Clinical Otolaryngology
- Healthcare utilization, follow‐up of guidelines and practice variation on rhinosinusitis in adults; a health care reimbursement claims study in the NetherlandsAbstract Objectives To provide insight into healthcare utilization of rhinosinusitis, compare data with clinical practice guideline recommendations and assess practice variation. Design Anonymized data from claims reimbursement registries of healthcare insurers were analyzed, from January 1st, 2016 until December 31st, 2016. Setting Secondary and tertiary care in the Netherlands. Participants Patients ≥ 18 years with diagnos
- Understanding and clinical relevance of chronic rhinosinusitis endotypesAbstract Background Chronic rhinosinusitis (CRS) is the downstream manifestation of heterogeneous pathophysiologic mechanisms leading to chronic sinonasal inflammation. Traditional grouping of patients by symptoms or clinical findings/phenotypes, are being replaced by classification of CRS patients based on the underlying pathophysiologic mechanisms: endotypes. Objective of review To provide an up‐to‐date review on the current knowledge
- Patient‐reported outcomes and inflammatory biomarkers in patients with locally advanced/metastatic urothelial carcinoma treated with durvalumab in phase 1/2 dose‐escalation study 1108Background Durvalumab has shown meaningful clinical activity in patients with metastatic urothelial carcinoma (mUC) in Study 1108 (NCT01693562). An important focus in treatment is health‐related quality of life (HRQOL). Here, patient‐reported outcomes (PROs) from Study 1108 and their relationship with inflammatory biomarkers are explored. Methods Disease‐related symptoms, functioning, and HRQOL were assessed with the Functional Assessment
- Patterns of recurrence and metastasis in BRCA1/BRCA2‐associated breast cancersBackground Breast cancer subtypes are associated with distinct metastatic patterns. Whether germline BRCA1/BRCA2 mutation status is independently associated with central nervous system (CNS) relapse, controlling for tumor subtype, is unknown. Methods Patients who were treated at Dana‐Farber Cancer Institute and diagnosed with a first locoregional recurrence (LRR) or metastasis between 1981 and 2014 were identified using 2 institutional reg
- Sorafenib and omacetaxine mepesuccinate as a safe and effective treatment for acute myeloid leukemia carrying internal tandem duplication of Fms‐like tyrosine kinase 3Background Omacetaxine mepesuccinate (OME) has antileukemic effects against acute myeloid leukemia (AML) carrying an internal tandem duplication of Fms‐like tyrosine kinase 3 (FLT3‐ITD). A phase 2 clinical trial was conducted to evaluate a combination treatment of sorafenib and omacetaxine mepesuccinate (SOME). Methods Relapsed or refractory (R/R) or newly diagnosed patients were treated with sorafenib (200‐400 mg twice daily) and OME (2 m
- Changes in internet use and wishes of cancer survivors: A comparison between 2005 and 2017Background Given the major changes in internet use for health communication, the objective of the current study was to compare the internet use and wishes of cancer survivors between 2005 and 2017. Methods The authors drew a sample of 390 patients in 2005 and 539 patients in 2017 who were diagnosed with breast (128 patients in 2005 and 143 patients in 2017), prostate (96 patients in 2005 and 126 patients in 2017), or gynecologic (89 patien
- A contemporary analysis of racial disparities in recommended and received treatment for head and neck cancerBackground Racial disparities in squamous cell carcinoma of the head and neck (HNSCC) negatively affect non‐Hispanic black (NHB) patients. This study was aimed at understanding how treatment is prescribed and received across all HNSCC subsites. Methods With the National Cancer Database, patients from 2004 to 2014 with surgically resectable HNSCCs, including tumors of the oral cavity (OC), oropharynx (OP), hypopharynx (HP), and larynx (LX),
- Health care utilization and steroid‐refractory toxicities from immune checkpoint inhibitorsBackground Anti–programmed death protein 1 (anti–PD‐1) agents have transformed the treatment of advanced melanoma and other cancers, but the rates of steroid‐refractory toxicities and health care utilization are not well described. This study assessed these endpoints in patients with melanoma treated with anti–PD‐1 with or without ipilimumab. Methods This study retrospectively evaluated 344 patients with metastatic melanoma treated with an
