- Effectiveness of fentanyl pectin nasal citrate in controlling episodes of breakthrough cancer pain triggered by routine radiotherapy proceduresAbstract Purpose The aim of the study was to evaluate the effectiveness of fentanyl pectin nasal spray (FPNS) in controlling procedural breakthrough cancer pain (BTCP) in advanced cancer patients undergoing radiotherapy. Materials and methods This study involved 62 advanced cancer patients,
- A three-platelet mRNA set: MAX, MTURN and HLA - B as biomarker for lung cancerAbstract Background During the development of tumors, tumors “educate” platelets causing changes in their mRNAs expression profiles and phenotypes, thereby, tumor-educated platelet (TEP) mRNA profile has the potential to diagnose lung cancer. The current study aimed to examine whether TEPs might be a potential biomarker for lung cancer diagnostics.
- MicroRNAs in tumor samples and urinary extracellular vesicles as a putative diagnostic tool for muscle-invasive bladder cancerAbstract Purpose The identification of biomarkers characterizing the invasive potential of bladder cancer could enhance the clinical management of individual patients and therefore improve prognosis. The aim of this study was to define a miRNA panel in tumor tissues as well as in urinary extracellular vesicles (EVs) for discriminating muscle-invasive bladder cancer (MIBC) from no
- Reduced intensity conditioning regimens including alkylating chemotherapy do not alter survival outcomes after allogeneic hematopoietic cell transplantation in chronic lymphocytic leukemia compared to low-intensity non-myeloablative conditioningAbstract Purpose The optimal dose intensity for conditioning prior to allogeneic hematopoietic stem cell transplantation (alloHSCT) for chronic lymphocytic leukemia (CLL) is unknown. Methods We retrospectively compared outcomes of patients who received a first alloHCST after non-myeloablativ
- Active surveillance of low-risk papillary thyroid carcinoma: a promising strategy requiring additional evidenceAbstract Purpose Papillary thyroid carcinoma (PTC), the most common malignant tumor of the thyroid, has been criticized as overtreated by some researchers in recent years. Active surveillance (AS) was first proposed at Kuma Hospital in 1993, and popularized in other institutes ever since. We provide a brief review of low-risk PTC active monitoring studies to date, and discuss the
- Comparison of procalcitonin and C-reactive protein as early diagnostic marker for the identification of transplant-related adverse events after allogeneic hematopoietic stem cell transplantation in pediatric patientsAbstract Purpose To evaluate serum procalcitonin (PCT) and C-reactive protein (CRP) as diagnostic biomarkers of transplant-related adverse events (TRAE) in pediatric patients undergoing hematopoietic stem cell transplantation (HSCT). Methods This study analyzed PCT and CRP levels of 214 pedi
- Molecular subtyping of gastric cancer with respect to the growth pattern of lymph-node metastasesAbstract Purpose Gastric cancer is the third leading cause of cancer-related death. Recently, innovative diagnostic and prognostic molecular subtypes have been proposed. We revealed that extranodal extension (ENE) of lymph-node metastases independently influences survival. Therefore, the aim of the present study was to evaluate novel molecular subtyping with regard to the growth
- Expression and clinical significance of PD-L1 and c-Myc in non-small cell lung cancerAbstract Background It is known that there are insufficient prognostic factors for non-small cell lung cancer (NSCLC). It was reported that PD-L1 was a prognostic factor for NSCLC,and c-Myc regulated the expression of PD-L1. Herein, we investigated c-Myc and PD-L1 expression and their association with overall survival (OS) in NSCLC.
