Abstract Episodic memory has a distinctive phenomenology. One way to capture what is distinctive about it is by using the notion of mental time travel: When we remember some fact episodically, we mentally travel to the moment at which we experienced it in the past. This way of distinguishing episodic memory from semantic memory calls for an explanation of what the experience of mental time travel is. In this paper, I suggest that a certain view about the content of memories can...
Wed Nov 20, 2019 02:00
Publication date: Available online 20 November 2019Source: Behavioural Brain ResearchAuthor(s): Eurídice Gómez-Padilla, Paola C. Bello-Medina, Uriel León-Jacinto, Erika Orta-Salazar, Gina L. Quirarte, Víctor Ramírez-Amaya, Roberto A. Prado-Alcalá, Sofía Díaz-CintraABSTRACTThe hippocampus plays a fundamental role in spatial learning and memory. Dentate gyrus (DG) granular neurons project mainly to proximal apical dendrites of neurons in the CA3 stratum lucidum and also, to some extent, to the basal...
Wed Nov 20, 2019 12:03
Publication date: Available online 20 November 2019Source: Behavioural Brain ResearchAuthor(s): Yusuf S. Althobaiti, Atiah H. AlmalkiAbstractObjectiveThe influence of environmental enrichment (EE) on reinstatement to methamphetamine (METH) seeking in rat model was investigated.MethodsWistar rats were divided to receive saline (1 ml/kg) or METH (1 mg/kg, i.p.) for 8 days during the conditioning training in the conditioned place preference (CPP) paradigm, which is one of the most popular models to...
Wed Nov 20, 2019 12:03
Breast cancer (BC) is a type of malignant tumor originating from the epithelial tissue of the mammary gland, and about 20% of breast cancers are human epidermal growth factor receptor 2 positive (HER2+), which is a subtype with more aggression. Recently, HER2-positive breast cancer is often accompanied by poor prognosis of patients, and targeted therapy showed a promising prospect. To combat this disease, novel therapeutic targets are still needed. Adenylate kinase 4 (AK4) is a member of the adenylate...
Wed Nov 20, 2019 10:05
The incidence rate of type 1 diabetes in Kuwait had been increasing exponentially and has doubled in within almost two decades. Therefore, there is a dire need for a careful systematic familial cohort study. Several immunogenetic factors affect the pathogenesis of the disease. The human leukocyte antigen (HLA) accounts for the major genetic susceptibility to the disease. The triggering agents initiate disease onset by type 1 destruction of pancreatic β-cells. Both HLA and anti-islet antibodies can...
Wed Nov 20, 2019 11:05
Antiviral Chemistry and Chemotherapy, Volume 27, Issue , January-December 2019.
Wed Nov 20, 2019 09:16
Abstract Sinusoidal obstruction syndrome (SOS) is a rare liver disorder due to hepatic vascular injury. Its rapid and accurate diagnosis is crucial for patient survival. SOS is often established clinically, based on Baltimore, modified Seattle, or European Society for Blood and Marrow Transplantation (EBMT) criteria. Unfortunately, such criteria are not highly specificity and fail to provide a timely, reliable differential diagnosis. The use of noninvasive imaging techniques,...
Wed Nov 20, 2019 02:00
Abstract Vitiligo is an autoimmune disease in which destruction of skin melanocytes results in patches of white skin and hair. Genome‐wide linkage studies and GWAS in European ancestry cases identified over 50 vitiligo susceptibility loci, defining a model of melanocyte‐directed autoimmunity. Vitiligo heritability is exceedingly high, ~2/3 coming from common and ~ 1/3 from rare genomic variants; ~20% of vitiligo risk is environmental. Vitiligo genetic risk is polygenic, with greater additive risk...
Tue Nov 19, 2019 20:56
Related ArticlesLack of DNA Damage Response at Low Radiation Doses in Adult Stem Cells Contributes to Organ Dysfunction. Clin Cancer Res. 2018 12 15;24(24):6583-6593 Authors: Nagle PW, Hosper NA, Barazzuol L, Jellema AL, Baanstra M, van Goethem MJ, Brandenburg S, Giesen U, Langendijk JA, van Luijk P, Coppes RP Abstract PURPOSE: Radiotherapy for head and neck cancer may result in serious side effects, such as hyposalivation, impairing the patient's quality...