- Two middle‐aged women with the Finnish variant of muscle‐eye‐brain disease (MEB)Abstract Muscle‐eye‐brain disease (MEB) is a recessively inherited rare disease. Sixteen different gene mutations are known, with the most common mutations in the POMGNT1 gene. The disease is now called congenital muscular dystrophy‐dystroglycanopathy type A3 (MDDGA3). It manifests itself as muscular dystrophy with eye and brain anomalies and intellectual disability. Previous clinical reports describe young patients. We have been able to follow
- Strategic considerations for applying the flipped classroom to neurology educationAbstract Nowadays, the ‘flipped classroom’ approach is taking the center stage within medical education. However, very few reports on the implementation of the flipped classroom in neurology have been published to date, and this educational model still represents a challenge for students and educators alike. In this manuscript, a group of neurology educators from the American Academy of Neurology's A.B. Baker Section on Neurological Education an
- Another sleepless night: Does a leader's poor sleep lead to subordinate's poor sleep? A spillover/crossover perspectiveAbstract Given the importance of sleep to an individual's health and well‐being, relatively little research has been conducted in the management and organizational behaviour literature on the relationship between sleep and work behaviour. Using spillover/crossover theory, we extended the current literature by investigating the possible supervisor–subordinate sleep relationship and introduced a serial mediation mechanism to answer how a superviso
- Chronic sleep loss disrupts blood–testis and blood–epididymis barriers, and reduces male fertilityAbstract Sleep loss increases blood–brain barrier permeability. As the blood–brain barrier and the blood–tissue barriers in the reproductive tract (blood–testis and blood–epididymis barriers) share common characteristics, we hypothesized that sleep restriction may also modify their barrier function. Previous reports showed that sleep loss decreased sperm viability and progressive fast mobility, which may be a consequence of altered blood–testis
- The Role of Innate Immunity in Asthma Development and Protection: Lessons from the EnvironmentAbstract Asthma, a complex, chronic disease characterized by airway inflammation, hyperresponsiveness and remodeling, affects over 300 million people worldwide. While the disease is typically associated with exaggerated allergen‐induced type 2 immune responses, these responses are strongly influenced by environmental exposures that stimulate innate immune pathways capable of promoting or protecting from asthma. The dual role played by innate imm
- LPS induces steroid‐resistant exacerbations in a mouse model of allergic airway disease collectively through IL‐13 and pulmonary macrophage activationAbstract Background Acute exacerbations of asthma represent a major burden of disease and are often caused by respiratory infections. Viral infections are recognised as significant triggers of exacerbations, however less is understood about the how microbial bioproducts such as the endotoxin (lipopolysaccharide (LPS)) trigger episodes. Indeed, increased levels of LPS have been linked to asthma onset, severity and steroid‐resistance Objec
Neuroradiology
- Placement of a Stent within a Flow Diverter Improves Aneurysm Occlusion Rates [INTERVENTIONAL]BACKGROUND AND PURPOSE:Placement of a stent within a flow diverter has been described previously but its consequences have not been analyzed. We evaluated the clinical and angiographic results of stent placement within a flow diverter during the same treatment session.MATERIALS AND METHODS:All patients treated with a Surpass flow diverter were retrospectively evaluated. Patients with previously deployed stents and procedures in which scaffolding
- Diagnostic Accuracy and Scope of Intraoperative Transoral Ultrasound and Transoral Ultrasound-Guided Fine-Needle Aspiration of Retropharyngeal Masses [HEAD & NECK]SUMMARY:The use of transoral sonography–guided fine-needle aspiration for intraoperative localization of retropharyngeal masses has been described by Fornage et al. The purpose of this study was to assess the accuracy of this technique. We reviewed the images and medical records of 26 patients with a retropharyngeal lesion suspicious for a metastatic lymph node of Rouviere identified on CT and/or PET/CT. There were 14 patients with a history of t
