Abstract Accumulating evidence has revealed that human cancers develop by sequentially mutating pivotal genes, including driver genes, and acquiring cancer hallmarks. For instance, cancer cells are addicted to the transcription factor NRF2 (NFE2L2), which is a driver gene and that utilizes the cellular cytoprotection system against oxidative stress and metabolic pathway reprogramming for sustaining high growth. Our group has recently discovered new addiction to the NRF2‐related factor NRF3 (NFE2L3)...
Tue Nov 19, 2019 18:37
AbstractIdentification of deleterious variants in HBOC susceptibility genes allows for increased clinical surveillance and early detection, and could predict the response to PARP inhibitor in patient with advanced ovarian carcinomas. To determine the prevalence and clinical prediction factors for hereditary breast and ovarian carcinoma syndrome, 882 selected individuals underwent multigene panel testing for hereditary breast and ovarian cancer (HBOC) risk assessment at the period from January 2015...
Tue Nov 19, 2019 18:31
Publication date: February 2020Source: Cancer Epidemiology, Volume 64Author(s): Marta Solans, Dora Romaguera, Esther Gracia-Lavedan, Amaia Molinuevo, Yolanda Benavente, Marc Saez, Rafael Marcos-Gragera, Laura Costas, Claudia Robles, Esther Alonso, Esmeralda de la Banda, Eva Gonzalez-Barca, Javier Llorca, Marta Maria Rodriguez-Suarez, Macarena Lozano-Lorca, Marta Aymerich, Elias Campo, Eva Gimeno-Vázquez, Gemma Castaño-Vinyals, Nuria AragonésAbstractIntroductionPreventable risk factors for chronic...
Wed Nov 20, 2019 14:12
Publication date: February 2020Source: Cancer Epidemiology, Volume 64Author(s): Lourdes Flores-Luna, Maria Mercedes Bravo, Elena Kasamatsu, Eduardo César Lazcano Ponce, Teresa Martinez, Javier Torres, Margarita Camorlinga-Ponce, Ikuko KatoAbstractObjectiveTo evaluate the risk factors associated with pre-neoplastic lesions and gastric cancer in countries with different cancer risk in Latin America.Methods1222 questionnaires of risk factors related to pre-neoplastic lesions and gastric cancer were...
Wed Nov 20, 2019 14:12
Cancers, Vol. 11, Pages 1825: MicroRNA-Mediated Metabolic Reprograming in Renal Cancer Cancers doi: 10.3390/cancers11121825 Authors: Bogusławska Popławski Alseekh Koblowska Iwanicka-Nowicka Rybicka Kędzierska Głuchowska Hanusek Tański Fernie Piekiełko-Witkowska Metabolic reprogramming is one of the hallmarks of renal cell cancer (RCC). We hypothesized that altered metabolism of RCC cells results from dysregulation of microRNAs targeting metabolically...
Wed Nov 20, 2019 02:00
Cancers, Vol. 11, Pages 1826: Molecular Targeting Therapy against EGFR Family in Breast Cancer: Progress and Future Potentials Cancers doi: 10.3390/cancers11121826 Authors: Maennling Tur Niebert Klockenbring Zeppernick Gattenlöhner Meinhold-Heerlein Hussain ：The epidermal growth factor receptor (EGFR) family contains four transmembrane tyrosine kinases (EGFR1/ErbB1, Her2/ErbB2, Her3/ErbB3 and Her4/ErbB4) and 13 secreted polypeptide ligands. EGFRs are overexpressed...
Wed Nov 20, 2019 02:00
Cancers, Vol. 11, Pages 1827: FLT3-ITD Activates RSK1 to Enhance Proliferation and Survival of AML Cells by Activating mTORC1 and eIF4B Cooperatively with PIM or PI3K and by Inhibiting Bad and BIM Cancers doi: 10.3390/cancers11121827 Authors: Watanabe Nogami Okada Akiyama Umezawa Miura FLT3-ITD is the most frequent tyrosine kinase mutation in acute myeloid leukemia (AML) associated with poor prognosis. We previously found that FLT3-ITD activates the mTORC1/S6K/4EBP1...
Wed Nov 20, 2019 02:00
Publication date: Available online 19 November 2019Source: European Journal of CancerAuthor(s): Priyanka Bandara, David O. Carpenter
Wed Nov 20, 2019 12:55
Abstract Objective People with a serious mental health condition are no more likely to receive a diagnosis of cancer than the general population but fare more poorly in terms of outcomes. The current study investigated whether a background of mental health problems (measured by contact with mental health services and psychotropic medication) predicted treatment outcomes over and above demographic and medical confounds for cancer patients at Counties Manukau Health. Methods The sample consisted...
