Related ArticlesAberrant activation of cyclin A-CDK induces G2/M-phase checkpoint in human cells. Cell Cycle. 2019 Nov 25;:1-13 Authors: Akaike Y, Chibazakura T Abstract Cyclin A-cyclin dependent kinase (CDK) activity is regulated by cyclin A proteolysis and CDK inhibitors (CKIs) during M and G1 phases. Our previous work has shown that constitutive activation of cyclin A-CDK in mouse somatic cells, by ectopic expression of stabilized human cyclin A2...
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Related Articles2-Styryl-4-aminoquinazoline derivatives as potent DNA-cleavage, p53-activation and in vivo effective anticancer agents. Eur J Med Chem. 2019 Nov 12;:111851 Authors: Wei XW, Yuan JM, Huang WY, Chen NY, Li XJ, Pan CX, Mo DL, Su GF Abstract Forty-eight analogues of CP-31398, an antitumor agent modulated the mutant p53 gene were synthesized and their cytotoxicities against four cancer cell lines with different p-53 status including bladder...
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Related ArticlesDMSO impairs the transcriptional program for maternal-to-embryonic transition by altering histone acetylation. Biomaterials. 2019 Nov 14;:119604 Authors: Kang MH, You SY, Hong K, Kim JH Abstract Dimethyl sulfoxide (DMSO) is widely used in basic and clinical research, yet its toxicity and biocompatibility properties remain elusive. Here, we report that exposure of mouse zygotes to 2% DMSO perturbed the transcriptional program, critical...
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Related ArticlesActivation of β-catenin signaling and its cross talk with estrogen and histone deacetylases in human uterine fibroids. J Clin Endocrinol Metab. 2019 Nov 25;: Authors: Ali M, Shahin SM, Ali Sabri N, Al-Hendy A, Yang Q Abstract CONTEXT: Uterine Fibroid (UF) is the most common benign tumor in myometrium (MM) of reproductive age women. However, mechanism underlying disease pathogenesis is largely unknown. OBJECTIVE: To explore the...
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Related ArticlesProteostasis failure and cellular senescence in long-term cultured postmitotic rat neurons. Aging Cell. 2019 Nov 25;:e13071 Authors: Ishikawa S, Ishikawa F Abstract Cellular senescence, a stress-induced irreversible cell cycle arrest, has been defined for mitotic cells and is implicated in aging of replicative tissues. Age-related functional decline in the brain is often attributed to a failure of protein homeostasis (proteostasis), largely...
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Related Articlesα-Mangostin suppresses the de novo lipogenesis and enhances the chemotherapeutic response to gemcitabine in gallbladder carcinoma cells via targeting the AMPK/SREBP1 cascades. J Cell Mol Med. 2019 Nov 25;: Authors: Shi Y, Fan Y, Hu Y, Jing J, Wang C, Wu Y, Geng Q, Dong X, Li E, Dong D Abstract High rates of de novo lipid synthesis have been discovered in certain kinds of tumours, including gallbladder cancer (GBC). Unlike several other...
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Orostachys japonicus exerts antipancreatic cancer activity through induction of apoptosis and cell cycle arrest in PANC-1 cells. Food Sci Nutr. 2019 Nov;7(11):3549-3559 Authors: Kim JH, Nam GS, Kim SH, Ryu DS, Lee DS Abstract Targeted therapy at the molecular level is important for pancreatic cancer treatment. This study looked over the anticancer activity of Orostachys japonicus in a human pancreatic cancer cell line, PANC-1. An ethyl acetate fraction...
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Imidazo[2,1-b]thiazole-Coupled Natural Noscapine Derivatives as Anticancer Agents. ACS Omega. 2019 Nov 19;4(21):19382-19398 Authors: Nagireddy PKR, Kommalapati VK, Siva Krishna V, Sriram D, Tangutur AD, Kantevari S Abstract Noscapine, a phthalide isoquinoline alkaloid isolated from the opium poppy Papaver somniferum, is traditionally being used as an anticough drug. With a safe in vitro toxicological profile, noscapine and its analogues have been explored...