- Unintended Consequences: Review of New Artifacts Introduced by Iterative Reconstruction CT Metal Artifact Reduction in Spine Imaging [SPINE]SUMMARY:Metal hardware serves as a common artifact source in spine CT imaging in the form of beam-hardening, photon starvation, and streaking. Postprocessing metal artifact reduction techniques have been developed to decrease these artifacts, which has been proved to improve visualization of soft-tissue structures and increase diagnostic confidence. However, metal artifact reduction reconstruction introduces its own novel artifacts that can mimic
- Radiology-Pathology Correlation: Mixed Solid and Cystic Mass in an Infant [PEDIATRICS]SUMMARY:Desmoplastic infantile tumors are rare supratentorial brain tumors that occur in pediatric patients. Desmoplastic infantile tumors are made up of 2 subtypes: desmoplastic infantile gangliogliomas and desmoplastic infantile astrocytomas. Desmoplastic infantile tumors are often identifiable on imaging on the basis of multiple characteristics. Nevertheless, pathologic analysis is required to confirm the diagnosis, particularly when the imagi
- Transitioning to Transradial Access for Cerebral Aneurysm Embolization [INTERVENTIONAL]BACKGROUND AND PURPOSE:Despite several retrospective studies showing the safety and efficacy of transradial access for cerebral angiography, neurointerventionalists are apprehensive about implementing TRA for neurointerventions. This reluctance is mainly due to anatomic factors, technical factors, and a long learning curve (relative to transfemoral access). We present here our experience of TRA transition for cerebral aneurysm embolization. Our a
Oral & Maxillofacial Surgery
- Implant-oriented navigation in orbital reconstruction part II: preclinical cadaver studyIn orbital reconstruction, the acquired position of an orbital implant can be evaluated with the aid of intraoperative navigation. Feedback of the navigation system is only obtained after positioning of the implant: the implant’s position is not tracked in real time during positioning. The surgeon has to interpret the navigation feedback and translate it to desired adjustments of the implant’s position. In a previous study, a real-time implant-or
- Splintless orthognathic surgery in edentulous patients—a pilot studyThe aim of this pilot study was to evaluate the accuracy and predictability of a splintless treatment protocol for edentulous patients undergoing orthognathic surgery in four consecutive cases. All operations were virtually planned, followed by computer-aided design of individual osteotomy guides and patient-specific fixation implants, which were three-dimensionally printed in titanium. In order to evaluate the discrepancy between the planned and
cortical auditory
- The impact of when, what and how predictions on auditory speech perception.Related ArticlesThe impact of when, what and how predictions on auditory speech perception. Exp Brain Res. 2019 Oct 01;: Authors: Pinto S, Tremblay P, Basirat A, Sato M Abstract An impressive number of theoretical proposals and neurobiological studies argue that perceptual processing is not strictly feedforward but rather operates through an interplay between bottom-up sensory and top-down predictive
- Computed tomography‐guided coil localization for video‐assisted thoracoscopic surgery of sub‐solid lung nodules: a retrospective studyAbstract Background Wedge resection via video‐assisted thoracoscopic surgery (VATS) is the best choice for the diagnosis of sub‐solid lung nodules. Preoperative localization is utilized to increase the success rate of this procedure. We aimed to evaluate the effectiveness of preoperative coil localization in VATS wedge resection for sub‐solid lung nodules. Methods From October 2015 to August 2018, 42 patients with 55 sub‐solid lung nodu
Sleep Medicine
- The meaning of the masticatory muscle tonic-type electromyographic pathway correlated with sleep bruxism and sleep-related breathing disorders - a polysomnographic studyPublication date: Available online 2 October 2019Source: Sleep MedicineAuthor(s): Joanna Smardz, Helena Martynowicz, Anna Wojakowska, Monika Michalek-Zrabkowska, Grzegorz Mazur, Tomasz Wieczorek, Mieszko WieckiewiczAbstractStudy objectivesThe coexistence of sleep-related breathing disorders (SRBD) and sleep bruxism (SB) is often mentioned in the literature. Polysomnography with video recording gives the best opportunity to identify both of these