Tue Nov 19, 2019 16:56
Abstract Background Both demoralization and depression are common forms of psychological distress in cancer patients. This study aimed to investigate the severity of demoralization in Chinese cancer patients and to explore the factors influencing depression and demoralization and their effects on quality of life to better understand the differences and the relationship between demoralization and depression. Methods Cross‐sectional study design, in‐patients sequentially recruited from a...
Tue Nov 19, 2019 16:47
Abstract CD248, also called endosialin or tumor endothelial marker‐1, is markedly upregulated in almost all cancers, including colon cancers. Changes in microRNA profiles are one of the direct causes of cancer development and progression. In this study, we investigated whether a change in CD248 expression in colon cancer cells could induce drug resistance after chemotherapy, and we explored the relationship between miR‐125b‐5p levels and CD248 expression in Toll‐like receptor (TLR)‐modified chemoresistant...
Tue Nov 19, 2019 18:04
Cancers, Vol. 11, Pages 1824: High Somatic Mutation and Neoantigen Burden Do Not Correlate with Decreased Progression-Free Survival in HCC Patients not Undergoing Immunotherapy Cancers doi: 10.3390/cancers11121824 Authors: Mauriello Zeuli Cavalluzzo Petrizzo Tornesello Buonaguro Ceccarelli Tagliamonte Buonaguro Cancer genome instability leads to accumulation of mutations which may result into tumor-specific mutated “neoantigens”, not...
Wed Nov 20, 2019 02:00
Cancers, Vol. 11, Pages 1823: The Transfer of Sphingomyelinase Contributes to Drug Resistance in Multiple Myeloma Cancers doi: 10.3390/cancers11121823 Authors: Faict Oudaert D’Auria Dehairs Maes Vlummens Veirman Bruyne Fostier Broek Schots Vanderkerken Swinnen Menu Multiple myeloma (MM) is well-known for the development of drug resistance, leading to relapse. Therefore, finding novel treatment strategies remains necessary. By performing...
Wed Nov 20, 2019 02:00
Cancers, Vol. 11, Pages 1822: Immunotherapy: A Challenge of Breast Cancer Treatment Cancers doi: 10.3390/cancers11121822 Authors: García-Aranda Redondo Breast cancer is the most commonly diagnosed cancer in women and is a leading cause of cancer death in women worldwide. Despite the significant benefit of the use of conventional chemotherapy and monoclonal antibodies in the prognosis of breast cancer patients and although the recent approval of the anti-PD-L1 antibody atezolizumab...
Wed Nov 20, 2019 02:00
Cancers, Vol. 11, Pages 1821: LSD1/KDM1A, a Gate-Keeper of Cancer Stemness and a Promising Therapeutic Target Cancers doi: 10.3390/cancers11121821 Authors: Karakaidos Verigos Magklara A new exciting area in cancer research is the study of cancer stem cells (CSCs) and the translational implications for putative epigenetic therapies targeted against them. Accumulating evidence of the effects of epigenetic modulating agents has revealed their dramatic consequences on cellular reprogramming...
Wed Nov 20, 2019 02:00
Background The optimal management of progressive brain metastases in patients with germ cell tumors (GCTs) remains unsettled. This study reports the management of 25 consecutive patients with relapsed GCTs and progressive brain metastases undergoing high‐dose chemotherapy (HDCT) with peripheral blood stem cell transplantation (PBSCT) at Indiana University from 2006 to 2016. Methods All patients were planned to undergo HDCT, which consisted of carboplatin at 700 mg/m2 on days 1 to 3 plus etoposide...
Tue Nov 19, 2019 21:01
Background After a diagnosis of prostate, breast, or colorectal cancer, Latinos experience higher mortality rates and lower health‐related quality of life (HRQOL) in comparison with other ethnic/racial groups. Patient navigation (PN) and lay community health workers or promotores are effective in increasing cancer screening and early‐stage diagnosis among Latinos. However, little is known about the effect of PN on HRQOL among Latino cancer survivors. Methods Latinos previously diagnosed with...
Tue Nov 19, 2019 21:01
Members of the Translational Breast Cancer Research Consortium conducted an expert‐driven literature review to identify a list of domains and to evaluate potential measures of these domains for inclusion in a list of preferred measures. Measures were included if they were easily available, free of charge, and had acceptable psychometrics based on published peer‐reviewed analyses. A total of 22 domains and 52 measures were identified during the selection process. Taken together, these measures form...