- Heterogeneity of childhood acute leukemia with mature B-cell immunophenotypeAbstract Background Flow cytometry (FCM) plays a crucial role in the differential diagnosis of Burkitt lymphoma/leukemia (BL) and B-cell precursor acute lymphoblastic leukemia (BCP-ALL). The presence of surface IgM (sIgM) alone or with light chain restriction indicates a mature blast phenotype (BIV by EGIL) and is usually observed in BL. However, sIgM expression could also be det
- Circular RNAs: pivotal molecular regulators and novel diagnostic and prognostic biomarkers in non-small cell lung cancerAbstract Purpose Circular RNAs (circRNAs), a large class of non-coding RNAs with covalently closed-loop structures, are abundant, stable, conserved, and have tissue and developmental-stage specificities. The biological functions of circRNAs are varied. Moreover, circRNAs participate in various pathological processes, especially in multiple cancers. Lung cancer is the most frequent mali
- Cross-talk between ribosome biogenesis, translation, and mTOR in CD133+ 4/CD44+ prostate cancer stem cellsAbstract Objective To investigate the gene expression profile of CSCs and to explore the key pathways and specific molecular signatures involved in the characteristic of CSCs. Materials and methods CD133+ /CD44+ CSCs and bulk population (non-CSCs) were isolated from DU-145 cells using fluorescence-activat
- Response to Letter to the Editor: Regarding “Teaching Radiation and Cancer Biology to Radiation Oncology Residents: A 40-Year Perspective”Publication date: Available online 19 October 2019Source: Practical Radiation OncologyAuthor(s): Barry S. Rosenstein
- Measurement of percentage dose at the surface for a 6 MV photon beamPublication date: November–December 2019Source: Reports of Practical Oncology & Radiotherapy, Volume 24, Issue 6Author(s): O.O. Galván De la Cruz, M.A. Rodríguez-Ávila, T. Rivera-Montalvo, O.A. García GarduñoAbstractAimTo evaluate if a radiochromic film (RF) Gafchromic EBT3 is suitable for surface dose measurements of radiotherapy treatments performed with a 6 MV linear accelerator. Two aspects of RF were analyzed, beam energy dependence and surf
- Formulation of normal tissue irradiation volumes in Co-60 and Ir-192 HDR ICBT of Ca cervix using Total Reference Air Kerma (TRAK)Publication date: November–December 2019Source: Reports of Practical Oncology & Radiotherapy, Volume 24, Issue 6Author(s): Ngangom Robert, R.P. Chauhan, Arun Oinam, Bhavana RaiAbstractAimThe aim of this study was to formulate isodose volume relations encompassed by isodose surfaces in Co-60 and Ir-192 HDR intracavitary brachytherapy (ICBT) of cervix carcinoma using the Total Reference Air Kerma (TRAK).BackgroundThe TRAK and isodose volumes are ra
- Evaluating the accuracy of geometrical distortion correction of magnetic resonance images for use in intracranial brain tumor radiotherapyPublication date: November–December 2019Source: Reports of Practical Oncology & Radiotherapy, Volume 24, Issue 6Author(s): Seyed Mehdi Bagherimofidi, Claus Chunli Yang, Roberto Rey-Dios, Madhava R. Kanakamedala, Ali FatemiAbstractAimDetermine the 1) effectiveness of correction for gradient-non-linearity and susceptibility effects on both QUASAR GRID3D and CIRS phantoms; and 2) the magnitude and location of regions of residual distortion before an
- Association between EGFR mutation and ageing, history of pneumonia and gastroesophageal reflux disease among patients with advanced lung cancerPublication date: November 2019Source: European Journal of Cancer, Volume 122Author(s): Won-Il Choi, Jihyeon Jeong, Choong Won LeeAbstractBackgroundEpidermal growth factor receptor (EGFR) mutation is the most frequently encountered oncogenic driver in lung cancer. Risk factors for EGFR mutation may help prevention, surveillance and diagnosis strategies of EGFR-mutated lung cancer.Patients and methodsA nationwide, retrospective, longitudinal, coho