- Abnormal intrinsic brain activity of the putamen is correlated with dopamine deficiency in idiopathic rapid eye movement sleep behavior disorderPublication date: Available online 2 October 2019Source: Sleep MedicineAuthor(s): Guanglu Li, Zhichun Chen, Liche Zhou, Mengsha Yao, Ningdi Luo, Wenyan Kang, Shengdi Chen, Jun LiuAbstractObjectivesTo investigate the changes in spontaneous neuronal activity of the striatum in idiopathic rapid eye movement (REM) sleep behavior disorder (iRBD) patients using regional homogeneity (ReHo) and amplitude of low-frequency fluctuation (ALFF) analysis. Furt
- The value of oral immunotherapyAbstract On July 10, 2019, the Institute for Clinical and Economic Review (ICER) published its final report on the effectiveness and value of AR101 and Viaskin® Peanut for peanut allergy1. At a threshold of $50,000 USD per quality‐adjusted life‐year (QALY), the report concludes that the limit of cost‐effectiveness is reached at an annual cost of $2,369 per year for ARA101 and $1,508 for Viaskin® peanut, which is in line with recent estimates fro
- Sociosexual behavioral patterns involving nulliparous female orangutans (Pongo sp.) reflect unique challenges during the adolescent periodBox plot of mating scores for adolescent females versus adult females showing a significant difference, with adolescent females having higher (more proceptive) mating scores than adult females (p = .001) Abstract The primate adolescent period is characterized by a series of changes in physiology, behavior, and social relationships. Orangutans have the slowest life history and the longest period of dependency of all primates. As members of a s
- The effects of natural substrate discontinuities on the quadrupedal gait kinematics of free‐ranging Saimiri sciureusTwo squirrel monkeys take different routes through their arboreal habitat. Both individuals encounter discontinuous substrates and adjust their quadrupedal gait kinematics, showing gait flexibility while walking. Abstract Wild primates encounter complex matrices of substrates that differ in size, orientation, height, and compliance, and often move on multiple, discontinuous substrates within a single bout of locomotion. Our current understandin
Cancers
- Cancers, Vol. 11, Pages 1493: Antileukemic Efficacy in Vitro of Talazoparib and APE1 Inhibitor III Combined with Decitabine in Myeloid MalignanciesCancers, Vol. 11, Pages 1493: Antileukemic Efficacy in Vitro of Talazoparib and APE1 Inhibitor III Combined with Decitabine in Myeloid Malignancies Cancers doi: 10.3390/cancers11101493 Authors: Kohl Flach Naumann Brendel Kleiner Weiss Seifarth Nowak Hofmann Fabarius Popp Malignant hematopoietic cells of myelodysplastic syndromes (MDS)/chronic myelomonocytic leukemias (CMML) and acute myeloid l
- Cancers, Vol. 11, Pages 1492: Classic Chromophobe Renal Cell Carcinoma Incur a Larger Number of Chromosomal Losses than Seen in the Eosinophilic SubtypeCancers, Vol. 11, Pages 1492: Classic Chromophobe Renal Cell Carcinoma Incur a Larger Number of Chromosomal Losses than Seen in the Eosinophilic Subtype Cancers doi: 10.3390/cancers11101492 Authors: Ohashi Schraml Angori Batavia Rupp Ohe Otsuki Kawasaki Kobayashi Kobayashi Miyazaki Shibuya Usuda Umezu Fujishima Furusato Osakabe Sugai Kuroda Tsuzuki Nagashima
- Cancers, Vol. 11, Pages 1491: Immune Dysfunctions and Immunotherapy in Colorectal Cancer: The Role of Dendritic CellsCancers, Vol. 11, Pages 1491: Immune Dysfunctions and Immunotherapy in Colorectal Cancer: The Role of Dendritic Cells Cancers doi: 10.3390/cancers11101491 Authors: Gessani Belardelli Colorectal cancer (CRC), a multi-step malignancy showing increasing incidence in today’s societies, represents an important worldwide health issue. Exogenous factors, such as lifestyle, diet, nutrition, environment and microbiota, contribute t
- Cancers, Vol. 11, Pages 1490: CRISPR-Cas9 Knockdown and Induced Expression of CD133 Reveal Essential Roles in Melanoma Invasion and MetastasisCancers, Vol. 11, Pages 1490: CRISPR-Cas9 Knockdown and Induced Expression of CD133 Reveal Essential Roles in Melanoma Invasion and Metastasis Cancers doi: 10.3390/cancers11101490 Authors: Simbulan-Rosenthal Dougherty Vakili Ferraro Kuo Alobaidi Aljehane Gaur1 Sykora Glasgow Agarwal Rosenthal CD133, known as prominin1, is a penta-span transmembrane glycoprotein presumably acancer stem cell