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Sox2+ cells in Sonic Hedgehog-subtype medulloblastoma resist p53-mediated cell-cycle arrest response and drive therapy-induced recurrence. Neurooncol Adv. 2019 May-Dec;1(1):vdz027 Authors: Treisman DM, Li Y, Pierce BR, Li C, Chervenak AP, Tomasek GJ, Lozano G, Zheng X, Kool M, Zhu Y Abstract Background: High-intensity therapy effectively treats most TP53 wild-type (TP53-WT) Sonic Hedgehog-subgroup medulloblastomas (SHH-MBs), but often cause long-term...
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Expression of Concern: The Role of the RACK1 Ortholog Cpc2p in Modulating Pheromone-Induced Cell Cycle Arrest in Fission Yeast. PLoS One. 2019;14(11):e0225013 Authors: PLOS ONE Editors PMID: 31765393 [PubMed - in process]
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Magnetic resonance imaging of mean cell size in human breast tumors. Magn Reson Med. 2019 Nov 25;: Authors: Xu J, Jiang X, Li H, Arlinghaus LR, McKinley ET, Devan SP, Hardy BM, Xie J, Kang H, Chakravarthy AB, Gore JC Abstract PURPOSE: Cell size is a fundamental characteristic of all tissues, and changes in cell size in cancer reflect tumor status and response to treatments, such as apoptosis and cell-cycle arrest. Unfortunately, cell size can currently...
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Brain-computer interface (BCI) researcher perspectives on neural data ownership and privacy. J Neural Eng. 2019 Nov 25;: Authors: Naufel SN, Klein E Abstract OBJECTIVE: BCI research and commercially available neural devices generate large amounts of neural data. These data have significant potential value to researchers and industry. Individuals from whose brains neural data derive may want to exert control over what happens to their neural data at study...
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Δύο γονίδια που φαίνεται ότι βοηθούν τα βλαστοκύτταρα του εντέρου στις καύσεις λίπους μπορεί να παίζουν σημαντικό ρόλο και στον καρκίνο του παχέος εντέρου σύμφωνα με νέα έρευνα του Πανεπιστημίου Rutgers. Η έρευνα που δημοσιεύθηκε στο Gastroenterology περιγράφει ένα νέο συσχετισμό ανάμεσα στον τρόπο που τα κύτταρα καταναλώνουν λίπος και εκείνον που τα γονίδια ρυθμίζουν την συμπεριφορά των βλαστοκυττάρων στα έντερα πειραματόζωων. «Πρόκειται για ένα ενδιαφέρον εύρημα επειδή οι επιστήμονες έδειξαν...
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Μία νέα έρευνα που δημοσιεύθηκε στο Journal of Neuropathology & Experimental Neurology εντόπισε ένα νέο γονίδιο το οποίο ενδέχεται να εξηγεί κατά ένα μεγάλο βαθμό τον γενετικό κίνδυνο ανάπτυξης της νόσου Αλτσχάιμερ. Η εμφάνιση της νόσου Αλτσχάιμερ σε προχωρημένη ηλικία, αποτελεί μία από τις πιο κοινές μορφές της νόσου. Αποτελεί μία εκφυλιστική νευρολογική πάθηση της οποίας δεν έχουν γίνει κατανοητές όλες οι πτυχές. Δυστυχώς, η περιπλοκότητα του ανθρώπινου γονιδιώματος και οι αδυναμίες προηγούμενων...
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Το ιχθυέλαιο ίσως να μπορεί να βοηθήσει τους ανθρώπους με καρδιακή ανεπάρκεια να αποφύγουν τις επαναλαμβανόμενες επισκέψεις στο νοσοκομείο, υποστηρίζει νέα μελέτη που δημοσιεύθηκε στο Circulation. Τα ευρήματα προέρχονται από την ανάλυση μιας κλινικής δοκιμής, κατά την οποία οι ερευνητές εξέτασαν την επίδραση του ιχθυελαίου και της βιταμίνης D στον κίνδυνο για καρδιακές παθήσεις και καρκίνο. Τα αποτελέσματα της δοκιμής ήταν ενθαρρυντικά, καθώς οι υγιείς ενήλικες μεγάλης ηλικίας που έλαβαν συμπληρώματα...