Wed Nov 20, 2019 13:29
Related ArticlesBalsa wood for precise intra-operative bone contouring in fibula free-flap mandible reconstruction. Eur Arch Otorhinolaryngol. 2019 Aug;276(8):2339-2343 Authors: Horowitz G, Warshavsky A, Fridman O, Yanko R, Raiser V, Gur E, Fliss DM, Zaretski A Abstract OBJECTIVE: To report a simple and novel method for intra-operative planning of fibula free flap reconstruction by means of a balsa wood (BW) model. STUDY DESIGN: Retrospective...
Wed Nov 20, 2019 13:29
Related ArticlesXanthelasma Palpebrarum: More than Meets the Eye. Indian J Otolaryngol Head Neck Surg. 2019 Oct;71(Suppl 1):439-446 Authors: Khode S, Tan SHT, Tan EA, Uppal S Abstract Xanthelasma palpebrarum (XP) is the most common form of cutaneous xanthomata, and is important aesthetically, because of its close relation to the eyes, as well as medically for its association with cardiovascular disease (CVD). To provide avant-garde review discussing...
Wed Nov 20, 2019 15:26
Related ArticlesBiomarkers in Head and Neck Cancer an Update. Indian J Otolaryngol Head Neck Surg. 2019 Oct;71(Suppl 1):1002-1011 Authors: Basheeth N, Patil N Abstract The study is aimed at establishing the purpose of tumour markers, their application, classification, diagnostic and therapeutic roles in the management of head and neck cancer. A literature review using Medline, Scopus, Google Scholar, the Cochrane Database of Systematic Reviews and the...
Wed Nov 20, 2019 15:26
Related ArticlesAppropriateness of Otic Quinolone Use among Privately Insured US Patients. Otolaryngol Head Neck Surg. 2019 Nov 19;:194599819889607 Authors: Tran PT, Winterstein AG, Wang X, Rhew K, Antonelli PJ Abstract OBJECTIVE: Considering emerging safety concerns involving otic quinolones, we assessed the extent of otic quinolone use for questionable indications. STUDY DESIGN: Descriptive cross-sectional study of a national sample of privately...
Wed Nov 20, 2019 15:26
Related ArticlesParticulate Matter 2.5 Causes Deficiency in Barrier Integrity in Human Nasal Epithelial Cells. Allergy Asthma Immunol Res. 2020 Jan;12(1):56-71 Authors: Xian M, Ma S, Wang K, Lou H, Wang Y, Zhang L, Wang C, Akdis CA Abstract PURPOSE: The effect of air pollution-related particulate matter (PM) on epithelial barrier function and tight junction (TJ) expression in human nasal mucosa has not been studied to date. This study therefore aimed...
Wed Nov 20, 2019 15:26
Related ArticlesDoes the Functional Liver Imaging Score Derived from Gadoxetic Acid-enhanced MRI Predict Outcomes in Chronic Liver Disease? Radiology. 2019 Nov 19;:190734 Authors: Bastati N, Beer L, Mandorfer M, Poetter-Lang S, Tamandl D, Bican Y, Elmer MC, Einspieler H, Semmler G, Simbrunner B, Weber M, Hodge JC, Vernuccio F, Sirlin C, Reiberger T, Ba-Ssalamah A Abstract Background Gadoxetic acid-enhanced MRI enables estimation of liver function in...
Wed Nov 20, 2019 16:01
Related ArticlesPrevalence and characterization of dysphagia in hospitalized patients. Neurogastroenterol Motil. 2019 Nov 19;:e13763 Authors: Spronk PE, Spronk LEJ, Lut J, Gnacke E, Mijnes D, van Munster B, Kröner A Abstract BACKGROUND: Information on the prevalence of dysphagia in a generalized hospitalized population is lacking. We aimed to gain information on the recognition of dysphagia by nursing staff and the swallow characteristics of patients...