- Cancers, Vol. 11, Pages 1489: Real-World Impact of Immune Checkpoint Inhibitors in Metastatic Uveal MelanomaCancers, Vol. 11, Pages 1489: Real-World Impact of Immune Checkpoint Inhibitors in Metastatic Uveal Melanoma Cancers doi: 10.3390/cancers11101489 Authors: Bol Ellebaek Hoejberg Bagger Larsen Klausen Køhler Schmidt Bastholt Kiilgaard Donia Svane Uveal melanoma (UM) is the most common intraocular malignancy in adults and shows a high rate of metastatic spread. As randomized clinical trials w
- Frontal theta and posterior alpha in resting EEG: A critical examination of convergent and discriminant validityAbstract Prior research has identified two resting EEG biomarkers with potential for predicting functional outcomes in depression: theta current density in frontal brain regions (especially rostral anterior cingulate cortex) and alpha power over posterior scalp regions. As little is known about the discriminant and convergent validity of these putative biomarkers, a thorough evaluation of these psychometric properties was conducted toward the go
- Cognitive resources are distributed among the entire auditory landscape in auditory scene analysisAbstract Although attention has been shown to enhance neural representations of selected inputs, the fate of unselected background sounds is still debated. The goal of the current study was to understand how processing resources are distributed among attended and unattended sounds during auditory scene analysis. We used a three‐stream paradigm with four acoustic features uniquely defining each sound stream (frequency, envelope shape, spatial loc
- Feedback processing in the context of social comparisonAbstract In many situations, social comparison calls for the evaluation of one´s own performance in relative terms by taking into account the performances of other people. Here, we investigated the effects of social comparison on performance monitoring with the help of ERPs. Two participants performed two identical experiments at the same time and in the same room. Instructions created a social context of cooperation by suggesting that participa
- The heart of cognitive control: Cardiac phase modulates processing speed and inhibitionAbstract Bodily states are heavily intertwined with cognitive processes. A prominent communication channel between bodily signals and brain structures is provided by baroreceptors. Their phasic activity associated with the cardiac phase has been shown to modulate cognitive control in socio‐emotional contexts. However, whether this effect is specific to the affective dimension or impacts general cognitive control processes remains controversial.
- Dissociable effects of reward magnitude on fronto‐medial theta and FRN during performance monitoringAbstract Reward processing is influenced by reward magnitude, as previous EEG studies showed changes in amplitude of the feedback‐related negativity (FRN) and reward positivity (RewP), or power of fronto‐medial theta (FMθ). However, it remains unclear whether these changes are driven by increased reward sensitivity, altered reward predictions, enhanced cognitive control, or a combination of these effects. To address this question, we asked 36 pa
- Morphological difference between pleural mesothelioma cells in effusion smears with either BAP1 loss or 9p21 homozygous deletion and reactive mesothelial cells without the gene alterationsWe previously characterized the morphological characteristics of malignant pleural mesothelioma (MPM) cells with 9p21 homozygous deletion (HD) using a combination of the virtual microscopy and fluorescence in situ hybridization (FISH). In this study, we investigated whether MPM cells with BRCA1‐associated protein 1 (BAP1) loss show the same morphological characteristics identified in MPM cells with 9p21 HD. MPM cells with either BAP1 loss detecte
- Novel human antibody against VEGFR2 shows therapeutic potential for leukemia and prostate cancerAbstract Vascular endothelial growth factor receptor 2 (VEGFR2) is highly expressed in tumor‐associated endothelial cells, where it modulates tumor‐promoting angiogenesis, and it is also found on the surface of tumor cells. Currently, there are no antibody therapeutics targeting VEGFR2 approvals for treatment of prostate cancer and leukemia. Therefore, development of novel efficacious anti‐VEGFR2 antibodies will benefit cancer patients. We used
