IJMS, Vol. 20, Pages 5944: Rapid Molecular Identification of Scolytinae (Coleoptera: Curculionidae) International Journal of Molecular Sciences doi: 10.3390/ijms20235944 Authors: Jonathan Eric Albo Jean-Philippe Marelli Alina Sandra Puig Routine identification of bark and ambrosia beetles is done using morphology. For people lacking the necessary taxonomic knowledge, proper identification of a novel specimen can be challenging and time consuming. This study compares the usefulness...
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IJMS, Vol. 20, Pages 5942: CSPG4 as Target for CAR-T-Cell Therapy of Various Tumor Entities–Merits and Challenges International Journal of Molecular Sciences doi: 10.3390/ijms20235942 Authors: Dennis C. Harrer Jan Dörrie Niels Schaft Targeting cancer cells using chimeric-antigen-receptor (CAR-)T cells has propelled adoptive T-cell therapy (ATT) to the next level. A plentitude of durable complete responses using CD19-specific CAR-T cells in patients suffering from various lymphoid...
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IJMS, Vol. 20, Pages 5941: Puf6 and Loc1 Are the Dedicated Chaperones of Ribosomal Protein Rpl43 in Saccharomyces cerevisiae International Journal of Molecular Sciences doi: 10.3390/ijms20235941 Authors: Kai-Jen Liang Le-Yun Yueh Ning-Hsiang Hsu Jui-Sheng Lai Kai-Yin Lo Ribosomal proteins are highly expressed, and the quality of ribosomal proteins must be rigorously controlled to build up a functional ribosome. Rpl43, ribosomal protein large subunit 43, is located nearby...
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IJMS, Vol. 20, Pages 5943: Atoms in Generalized Orbital Configurations: Towards Atom-Dedicated Density Functionals International Journal of Molecular Sciences doi: 10.3390/ijms20235943 Authors: Ana Maria Toader Maria Cristina Buta Dan Maftei Mihai V. Putz Fanica Cimpoesu Deriving a practical formula for the atomic body with generalized shell occupations, we perform a detective analysis of the radial distribution in the exchange energy, hinting at ideas about new types of...
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IJMS, Vol. 20, Pages 5939: Apolipoprotein C1: Its Pleiotropic Effects in Lipid Metabolism and Beyond
IJMS, Vol. 20, Pages 5939: Apolipoprotein C1: Its Pleiotropic Effects in Lipid Metabolism and Beyond International Journal of Molecular Sciences doi: 10.3390/ijms20235939 Authors: Elena V. Fuior Anca V. Gafencu Apolipoprotein C1 (apoC1), the smallest of all apolipoproteins, participates in lipid transport and metabolism. In humans, APOC1 gene is in linkage disequilibrium with APOE gene on chromosome 19, a proximity that spurred its investigation. Apolipoprotein C1 associates with...
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IJMS, Vol. 20, Pages 5938: QSAR Models for Predicting Five Levels of Cellular Accumulation of Lysosomotropic Macrocycles International Journal of Molecular Sciences doi: 10.3390/ijms20235938 Authors: Ulf Norinder Vesna Munic Kos Drugs that accumulate in lysosomes reach very high tissue concentrations, which is evident in the high volume of distribution and often lower clearance of these compounds. Such a pharmacokinetic profile is beneficial for indications where high tissue penetration...
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IJMS, Vol. 20, Pages 5940: Species Identification of Oaks (Quercus L., Fagaceae) from Gene to Genome
IJMS, Vol. 20, Pages 5940: Species Identification of Oaks (Quercus L., Fagaceae) from Gene to Genome International Journal of Molecular Sciences doi: 10.3390/ijms20235940 Authors: Xinbo Pang Hongshan Liu Suran Wu Yangchen Yuan Haijun Li Junsheng Dong Zhaohua Liu Chuanzhi An Zhihai Su Bin Li Species identification of oaks (Quercus) is always a challenge because many species exhibit variable phenotypes that overlap with other species. Oaks are notorious for interspecific...