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Ένας άνθρωπος που μένει κοντά σε ένα πολυσύχναστο και πολύβουο δρόμο έχει έως και 10% μεγαλύτερο κίνδυνο εμφάνισης καρκίνου του πνεύμονα, ενώ τα παιδιά που μένουν λιγότερο από 50 μέτρα μακριά από πολυσύχναστους δρόμους έχουν 14% βραδύτερη ανάπτυξη των πνευμόνων τους, σύμφωνα με τα όσα δείχνει νέα επιστημονική μελέτη που πραγματοποιήθηκε από το Κολέγιο King’s στο Λονδίνο. Οι ερευνητές, μάλιστα, αναφέρουν ότι ο περιορισμός της ατμοσφαιρικής ρύπανσης κατά 1/5 στις πιο μεγάλες πόλεις της Αγγλίας θα...
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Νέα μελέτη που δημοσιεύεται στο Menopause δείχνει πως η σεξουαλική δυσλειτουργία αυξάνεται κατά σχεδόν 30% σε αυτή την περίοδο, ενώ η κολπική ξηρότητα συχνά έχει τη μεγαλύτερη επίδραση στην επιθυμία, τη διέγερση, τη λίπανση του κόλπου και γενικά στην ικανοποίηση. Υπάρχουν πολλοί και διάφοροι παράγοντες που μπορούν να επηρεάσουν αρνητικά τη σεξουαλική λειτουργία, συμπεριλαμβάνοντας την ψυχική και τη συναισθηματική κατάσταση, τη γήρανση, τα χρόνια ιατρικά προβλήματα και η κατάσταση της εμμηνόπαυσης....
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Related ArticlesManagement of Gorham Stout disease with skull-base defects: Case series of six children and literature review. Int J Pediatr Otorhinolaryngol. 2019 Sep;124:152-156 Authors: Simon F, Luscan R, Khonsari RH, Toubiana J, Belhous K, James S, Blauwblomme T, Zerah M, Denoyelle F, Donadieu J, Couloigner V Abstract BACKGROUND: Gorham-Stout disease (GSD) is a rare lymphatic disorder which results in bone destruction. Defects of the skull base...
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Related ArticlesLogistic Regression Analysis of Risk Factors for Intracranial Infection After Multiple Traumatic Craniotomy and Preventive Measures. J Craniofac Surg. 2019 Oct;30(7):1946-1948 Authors: Yao J, Liu D Abstract BACKGROUND AND OBJECTIVE: The aim of this study was to study the risk factors of intracranial infection after traumatic craniotomy in multiple trauma to provide references for clinical prevention and control of intracranial infection....
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Endoscopic Endonasal Repair of Spontaneous Cerebrospinal Fluid Leaks Using Multilayer Composite Graft and Vascularized Pedicled Nasoseptal Flap Technique. Allergy Rhinol (Providence). 2019 Jan-Dec;10:2152656719888622 Authors: Kim-Orden N, Shen J, Or M, Hur K, Zada G, Wrobel B Abstract Background: Endoscopic repair of cerebrospinal fluid (CSF) fistulas is a fundamental practice in anterior skull base surgery due to high success rates and low morbidity...
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Related ArticlesDelayed Dural Arteriovenous Fistula at the Transverse-Sigmoid Sinus Secondary to Petroclival Meningioma Surgery Via Far Lateral Approach. J Craniofac Surg. 2019 Oct;30(7):e583-e585 Authors: Xue X, Hou Y, Chen J, Yuan X, Sun G, Guo L Abstract Intracranial dural arteriovenous fistulas (DAVFs) are typified by pathological anastomoses between meningeal arteries and dural venous sinuses or cortical veins. There are many causes contributing...
