Abstract Immune checkpoint blockade has demonstrated significant anti-tumor immunity in an array of cancer types, yet the underlying regulatory mechanism of it is still obscure, and many problems remain to be solved. As an inhibitory costimulatory signal of T-cells, the programmed cell death 1 (PD-1)/programmed cell death ligand 1 (PD-L1) pathway can paralyze T-cells at the tumor site, enabling the immune escape of tumor cells. Although many antibodies targeting PD-1/PD-L1 have...
Wed Nov 20, 2019 02:00
Abstract Oral squamous cell carcinoma (OSCC) accounts for more than 90% of all oral cancers and has been listed as sixth most common human cancer. Due to late diagnosis and insufficient therapeutic response among patients, the survival rate remains very low accentuating the importance of early diagnostic markers. The study aimed to identify differentially expressed proteins in search for putative serum biomarkers and drug targets. Serum samples (n = 45) were depleted and resolved...
Wed Nov 20, 2019 02:00
Abstract Previous studies indicated that cyclin D1 shown the potential as a tumor biomarker. However, the prognostic value of cyclin D1 in renal cell carcinoma (RCC) remains controversial. This study investigated the correlation of cyclin D1 expression with the prognostic and clinicopathological features in RCC patients. We systematically searched the database of PubMed, Embase, Cochrane, and Web of Science updated on November 26, 2017. Eighteen studies with 2282 patients satisfied...
Wed Nov 20, 2019 02:00
Abstract Purpose Although local inflammatory response (LIR) is a reliable survival marker in colon cancers (CCs), there is no consensus on its use in daily practice. We investigated the prognostic value of LIR in a highly homogeneous population with a well-designed methodology. Methods Eighty stage-IIB CC patients operated between 2002 and 2012 were included...
Wed Nov 20, 2019 02:00
Background Fine‐needle aspiration (FNA), a minimally invasive and cost‐effective procedure, often is used in the initial diagnosis of thymic lesions. However, the diagnosis can be challenging. Knowledge of the diagnostic pitfalls is important to improve diagnostic accuracy. Methods The authors retrospectively searched the pathology database of The University of Texas MD Anderson Cancer Center for FNA cases using the keywords “thymoma” or “thymic” in cytologic diagnoses or in corresponding...
Tue Nov 19, 2019 16:13
Tue Nov 19, 2019 16:10
Background Basaloid salivary gland neoplasms (BSNs), which include benign primary tumors and primary or metastatic malignancies, show overlapping morphology in fine‐needle aspiration (FNA). The Milan system recommends assigning a grade (low or high) to malignant salivary neoplasms because of the impact on surgical planning. This study investigated cytomorphologic features of BSNs on FNA that would help to favor a high‐grade malignancy over a low‐grade malignancy or a benign tumor. Methods Two...
Tue Nov 19, 2019 16:09
A schematic diagram of the approximate intracranial relationships between the facial, glossopharyngeal and vagus nerves. Abstract The array of end organ innervations of the vagus nerve, coupled with increased basic science evidence, has led to vagus nerve stimulation (VNS) being explored as a management option in a number of clinical disorders, such as heart failure, migraine and inflammatory bowel disease. Both invasive (surgically implanted) and non‐invasive (transcutaneous) techniques...
Tue Nov 19, 2019 18:34
Publication date: Available online 19 November 2019Source: Pathology - Research and PracticeAuthor(s): Thitsamay Luangxay, Tomo Osako, Rika Yonekura, Yoshiya Sugiura, Mari Kikuchi, Naoya Gomi, Takayuki Ueno, Shinji Ohno, Rikuo Machinami, Kengo Takeuchi, Futoshi AkiyamaAbstractGiant cell tumors of soft tissue (GCT-ST) arising in the breast are extremely rare. We report a unique case of breast GCT-ST coincident with ductal carcinoma in situ (DCIS), diagnosed with histological, immunohistochemical,...
Wed Nov 20, 2019 12:16
Abstract Pseudoglandular schwannoma (PGS) is a rare morphological variant of benign schwannoma. PGS is quite distinct from the somewhat better characterized glandular schwannoma variant. PGS is characterized by the presence of gland‐like structures lined with pseudocolumnar or cuboidal‐like neoplastic Schwann cells lining variably sized cystic space cells. Herein, we describe a rare case of PGS in a 17‐year‐old adolescent boy with a neck mass 8.5 cm in diameter present for 2 years with a recent...
Tue Nov 19, 2019 20:57
Introduction Knowledge of the anatomy of the male pelvic floor is important to avoid damaging the pelvic floor muscles during surgery. We set out to explore the structure and innervation of the smooth muscle of the whole pelvic floor using male fetuses. Material and Methods We removed en‐bloc the entire pelvis of three male fetuses. The specimens were serially sectioned before being stained with Masson's trichrome and hematoxylin and eosin, and immunostained for smooth muscles, and somatic,...
Tue Nov 19, 2019 21:16
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