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IJMS, Vol. 20, Pages 5934: TGFB1-Mediated Gliosis in Multiple Sclerosis Spinal Cords Is Favored by the Regionalized Expression of HOXA5 and the Age-Dependent Decline in Androgen Receptor Ligands International Journal of Molecular Sciences doi: 10.3390/ijms20235934 Authors: Serge Nataf Marine Guillen Laurent Pays In multiple sclerosis (MS) patients with a progressive form of the disease, spinal cord (SC) functions slowly deteriorate beyond age 40. We previously showed that in the...
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IJMS, Vol. 20, Pages 5936: Heterozygous Ldlr-Deficient Hamster as a Model to Evaluate the Efficacy of PCSK9 Antibody in Hyperlipidemia and Atherosclerosis International Journal of Molecular Sciences doi: 10.3390/ijms20235936 Authors: Yue Wu Ming-Jiang Xu Zhiyou Cao Chun Yang Jinjie Wang Bijue Wang Jian Liu Yuhui Wang Xunde Xian Fang Zhang George Liu Xiaoli Chen Proprotein convertase subtilisin/kexin type 9 (PCSK9) plays a key role in cholesterol homeostasis...
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IJMS, Vol. 20, Pages 5937: Dysregulated Choline, Methionine, and Aromatic Amino Acid Metabolism in Patients with Wilson Disease: Exploratory Metabolomic Profiling and Implications for Hepatic and Neurologic Phenotypes International Journal of Molecular Sciences doi: 10.3390/ijms20235937 Authors: Tagreed A. Mazi Gaurav V. Sarode Anna Czlonkowska Tomasz Litwin Kyoungmi Kim Noreene M. Shibata Valentina Medici Wilson disease (WD) is a genetic copper overload condition characterized...
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IJMS, Vol. 20, Pages 5935: Endomorphin-2- and Neurotensin- Based Chimeric Peptide Attenuates Airway Inflammation in Mouse Model of Nonallergic Asthma International Journal of Molecular Sciences doi: 10.3390/ijms20235935 Authors: Ewelina Russjan Kryspin Andrzejewski Dorota Sulejczak Patrycja Kleczkowska Katarzyna Kaczyńska We examined anti-inflammatory potency of hybrid peptide-PK20, composed of neurotensin (NT) and endomorphin-2 (EM-2) pharmacophores in a murine model of...
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JCM, Vol. 8, Pages 2071: Ankle Brachial Index in Different Types of Popliteal Artery Entrapment Syndrome: A Systematic Review of Case Reports Journal of Clinical Medicine doi: 10.3390/jcm8122071 Authors: Felice Sirico Stefano Palermi Francesco Gambardella Eduardo Capuano Umberto Ferrari Veronica Baioccato Clotilde Castaldo Franca Di Meglio Daria Nurzynska Similar to other peripheral artery diseases, vessel narrowing in popliteal artery entrapment syndrome (PAES)...
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Membranes, Vol. 9, Pages 158: Concentration of 1,3-dimethyl-2-imidazolidinone in Aqueous Solutions by Sweeping Gas Membrane Distillation: From Bench to Industrial Scale Membranes doi: 10.3390/membranes9120158 Authors: Ricardo Abejón Hafedh Saidani André Deratani Christophe Richard José Sánchez-Marcano Sweeping gas membrane distillation (SGMD) is a useful option for dehydration of aqueous solvent solutions. This study investigated the technical viability and competitiveness...
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Membranes, Vol. 9, Pages 157: A Bibliometric Survey of Paraffin/Olefin Separation Using Membranes Membranes doi: 10.3390/membranes9120157 Authors: Débora Micheline Vaz de Miranda Luciana da Silva Dutra Débora Way Nicolis Amaral Frederico Wegenast Maria Clara Scaldaferri Normando Jesus José Carlos Pinto Bibliometric studies allow to collect, organize and process information that can be used to guide the development of research and innovation and to provide basis for...
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Metabolites, Vol. 9, Pages 290: Metabolic Fingerprint of Chronic Obstructive Lung Diseases: A New Diagnostic Perspective Metabolites doi: 10.3390/metabo9120290 Authors: Dimitris Tsoukalas Evangelia Sarandi Maria Thanasoula Anca Oana Docea Gerasimos Tsilimidos Daniela Calina Aristides Tsatsakis Chronic obstructive lung disease (COLD) is a group of airway diseases, previously known as emphysema and chronic bronchitis. The heterogeneity of COLD does not allow early diagnosis...
