Publication date: Available online 26 November 2019Source: NeuroImageAuthor(s): Adriana L. Ruiz-Rizzo, Florian Beissner, Kathrin Finke, Hermann J. Müller, Claus Zimmer, Lorenzo Pasquini, Christian SorgAbstractIn mammals, the hippocampus, entorhinal, perirhinal, and parahippocampal cortices (i.e., core regions of the human medial temporal lobes, MTL) are locally interlaced with the adjacent amygdala nuclei at the structural and functional levels. At the global brain level, the human MTL has been described...
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Related ArticlesComparison of the longitudinal effects of persistent periodic breathing and apnoea on cerebral oxygenation in term- and preterm-born infants. J Physiol. 2018 12;596(23):6021-6031 Authors: Horne RSC, Sun S, Yiallourou SR, Fyfe KL, Odoi A, Wong FY Abstract KEY POINTS: Periodic breathing and apnoea were more common in preterm compared to age-matched term-born infants across the first 6 months after term-corrected age. Periodic breathing...
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Related ArticlesImpact of Lifestyle Modification on Atrial Fibrillation. Am J Cardiol. 2019 Oct 26;: Authors: Wingerter R, Steiger N, Burrows A, Estes NAM Abstract Atrial Fibrillation (AF) is the most common arrhythmia in adults, and the rapid increase in AF prevalence has been classified by experts as an epidemic. The mechanisms of AF are complex and incompletely understood. While many aspects of management are now based on high quality evidence, other...
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Related ArticlesAssociation between sleep disordered breathing and epigenetic age acceleration: Evidence from the Multi-Ethnic Study of Atherosclerosis. EBioMedicine. 2019 Nov 21;: Authors: Li X, Joehanes R, Hoeschele I, Rich SS, Rotter JI, Levy D, Liu Y, Redline S, Sofer T Abstract BACKGROUND: Sleep disordered breathing (SDB) is a common disorder that results in oxidative stress and inflammation and is associated with multiple age-related health outcomes....
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Evaluation of Liver Functions Based on Serum Aminotransferase Enzyme Levels in Patients with Obstructive Sleep Apnea Syndrome. Indian J Otolaryngol Head Neck Surg. 2019 Nov;71(Suppl 3):1679-1682 Authors: Atan D, Köseoğlu S, Özcan KM, İkincioğulları A, Topak AB, Özcan İ, Dere H Abstract Obstructive sleep apnea syndrome (OSAS) is associated with fatty liver disease. In the present study, relations between alanine aminotransferase (ALT) and aspartate aminotransferase...
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Nightly sleep apnea severity in patients with atrial fibrillation: Potential applications of long-term sleep apnea monitoring. Int J Cardiol Heart Vasc. 2019 Sep;24:100424 Authors: Linz D, Baumert M, Desteghe L, Kadhim K, Vernooy K, Kalman JM, Dobrev D, Arzt M, Sastry M, Crijns HJGM, Schotten U, Cowie MR, McEvoy RD, Heidbuchel H, Hendriks J, Sanders P, Lau DH Abstract In patients with atrial fibrillation (AF), the prevalence of moderate-to-severe sleep-disordered...
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Safety and cost of drug-induced sleep endoscopy outside the operating room. Laryngoscope. 2019 Nov 25;: Authors: Bergeron M, Lee DR, DeMarcantonio MA, Kandil A, Mahmoud MA, Fleck RJ, Ishman SL Abstract INTRODUCTION: Drug-induced sleep endoscopy (DISE) is used to assess site of obstruction for patients in a pharmacologically induced sleep-like state. It is traditionally performed in the operating room (OR), however, no data exists regarding the feasibility...
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Epidemiological Association Between Systemic Diseases and Keratoconus in a Korean Population: A 10-Year Nationwide Cohort Study. Cornea. 2019 Nov 21;: Authors: Lee HK, Jung EH, Cho BJ Abstract PURPOSE: To investigate the association of systemic diseases with keratoconus in the general Korean population. METHODS: This is a nationwide population-based retrospective cohort study using the Korean National Health Insurance Service-National Sample...
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Obstructive Sleep Apnea-Hypopnea Syndrome and Keratoconus: An Epiphenomenon Related to Sleep Position? Cornea. 2019 Nov 21;: Authors: Gatinel D, Galvis V, Tello A, Niño CA, Rey JJ, Camacho PA, Serrano SE PMID: 31764281 [PubMed - as supplied by publisher]
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Long-term complications of palate surgery: A multicenter study of 217 patients. Laryngoscope. 2019 Nov 25;: Authors: Pang KP, Vicini C, Montevecchi F, Piccin O, Chandra S, Yang HC, Agrawal V, Chung JCK, Chan YH, Pang SB, Pang KA, Pang EB, Rotenberg B Abstract OBJECTIVES/HYPOTHESIS: To investigate long-term complications of newer reconstructive palate surgery techniques. STUDY DESIGN: Retrospective case-series analysis. METHODS: Retrospective...
