Abstract Epilepsy is one of the most prevalent neurological diseases and although numerous novel anticonvulsants have been approved, the proportion of patients who are refractory to medical treatment of seizures and have progressive co-morbidities such as cognitive impairment and depression remains at about 20–30%. In the last decade, extensive research has identified a therapeutic capacity of the components of the brain renin–angiotensin system (RAS) in seizure- and epilepsy-related...
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Abstract Liver transplantation is one of the most commonly performed surgical procedures for the treatment of end-stage liver disease and hepatocellular carcinoma. Post-transplantation complications include vascular, nonvascular, and biliary. Common imaging techniques used to evaluate the hepatic graft are ultrasonography (US), CT, MR imaging, cholangiography, angiography, and scintigraphy. The purposes of this pictorial review are to review imaging findings of complications of...
Sat Nov 02, 2019 02:00
Abstract Vessel co-option is the movement of cancer cells towards and along the pre-existing vasculature and is an alternative to angiogenesis to gain access to nutrients. Vessel co-option has been shown as a strategy employed by some glioblastoma (GBM) cells to invade further into the brain, leading to one of the greatest challenges in treating GBM. In GBM, vessel co-option may be an intrinsic feature or an acquired mechanism of resistance to anti-angiogenic treatment. Here, we...
Sat Nov 02, 2019 02:00
Abstract The propensity account of fitness intends to solve the classical tautologicity issue by identifying fitness with a disposition, the ability to survive and reproduce. As proponents recognized early on, this account requires operational independence from actual reproductive success to avoid circularity and vacuousness charges. They suggested that operational independence is achieved by measuring fitness values through optimality models. Our goal in this article is to develop...
Sat Nov 02, 2019 02:00
Abstract In freshwater ecosystem, phototrophic biofilms play a crucial role through adsorption and sequestration of organic and inorganic pollutants. However, extracellular polymeric substance (EPS) secretion by phototrophic biofilms exposed to metals is poorly documented. This work evaluated the physiological responses of phototrophic biofilms by exposing three microorganisms (cyanobacterium Phormidium autumnale, diatom Nitzschia palea and green alga Uronema confervicolum) to...
Sat Nov 02, 2019 02:00
Abstract Roasting is an important step in the production of edible argan oils. The effect of argan kernel roasting temperature (ranging from 150 to 200 °C) and time (from 10 to 50 min), on oil yield, contents in total phenolic compounds, α- and γ-tocopherol, and oxidative stability, was researched using response surface methodology. Increases in roasting temperature and time have a significant effect on all the responses. This study showed that the optimum roasting conditions of...
Sat Nov 02, 2019 02:00
Abstract Background and Objective The economic assessment of immuno-oncology agents in Chinese patients is limited despite a need for new therapies. Nivolumab is the first immune checkpoint inhibitor approved for the second-line treatment of non-small cell lung cancer (NSCLC) in China, and it significantly prolongs overall survival. However, considering the high cost of nivolumab, it is urgent to assess its value in China in terms of both...
Sat Nov 02, 2019 02:00
Abstract Background and Objectives Oxycodone tamper resistant (OTR) is a new extended-release abuse-deterrent formulation providing improvements in the tamper resistant characteristics. This study aimed to investigate the pharmacokinetic properties of the new OTR tablets and evaluate the bioequivalence of oxycodone from OTR and the original extended release (ER) formulation tablets administered with an opioid antagonist in patients with...
Sat Nov 02, 2019 02:00
Abstract D-lactic acid (DLA) serves as a key monomer enhancing both the mechanical and thermal properties of Poly(lactic) acid films and coatings, extensively used in the food packaging industry. Economically viable production of optically pure DLA by Lactobacillus delbrueckii NBRC3202 was achieved using a low–cost carbon source, Kodo millet bran residue hydrolysate (KMBRH) and nitrogen source (casein enzyme hydrolysate (CEH) resulting in a high DLA yield of 0.99 g g−1 and KMBRH...
Sat Nov 02, 2019 02:00
Abstract The study was initiated to evaluate constructed wetland technology as a method for treating alkaline (pH 8.0–8.6) drainage high in Al, Mo, V, As and Ga originating from bauxite residue storage areas. Pilot-scale horizontal flow constructed wetlands were operated over a 40-week period using three filter materials (granitic gravel, bauxite and alum water treatment sludge), and half of the wetlands were planted with Phragmites australis and the other half left unplanted....
Sat Nov 02, 2019 02:00
Abstract The surface soils were collected from four areas in the Yellow River Delta (YRD), including three functional areas in the natural reserve of the YRD (the core area, buffer area, and experimental area) and a neighboring area of the natural reserve. The total concentrations, speciations, contamination status, and health risk assessments of the mercury (Hg) and arsenic (As) in surface soils of the YRD were investigated. The average Hg concentration was about three times that...
Sat Nov 02, 2019 02:00
Abstract The twofold aim of this study was to investigate the long-term landscape development in an intensely cultivated region of south-western Scania, southern Sweden, and to discuss the potential of pollen records from wells for this purpose. Pollen records from 36 different wells from 12 archaeological sites were compiled. Based on 35 of the wells, ranging ca 800 cal bc–cal ad 1900, regional vegetation cover for seven different time-windows was quantified using the REVEALS...
Sat Nov 02, 2019 02:00
Abstract Oils are subject to several reactions that lead to physical–chemical, sensory and nutritional deterioration. This deterioration process is called rancidity or lipid oxidation, a spontaneous and irreversible phenomenon that can be delayed by the addition of antioxidants. Usually, vegetable oil producers choose to add antioxidants to the upper limit permitted by applicable law as it is not entirely clear the ideal dosages of pure or combined antioxidants designated for this...
Sat Nov 02, 2019 02:00
Abstract Adjustment of cerebral blood flow (CBF) to neuronal activity via neurovascular coupling (NVC) plays an important role in the maintenance of healthy cognitive function. Strong evidence demonstrates that age-related cerebromicrovascular endothelial dysfunction and consequential impairment of NVC responses contribute importantly to cognitive decline. Recent studies demonstrate that NAD+ availability decreases with age in the vasculature and that supplemental NAD+ precursors...
Sat Nov 02, 2019 02:00
Abstract The purpose of this study was to determine whether there is any correlation between dacryocystitis with deviated nasal septum and sinusitis. A retrospective study of 50 patients who were diagnosed with dacryocystitis were included in the study. The patients included were operated between July 2018 and February 2017. All patients were assessed and operated by a single surgeon. We found in the study that 38 patients had deviated nasal septum to the diseased side and were...
Sat Nov 02, 2019 02:00
Abstract Raynaud’s phenomenon (RP) is a clinical disorder characterized by recurrent, reversible episodes of digital vasospasm. RP can be classified as primary (pRP) or secondary, depending on whether it occurs as a benign condition (not disease-associated) or is associated with other diseases, mainly of the connective tissues. In both cases, it can be triggered by environmental factors, as indicated by the increased incidence of pRP episodes following exposure to cold,...
Sat Nov 02, 2019 02:00
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