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Metabolites, Vol. 9, Pages 289: Untargeted Metabolomics-Based Screening Method for Inborn Errors of Metabolism using Semi-Automatic Sample Preparation with an UHPLC- Orbitrap-MS Platform Metabolites doi: 10.3390/metabo9120289 Authors: Ramon Bonte Michiel Bongaerts Serwet Demirdas Janneke G. Langendonk Hidde H. Huidekoper Monique Williams Willem Onkenhout Edwin H. Jacobs Henk J. Blom George J. G. Ruijter Routine diagnostic screening of inborn errors of metabolism...
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Microorganisms, Vol. 7, Pages 615: Characterization of Non-O157 STEC Infecting Bacteriophages Isolated from Cattle Faeces in North-West South AfricaMicroorganisms doi: 10.3390/microorganisms7120615Authors:Emmanuel W. BumunangTim A. McAllisterKim StanfordHany AnanyYan D. NiuCollins N. AtebaNon-O157 Shiga toxin-producing Escherichia coli (STEC) E. coli are emerging pathotypes that are frequently associated with diseases in humans around the world. The consequences of these serogroups for public health...
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Microorganisms, Vol. 7, Pages 616: Changes of Root Endophytic Bacterial Community Along a Chronosequence of Intensively Managed Lei Bamboo (Phyllostachys praecox) Forests in Subtropical ChinaMicroorganisms doi: 10.3390/microorganisms7120616Authors:Xiaoping ZhangZheke ZhongXu GaiXuhua DuFangyuan BianChuanbao YangGuibin GaoXing WenEndophytic bacteria widely exist inside plant tissues and have an important role in plant growth and development and the alleviation of environmental stress. However, little...
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Microorganisms, Vol. 7, Pages 617: Interactions Screenings Unearth Potential New Divisome Components in the Chlamydia-Related Bacterium, Waddlia chondrophilaMicroorganisms doi: 10.3390/microorganisms7120617Authors:Firuza BayramovaNicolas JacquierGilbert GreubChlamydiales order members are obligate intracellular bacteria, dividing by binary fission. However, Chlamydiales lack the otherwise conserved homologue of the bacterial division organizer FtsZ and certain division protein homologues. FtsZ might...
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Microorganisms, Vol. 7, Pages 614: Analysis of the Degradation of Broad-Spectrum Cephalosporins by OXA-48-Producing Enterobacteriaceae Using MALDI-TOF MSMicroorganisms doi: 10.3390/microorganisms7120614Authors:Marina OviañoMaría Rosario RodicioJürgen J. HeinischRosaura RodicioGermán BouJavier FernándezThe objective of the study was to evaluate the activity of OXA-48 against different broad-spectrum cephalosporins and to identify the reaction products by MALDI-TOF MS. The action of OXA-48 on cefotaxime,...
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Molecules, Vol. 24, Pages 4316: Synthesis and In Vitro Evaluation of Novel Liver X Receptor Agonists Based on Naphthoquinone Derivatives Molecules doi: 10.3390/molecules24234316 Authors: Tatsuma Nishioka Kaori Endo-Umeda Yuki Ito Akane Shimoda Atsuko Takeuchi Chisato Tode Yoshihisa Hirota Naomi Osakabe Makoto Makishima Yoshitomo Suhara We aimed to synthesize novel liver X receptor (LXR) agonists with potent agonist activity and subtype selectivity. Our synthetic...
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Molecules, Vol. 24, Pages 4317: Polypropylene Glycol-Polyoxytetramethylene Glycol Multiblock Copolymers with High Molecular Weight: Synthesis, Characterization, and Silanization Molecules doi: 10.3390/molecules24234317 Authors: Wei Hu Lei Wang Quanyong Wang Anbo Luan Yuliang Mai Linjia Huang Yongjun Chen Shijing Yan Wenjie Xiong The high crystallization at room temperature and high cost of polyoxytetramethylene glycol (PTMG) have become obstacles to its application....