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Validation of fatty liver index and hepatic steatosis index for screening of non-alcoholic fatty liver disease in adults with obstructive sleep apnea hypopnea syndrome. Chin Med J (Engl). 2019 Nov 20;132(22):2670-2676 Authors: Chen LD, Huang JF, Chen QS, Lin GF, Zeng HX, Lin XF, Lin XJ, Lin L, Lin QC Abstract BACKGROUND: Obstructive sleep apnea hypopnea syndrome (OSAHS) is a contributing factor for non-alcoholic fatty liver disease (NAFLD). Non-invasive...
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Ultrasonographic evaluation of abdominal wall fat index, carotid intima-media thickness and plaque score in obstructive sleep apnea syndrome. Med Ultrason. 2019 Nov 24;21(4):422-426 Authors: Çetin N, Güneş Tatar İ, Yüceege M, Ergun O, Hekimoğlu B Abstract AIMS: Obstructive sleep apnea syndrome (OSAS) is strongly related with increased risk of cardiovascular diseases andvisceral obesity. Abdominal wall fat index (AFI) is an indicator of visceral fat accumulation...
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Publication date: Available online 25 November 2019Source: The Journal of Prosthetic DentistryAuthor(s): Ana Elisa Kauling, Jan-Frederik Güth, Kurt Erdelt, Daniel Edelhoff, Christine KeulAbstractStatement of problemSpeed sintering has been introduced to enable single-visit monolithic zirconia prostheses. However, the fit and fracture load of zirconia 3-unit monolithic fixed partial dentures (FPDs) after speed sintering are unknown.PurposeThe purpose of this in vitro study was to test the properties...
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Publication date: Available online 25 November 2019Source: The Journal of Prosthetic DentistryAuthor(s): Junying Li, Zhaozhao Chen, Bo Dong, Hom-Lay Wang, Haiyang YuAbstractA fully digital workflow for designing and manufacturing a splinted framework and a custom tray for the impression of multiple implants placed with guided surgery is described. This digital workflow protocol does not require extra visits after surgery to prepare for the definitive impression because of the use of preoperative...
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Publication date: Available online 25 November 2019Source: The Journal of Prosthetic DentistryAuthor(s): Chase S. Linsley, Pierre Chesnot, Kumar C. Shah, Benjamin M. Wu, James Park, Young R. SeoAbstractStatement of problemA nitinol sleeve that uses shape memory to rapidly unlock dental restorations from implant abutments has been developed to allow prosthesis removal for assessment and maintenance, and clinical treatment has been promising. However, objective studies that evaluate the wear and retention...
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Publication date: Available online 25 November 2019Source: The Journal of Prosthetic DentistryAuthor(s): Waseem Khalaila, Minaem Nasser, Zeev OrmianerAbstractStatement of problemAlthough the Periotest has been shown to provide reliable information about initial implant stability, whether Periotest values (PTVs) can be correlated with the stability of implants in function for several years is unclear.PurposeThe purpose of this prospective clinical study was to investigate implant stability by using...
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Publication date: Available online 25 November 2019Source: The Journal of Prosthetic DentistryAuthor(s): Chandur P.K. Wadhwani, Kwok-Hung ChungAbstractCustom castable abutments with metal bases can be waxed and cast. However, the devesting stage may damage the milled metal base when airborne-particle abrasion is used. This may affect the abutment-to-implant joint, as well as the screw seat. Either of these can result in an improper connection that may produce a negative effect on joint performance....
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Publication date: Available online 25 November 2019Source: The Journal of Prosthetic DentistryAuthor(s): Wei Liu, Xin Zhang, Hai Qing, Jian WangAbstractStatement of problemThe LOCATOR system has been widely used for 2-implant-retained mandibular overdentures (2-MOs), but the influence of different LOCATOR attachments on the stability of 2-MOs has not been assessed.PurposeThe purpose of this in vitro study was to investigate the stability of 2-MOs anchored by LOCATOR attachments with different retentive...
