Related ArticlesOxaliplatin-induced neuropathy: the preventive effect of a new super-oxide dismutase modulator. Oncotarget. 2019 Nov 05;10(60):6418-6431 Authors: Guillaumot MA, Cerles O, Bertrand HC, Benoit E, Nicco C, Chouzenoux S, Schmitt A, Batteux F, Policar C, Coriat R Abstract By using the differential in level of oxidative status between normal and cancer cells, SuperOxide Dismutase (SOD) mimetics can have anti-tumor efficacy and prevent oxaliplatin-induced...
Wed Nov 20, 2019 16:18
Related ArticlesVolasertib preclinical activity in high-risk hepatoblastoma. Oncotarget. 2019 Nov 05;10(60):6403-6417 Authors: Kats D, Ricker CA, Berlow NE, Noblet B, Nicolle D, Mevel K, Branchereau S, Judde JG, Stiverson CD, Stiverson CL, Svalina MN, Settelmeyer T, Matlock K, Lathara M, Mussini C, Geller JI, Noakes C, Sloma I, Bharathy N, Cairo S, Keller C Abstract Relapsed and metastatic hepatoblastoma represents an unmet clinical need with limited...
Wed Nov 20, 2019 16:18
Related ArticlesBreathing the air of mitochondrial respiration via an important oncotarget - mitochondrial glycerophosphate dehydrogenase (mGPDH). Oncotarget. 2019 Nov 05;10(60):6400-6402 Authors: Thakur S, Klubo-Gwiezdzinska J PMID: 31741705 [PubMed]
Wed Nov 20, 2019 16:18
Related ArticlesThe utility of lateral neck radiographs in the management of fish bones. J Laryngol Otol. 2019 Nov 19;:1-4 Authors: Pitts-Tucker T, Biggs TC, Patel NN Abstract BACKGROUND: Lateral neck radiographs are commonly used in the investigation and management of patients presenting with suspected fish bone impaction. The effectiveness of these is questioned, as many fish do not have radio-opaque bones. OBJECTIVE: This study evaluated...
Wed Nov 20, 2019 14:14
Related ArticlesA novel in situ multiplex immunofluorescence panel for the assessment of tumor immunopathology and response to virotherapy in pediatric glioblastoma reveals a role for checkpoint protein inhibition. Oncoimmunology. 2019;8(12):e1678921 Authors: Bernstock JD, Vicario N, Rong L, Valdes PA, Choi BD, Chen JA, DiToro D, Osorio DS, Kachurak K, Gessler F, Johnston JM, Atkinson TP, Whitley RJ, Bag AK, Gillespie GY, Markert JM, Maric D, Friedman GK Abstract...
Wed Nov 20, 2019 16:17
Related ArticlesPatients with melanoma of unknown primary show better outcome under immune checkpoint inhibitor therapy than patients with known primary: preliminary results. Oncoimmunology. 2019;8(12):e1677139 Authors: Gambichler T, Chatzipantazi M, Schröter U, Stockfleth E, Gedik C Abstract Background: Melanoma of unknown primary (MUP) is an uncommon clinical subtype of melanoma of known primary (MKP). Objectives: We aimed to compare treatment outcomes...
Wed Nov 20, 2019 16:17
Related ArticlesTargeting the TIGIT-PVR immune checkpoint axis as novel therapeutic option in breast cancer. Oncoimmunology. 2019;8(12):e1674605 Authors: Stamm H, Oliveira-Ferrer L, Grossjohann EM, Muschhammer J, Thaden V, Brauneck F, Kischel R, Müller V, Bokemeyer C, Fiedler W, Wellbrock J Abstract Immune checkpoints are intensively investigated as targets in cancer therapy. T-cell immunoreceptor with immunoglobulin (Ig) and ITIM domains (TIGIT) and...
Wed Nov 20, 2019 16:17
Related ArticlesPrognostic profiling of the immune cell microenvironment in Ewing´s Sarcoma Family of Tumors. Oncoimmunology. 2019;8(12):e1674113 Authors: Stahl D, Gentles AJ, Thiele R, Gütgemann I Abstract Ewing´s Sarcoma Family of Tumors (ESFT) are clinically aggressive bone and soft tissue tumors in children and young adults. Analysis of the immune tumor microenvironment (TME) provides insight into tumor evolution and novel treatment options. So far,...