- UCBG 2-04: Long-term results of the PACS 04 trial evaluating adjuvant epirubicin plus docetaxel in node-positive breast cancer and trastuzumab in the human epidermal growth factor receptor 2–positive subgroupPublication date: November 2019Source: European Journal of Cancer, Volume 122Author(s): Véronique D'Hondt, Jean-Luc Canon, Lise Roca, Christelle Levy, Jean-Yves Pierga, Fanny Le Du, Mario Campone, Isabelle Desmoulins, Anthony Goncalves, Marc Debled, Maria Rios, Jean-Marc Ferrero, Daniel Serin, Anne-Claire Hardy-Bessard, Gilles Piot, Etienne Brain, Nadine Dohollou, Hubert Orfeuvre, Jerome Lemonnier, Henri RochéAbstractPurposeWe conducted a double-
- Cancers, Vol. 11, Pages 1598: Diagnostic and Prognostic Value of B4GALT1 Hypermethylation and Its Clinical Significance as a Novel Circulating Cell-Free DNA Biomarker in Colorectal CancerCancers, Vol. 11, Pages 1598: Diagnostic and Prognostic Value of B4GALT1 Hypermethylation and Its Clinical Significance as a Novel Circulating Cell-Free DNA Biomarker in Colorectal Cancer Cancers doi: 10.3390/cancers11101598 Authors: Francesco Picardo Antonella Romanelli Laura Muinelo-Romay Tommaso Mazza Caterina Fusilli Paola Parrella Jorge Barbazán Rafael Lopez-López Raffaela Barbano Mariangela De Robertis C
- Cancers, Vol. 11, Pages 1599: Targeting Autophagy for Cancer Treatment and Tumor ChemosensitizationCancers, Vol. 11, Pages 1599: Targeting Autophagy for Cancer Treatment and Tumor Chemosensitization Cancers doi: 10.3390/cancers11101599 Authors: Marta Pérez-Hernández Alain Arias David Martínez-García Ricardo Pérez-Tomás Roberto Quesada Vanessa Soto-Cerrato Autophagy is a tightly regulated catabolic process that facilitates nutrient recycling from damaged organelles and other cellular components through lysosomal degr
- Cancers, Vol. 11, Pages 1596: Identification of Celastrol as a Novel YAP-TEAD Inhibitor for Cancer Therapy by High Throughput Screening with Ultrasensitive YAP/TAZ–TEAD BiosensorsCancers, Vol. 11, Pages 1596: Identification of Celastrol as a Novel YAP-TEAD Inhibitor for Cancer Therapy by High Throughput Screening with Ultrasensitive YAP/TAZ–TEAD Biosensors Cancers doi: 10.3390/cancers11101596 Authors: Kazem Nouri Taha Azad Min Ling Helena J. Janse van Rensburg Alexander Pipchuk He Shen Yawei Hao Jianmin Zhang Xiaolong Yang The Hippo pathway has emerged as a key signaling pathway that r
- Cancers, Vol. 11, Pages 1600: Mutational Landscape of the BAP1 Locus Reveals an Intrinsic Control to Regulate the miRNA Network and the Binding of Protein Complexes in Uveal MelanomaCancers, Vol. 11, Pages 1600: Mutational Landscape of the BAP1 Locus Reveals an Intrinsic Control to Regulate the miRNA Network and the Binding of Protein Complexes in Uveal Melanoma Cancers doi: 10.3390/cancers11101600 Authors: Amit Sharma Arijit Biswas Hongde Liu Sagnik Sen Anoosha Paruchuri Panagiotis Katsonis Olivier Lichtarge Tikam Chand Dakal Ujjwal Maulik M. Michael Gromiha Sanghamitra Bandyopadhyay
- Lenalidomide maintenance post-transplantation in newly diagnosed multiple myeloma: real-world outcomes and costs.Related ArticlesLenalidomide maintenance post-transplantation in newly diagnosed multiple myeloma: real-world outcomes and costs. Future Oncol. 2019 Oct 18;: Authors: Hari P, Ung B, Abouzaid S, Agarwal A, Parikh K Abstract Aim: To compare real-world outcomes and costs among patients with newly diagnosed multiple myeloma receiving lenalidomide-only maintenance (Len-Mt) versus no maintenance after auto
- Augmenting the randomized controlled trial with real-world data to aid clinical decision making in metastatic renal cell carcinoma: a systematic review and meta-analysis.Related ArticlesAugmenting the randomized controlled trial with real-world data to aid clinical decision making in metastatic renal cell carcinoma: a systematic review and meta-analysis. Future Oncol. 2019 Oct 18;: Authors: Moran M, Nickens D, Adcock K, Bennetts M, Charnley N, Fife K Abstract Aim: To evaluate how efficacy outcomes from real-world data (RWD) can support those from randomized controlle