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Linking miR-138 and USP10-P53 signaling. Oncotarget. 2019 Nov 12;10(61):6541-6542 Authors: Cui R PMID: 31762935 [PubMed]
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Targeting phosphatases in cancer: suppression of many versus the ablation of one. Oncotarget. 2019 Nov 12;10(61):6543-6545 Authors: D'Arcy BM, Prakash A, Honkanen RE PMID: 31762936 [PubMed]
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Evaluation of a ConvitVax/anti-PD-1 combined immunotherapy for breast cancer treatment. Oncotarget. 2019 Nov 12;10(61):6546-6560 Authors: Godoy-Calderón MJ, González-Marcano E, Carballo J, Convit AF Abstract Breast cancer therapies using checkpoints alone have not been highly effective. Based on previous experiences using the ConvitVax, an autologous tumor cells/bacillus Calmette-Guérin (BCG)/formalin-based vaccine, in breast cancer and the potential...
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The growth of a xenograft breast cancer tumor model with engineered hyaluronan-accumulating stroma is dependent on hyaluronan and independent of CD44. Oncotarget. 2019 Nov 12;10(61):6561-6576 Authors: Zhao C, Thompson BJ, Chen K, Gao F, Blouw B, Marella M, Zimmerman S, Kimbler T, Garrovillo S, Bahn J, Huang L, Huang Z, Shepard HM, Rosengren S, Thanos CD, Maneval DC Abstract Hyaluronan accumulation in the tumor microenvironment is associated with poor...
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High expression of apoptosis protein (Api-5) in chemoresistant triple-negative breast cancers: an innovative target. Oncotarget. 2019 Nov 12;10(61):6577-6588 Authors: Bousquet G, Feugeas JP, Gu Y, Leboeuf C, Bouchtaoui ME, Lu H, Espié M, Janin A, Benedetto MD Abstract Anti-apoptotic protein-5 (API-5) is a survival protein interacting with the protein acinus, preventing its cleavage by caspase-3 and thus inhibiting apoptosis. We studied the effect of...
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The long non-coding RNA PCA3: an update of its functions and clinical applications as a biomarker in prostate cancer. Oncotarget. 2019 Nov 12;10(61):6589-6603 Authors: Lemos AEG, Matos ADR, Ferreira LB, Gimba ERP Abstract Prostate cancer antigen 3 (PCA3) is an overexpressed prostate long non-coding RNA (lncRNA), transcribed from an intronic region at the long arm of human chromosome 9q21-22. It has been described that PCA3 modulates prostate cancer (PCa)...
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Tumor mutational burden in lung cancer: a systematic literature review. Oncotarget. 2019 Nov 12;10(61):6604-6622 Authors: Willis C, Fiander M, Tran D, Korytowsky B, Thomas JM, Calderon F, Zyczynski TM, Brixner D, Stenehjem DD Abstract Purpose: To assess the association of tumor mutational burden (TMB) with clinical outcomes, other biomarkers and patient/disease characteristics in patients receiving therapy for lung cancer. Results: In total, 4,303 publications...
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The multifaceted anti-cancer effects of BRAF-inhibitors. Oncotarget. 2019 Nov 12;10(61):6623-6640 Authors: Croce L, Coperchini F, Magri F, Chiovato L, Rotondi M Abstract The BRAF gene is commonly involved in normal processes of cell growth and differentiation. The BRAF (V600E) mutation is found in several human cancer, causing an increase of cell proliferation due to a modification of the ERK/MAPK-signal cascade. In particular, BRAFV600E mutation is...
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Correction: The combination effect of homoharringtonine and ibrutinib on FLT3-ITD mutant acute myeloid leukemia. Oncotarget. 2019 Nov 12;10(61):6641-6642 Authors: Li X, Yin X, Wang H, Huang J, Yu M, Ma Z, Li C, Zhou Y, Yan X, Huang S, Jin J Abstract [This corrects the article DOI: 10.18632/oncotarget.14463.].PMID: 31762943 [PubMed - in process]
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Correction: Metabolic pathway for the universal fluorescent recognition of tumor cells. Oncotarget. 2019 Nov 12;10(61):6643 Authors: Fernandez-Carrascal A, Garcia-Algar M, Nazarenus M, Torres-Nuñez A, Guerrini L, Feliu N, Parak WJ, Garcia-Rico E, Alvarez-Puebla RA Abstract [This corrects the article DOI: 10.18632/oncotarget.18551.].PMID: 31762944 [PubMed - in process]
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Correction: Aspartate β-hydroxylase expression promotes a malignant pancreatic cellular phenotype. Oncotarget. 2019 Nov 12;10(61):6644-6646 Authors: Dong X, Lin Q, Aihara A, Li Y, Huang CK, Chung W, Tang Q, Chen X, Carlson R, Nadolny C, Gabriel G, Olsen M, Wands JR Abstract [This corrects the article DOI: 10.18632/oncotarget.2840.].PMID: 31762945 [PubMed - in process]
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Dating population divergence within species from molecular data and relating such dating to climatic and biogeographic changes is not trivial. Yet it can help formulating evolutionary hypotheses regarding local adaptation and future responses to changing environments. Key issues include statistical selection of a demographic and historical scenario among a set of possible scenarios, and estimation of the parameter(s) of interest under the chosen scenario. Such inferences greatly benefit from new...