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Functional and Aesthetic Outcomes of Extracorporeal Septoplasty: A Systematic Review and Meta-Analyses. Ann Otol Rhinol Laryngol. 2019 Nov 24;:3489419891450 Authors: Bresler A, Povolotskiy R, Nguyen B, Zuliani GF, Eloy JA, Paskhover B, Svider P Abstract OBJECTIVE: The safety and efficacy of extracorporeal septoplasty (ECS) has long been debated. Our objective was to determine this technique's functional and aesthetic outcomes and complications through...
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Primary Spheno-Petro-Clival Tuberculosis. Indian J Otolaryngol Head Neck Surg. 2019 Nov;71(Suppl 3):1796-1799 Authors: Verma H, Panda S, Sikka K, Irugu DVK, Thakar A Abstract The increase awareness and advent of anti-tuberculosis therapy led to decline in tuberculosis. Now a resurgence of tuberculosis is with immunosuppression and with resistant strains. The detection rate of extrapulmonary is increased with the advent of newer modalities of detection,...
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Radiological Study of the Ethmoidal Arteries in the Nasal Cavity and Its Pertinence to the Endoscopic Surgeon. Indian J Otolaryngol Head Neck Surg. 2019 Nov;71(Suppl 3):1994-1999 Authors: Kho JPY, Tang IP, Tan KS, Koa AJ, Prepageran N, Rajagopalan R Abstract We studied the ethmoidal arteries using preexisting computer tomography of the paranasal sinuses (CT PNS) and statistically scrutinized data obtained between genders. A descriptive study from 77...
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Sphenoid Mucocele: A Complication of Skull Base Reconstruction with Nasoseptal Flap-A Critical Review and Our Experience. Indian J Otolaryngol Head Neck Surg. 2019 Nov;71(Suppl 3):2151-2156 Authors: Janakiram TN, Karunasagar A Abstract The evolution of expanded endoscopic skull base surgery has enabled development of minimally invasive approaches for resection of large skull base tumors with the nasoseptal flap proving to be an indispensable tool in...
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Carotid body tumor resection utilizing a covered stent graft to enable resection of the tumor en bloc with the internal carotid artery. J Vasc Surg Cases Innov Tech. 2019 Dec;5(4):481-484 Authors: Alqaim M, Puri AS, Vaezi AE, Schanzer A Abstract Surgical excision is the primary treatment for carotid body tumors (CBT) and infrequently involves carotid vessels reconstruction. A CBT that extends distally to the level of the skull base makes surgical reconstruction...
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Rate of rhinosinusitis and sinus surgery following a minimally destructive approach to endoscopic transsphenoidal hypophysectomy. Int Forum Allergy Rhinol. 2019 Nov 25;: Authors: Rimmer RA, Vimawala S, Chitguppi C, Reilly EK, Graf AE, Fastenberg JH, Evans JJ, Rosen MR, Rabinowitz MR, Nyquist GG Abstract BACKGROUND: There remains considerable variation in the extent of sinonasal preservation during the approach for endoscopic transsphenoidal hypophysectomy...
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Paneth cell adenocarcinoma of the colon: A rare entity. Int J Surg Case Rep. 2019 Nov 04;65:313-316 Authors: Nihed A, Soumaya M, Atika B, Ilhem BJ, Atef BA, Fehmi H, Moncef M Abstract INTRODUCTION: Amongst the morphotypes of colorectal adenocarcinomas, the rich cell type of Paneth constitutes a rare histopathologic variant of adenocarcinoma, which can be observed all along the digestive tract but also in other organs such as the prostate or the breast....
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Long-term survival with stable disease after multidisciplinary treatment for synchronous liver metastases from gastric cancer: A case report. Int J Surg Case Rep. 2019 Aug 20;65:317-321 Authors: Shi W, Wang J, Zhang W, Shou T Abstract INTRODUCTION: The liver is one of the most common sites of hematogenous metastases of gastric cancer. The 5-year overall survival rate of synchronous liver metastases from gastric cancer was less than 27%. We report a rare...