Wed Nov 20, 2019 16:17
Related ArticlesToll-like receptor 3 -926T>A increased the risk of breast cancer through decreased transcriptional activity. Oncoimmunology. 2019;8(12):e1673126 Authors: Fan L, Zhou P, Chen AX, Liu GY, Yu KD, Shao ZM Abstract Toll-like receptor 3 (TLR3) is a viral sensor that induces apoptosis in response to double-stranded RNA (dsRNA). Common genetic changes in the TLR3 gene may influence breast cancer susceptibility and development. However, all...
Wed Nov 20, 2019 16:17
Related ArticlesTumor-infiltrating lymphocytes from human prostate tumors reveal anti-tumor reactivity and potential for adoptive cell therapy. Oncoimmunology. 2019;8(12):e1672494 Authors: Yunger S, Bar El A, Zeltzer LA, Fridman E, Raviv G, Laufer M, Schachter J, Markel G, Itzhaki O, Besser MJ Abstract Advanced prostate cancer remains incurable and is the second leading cause of mortality in men. Immunotherapy based on the adoptive transfer of tumor-infiltrating...
Wed Nov 20, 2019 16:17
Related ArticlesBone marrow expands the repertoire of functional T cells targeting tumor-associated antigens in patients with resectable non-small-cell lung cancer. Oncoimmunology. 2019;8(12):e1671762 Authors: Safi S, Yamauchi Y, Stamova S, Rathinasamy A, Op den Winkel J, Jünger S, Bucur M, Umansky L, Warth A, Herpel E, Eichhorn M, Winter H, Hoffmann H, Beckhove P Abstract The efficacy of cancer immunotherapy may be improved by increasing the number...
Wed Nov 20, 2019 16:17
Related ArticlesIn vivo generated human CAR T cells eradicate tumor cells. Oncoimmunology. 2019;8(12):e1671761 Authors: Agarwal S, Weidner T, Thalheimer FB, Buchholz CJ Abstract Chimeric antigen receptor (CAR) T cells are in prime focus of current research in cancer immunotherapy. Facilitating CAR T cell generation is among the top goals. We have recently demonstrated direct in vivo generation of human CD19-CAR T cells by targeting CD8+ cells using lentiviral...
Wed Nov 20, 2019 16:17
Related ArticlesIntraperitoneal cancer-immune microenvironment promotes peritoneal dissemination of gastric cancer. Oncoimmunology. 2019;8(12):e1671760 Authors: Sakamoto S, Kagawa S, Kuwada K, Ito A, Kajioka H, Kakiuchi Y, Watanabe M, Kagawa T, Yoshida R, Kikuchi S, Kuroda S, Tazawa H, Fujiwara T Abstract A solid tumor consists of cancer and stromal cells, which comprise the tumor microenvironment (TME). Tumor-associated macrophages (TAMs) are usually...
Wed Nov 20, 2019 16:17
Related ArticlesOrganotypic tumor slice cultures provide a versatile platform for immuno-oncology and drug discovery. Oncoimmunology. 2019;8(12):e1670019 Authors: Sivakumar R, Chan M, Shin JS, Nishida-Aoki N, Kenerson HL, Elemento O, Beltran H, Yeung R, Gujral TS Abstract Organotypic tumor slices represent a physiologically-relevant culture system for studying the tumor microenvironment. Systematic characterization of the tumor slice culture system will...
Wed Nov 20, 2019 16:17
Related ArticlesImmunogenic cell death in a combined synergic gene- and immune-therapy against cancer. Oncoimmunology. 2019;8(12):e1667743 Authors: Nayagom B, Amara I, Habiballah M, Amrouche F, Beaune P, de Waziers I Abstract It was previously demonstrated that engineered mesenchymal stem cells (MSCs) which express a high level of a very efficient modified gene CYP2B6* (CYP2B6TM-RED) acting as a suicide gene (MSC-2B6*) in combination with cyclophosphamide...
Wed Nov 20, 2019 16:17
Related ArticlesIdentification of novel, immune-mediating extracellular vesicles in human lymphatic effluent draining primary cutaneous melanoma. Oncoimmunology. 2019;8(12):e1667742 Authors: Maus RLG, Jakub JW, Hieken TJ, Nevala WK, Christensen TA, Sutor SL, Flotte TJ, Markovic SN Abstract Epithelial tumors including melanoma often first metastasize to regional, sentinel lymph nodes (SLN). Thus, the presence of SLN metastases is a critical prognostic...
