulsivity and inattention. ADHD is thought to affect about 3%–9% of school-age children and young people in the UK. With increased awareness and early identification of ADHD, and the long-term impact of the condition, there is a growing demand for ADHD services for both assessment and treatment of children and young people with the condition. Demand and capacity modelling...
Wed Oct 30, 2019 09:15
Abstract Peeling skin disease is a rare genodermatosis characterized by superficial exfoliation or peeling of the skin. Peeling skin disease is caused by biallelic mutations in CDSN as an autosomal recessive trait. Monoallelic mutations in CDSN have also been described in an autosomal dominant inherited genodermatosis: hypotrichosis simplex of the scalp. This disease is characterized by progressive hair loss of the scalp with onset after early childhood. Clinical data were obtained from a patient...
Tue Oct 29, 2019 19:18
Objective To examine the long-term risk of stroke in women who have experienced symptomatic menopausal transition. Methods In this nationwide, population-based cohort study conducted from January 1, 2000 to December 31, 2013, we identified 22,058 women with no prior history of stroke, who experienced symptomatic menopausal transition at ≥45 years of age. Moreover, 22,058 women without symptomatic menopause were matched by propensity scores and enrolled as a comparison group. The propensity...
Wed Oct 30, 2019 02:00
The isolation and culture of dorsal root ganglion (DRG) neurons cause adaptive changes in the expression and regulation of ion channels, with consequences on neuronal excitability. Considering that not all neurons survive the isolation and that DRG neurons are heterogeneous, it is difficult to find the cellular subtype of interest. For this reason, researchers opt for DRG-derived immortal cell lines to investigate endogenous properties. The F-11 cell line is a hybridoma of embryonic rat DRG neurons...
Wed Oct 30, 2019 02:00
Background Because of its status as an ecocivilization pilot city, fundamental research on spatial distribution patterns and impact factors of the avian community within the Xiong’an New Area is necessary for future ecological planning and mitigation of negative impacts from future urbanization. Gradient research within small cities can provide important information for the development of urbanization gradient patterns of avian communities. ...
Wed Oct 30, 2019 02:00
Background Although several risk factors for nosocomial diarrhea have been identified, the detail of association between these factors and onset of nosocomial diarrhea, such as degree of importance or temporal pattern of influence, remains unclear. We aimed to determine the association between risk factors and onset of nosocomial diarrhea using machine learning algorithms. Methods We retrospectively collected data of...
Wed Oct 30, 2019 02:00
Background Interleukin-35 (IL-35) is a recently discovered cytokine that plays a role in immune suppression and has therefore been the subject of a great deal of research. A bibliometric analysis of the global research concerning IL-35, however, is rare. Objectives The aim of this research was to assess the international scientific output of IL-35 research and explore its hotspots and frontiers from 2009 to 2018 by bibliometric...
Wed Oct 30, 2019 02:00
Abstract Purpose Mycophenolic acid (MPA) is a fungal metabolite with a variety of biological activities and widely applied in clinical practices. We herein aimed to isolate a new Penicillium brevicompactum strain from the fruiting body of Inonotus obliquus to improve the production of MPA. Methods The fruiting body of Inonotus obliquus was used to isolate...
Wed Oct 30, 2019 02:00
In this study, we demonstrate that outer membrane vesicles (OMVs) derived from the faeces of Alzheimer's disease (AD) patients enter the brain, break the blood–brain barrier (BBB), induce marked neuroinflammation and specifically aggravate tau hyperphosphorylation, thus potentially inducing behavioural cognitive impairment Abstract Outer membrane vesicles (OMVs) are nanosized vesicles produced by the gut microbiota (GM). The GM is well‐known to be involved in the pathological process of Alzheimer's...
Tue Oct 29, 2019 18:15
Abstract Premature ovarian failure (POF) usually happens former to the age of 40 and affects the female physiological state premenopausal period. In this condition, ovaries stop working long before the expected menopausal time. Of diagnostic symptoms of the disease, one can mention amenorrhea and hypoestrogenism. The cause of POF in most cases is idiopathic; however, cancer therapy may also cause POF. Commonly utilized therapies such as hormone therapy, in‐vitro activation, and regenerative medicine...
Tue Oct 29, 2019 18:14
miR‐574‐5p inactive c‐Jun N‐terminal kinase/extracellular‐signal‐regulated kinase pathways resulting in decreased cell proliferation, enhanced cell apoptosis and weakens milk synthesis by protein kinase B–mammalian target of rapamycin pathway via mitogen‐activated protein kinase kinase kinase 9 and AKT3 in goat mammary epithelial cells, meanwhile, circ‐016910 acts as a sponge for miR‐574‐5p and shows a circRNA–miRNA–mRNA network to undertake biological effects. Abstract Incremental proofs demonstrate...