- Is colorectal cancer a more aggressive disease in young patients? A population-based study from the Czech RepublicPublication date: December 2019Source: Cancer Epidemiology, Volume 63Author(s): Petr Kocián, Ivana Svobodová, Denisa Krejčí, Milan Blaha, Robert Gürlich, Ladislav Dušek, Jiří Hoch, Adam WhitleyAbstractIntroductionThe incidence of colorectal cancer in young patients is increasing. The goal of this study was to investigate whether clinicopathological features and survival differed between young, middle-aged and elderly patients.MethodsThe Czech Nat
- Hospitalization outcomes and racial disparities in cervical cancer patients: An analysis of the national inpatient sample data from 2002 to 2014Publication date: December 2019Source: Cancer Epidemiology, Volume 63Author(s): Gurudatta Naik, Amrita Mukherjee, Tomi Akinyemiju, Sadeep ShresthaAbstractBackgroundLittle is known about outcomes in patients after being hospitalized for care of cancer or comorbid conditions and the disparity between African-American and White cervical cancer patients.MethodsUsing the national inpatient sample (HCUP-NIS) database of the Healthcare Cost and Utilizat
- Cancers, Vol. 11, Pages 1597: Cold Atmospheric Plasma-Treated PBS Eliminates Immunosuppressive Pancreatic Stellate Cells and Induces Immunogenic Cell Death of Pancreatic Cancer CellsCancers, Vol. 11, Pages 1597: Cold Atmospheric Plasma-Treated PBS Eliminates Immunosuppressive Pancreatic Stellate Cells and Induces Immunogenic Cell Death of Pancreatic Cancer Cells Cancers doi: 10.3390/cancers11101597 Authors: Jinthe Van Loenhout Tal Flieswasser Laurie Freire Boullosa Jorrit De Waele Jonas Van Audenaerde Elly Marcq Julie Jacobs Abraham Lin Eva Lion Heleen Dewitte Marc Peeters Sylvia Dewil
- LEF1 supports metastatic brain colonization by regulating glutathione metabolism and increasing ROS resistance in breast cancerMore than half of all brain metastases show infiltrating rather than displacing growth at the macro‐metastasis/brain parenchyma interface (MMPI), a finding associated with shorter survival. The Lymphoid Enhancer‐binding Factor‐1 (LEF1) is an epithelial‐mesenchymal transition (EMT) transcription factor that is commonly overexpressed in brain‐colonizing cancer cells. Here, we overexpressed LEF1 in an in vivo breast cancer brain colonization model.
- Phase 1 dose‐finding study of metformin in combination with concurrent cisplatin and radiotherapy in patients with locally advanced head and neck squamous cell cancerBackground The 5‐year overall survival (OS) rate remains at 50% for patients with locally advanced head and neck squamous cell carcinoma (LAHNSCC), thereby underscoring the need for improved treatments. An antidiabetic agent, metformin, was found in retrospective studies to improve survival in patients with HNSCC. Therefore, the authors conducted a phase 1 dose escalation study combining metformin with chemoradiotherapy in patients with LAHNSCC.
- Trajectories of social resource use among informal lung cancer caregiversBackground Social support is a key component in maintaining cancer caregiver well‐being, and many resources exist to facilitate caregivers' use of social support (eg, cancer support groups). This study sought to determine how informal cancer caregivers use social resources over the course of caregiving. Methods The data are from the Comprehensive Health Enhancement Support System study of informal caregivers (n = 202) of patients with rece
- Blinatumomab compared with standard of care for the treatment of adult patients with relapsed/refractory Philadelphia chromosome–positive B‐precursor acute lymphoblastic leukemiaBackground A single‐arm, phase 2 trial demonstrated the efficacy and safety of blinatumomab, a bispecific T‐cell–engaging antibody construct, in patients with relapsed/refractory (r/r) Philadelphia chromosome–positive (Ph+) acute lymphoblastic leukemia (ALL), a rare hematologic malignancy with limited treatment options. This study compared outcomes with blinatumomab with those of a historical control treated with the standard of care (SOC).