Wed Nov 20, 2019 16:08
Publication date: Available online 20 November 2019Source: Sleep MedicineAuthor(s): Poul Jennum, Rikke Ibsen, Jakob KjellbergAbstractObjectivesThere is limited information about the long-term consequences of childhood- and adolescent-onset narcolepsy on educational and social factors. Here, we estimate the long-term socioeconomic consequences and health care costs of narcolepsy.MethodsThe prospective cohort study included Danish individuals with narcolepsy onset in childhood or adolescence, diagnosed...
Wed Nov 20, 2019 14:22
Prevalence of dysphagia in hospitalized patients and awareness by nurses in the general wards. Abstract Background Information on the prevalence of dysphagia in a generalized hospitalized population is lacking. We aimed to gain information on the recognition of dysphagia by nursing staff and the swallow characteristics of patients with and without dysphagia. Methods The Eating Assessment Tool (EAT‐10) and the volume‐viscosity water swallow test (VVST) were utilized to assess the prevalence...
Tue Nov 19, 2019 16:54
Cochlear implant in patients with single sided deafness: hearing results and communicative benefits.
Related ArticlesCochlear implant in patients with single sided deafness: hearing results and communicative benefits. Cochlear Implants Int. 2019 Nov 19;:1-9 Authors: García JM, Urquijo DP, Puerta M, Mosquera CA, Hernández LM, Aparicio ML, Barón C, Otoya Tono AM, Peñaranda A Abstract Objective: Evaluate auditory results and communicative benefits in adult patients with single-sided deafness (SSD) treated with cochlear implantation.Study Design: Observational...
Wed Nov 20, 2019 14:53
Abstract Objectives To explore impairments due to tooth loss and expectations of prosthetic replacements in an urban and a rural group of patients in Sweden. Material and Methods Semi‐structured interviews were performed on 35 partially edentulous patients from prosthodontic specialist clinics located in an urban and a rural area in Sweden. The interviews focused on impairments due to tooth loss and expectations of prosthetic restorations. Analysis was made using the grounded theory approach,...
Tue Nov 19, 2019 17:41
Abstract Objective This study aims to verify the associations among sleep bruxism (SB), sleep arousal (SA), and concurrent body movements. Material and Methods Subjects underwent a standard overnight polysomnography test and audio‐video recordings. Sleep quality was evaluated according to the Rechtschaffen and Kales criteria, while SA was determined as per the American Sleep Disorders Association criteria. Analyses were performed by an external institution after masking of the subjects’...
Tue Nov 19, 2019 21:10
Abstract Background The oral health of seniors in nursing homes is compromised. Furthermore, reduced chewing efficiency is described to be associated with reduced cognition. However, studies investigating how prosthetic status affects the chewing efficiency of nursing home residents are not available. Objective To evaluate associations between prosthetic status, dementia and chewing efficiency of seniors in nursing homes. Methods This study was performed in eight nursing homes. In...
Tue Nov 19, 2019 22:14
Publication date: Available online 19 November 2019Source: European Journal of Vascular and Endovascular SurgeryAuthor(s): Anne Cervin, Anders Wanhainen, Martin BjörckBackgroundData on the prevalence of popliteal artery aneurysm (PA) are scarce and difficult to interpret as the definition differs among papers. The aim was to investigate the prevalence among men with screening detected abdominal aortic aneurysms (≥30 mm, AAAs) and subaneurysmal aortic dilatation (25–29 mm, SAA), and to explore whether...
Wed Nov 20, 2019 15:42
Abstract To understand the mechanisms of N3 sleep interruptions in patients with sleepwalking episodes and/or sleep terrors (SW/ST), we evaluated whether autonomic reactions preceded or accompanied behavioural arousals from NREM sleep stage N3. In 20 adult patients with SW/ST and 20 matched controls without parasomnia, heart rate and pulse wave amplitude were measured beat‐to‐beat during the 10 beats preceding and during the 15 beats succeeding a motor arousal from N3 sleep. Respiratory rate and...
Tue Nov 19, 2019 17:03
Publication date: December 2019Source: Magnetic Resonance Imaging, Volume 64Author(s):
Wed Nov 20, 2019 17:47
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b09191
Wed Nov 20, 2019 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b12431
Wed Nov 20, 2019 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b09043
Wed Nov 20, 2019 07:00
Abstract Background Oral lichenoid reaction (OLR) is a type IV cell-mediated immune response in the oral cavity. There is an established relationship between various dental materials and OLR, but few cases reports reported the occurrence of a lichenoid reaction in association with the use of a Hawley retainer. Case presentation A female patient...