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Mutation is the ultimate source of all genetic novelty and the cause of heritable genetic disorders. Mutational burden has been linked to complex disease, including neurodevelopmental disorders such as schizophrenia and autism. The rate of mutation is a fundamental genomic parameter and direct estimates of this parameter have been enabled by accurate comparisons of whole-genome sequences between parents and offspring. Studies in humans have revealed that the paternal age at conception explains most...
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Related ArticlesA Unique Case of Non-Cardiac Chest Pain Caused by Mepolizumab: Case Report and Review of the Literature. J Neurogastroenterol Motil. 2019 Nov 25;: Authors: Korbitz PM, Gallagher JP, Md NB, Md WM PMID: 31760716 [PubMed - as supplied by publisher]
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Standardized and Scalable Assay to Study Perfused 3D Angiogenic Sprouting of iPSC-derived Endothelial Cells In Vitro. J Vis Exp. 2019 Nov 06;(153): Authors: van Duinen V, Stam W, Borgdorff V, Reijerkerk A, Orlova V, Vulto P, Hankemeier T, van Zonneveld AJ Abstract Pre-clinical drug research of vascular diseases requires in vitro models of vasculature that are amendable to high-throughput screening. However, current in vitro screening models that have...
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O-cresol Concentration Online Measurement Based On Near Infrared Spectroscopy Via Partial Least Square Regression. J Vis Exp. 2019 Nov 08;(153): Authors: Chen Z, Zheng N, Luan X, Liu F Abstract Unlike macroscopic process variables, near-infrared spectroscopy provides process information at the molecular level and can significantly improve the prediction of the components in industrial processes. The ability to record spectra for solid and liquid samples...
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Expression and Purification of Nuclease-Free Oxygen Scavenger Protocatechuate 3,4-Dioxygenase. J Vis Exp. 2019 Nov 08;(153): Authors: Messer RK, Lopez MA, Senavirathne G, Yoder KE Abstract Single molecule (SM) microscopy is used in the study of dynamic molecular interactions of fluorophore labeled biomolecules in real time. However, fluorophores are prone to loss of signal via photobleaching by dissolved oxygen (O2). To prevent photobleaching and extend...
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CO2-Lasertonsillotomy Under Local Anesthesia in Adults. J Vis Exp. 2019 Nov 06;(153): Authors: Wong Chung JERE, van Helmond N, van Geet R, van Benthem PPG, Blom HM Abstract Tonsil-related complaints are very common among the adult population. Tonsillectomy under general anesthesia is currently the most performed surgical treatment in adults for such complaints. Unfortunately, tonsillectomy is an invasive treatment associated with a high complication...
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Preparing a Celadonite Electron Source and Estimating Its Brightness. J Vis Exp. 2019 Nov 05;(153): Authors: Salançon E, Degiovanni A, Lapena L, Morin R Abstract The electron celadonite source described here performs well in a low-energy electron point-source projection microscope in long-range imaging. It presents major advantages compared to sharp metal tips. Its robustness affords a lifetime of months and it can be used under relatively high pressure....
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Desensitization and Recovery of Crayfish Photoreceptors Upon Delivery of a Light Stimulus. J Vis Exp. 2019 Nov 09;(153): Authors: Barriga-Montoya C, de la O-Martínez A, Picones A, Hernández-Cruz A, Fuentes-Pardo B, Gómez-Lagunas F Abstract A method to study desensitization and recovery of crayfish photoreceptors is presented. We performed intracellular electrical recordings of photoreceptor cells in isolated eyestalks using the discontinuous single electrode-switched...
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Lab-on-a-CD Platform for Generating Multicellular Three-dimensional Spheroids. J Vis Exp. 2019 Nov 07;(153): Authors: Kim D, Lee GH, Park J, Lee JC, Park JY Abstract A three-dimensional spheroid cell culture can obtain more useful results in cell experiments because it can better simulate cell microenvironments of the living body than two-dimensional cell culture. In this study, we fabricated an electrical motor-driven lab-on-a-CD (compact disc) platform,...
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