- The impact of underinsurance on bladder cancer diagnosis, survival, and care delivery for individuals under the age of 65 yearsBackground Health insurance is a key mediator of health care disparities. Outcomes in bladder cancer, one of the costliest diseases to treat, may be especially sensitive to a patient's insurance status. Methods The Surveillance, Epidemiology, and End Results registry and the National Cancer Data Base were used to identify individuals younger than 65 years who were diagnosed with bladder cancer from 2007 to 2014. The associations between th
- Barriers and facilitators of risk‐based health care for adult survivors of childhood cancer: A report from the Childhood Cancer Survivor StudyBackground Optimal risk‐based survivor health care includes surveillance for late effects and education targeted at reducing or preventing risky health behaviors. Understanding the reasons for a lack of risk‐based follow‐up care is essential. Methods Adult participants from the Childhood Cancer Survivor Study were surveyed about having a cancer‐related visit in the past 2 years and the likelihood of having a cancer‐related visit in the fut
- Is screening for psychosocial risk factors associated with mental health care in older adults with cancer undergoing surgery?Background Surgery is a notable stressor for older adults with cancer, who often are medically and psychosocially complex. The current study examined rates of preoperative psychosocial risk factors in older adults with cancer who were undergoing elective surgery and the relationship between these risk factors and the provision of mental health services during the postoperative hospitalization. Methods A total of 1211 patients aged ≥75 year
- Cancers, Vol. 11, Pages 1594: Plasma Metabolomics Identifies Lipid and Amino Acid Markers of Weight Loss in Patients with Upper Gastrointestinal CancerCancers, Vol. 11, Pages 1594: Plasma Metabolomics Identifies Lipid and Amino Acid Markers of Weight Loss in Patients with Upper Gastrointestinal Cancer Cancers doi: 10.3390/cancers11101594 Authors: Janice Miller Ahmed Alshehri Michael I. Ramage Nathan A. Stephens Alexander B. Mullen Marie Boyd James A. Ross Stephen J. Wigmore David G. Watson Richard J.E. Skipworth Cachexia is a multifactorial wasting syndro
- Cancers, Vol. 11, Pages 1595: Single-Cell Analysis of Circulating Tumor Cells: Why Heterogeneity MattersCancers, Vol. 11, Pages 1595: Single-Cell Analysis of Circulating Tumor Cells: Why Heterogeneity Matters Cancers doi: 10.3390/cancers11101595 Authors: Su Bin Lim Chwee Teck Lim Wan-Teck Lim Unlike bulk-cell analysis, single-cell approaches have the advantage of assessing cellular heterogeneity that governs key aspects of tumor biology. Yet, their applications to circulating tumor cells (CTCs) are relatively limited, due mainly
- Trastuzumab in combination with paclitaxel enhances antitumor activity by promoting apoptosis in human epidermal growth factor receptor 2-positive trastuzumab-resistant gastric cancer xenograft modelsTrastuzumab, a humanized anti-human epidermal growth factor receptor 2 antibody drug, is the first-line therapy for human epidermal growth factor receptor 2-positive breast and gastric cancer. For breast cancer, the benefit of continuous treatment with trastuzumab after it becomes refractory to first-line therapy has been demonstrated. However, it is unclear whether trastuzumab can show similar efficacy as a second-line treatment for gastric canc
- An 1H NMR study of the cytarabine degradation in clinical conditions to avoid drug waste, decrease therapy costs and improve patient compliance in acute leukemiaCytarabine, the 4-amino-1-(β-D-arabinofuranosyl)-2(1H)-pyrimidinone, (ARA-C) is an antimetabolite cytidine analogue used worldwide as key drug in the management of leukaemia. As specified in the manufacturers’ instructions, once the components—sterile water and cytarabine powder—are unpackaged and mixed, the solution begins to degrade after 6 hours at room temperature and 12 hours at 4°C. To evaluate how to avoid wasting the drug in short-term, l
