[ 18 F]Fluciclatide PET as a biomarker of response to combination therapy of pazopanib and paclitaxel in platinum-resistant/refractory ovarian cancer

Abstract Background Angiogenesis is a driver of platinum resistance in ovarian cancer. We assessed the effect of combination pazopanib and paclitaxel followed by maintenance pazopanib in patients with platinum-resistant/refractory ovarian cancer. Integrins αvβ3 and αvβ5 are both upregulated in tumor-associated vasculature. [18F]Fluciclatide is a novel PET tracer that has high affinity for integrins αvβ3/5, and was used to assess the anti-angiogenic...

European Journal of Nuclear Medicine and Molecular Imaging

02:00

Spontaneous network activity <35 Hz accounts for variability in stimulus-induced gamma responses

Publication date: Available online 20 November 2019Source: NeuroImageAuthor(s): Jan Hirschmann, Sylvain Baillet, Mark Woolrich, Alfons Schnitzler, Diego Vidaurre, Esther FlorinAbstractGamma activity is thought to serve several cognitive processes, including attention and memory. Even for the simplest stimulus, the occurrence of gamma activity is highly variable, both within and between individuals. The sources of this variability, however, are largely unknown.In this paper, we address one possible...

NeuroImage

Wed Nov 20, 2019 18:44

In response to the letter “[¹¹C]raclopride and extrastriatal binding to D2/3 receptors”

Publication date: Available online 20 November 2019Source: NeuroImageAuthor(s): Jonas E. Svensson, Martin Schain, Pontus Plavén-Sigray, Simon Cervenka, Mikael Tiger, Magdalena Nord, Christer Halldin, Lars Farde, Johan Lundberg

NeuroImage

Wed Nov 20, 2019 18:44

Predicting response originality through brain activity: An analysis of changes in EEG alpha power during the generation of alternative ideas

Publication date: Available online 19 November 2019Source: NeuroImageAuthor(s): Sergio Agnoli, Marco Zanon, Serena Mastria, Alessio Avenanti, Giovanni Emanuele CorazzaAbstractGrowing neurophysiological evidence points to a role of alpha oscillations in divergent thinking (DT). In particular, studies have shown a consistent EEG alpha synchronization during performance on the Alternative Uses Task (AUT), a well-established DT task. However, there is a need for investigating the brain dynamics underlying...

NeuroImage

Wed Nov 20, 2019 18:44

MiR-6803-5p Promotes Cancer Cell Proliferation and Invasion via PTPRO/NF-κB Axis in Colorectal Cancer

Accumulated studies have implicated microRNAs (miRNAs) exert modifying effects on colorectal cancer (CRC). Protein tyrosine phosphatase, receptor type O (PTPRO) has been identified as a tumor suppressor in several kinds of cancer, including CRC. Previously, we have found that exosome-encapsulated miR-6803-5p is increased in CRC. However, the mechanism of miR-6803-5p in CRC is not clear yet. This study is aimed at elucidating the effect of miR-6803-5p in colorectal carcinogenesis. Expression of miR-6803-5p...

Mediators of Inflammation

Wed Nov 20, 2019 17:05

Detección de osteoma osteoide multicéntrico en hueso parietal y costilla mediante PET/TC con ¹⁸F-NaF

Publication date: Available online 19 November 2019Source: Revista Española de Medicina Nuclear e Imagen MolecularAuthor(s): H. Liu, Y. Zhao, Y. Xia, Z. Wang, Y. Chen

Revista Española de Medicina Nuclear e Imagen Molecular

Wed Nov 20, 2019 17:04

Dance Training Improves Cytokine Secretion and Viability of Neutrophils in Diabetic Patients

Background. Evidence suggests that exercise improves neutrophil function. The decreased functional longevity of neutrophils and their increased clearance from infectious sites contribute to the increased susceptibility to infection and severity of infection observed in patients with diabetes. Objective. Herein, we investigated the effects of a dance program on neutrophil number, function, and death in type 2 diabetes mellitus (T2DM) patients and healthy volunteers. Methods. Ten patients with T2DM...

Mediators of Inflammation

Wed Nov 20, 2019 12:05

CSF flow jet: novel CT myelogram finding of CSF leak through dural tear in traumatic pseudomeningocele

Publication date: Available online 20 November 2019Source: Clinical ImagingAuthor(s): Michael J. Lee, Remy Lobo, Brandon W. Smith, Lynda J.-S. Yang, Ashok SrinivasanAbstractDetermining the exact location of dural violation after traumatic pre-ganglionic (avulsion) injury of the brachial plexus with associated progressively enlarging pseudomeningocele is critical for treatment, but current imaging by MR and CT myelogram remains inadequate as there are often only indirect imaging features. We present...

Clinical Imaging

Wed Nov 20, 2019 12:50

Computed tomographic assessment of lean body mass in patients on selective androgen receptor modulator

Publication date: Available online 20 November 2019Source: Clinical ImagingAuthor(s): Richard Thomas, Atul B. Shinagare, Michael H. Rosenthal, Brandon Lee, Heather A. Jacene, Mary A. Johnston, Beth A. Overmoyer

Clinical Imaging

Wed Nov 20, 2019 12:50

Optimizing patient experience scores in outpatient breast centers

Publication date: Available online 20 November 2019Source: Clinical ImagingAuthor(s): Karen Gerlach, Kanchan Phalak, Jay R. ParikhAbstractHigh patient experience scores in outpatient radiology is a goal that impacts patient care and compliance. There are secondary positive effects on employee engagement and retention as well as reimbursement and increased market share. Effective administrative and physician leadership is critical in obtaining employee buy-in to the importance of customer experience....

Clinical Imaging

Wed Nov 20, 2019 12:50

Apparent diffusion coefficient value in breast papillary lesions without atypia at core needle biopsy

Publication date: Available online 20 November 2019Source: Clinical ImagingAuthor(s): Tagliati Corrado, Ercolani Paola, Marconi Elisabetta, Simonetti Barbara Franca, Giuseppetti Gian Marco, Giovagnoni AndreaAbstractPurposeThe main aim of the study was to assess if the mean apparent diffusion coefficient (ADC) value was significantly different between papillary lesions (PL) without atypia and PLs with atypical or malignant foci. A secondary objective was to evaluate if patients mean age, MRI BI-RADS®...

Clinical Imaging

Wed Nov 20, 2019 12:50