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Molecules, Vol. 24, Pages 4314: Development of Targeted Alpha Particle Therapy for Solid Tumors Molecules doi: 10.3390/molecules24234314 Authors: Narges K. Tafreshi Michael L. Doligalski Christopher J. Tichacek Darpan N. Pandya Mikalai M. Budzevich Ghassan El-Haddad Nikhil I. Khushalani Eduardo G. Moros Mark L. McLaughlin Thaddeus J. Wadas David L. Morse Targeted alpha-particle therapy (TAT) aims to selectively deliver radionuclides emitting α-particles...
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Molecules, Vol. 24, Pages 4313: Parabens Adsorption onto Activated Carbon: Relation with Chemical and Structural Properties Molecules doi: 10.3390/molecules24234313 Authors: Astrid Roxanna Moreno-Marenco Liliana Giraldo Juan Carlos Moreno-Piraján Parabens (alkyl-p-hidroxybenzoates) are antimicrobial preservatives used in personal care products, classified as an endocrine disruptor, so they are considered emerging contaminants. A raw version of activated carbons obtained from African...
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Molecules, Vol. 24, Pages 4315: Application of Solid Dispersion Technique to Improve Solubility and Sustain Release of Emamectin Benzoate Molecules doi: 10.3390/molecules24234315 Authors: Bin Bin Huang Dong Xu Liu De Kun Liu Gang Wu The solid dispersion technique, which is widely used in the medical field, was applied to prepare a pesticide dosage form of emamectin benzoate (EM). The preparation, physicochemical characterization, aqueous solubility, release dynamics, photolytic...
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Molecules, Vol. 24, Pages 4311: Lipophilicity Determination of Antifungal Isoxazolo[3,4-b]pyridin-3(1H)-ones and Their N1-Substituted Derivatives with Chromatographic and Computational Methods Molecules doi: 10.3390/molecules24234311 Authors: Krzesimir Ciura Joanna Fedorowicz Filip Andrić Petar Žuvela Katarzyna Ewa Greber Paweł Baranowski Piotr Kawczak Joanna Nowakowska Tomasz Bączek Jarosław Sączewski The lipophilicity of a molecule is a well-recognized as...
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Molecules, Vol. 24, Pages 4310: Chemometric Characterization of Strawberries and Blueberries according to Their Phenolic Profile: Combined Effect of Cultivar and Cultivation System Molecules doi: 10.3390/molecules24234310 Authors: Milica Fotirić Akšić Dragana Dabić Zagorac Milica Sredojević Jasminka Milivojević Uroš Gašić Mekjell Meland Maja Natić Chemical characterizations of leaves and fruits that were obtained from organically and integrally produced strawberries...
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Molecules, Vol. 24, Pages 4309: Concepts and Core Principles of Fragment-Based Drug Design Molecules doi: 10.3390/molecules24234309 Authors: Philine Kirsch Alwin M. Hartman Anna K. H. Hirsch Martin Empting In this review, a general introduction to fragment-based drug design and the underlying concepts is given. General considerations and methodologies ranging from library selection/construction over biophysical screening and evaluation methods to in-depth hit qualification and...
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Molecules, Vol. 24, Pages 4312: Nasal Drug Delivery of Anticancer Drugs for the Treatment of Glioblastoma: Preclinical and Clinical Trials Molecules doi: 10.3390/molecules24234312 Authors: Franciele Aline Bruinsmann Gustavo Richter Vaz Aline de Cristo Soares Alves Tanira Aguirre Adriana Raffin Pohlmann Silvia Stanisçuaski Guterres Fabio Sonvico Glioblastoma (GBM) is the most lethal form of brain tumor, being characterized by the rapid growth and invasion of the surrounding...
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Molecules, Vol. 24, Pages 4308: Synthesis, Antimicrobial, and Anti-Proliferative Activities of Novel 4-(Adamantan-1-yl)-1-arylidene-3-thiosemicarbazides, 4-Arylmethyl N′-(Adamantan-1-yl)piperidine-1-carbothioimidates, and Related Derivatives Molecules doi: 10.3390/molecules24234308 Authors: Aamal A. Al-Mutairi Monirah A. Al-Alshaikh Fatmah A. M. Al-Omary Hanan M. Hassan Areej M. El-Mahdy Ali A. El-Emam The reaction of 4-(adamantan-1-yl)-3-thiosemicarbazide 3 with various...