- Everolimus, letrozole, and metformin in women with advanced or recurrent endometrioid endometrial cancer: A multi-center, single arm, phase II studyPurpose: Treatment for patients with recurrent endometrioid endometrial cancer (EEC) are limited as paclitaxel is the only second line chemotherapy with a response rate >13%. Targeting PIK3/mTOR in combination with hormonal therapy has shown promise. The addition of metformin may enhance this response. We conducted a phase II study evaluating everolimus, letrozole, and metformin in advanced/recurrent ECC. Experimental Design: A Simon two-stage
- Metabolic Subtyping for Novel Personalized Therapies Against Pancreatic CancerThrough metabolic subtyping, metabolic vulnerabilities can be exploited for developing efficacious treatments. A glycolytic subtype indicates poor survival in pancreatic cancer patients, whereas a cholesterogenic subtype correlates with better outcomes potentially due to more energy expenditure. Personalized medicine holds great promise for improving therapy outcomes by optimally targeting metabolic pathways.
- Pronounced clinical response following the oncolytic vaccinia virus GL-ONC1 and chemotherapy in a heavily pretreated ovarian cancer patientHeavily pretreated ovarian cancer patients become progressively chemoresistant, and thereafter, only scant treatments potentially accord reasonable, albeit limited clinical efficacy. We describe a case involving a 67-year-old ovarian cancer patient who underwent multiple lines of chemotherapy and presented with recurrent disease and a CA-125 of 4112 U/mL. Thenceforth, she was treated with GL-ONC1 oncolytic viral therapy that was administered lapa
- Overcoming the resistance to BRAF inhibitor by the double BRAF and MEK inhibitions in advanced melanoma: a case reportThe advent of BRAF and MEK inhibitors changed the landscape of the management of BRAF mutated melanoma patients. In this article, we report the case of a 51-year-old man with BRAF mutated locally advanced cutaneous melanoma of the head who demonstrated a limited response to initial anti-BRAF monotherapy followed by extensive surgery. Anti-PD1 therapy failed to reverse the disease progression. However, subsequent double inhibition of the BRAF and
- Sinomenine sensitizes human gastric cancer cells to cisplatin through negative regulation of PI3K/AKT/Wnt signaling pathwaySinomenine (SIN) has been reported its antitumor effects on various types of human cancers, but there is no available information regarding the antitumor effects of SIN and cisplatin on gastric cancer. Here, we examined the antitumor effects of SIN combined with cisplatin on gastric cancer cells as well as the underlying biological mechanisms. CCK-8 assay and Calcusyn 2.0 software analysis, Hoechst 33258 staining and flow cytometry, transwell ass
- An autophagy-dependent cell death of MDA-MB-231 cells triggered by a novel Rhein derivative 4FTriple negative breast cancer (TNBC) has very poor prognosis and no efficacious therapeutic options due to the absence of a validated molecular target. Therefore, novel therapeutic strategies against TNBC are urgently needed. Our team synthesized and screened a series of compounds derived from Rhein, of which 4F was selected for further analysis based on its ability to produce the vacuolated appearance of cells. Using Cell counting kit-8 assay, c
- Synergistic anti-tumour effects of Clostridium butyricum in combination with apatinib in CT26 colorectal tumour-bearing miceTo investigate the synergistic antitumour effect of Clostridium butyricum combined with apatinib on colorectal cancer in mice. Murine colorectal carcinoma cell line CT26.WT cells were xenografted into the skin of BALB/c mice. Tumour-bearing mice were randomly divided into four groups, and given different treatment options (PBS control; C. butyricum; apatinib; C. butyricum + apatinib). Real-time PCR was used to detect C. butyricum content in the i