Wed Nov 20, 2019 02:00
Abstract Background The aim of this study was to compare free fluoride concentration and total fluoride concentration in mouthwashes. Methods Fluorine-containing mouthwashes from various companies and manufacturers (Colgate Total Plax Classic Mint®, Colgate-Palmolive, New York, USA; Colgate Total Plax Gentle Mint®, Colgate-Palmolive, New York,...
Wed Nov 20, 2019 02:00
High Altitude Medicine &Biology, Ahead of Print.
Wed Nov 20, 2019 19:50
High Altitude Medicine &Biology, Ahead of Print.
Wed Nov 20, 2019 19:50
Abstract Exercise is an efficacious therapy for many chronic diseases. Integrating efficacious evidence-based interventions (EBIs), such as exercise, into daily healthcare practice is a slow and complex pursuit. Implementation science seeks to understand and address this phenomenon by conducting studies about the methods used to promote the routine uptake of EBIs. The purpose of this article is to explore implementation science and a common conceptual framework in the discipline,...
Wed Nov 20, 2019 02:00
Abstract Patients’ perceptions on what makes a better care experience for head and neck cancer (HNca) have not been widely sought. Patients’ perceptions can play a crucial role in shaping quality care and client involvement. To investigate patients’ perspectives on what makes a better care experience while undergoing rehabilitation for oropharyngeal dysphagia secondary to HNca. Qualitative data were collected in the form of semi-structured interviews from eight patients after they...
Wed Nov 20, 2019 02:00
Ferric oxides and (oxy)hydroxides, although very vast reserve and low cost, are rarely considered for oxygen evolution reaction (OER) due to the too high spin sate (e g filling ~2.0) suppressing the bonding strength with reaction intermediates. Here, we report a facile adsorption‐oxidation strategy to anchor Fe(III) atomically on ultrathin TiO 2 nanobelt to synergistically lower the spin state (e g filling ~1.08) to enhance the adsorption with oxygen‐containing intermediates and improve the...
Tue Nov 19, 2019 11:37
Due to a high density of negative charges on its surface, DNA condenses cations as counterions, forming the so‐called ‘ion atmosphere’. Although the release of counterions upon DNA‐protein association has been postulated to have a major contribution to the binding thermodynamics, this release remains to be confirmed through a direct observation of the ions. Here, using NMR spectroscopy, we characterize the ion atmosphere around DNA and directly detect the release of counterions upon DNA‐protein association....
Tue Nov 19, 2019 11:56
Abstract Herein, we report a Cu‐catalyzed enantioselective allylic alkylation using a γ ‐butyrolactone‐derived silyl ketene acetal as a nucleophile. Critical to the development of this work was the identification of a novel mono‐picolinamide ligand with the appropriate steric and electronic properties to afford the desired alkylation products in high yields (up to 96%) and high levels of enantiomeric excess (up to 95%). Aryl, aliphatic, and unsubstituted allylic chlorides bearing a broad range...
Tue Nov 19, 2019 17:41
It is of vital importance to capture lanthanides (nuclear fission products) from waste solutions for radionuclide remediation due to their hazards. Herein the effective separation of lanthanides are achieved by an acid/base‐stable and radiation‐resistant vanadate, namely, [Me2NH2]V3O7 (1). It exhibits high adsorption capacities for lanthanides (e. g., qmEu = 161.4 mg/g; qmSm = 139.2 mg/g). And high adsorption capacities are maintained over a pH range of 2.0 – 6.9 (e. g., qmEu = 75.1 mg/g at low pH...
Tue Nov 19, 2019 17:55
Constraining a molecule in its bioactive conformation via macrocyclization represents an attractive strategy to rationally design functional chemical probes. While this approach has been applied to enzyme inhibitors or receptor antagonists, to date it remains unprecedented for bifunctional molecules that bring proteins together, such as PROTAC degraders. Here, we report the design and synthesis of a first macrocyclic PROTAC by adding a second cyclizing linker to the BET degrader MZ1. A co‐crystal...
Tue Nov 19, 2019 18:24
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