Wed Nov 20, 2019 16:17
Related ArticlesSystems analysis of barrier molecule and ARNT-related gene expression regulation in melanoma. Oncoimmunology. 2019;8(12):e1665978 Authors: Leick KM, Obeid JM, Bekiranov S, Slingluff CL Abstract Background: We have identified, in melanomas, a set of genes encoding proteins that mediate mechanical barrier function in normal skin (barrier molecule genes, BMGs) and whose overexpression is associated with decreased immune signatures and shorter...
Wed Nov 20, 2019 16:17
Related ArticlesFirst report on two cases of pleomorphic dermal sarcoma successfully treated with immune checkpoint inhibitors. Oncoimmunology. 2019;8(12):e1665977 Authors: Klein S, Persa OD, Mauch C, Noh KW, Pappesch R, Wagener-Ryczek S, Buettner R, Quaas A, Helbig D Abstract Pleomorphic dermal sarcoma (PDS) is one of the most common sarcoma of the skin. Currently, limited treatment options exist for advanced stages of the disease. While immune checkpoint...
Wed Nov 20, 2019 16:17
Related ArticlesHVEM has a broader expression than PD-L1 and constitutes a negative prognostic marker and potential treatment target for melanoma. Oncoimmunology. 2019;8(12):e1665976 Authors: Malissen N, Macagno N, Granjeaud S, Granier C, Moutardier V, Gaudy-Marqueste C, Habel N, Mandavit M, Guillot B, Pasero C, Tartour E, Ballotti R, Grob JJ, Olive D Abstract HVEM (Herpes Virus Entry Mediator) engagement of BTLA (B and T Lymphocyte Attenuator) triggers...
Wed Nov 20, 2019 16:17
Related ArticlesIFNβ-producing CX3CR1+ macrophages promote T-regulatory cell expansion and tumor growth in the APCmin/+ / Bacteroides fragilis colon cancer model. Oncoimmunology. 2019;8(12):e1665975 Authors: Gu T, Li Q, Egilmez NK Abstract Increased T-regulatory cell activity drives tumor progression in the compound APCmin/+/enterotoxic Bacteroides fragilis colon cancer model. At the same time, how microbially-induced inflammation promotes T-regulatory...
Wed Nov 20, 2019 16:17
Related ArticlesPredictors of benefits from frontline chemoimmunotherapy in stage IV non-small-cell lung cancer: a meta-analysis. Oncoimmunology. 2019;8(12):e1665974 Authors: El-Osta HE, Mott FE, Burt BM, Wang DY, Sabichi AL Abstract Background: Immune checkpoint inhibitors (ICIs) have dramatically expanded the therapeutic landscape of non-small-cell lung cancer (NSCLC). In a previous study, gender, smoking history, and PD-L1 status were found to influence...
Wed Nov 20, 2019 16:17
Related ArticlesAntibiotic use and the efficacy of immune checkpoint inhibitors in cancer patients: a pooled analysis of 2740 cancer patients. Oncoimmunology. 2019;8(12):e1665973 Authors: Huang XZ, Gao P, Song YX, Xu Y, Sun JX, Chen XW, Zhao JH, Wang ZN Abstract The gut microbiota plays a critical role in the anti-tumor immune response. There is increasing data showing that antibiotics (ATBs) change the composition of the gut microbiota and affect the...
Wed Nov 20, 2019 16:17
Related ArticlesTumor cell expression of B7-H4 correlates with higher frequencies of tumor-infiltrating APCs and higher CXCL17 expression in human epithelial ovarian cancer. Oncoimmunology. 2019;8(12):e1665460 Authors: MacGregor HL, Garcia-Batres C, Sayad A, Elia A, Berman HK, Toker A, Katz SR, Shaw PA, Clarke BA, Crome SQ, Robert-Tissot C, Bernardini MQ, Nguyen LT, Ohashi PS Abstract B7-H4, an immune suppressive member of the B7 family, is highly expressed...