Tue Nov 19, 2019 20:59
Background The impact of the allelic burden of ASXL1, DNMT3A, JAK2, TET2, and TP53 mutations on survival remains unclear in patients with newly diagnosed acute myeloid leukemia (AML). Methods The authors assessed bone marrow aspirates from 421 patients with newly diagnosed AML using next‐generation sequencing for ASXL1, DNMT3A, JAK2, TET2, and TP53 mutations, defined as the presence of mutations in ASXL1, DNMT3A, JAK2, TET2, or TP53 with a minimum variant allele frequency (VAF) of 5%. ...
Tue Nov 19, 2019 16:32
Background Screening colonoscopy (SC) for colorectal cancer (CRC) is underused by Latino individuals. The current randomized clinical trial examined the impact of 3 interventions: 1) patient navigation; 2) patient navigation plus standard Centers for Disease Control and Prevention print materials; and 3) patient navigation plus culturally targeted print materials for Latinos referred for SC. Demographic, personal and health history, and psychometric factors associated with SC also were examined....
Tue Nov 19, 2019 16:07
Background The purpose of this study was to assess treatment choices among men with prostate cancer who presented at The University of Texas MD Anderson Cancer Center multidisciplinary (MultiD) clinic compared with nationwide trends. Methods In total, 4451 men with prostate cancer who presented at the MultiD clinic from 2004 to 2016 were analyzed. To assess nationwide trends, the authors analyzed 392,710 men with prostate cancer who were diagnosed between 2004 and 2015 from the Surveillance,...
Tue Nov 19, 2019 15:00
Tue Nov 19, 2019 15:00
Lung cancer is the number one cause of cancer‐related death worldwide with cigarette smoking as its major risk factor. Although the incidence of lung cancer in never smokers is rising, this subgroup of patients is under‐represented in genomic studies of lung cancer. Here, we assembled a prospective cohort of 46 never‐smoking, non‐small cell lung cancer (NSCLC) patients and performed whole‐exome and low‐coverage whole‐genome sequencing on tumours and matched germline DNA. We observed fewer somatic...
Tue Nov 19, 2019 18:14
In Belgium, variations in thyroid cancer incidence were observed around the major nuclear sites. The present ecological study investigates whether there is an excess incidence of thyroid cancer among people living in the vicinity of the four nuclear sites at the smallest Belgian geographical level. Rate ratios were obtained from a Bayesian hierarchical model for areas of varying sizes around the nuclear sites. Focused hypothesis tests and generalized additive models were performed to test the hypothesis...
Tue Nov 19, 2019 17:57
Prediction of clinical benefit from androgen deprivation therapy in salivary duct carcinoma patients
Androgen deprivation therapy (ADT) is first‐line palliative treatment in androgen receptor positive (AR+) salivary duct carcinoma (SDC), and response rates are 17.6‐50.0%. We investigated potential primary ADT resistance mechanisms for their predictive value of clinical benefit from ADT in a cohort of recurrent/metastatic SDC patients receiving palliative ADT (n=30). We examined mRNA expression of androgen receptor (AR), AR splice variant‐7, intratumoral androgen synthesis enzyme‐encoding genes AKR1C3,...
Tue Nov 19, 2019 17:49
Protein kinase D3 (PKD3) is upregulated in triple‐negative breast cancer (TNBC) and associated with cell proliferation and metastasis development but its precise pro‐oncogenic function is unknown. Here we show that PKD3 is required for the maintenance of the TNBC stem cell population. Depletion of PKD3 in MDA‐MB‐231 cells reduced the cancer stem cell frequency in vitro and tumor initiation potential in vivo. We further provide evidence that the RhoGEF GEF‐H1 is upstream of PKD3 activation in TNBC...
Tue Nov 19, 2019 17:39
The association between body mass index (BMI) and non‐cardia gastric cancer (NCGC) risk remains controversial. The purpose of this study was to examine the association of BMI with NCGC risk with consideration of Helicobacter pylori (HP) biomarkers. This international nested case‐control study, composed of 1,591 incident NCGC cases and 1,953 matched controls, was established from 8 cohorts in China, Japan, and Korea, where the majority of NCGCs are diagnosed worldwide. HP antibody biomarkers were...
Tue Nov 19, 2019 17:29
The activation of tumour-associated macrophages (TAMs) contributes to the progression of hepatocellular carcinoma (HCC). SIRT4 acts as a tumour suppressor of tumour growth by regulating cell metabolism, inflam...
Tue Nov 19, 2019 02:00
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