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Publication date: Available online 26 November 2019Source: Journal of ProteomicsAuthor(s): Xiaochun Li, Hongbin Qiao, Fanglin Qin, Guifeng Cheng, Jinming Liu, Hao Li, Shaopeng Gu, Yamei JinAbstractIn schistosomiasis, eggs produced by bisexual infected mature female schistosome worms (FMS) are the main cause of pathological damage to the host and the dissemination of the disease. Single-sex infected female worms (FSS) cannot completely develop to sexual maturity or produce normal eggs. In this study,...
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Related ArticlesAngiographic Characterization of the External Carotid Artery: Special Attention to Variations in Branching Patterns. Tohoku J Exp Med. 2019;249(3):185-192 Authors: Yamamoto D, Koizumi H, Ishima D, Kuroda H, Shibahara I, Niki J, Miyasaka K, Watanabe T, Kondo R, Kumabe T Abstract Knowledge of branching patterns of external carotid artery (ECA) is essential for planning and execution of head and neck surgeries. Digital subtraction angiography...
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Related ArticlesMorning Mastication Enhances Postprandial Glucose Metabolism in Healthy Young Subjects. Tohoku J Exp Med. 2019;249(3):193-201 Authors: Sato A, Ohtsuka Y, Yamanaka Y Abstract Postprandial glucose concentration is dependent on the time of day and its concentration in the morning is lower than in the evening. However, whether it is dependent on mastication at different times of the day has not been studied before. We hypothesized that mastication...
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134 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: head and neck These pubmed results were generated on 2019/11/26PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
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Abstract Purpose of Review The infectious complications of transplantation can have devastating consequences for patients. Early and accurate diagnosis is essential to good outcomes. This review describes recent advances in pathogen-directed diagnostic testing and discusses the role of new methods for transplant infectious diseases. Recent Findings ...
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Abstract Purpose of Review Modern advances in oncologic and end-organ therapies have led to an increase in immunocompromised patients and a corresponding rise in acute invasive fungal sinusitis (AIFS). Here, we present a comprehensive medical and surgical approach to the diagnosis and management of immunocompromised cancer and transplant patients with AIFS. ...
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Related ArticlesImprovement of dose distribution in ocular brachytherapy with 125I seeds 20-mm COMS plaque followed to loading of choroidal tumor by gold nanoparticles. J Cancer Res Ther. 2019 Jul-Sep;15(3):504-511 Authors: Zabihzadeh M, Rezaee H, Hosseini SM, Feghhi M, Danyaei A, Hoseini-Ghahfarokhi M Abstract Aims and Objectives: Brachytherapy using removable ophthalmic plaques loaded with suitable small sealed radioactive seeds adjacent to the ocular's...
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Prolonged Response to Regorafenib in a Patient with Iodine Refractory Thyroid Cancer. Case Rep Oncol. 2019 Sep-Dec;12(3):791-795 Authors: Wong SK, Chu QSC, Spratlin JL, Sangha R, McEwan AJB, Morrish DW, Arndt D, Sergenson G, Cleton A, Huang F, Sawyer MB Abstract Thyroid cancer is the most common type of endocrine malignancy. Cornerstones of thyroid cancer treatment include surgery, radioactive iodine ablation, and thyroid stimulating hormone suppression....
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Chemical and biological studies of Re(I)/Tc(I) thiosemicarbazonate complexes relevant for the design of radiopharmaceuticals. J Inorg Biochem. 2019 Nov 11;203:110917 Authors: Argibay-Otero S, Gano L, Fernandes C, Paulo A, Carballo R, Vázquez-López EM Abstract Five thiosemicarbazones (H2Ln) derived from 4,6-diacetylresorcinol (n = 1-4) and salicylaldehyde (n = 5) have been synthesized and spectroscopically characterized. Single crystal X-ray diffraction...
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