- Intracranial remission with brigatinib rechallenge as fifth-line ALK inhibition therapy in a lung cancer patientSeveral anaplastic lymphoma kinase (ALK) tyrosine kinase inhibitors have been developed for the treatment of EML4-ALK-rearranged non-small-cell lung cancer, with the newer generation agents brigatinib, alectinib and lorlatinib showing pronounced central nervous system activities. Intracranial efficacy is an important feature for these agents, as metastatic lesions frequently occur in the central nervous system in the ALK-positive setting. Here, w
- Proanthocyanidins attenuate breast cancer-induced bone metastasis by inhibiting Irf-3/c-jun activationWe have previously demonstrated the pivotal role of Jnk-mediated Irf-3/c-Jun in regulating nuclear factor kappa-Β ligand (RANKL)-induced osteoclastogenesis. Here, we demonstrated that proanthocyanidins (PACs) target Irf-3 to alleviate breast cancer-induced activation of osteoclasts. We also found that PACs induced apoptosis of osteoclast precursors by upregulating the ratio of bax/bcl-2 and activating caspase-3 activity. Such bone protective effe
- Antitumor effect of a short peptide on p53-null SKOV3 ovarian cancer cellsFibroblast growth factor-2 (FGF2) is a protein ligand, which exerts essential roles in development, angiogenesis, and tumor progression via activation of the downstream signaling cascades. Accumulating evidence has demonstrated that FGF2 is involved in the progression of ovarian cancer, providing a novel potential target for ovarian cancer therapy. In this study, we showed that FGF2 is significantly increased in ovarian tumors, and is negatively
- Matrine enhances the efficacy of adriamycin chemotherapy in osteosarcoma cells by the STAT3 pathwayMatrine and adriamycin have been extensively considered to be effective in anticancer therapies. However, the role of matrine in the antitumor activity of adriamycin against human osteosarcoma (OS) remains elusive. The aim of this study was to investigate the effect of matrine in OS chemotherapy of adriamycin. In the study, we found that matrine promoted the inhibitory effect of adriamycin against OS cell proliferation and growth. Wound healing a
- Efficacy of gefitinib at reduced dose in EGFR mutant non-small cell lung carcinomaAs a first-generation epidermal growth factor receptor-tyrosine kinase inhibitor, gefitinib was approved by the US Food and Drug Administration for treatment of advanced non-small cell carcinoma with sensitizing EGFR mutations. Gefitinib is known to have adverse effects, which may necessitate dose reduction or even change to alternative preparation of epidermal growth factor receptor-tyrosine kinase inhibitor. There has been concern on dose reduc
- LncRNA ANRIL promotes cell growth, migration and invasion of hepatocellular carcinoma cells via sponging miR-144Antisense non-coding RNA in the INK4A locus (ANRIL) has been recognized as a cancer-related lncRNA in hepatocellular carcinoma previously. This study aimed to reveal the functional effects and mechanisms of ANRIL on hepatocellular carcinoma cells in vitro. The expression of ANRIL in hepatocellular carcinoma cell lines (MHCC97 and Li-7) and non-tumourigenic liver cell line THLE-3 was detected by qRT-PCR. The expression of ANRIL, miR-144 and PBX3 i
- Appearance of cutaneous melanoma and subcutaneous metastases in metastatic gastric carcinoma undergoing chemotherapy with oral 5-fluorouracil prodrugMetastatic skin lesions of gastric cancers usually appear as nonspecific, firm, and hyperpigmented nodules. However, they occasionally present as unusual skin manifestations that mimic other skin disorders. We describe a case of multiple cutaneous metastases from gastric cancer resembling sebaceous cysts with a synchronous melanoma, in a patient after fluoropyrimidine-based systemic chemotherapy. Melanoma occurring as a second cancer has been rec
ΩτοΡινοΛαρυγγολόγος Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,
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Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com,
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00306932607174,
alsfakia@gmail.com,
Anapafseos 5 Agios Nikolaos 72100 Crete Greece,
Medicine by Alexandros G. Sfakianakis,
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