Analog Retinal Redshifts Visible Absorption of QuasAr Transmembrane Voltage Sensors into Near‐infrared

Gaoxiang Mei, Natalia Mamaeva, Srividya Ganapathy, Peng Wang, Willem J. DeGrip, Kenneth J. Rothschild

Version of Record online: 10 November 2019

 

QuasAr1 and QuasAr2, mutants of archaerhodopsin‐3, are used in optogenetic applications as fluorescent transmembrane voltage sensors. The native A1 retinal chromophore was substituted with a synthetic retinal analog MMAR containing a methylamino modified dimethylphenyl ring. The absorption, excitation and emission spectra were shifted from the visible to the near‐IR spectral region. FT‐Raman reveals information about the isomeric configuration of the MMAR chromophore in QuasArs.

Special Issue Invited Reviews

The Course of Immune Stimulation by Photodynamic Therapy: Bridging Fundamentals of Photochemically Induced Immunogenic Cell Death to the Enrichment of T‐Cell Repertoire

Shubhankar Nath, Girgis Obaid, Tayyaba Hasan

Version of Record online: 10 November 2019

 

Photodynamic therapy (PDT) is a potentially immunogenic anti‐tumor treatment modality that utilizes the spatiotemporal combination of a photosensitizer (PS), light, and oftentimes oxygen, to generate therapeutic cytotoxic molecules. Upon light irradiation (PDT), tumor cells undergo cell‐death pathways and release damage‐associated molecular patterns (DAMPs) and tumor‐specific antigens (TSAs) in the tumor microenvironment. Dendritic cells (DCs) internalize the TSAs and activate T cells, which undergo clonal expansion. As a result, tumor‐reactive T cell repertoire is thought to be enriched. Activated T cells reach the primary or metastatic tumor sites via systemic circulation and eliminate the tumors.

Research Articles

Effect of Photobiomodulation on Repairing Pressure Ulcers in Adult and Elderly Patients: A Systematic Review

Francislene de Fatima Cordeiro Petz, Jorge Vinicius Cestari Félix, Hellen Roehrs, Franciele Soares Pott, Janislei Giseli Dorociaki Stocco, Rodrigo Labat Marcos, Marineli Joaquim Meier

Version of Record online: 10 November 2019

 

Pressure ulcers are highly prevalent among adult and elderly patients where risk factors vary. In addition to guidelines to the conventional treatment, some auxiliary therapies such as photobiomodulation have shown promising results in wound healing. In this systematic review, only 5 papers were selected according to the eligibility criteria of this research. It was observed that PBMT red wavelength, similar to standard care, promoted tissue repair with a reduced lesion area.

Photochemistry and Photobiology Accepted Articles Accepted, unedited articles published online and citable. The final edited and typeset Version of Record will appear in the future.

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RESEARCH ARTICLES

Mechanistic Studies on the Salicylate‐Catalyzed Peroxyoxalate Chemiluminescence in Aqueous Medium

Maidileyvis C. Cabello, Glalci A. Souza, Liena V. Bello, Wilhelm J. Baader

First Published: 16 November 2019

RESEARCH ARTICLES

Photobiomodulation Therapy for Attenuating the Dystrophic Phenotype of Mdx Mice

Aline Barbosa Macedo, Daniela Sayuri Mizobuti, Tulio de Almeida Hermes, Rafael Dias Mâncio, Adriana Pertille, Larissa Akemi Kido, Valéria Helena Alves Cagnon, Elaine Minatel

First Published: 16 November 2019

Special Issue Research Article

Reactive Oxygen Species Explicit Dosimetry for Photofrin‐mediated Pleural Photodynamic Therapy

Yi Hong Ong, Andreaa Dimofte, Michele M. Kim, Jarod C. Finlay, Tianqi Sheng, Sunil Singhal, Keith A. Cengel, Arjun G. Yodh, Theresa M. Busch, Timothy C. Zhu

First Published: 15 November 2019

SPECIAL ISSUE RESEARCH ARTICLES

Synthesis and Characterization of Ru(II) Complexes with π‐Expansive Imidazophen Ligands for the Photokilling of Human Melanoma Cells

Goutam Ghosh, Huimin Yin, Susan M.A. Monro, Tariq Sainuddin, Lloyd Lapoot, Alexander Greer, Sherri A. McFarland

First Published: 15 November 2019

Research Articles

Opsin3 Down‐regulation Induces Apoptosis of Human Epidermal Melanocytes via Mitochondrial Pathway

Wang Yu, Lan Yinghua, Lu Hongguang

First Published: 15 November 2019

RESEARCH ARTICLES

Dibenzothiophene Sulfone Derivatives as Plasma Membrane Dyes

John T. Petroff II, Scott Grady, Christopher K. Arnatt, Ryan D. McCulla

First Published: 12 November 2019