- Pancreatoblastoma: Cytologic and histologic analysis of 12 adult cases reveals helpful criteria in their diagnosis and distinction from common mimicsBackground Pancreatoblastoma (PBL) is a rare malignant pancreatic tumor seen predominantly in childhood, and its cytologic diagnosis remains challenging. Methods Twelve fine‐needle‐aspirations from 11 adults were analyzed. Results In total, 6 men and 5 women (median age, 45 years; age range, 32‐60 years) had tumors measuring a median 5.6 cm (range, 2.5‐12 cm) located in the pancreatic head (n = 7) or tail (n = 4), including 3 with fa
The American Journal of Surgical Pathology - Published Ahead-of-Print
- Impact of Histopathologic Changes Induced by Polyethylene Glycol Hydrogel Pleural Sealants Used During Transthoracic Biopsy on Lung Cancer Resection Specimen StagingPatients undergoing transthoracic needle core lung biopsy (TTNB) are at risk for biopsy-related pneumothorax. Instilling pleural sealant at the pleural puncture site reduces this risk. The impact of histologic changes associated with pleural sealant on assessing the histologic type and pathologic stage in lung cancer resection specimens has not been previously evaluated. All lung cancer resection specimens from 2015 to 2018 in which polyethylene
Journal of Cancer Research and Clinical Oncology
- The effectiveness of Wilms tumor screening in Beckwith–Wiedemann spectrumAbstract Purpose It is well documented that patients with Beckwith–Wiedemann spectrum (BWS) have a significantly higher risk of developing Wilms tumor (WT) than the general population. There has been little research on the timing of WT diagnosis in BWS in regard to optimizing suggested screening protocols. Methods
OEM Online First
- Impact of depressive symptoms on worklife expectancy: a longitudinal study on Danish employeesObjectiveDepressive symptoms are associated with sickness absence, work disability and unemployment, but little is known about worklife expectancy (WLE). This study investigates the impact of depressive symptoms on the WLE of a large sample of Danish employees.MethodsWe used occupational health survey data of 11 967 Danish employees from 2010 and linked them with register data on salary and transfer payments from 2010 to 2015. Depressive symptoms
- Synchronous bilateral adrenalectomy in ACTH-dependent hypercortisolism: predictors, biomarkers and outcomesAbstract Introduction Hypercortisolism requires a prompt therapeutic management to reduce the risk of development of a potential fatal emergency. A synchronous bilateral adrenalectomy (SBA) is effective in recovering hypercortisolism. However, specific indications for an SBA are not available. We aimed to evaluate the outcome of patients who underwent an SBA and to identify biomarkers
- Risk factors for vertebral fracture in primary hyperparathyroidismAbstract Purpose Screening for vertebral fractures (VF) in primary hyperparathyroidism (PHPT) is recommended, but there are limited data regarding which patients are at greatest risk for VF. We evaluated risk factors for VF in PHPT. Methods This is a retrospective cross-sectional analysis of 117 participa
- 68 Ga-DOTATOC PET/CT in detecting neuroendocrine tumours responsible for initial or recurrent paraneoplastic Cushing’s syndromeAbstract Purpose Paraneoplastic Cushing’s syndrome (PCS) is frequently caused by neuroendocrine tumours (NETs). Approximately 20% of tumours are still occult years later. Gallium-68 somatostatin receptor-PET/CT is promising for the detection of the causal primary NET, but its role in case of recurrent PCS is rarely reported. We report our experience with DOTATOC PET/CT in localising th
- Cardiovascular autonomic neuropathy as a cause of fatigue in chronic hypoparathyroidismAbstract Purpose Hypoparathyroidism (hypoPT) results in an impairment of quality of life (QoL), an increase in fatigue and a higher risk of mortality. Cardiovascular autonomic neuropathy (CAN) is an impairment of the cardiovascular autonomic system and is associated with increased mortality and fatigability. Patients with hypoPT show an increased risk of CAN. However, no previous studi
ΩτοΡινοΛαρυγγολόγος Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,
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Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com,
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00302841026182,
00306932607174,
alsfakia@gmail.com,
Anapafseos 5 Agios Nikolaos 72100 Crete Greece,
Medicine by Alexandros G. Sfakianakis
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