Tue Oct 29, 2019 18:13
We found that miR‐22‐3p acted as an intracellular molecular to promote primary sensory neuron neurite growth by removing CBL‐induced p‐EGFR degradation. This study clarified the new neurite regulation mechanisms and provided novel treatment targets for spinal cord sensory dysfunction. Abstract Spinal cord injury (SCI) is a devastating disease. Strategies that enhance the intrinsic regenerative ability are very important for the recovery of SCI to radically prevent the occurrence of sensory disorders....
Tue Oct 29, 2019 18:13
Abstract CD8+ T cells play a vital role in cancer immunotherapy and can be shaped by metabolism. Avasimibe is an acyl coenzyme A‐cholesterol acyltransferase (ACAT) inhibitor, which has been clinically verified safe in other phase Ⅲ clinical trials. It can potentiate the killing function of CD8+ T cells by modulating cholesterol metabolism. Doxorubicin (DOX) is an anticancer drug widely used in many cancers to induce tumor cell apoptosis. Unfortunately, DOX also can induce toxic and side effects...
Tue Oct 29, 2019 18:13
miR‐34a suppressed the migration, invasion, and cell growth of oral squamous cell carcinoma (OSCC) by down regulating the special AT‐rich sequence‐binding protein 2 (SATB2) expression. Abstract In various kinds of carcinomas, the special AT‐rich sequence‐binding protein 2 (SATB2) with its atypical expression promotes the metastasis and progression of the tumor, though in the oral squamous cell carcinoma (OSCC) its inherent mechanism and the status of SATB2 remain unclear. The role played by the...
Tue Oct 29, 2019 18:12
Alkaline phosphatase production, calcium deposits, osteocalcin, and osteopontin expression, and the bone formation were found upregulated in vitro and in vivo following bone morphogenetic protein 2 (BMP‐2)‐induced osteogenic differentiation, and adenosine 5’‐monophosphate‐activated protein kinase (AMPK) and Wnt signal activation by focal adhesion kinase could effectively regulate BMP2‐enhanced osteogenic differentiation of human urine‐derived stem cells (hUSCs). These findings taken together indicated...
Tue Oct 29, 2019 18:12
15‐Lipoxygenase‐1 (15‐LOX‐1) has a role in doxorubicin resistance in cancer cells. Role of 15‐LOX‐1 is cell‐ and/or drug‐specific. 15‐LOX‐1 triggers apoptosis and modulates cell membrane to induce cell death and resensitize the doxorubicin resistance in MCF7 cells. Abstract Lipoxygenases (LOXs) are a family of enzymes that can oxygenate polyunsaturated fatty acids. As a member of the family, 15‐lipoxygenase‐1 (15‐LOX‐1) specifically metabolizes arachidonic acid and linoleic acid. 15‐LOX‐1 can...
Tue Oct 29, 2019 18:11
We established an eight‐long noncoding RNA (lncRNA) signature to predict the survival of patients with estrogen receptor‐positive breast cancer receiving endocrine therapy. We have built a nomogram that integrated the conventional clinicopathological features and the eight‐lncRNA‐based signature. Abstract Long noncoding RNAs (lncRNAs) have the main role in the tumorigenesis of breast cancer. In the present study, lncRNA expression profiling was collected to identify a lncRNA expression signature...
Tue Oct 29, 2019 18:11
Emerging data revealed that microRNAs (miRNAs) have prominent implications for regulating cellular proliferation, differentiation, apoptosis, and metabolism through targeting the phosphoinositide 3‐kinase/protein kinase B/mammalian target of rapamycin (PI3K/AKT/mTOR) signaling axis. The present study summarizes the major findings about the regulatory role of miRNAs in PI3K/AKT/mTOR pathway in the pathogenesis of hepatocellular carcinoma. Abstract Hepatocellular carcinoma (HCC) is one of the common...
Tue Oct 29, 2019 18:11
In this review, we introduce the relationship between gut microbiome and cancer immunotherapy, and expound the impact of gut microbiome on efficacy and toxicity of cancer immunotherapy. Further, we review approaches to manipulating gut microbiome to regulate response to immune checkpoint inhibitors (ICIs), and discuss the current challenges and propose future directions to improve cancer immunotherapy via gut microbiome manipulation. Abstract Gut microbiome has received significant attention...
Tue Oct 29, 2019 18:10
In general, the current project was performed for designing a potent scFv‐engineered RNase A for the induction of death to Her1‐positive cells. The results of this study showed that our designed immunotoxin was able to induce death with an IC50 of 50 nM, and consequently, it can be a promising tool for cancer therapy. Abstract The present study was performed to design an immunotoxin consisting of engineered RNase A and scFv of Cetuximab. To accomplish this study goal, at first to evade RNase...
Tue Oct 29, 2019 18:10
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