Wed Nov 20, 2019 16:17
Related ArticlesPre-diagnostic anthropometry, sex, and risk of colorectal cancer according to tumor immune cell composition. Oncoimmunology. 2019;8(12):e1664275 Authors: Berntsson J, Eberhard J, Nodin B, Leandersson K, Larsson AH, Jirström K Abstract Obesity is a well-established risk factor for colorectal cancer (CRC), but the association with the tumor microenvironment has been sparsely described. Herein, we examined the relationship between pre-diagnostic...
Wed Nov 20, 2019 16:17
Related ArticlesComplete response in patients with locally advanced rectal cancer after neoadjuvant treatment with nivolumab. Oncoimmunology. 2019;8(12):e1663108 Authors: Zhang J, Cai J, Deng Y, Wang H Abstract Introduction: PD-1 inhibitors have been approved for the treatment of dMMR patients with metastatic colorectal cancer, but the efficacy of neoadjuvant treatment with PD-1 in dMMR locally advanced rectal cancer (LARC) patients has not yet been...
Wed Nov 20, 2019 16:17
Related ArticlesT cell recognition of novel shared breast cancer antigens is frequently observed in peripheral blood of breast cancer patients. Oncoimmunology. 2019;8(12):e1663107 Authors: Viborg N, Ramskov S, Andersen RS, Sturm T, Fugmann T, Bentzen AK, Rafa VM, Straten PT, Svane IM, Met Ö, Hadrup SR Abstract Advances within cancer immunotherapy have fueled a paradigm shift in cancer treatment, resulting in increasing numbers of cancer types benefitting...
Wed Nov 20, 2019 16:17
Related ArticlesThe role of myeloid-derived suppressor cells in endometrial cancer displaying systemic inflammatory response: clinical and preclinical investigations. Oncoimmunology. 2019;8(12):e1662708 Authors: Yokoi E, Mabuchi S, Komura N, Shimura K, Kuroda H, Kozasa K, Takahashi R, Sasano T, Kawano M, Matsumoto Y, Kodama M, Hashimoto K, Sawada K, Kimura T Abstract Systemic inflammatory responses including thrombocytosis, leukocytosis, or neutrophilia...
Wed Nov 20, 2019 16:17
Related ArticlesBeneficial modulation of the tumor microenvironment and generation of anti-tumor responses by TLR9 agonist lefitolimod alone and in combination with checkpoint inhibitors. Oncoimmunology. 2019;8(12):e1659096 Authors: Kapp K, Volz B, Oswald D, Wittig B, Baumann M, Schmidt M Abstract Activation of Toll-like receptor 9 (TLR9) is known to foster innate and adaptive immune responses and thus improve immune-mediated control of malignant disease....
Wed Nov 20, 2019 16:17
Related ArticlesIdentification of a prognostic immune signature for cervical cancer to predict survival and response to immune checkpoint inhibitors. Oncoimmunology. 2019;8(12):e1659094 Authors: Yang S, Wu Y, Deng Y, Zhou L, Yang P, Zheng Y, Zhang D, Zhai Z, Li N, Hao Q, Song D, Kang H, Dai Z Abstract Cervical cancer (CC) is a leading cause of cancer-related death in women. Limited studies have investigated whether immune-related genes (IRGs) or tumor...
Wed Nov 20, 2019 16:17
Related ArticlesExpression of Tumor-mediated CD137 ligand in human colon cancer indicates dual signaling effects. Oncoimmunology. 2019;8(12):e1651622 Authors: Grimmig T, Gasser M, Moench R, Zhu LJ, Nawalaniec K, Callies S, Wagner M, Polat B, Mothi SS, Luo Y, Ribas CM, Malafaia O, Hsiao LL, Waaga-Gasser AM Abstract CD137-targeting immune therapy, which activates anti-tumor T effector cell responses, seems to be an attractive concept in clinical oncology....
Wed Nov 20, 2019 16:17
Related ArticlesLow CD4⁺/CD25⁺/CD127⁻ regulatory T cell- and high INF-γ levels are associated with improved survival of neuroblastoma patients treated with long-term infusion of ch14.18/CHO combined with interleukin-2. Oncoimmunology. 2019;8(12):1661194 Authors: Troschke-Meurer S, Siebert N, Marx M, Zumpe M, Ehlert K, Mutschlechner O, Loibner H, Ladenstein R, Lode HN Abstract Immunotherapy with the anti-GD2 antibody (Ab) ch14.18/CHO in combination with...