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Molecules, Vol. 24, Pages 4306: Investigating the Effect of Artificial Flavours and External Information on Consumer Liking of Apples Molecules doi: 10.3390/molecules24234306 Authors: Isabella Endrizzi Eugenio Aprea Emanuela Betta Mathilde Charles Jessica Zambanini Flavia Gasperi In this paper, the influence of flavour modification, artificially induced, on consumer acceptability of apple fruit is studied. The method consists of modifying the flavour of a real food matrix...
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Molecules, Vol. 24, Pages 4307: The Assembly of Porphyrin Systems in Well-Defined Nanostructures: An Update Molecules doi: 10.3390/molecules24234307 Authors: Gabriele Magna Donato Monti Corrado Di Natale Roberto Paolesse Manuela Stefanelli The interest in assembling porphyrin derivatives is widespread and is accounted by the impressive impact of these suprastructures of controlled size and shapes in many applications from nanomedicine and sensors to photocatalysis and optoelectronics....
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Nanomaterials, Vol. 9, Pages 1690: Bending and Elastic Vibration of a Novel Functionally Graded Polymer Nanocomposite Beam Reinforced by Graphene Nanoplatelets Nanomaterials doi: 10.3390/nano9121690 Authors: Yuewu Wang Ke Xie Tairan Fu Congling Shi A novel functionally graded (FG) polymer-based nanocomposite reinforced by graphene nanoplatelets is proposed based on a new distribution law, which is constructed by the error function and contains a gradient index. The variation...
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Nutrients, Vol. 11, Pages 2879: Differential Physiological Responses Elicited by Ancient and Heritage Wheat Cultivars Compared to Modern Ones Nutrients doi: 10.3390/nu11122879 Authors: Enzo Spisni Veronica Imbesi Elisabetta Giovanardi Giovannamaria Petrocelli Patrizia Alvisi Maria Chiara Valerii Although ancient, heritage, and modern wheat varieties appear rather similar from a nutritional point of view, having a similar gluten content and a comparable toxicity linked...
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Nutrients, Vol. 11, Pages 2880: Effects of Vitamin D and Calcium Fortified Yogurts on Gait, Cognitive Performances, and Serum 25-Hydroxyvitamin D Concentrations in Older Community-Dwelling Females: Results from the GAit, MEmory, Dietary and Vitamin D (GAME-D2) Randomized Controlled Trial Nutrients doi: 10.3390/nu11122880 Authors: Olivier Beauchet Cyrille P. Launay Kevin Galery Christine Vilcocq Flore Dontot-Payen Brigitte Rousseau Valérie Benoit Gilles Allali Background:...
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Nutrients, Vol. 11, Pages 2878: Dietary Patterns and Components in Nonalcoholic Fatty Liver Disease (NAFLD): What Key Messages Can Health Care Providers Offer? Nutrients doi: 10.3390/nu11122878 Authors: Kiarash Riazi Maitreyi Raman Lorian Taylor Mark G. Swain Abdel Aziz Shaheen Nonalcoholic fatty liver disease (NAFLD) is a rising epidemic worldwide and will be the leading cause of cirrhosis, hepatocellular carcinoma, and liver transplant within the next decade. NAFLD is considered...
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Pathogens, Vol. 8, Pages 265: The Importance of Vaccinating Children and Pregnant Women against Influenza Virus Infection Pathogens doi: 10.3390/pathogens8040265 Authors: Ravi S Misra Jennifer L Nayak Influenza virus infection is responsible for significant morbidity and mortality in the pediatric and pregnant women populations, with deaths frequently caused by severe influenza-associated lower respiratory tract infection and acute respiratory distress syndrome (ARDS). An appropriate...
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Pathogens, Vol. 8, Pages 266: Genetic Diversity among Pseudorabies Viruses Isolated from Dogs in France from 2006 to 2018 Pathogens doi: 10.3390/pathogens8040266 Authors: Céline Deblanc Aurélie Oger Gaëlle Simon Marie-Frédérique Le Potier Pseudorabies (PR), also known as Aujeszky’s disease, is an economically important disease for the pig industry. It has been eradicated in domestic pigs in many European countries, including France, but its causative agent—Suid...
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