Ocular allergy (OA), interchangeably known as allergic conjunctivitis, is a common immunological hypersensitivity disorder affecting up to 40% of the population. OA has been increasing in frequency with symptoms of itching, redness, and swelling that significantly impacts an individual’s quality of life (QOL). OA is an often underdiagnosed and under-treated health problem as only 10% of patients with OA symptoms seek medical attention while the majority of patients manage with over the counter medications...
Wed Nov 20, 2019 02:00
The immunoglobulin G4 (IgG4) is the least abundant serum IgG subclass in humans1,2. Like IgE, IgG4 synthesis is dependent on Th2 cell activation; unlike IgE, however, IgG4 does not play a role in allergic sensitization but rather in tolerance1,2. Specific serum IgG4 is commonly used as marker of tolerance in allergic disease, particularly after immunotherapy2,3. Few studies have investigated the distribution of total serum IgG4 concentrations4–6. Recently, much attention has been given to serum IgG4...
Wed Nov 20, 2019 02:00
Tue Nov 19, 2019 16:28
Background A randomized controlled trial was held to compare nonabsorbable packs to steroid‐eluting absorbable stents as middle meatal spacers after endoscopic sinus surgery in patients with chronic rhinosinusitis (CRS). Methods CRS patients were randomly assigned to receive either nonabsorbable Merocel packs wrapped in non‐latex glove material (packing type A) or Propel steroid eluting stents (packing type B). Twenty‐two–item Sino‐Nasal Outcome Test (SNOT‐22) scores were collected preoperatively...
Tue Nov 19, 2019 16:18
Publication date: Available online 19 November 2019Source: Journal of Allergy and Clinical ImmunologyAuthor(s): Katherine E. Lowe, Kathryn E. Mansfield, Antonella Delmestri, Liam Smeeth, Amanda Roberts, Katrina Abuabara, Daniel Prieto-Alhambra, Sinéad M. LanganBackgroundLimited evidence suggests increased fracture risk in people with atopic eczema. Any link could have substantial effect; atopic eczema is common, and fractures have associated morbidity and mortality.ObjectiveWe sought to examine whether...
Wed Nov 20, 2019 17:08
Publication date: Available online 19 November 2019Source: Journal of Allergy and Clinical ImmunologyAuthor(s): Shuli Li, Pan Kang, Weigang Zhang, Zhe Jian, Qian Zhang, Xiuli Yi, Sen Guo, Weinan Guo, Qiong Shi, Bing Li, Yuanmin He, Pu Song, Ling Liu, Kai Li, Gang Wang, Tianwen Gao, Chunying LiAbstractBackgroundKeratinocytes can function as innate immune cells under oxidative stress and aggravate cutaneous T cell response that undermines melanocytes in vitiligo. The NLR family pyrin domain containing...
Wed Nov 20, 2019 17:08
Publication date: Available online 20 November 2019Source: Annals of Allergy, Asthma & ImmunologyAuthor(s): Iago Carballo, Bernardo Sopeña, Mayka Freire, Carmen Vidal, Arturo Gonzalez-Quintela
Wed Nov 20, 2019 16:33
Abstract Allergen cross‐reactivities occur when IgE antibodies, originally raised against a specific allergen, bind to identical or highly similar surface areas of another related allergen. It is a commonly held view that cross‐reactivity requires more than 70% sequence identity, while proteins that share less than 50% sequence identity are rarely cross‐reactive. This also implies that cross‐reactive proteins have a similar 3D fold and belong to the same protein family. At first, the existence of...
Wed Nov 20, 2019 11:00
Abstract Diagnosis in suspected hypersensitivity reactions to non‐steroidal anti‐inflammatory drugs (NSAIDs) is complex as different mechanisms are involved: specific (selective responders, SRs) and non‐specific immunologically mediated (cross‐intolerants, CIs) (1‐3) (Table 1).
Tue Nov 19, 2019 15:58
Abstract The respiratory epithelium of the upper airways is a first‐line defense against inhaled irritants, pathogens and allergens. It ensures a physical barrier provided by apical junctions and mucociliary clearance to avoid excessive activation of the immune system. The epithelium also forms a chemical and immunological barrier, extensively equipped to protect the airways against external aggressions before the adaptive immune system is required. Under normal circumstances, the epithelium is...
Wed Nov 20, 2019 11:52
Abstract Objective While chronic inflammation is a well‐established risk factor for malignancy, studies evaluating the relationship between allergic inflammation and cancer have revealed conflicting results. Here, we aimed to assess the association between allergic inflammation in the lung (asthma), skin (eczema) or esophagus (eosinophilic esophagitis; EoE) and cancer at the organ site. Design We conducted a systematic review of the literature to identify observational studies (case‐control,...
Tue Nov 19, 2019 18:49
Abstract Background Allergic sensitization to storage mites has mostly been related to occupational exposures like farming, grain/cattle handling, whereas for non‐occupational settings, storage mite sensitization has been attributed to cross‐reactivity with house dust mite (HDM) allergens. Objective we aimed to describe the prevalence of allergic sensitization to storage mites, co‐sensitization to HDM allergens and respiratory symptoms in Denmark, Iceland, Norway and Sweden. Methods...
Tue Nov 19, 2019 18:41
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