Wed Nov 20, 2019 16:17
Related ArticlesPD-L1 regulation by SDH5 via β-catenin/ZEB1 signaling. Oncoimmunology. 2019;8(12):1655361 Authors: Tuo Z, Zong Y, Li J, Xiao G, Zhang F, Li G, Wang S, Lv Y, Xia J, Liu J Abstract Programmed death-ligand 1 (PD-L1) is a crucial target for lung cancer immunotherapy. In lung cancer patients with high PD-L1 expression, blocking or reducing its expression can inhibit tumor growth. PD-L1 is regulated by signaling pathways, transcription factors...
Wed Nov 20, 2019 16:17
Related ArticlesComparison of Sublingual Immunotherapy in Patients With Allergic Rhinitis Sensitive to House Dust Mites in Korea. Ear Nose Throat J. 2019 Nov 19;:145561319882593 Authors: Jung JH, Kang TK, Kang IG, Kim ST Abstract The aim of this study was to investigate the clinical outcomes of sublingual immunotherapy (SLIT) using 2 kinds of SLIT medications (LAIS and Staloral) in patients with allergic rhinitis for Dermatophagoides pteronyssinus and...
Wed Nov 20, 2019 14:09
Automated analysis of bone-conduction cortical auditory evoked potential in normal-hearing neonates.
Related ArticlesAutomated analysis of bone-conduction cortical auditory evoked potential in normal-hearing neonates. Braz J Otorhinolaryngol. 2019 Oct 31;: Authors: Brito DS, Durante AS Abstract INTRODUCTION: The cortical auditory evoked potential allows the possibility of objectively evaluating the entire auditory system, which is desirable in the pediatric population. Bone conduction auditory stimulation is recommended in the differential diagnosis...
Wed Nov 20, 2019 14:06
Related ArticlesComparison of Spontaneous Temporal Bone Cerebrospinal Fluid Leaks From the Middle and Posterior Fossa. Otol Neurotol. 2019 Nov 15;: Authors: Cooper T, Choy MH, Gardner PA, Hirsch BE, McCall AA Abstract OBJECTIVES: To compare patients surgically managed for spontaneous cerebrospinal fluid (CSF) leaks of the temporal bone arising from the middle cranial fossa (MCF) and posterior cranial fossa (PCF) and to describe the surgical management...
Wed Nov 20, 2019 16:03
Related ArticlesEvaluation of Risk Factors for Cerebrospinal Leakage in Pediatric Patients With Cerebral Palsy Treated With Intrathecal Baclofen. J Pediatr Orthop. 2019 Nov 14;: Authors: Imerci A, Rogers KJ, Miller F, Sees JP Abstract BACKGROUND: Insertion of an intrathecal baclofen (ITB) pump can provide significant benefits in patients with cerebral palsy (CP). However, there are little data describing the risk of complications. Specifically, there...
Wed Nov 20, 2019 16:03
Related ArticlesPeri-operative Lumbar Drains for Trans-Sphenoidal resection of Pituitary Adenomas. J Pak Med Assoc. 2019 Nov;69(11):1752-1754 Authors: Hani U, Bakhshi SK, Shamim MS Abstract Trans-sphenoidal approach for resection of pituitary adenomas is a safe and common neurosurgical procedure. It can be done both through microscopic or endoscopic methods, and both methods can be facilitated by a perioperative lumbar drain insertion, that in theory...
Wed Nov 20, 2019 14:01
Related ArticlesTeaching NeuroImages: Cerebrospinal fluid leakage observed from skin after acupuncture. Neurology. 2019 03 05;92(10):e1141-e1142 Authors: Noh SM, Lee KM, Kim BJ PMID: 30833482 [PubMed - indexed for MEDLINE]
Wed Nov 20, 2019 14:01
Related ArticlesBreath Tests for the Non-invasive Diagnosis of Small Intestinal Bacterial Overgrowth: A Systematic Review With Meta-analysis. J Neurogastroenterol Motil. 2019 Nov 19;: Authors: Losurdo G, Leandro G, Ierardi E, Perri F, Barone M, Principi M, Leo AD Abstract Background/Aims: Small intestinal bacterial overgrowth (SIBO) diagnosis is usually based on non-invasive breath tests (BTs), namely lactulose BT (LBT) and glucose BT (GBT). However,...
Wed Nov 20, 2019 17:01
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