Edentulous left maxillary ridge ulcerative swelling Publication date: Available online 28 November 2019 Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology Author(s): Chih-Huang Tseng, Chang-Wei Su, Ching-Yi Chen, Wen-Chen Wang, Yuk-Kwan Chen

Recurrent oral erythema multiforme: a case series report and review of the literature Publication date: Available online 28 November 2019 Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology Author(s): Yuqi Du, Fei Wang, Tiannan Liu, Xin Jin, Hang Zhao, Qianming Chen, Xin Zeng Abstract Recurrent oral erythema multiforme (ROEM) is now accepted as a less-recognized sub-type of erythema multiforme (EM). The diagnosis is based on the exclusion of other similar diseases, typical clinical features such as recurrent irregular painful erosions of oral mucosa without skin lesions and frequently evidence of past herpes simplex virus infection. Here we report three cases diagnosed as ROEM according to the three above characteristics. In addition, the article reviews the epidemiology, etiology, clinical manifestations, basis for diagnosis and treatment of ROEM and highlights the need for prophylaxis.

Dose reduction in head and neck organs through shielding and application of different scanning parameters in CBCT: an effective dose study using an adult male anthropomorphic phantom Publication date: Available online 28 November 2019 Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology Author(s): Diana Attaia, Stephanie Ting, Brandon Johnson, Mohamed I Masoud, Shaimaa Abu el Sadat, Mona Abu El Fotouh, Bernard Friedland Abstract Objectives : To determine the effect of shielding and scanning parameters on radiation dose reduction to head and neck organs in cone beam computed tomography. Study Design : An anthropomorphic phantom and optically stimulated luminescent dosimeters were used to calculate the changes in effective or equivalent doses to 9 anatomic structures with the addition of a thyroid collar, radiation safety glasses, and a radiation safety cap, using different scanning protocols on a CS 9300 CBCT unit. Results : The thyroid collar alone yielded dose reductions of 46% to the thyroid gland and at least 38% to the esophagus, but no more than 12% to the salivary glands. The radiation safety cap significantly reduced doses to the brain and pituitary gland. Full shielding resulted in dose reductions of at least 50% in the thyroid gland, at least 47% in the esophagus, and approximately 35% in the brain and pituitary gland. Significant dose reductions were recorded for all tissues with the “low dose” setting compared to the standard setting. Conclusion : Increased protection of head and neck organs can be achieved using various forms of shielding in CBCT imaging, with selection of the most appropriate scanning parameters based on the purpose of examination.

Mandible handling in surgical treatment of oral squamous cell carcinoma (OSCC): lessons from clinical results after marginal and segmental mandibulectomy Publication date: Available online 27 November 2019 Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology Author(s): Christoph K Sproll, Henrik Holtmann, Lara K Schorn, Theresa M Jansen, Julia Reifenberger, Inga Boeck, Majeed Rana, Norbert R Kübler, Julian Lommen Abstract Objective Aim of this retrospective single center study was the analysis of long-term results after marginal and segmental mandibulectomies in oral squamous cell carcinoma (OSCC) patients. Study design 259 patients treated for OSCC using a mandibulectomy between 1996 and 2010. Data acquisition consisted of analysis of operation reports, reevaluation of histological bone specimens and collection of clinical follow-up data. Results 86.5 % of patients received segmental and 13.5 % marginal mandibulectomies. Patients receiving segmental mandibulectomy generally displayed a higher TNM-stage. 47 % of segmental and 14 % of marginal mandibulectomies showed bone infiltration (pT4a). Of all patients with bone infiltration 49 % showed an invasive and 35 % an erosive histological infiltration pattern. We found healthy residual crestal bone height in 43 % of all segmental mandibulectomies. Merely 8 % of all patients were prosthodontically rehabilitated. Regarding prognostic parameters there was no significant difference between patients receiving marginal and segmental mandibulectomies. Conclusion Since healthy residual crestal bone height was found in 43 % of all segmental mandibulectomies it is conceivable that a huge amount of patients would profit from marginal mandibulectomy at least in cases of absent or erosive bone infiltration pattern since the residual crestal bone is functionally stable.

“Changes of the condylar position after modified disk repositioning: a retrospective study based on magnetic resonance imaging” Publication date: Available online 27 November 2019 Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology Author(s):

Relationship between anxiety, quality of life, and sociodemographic characteristics and temporomandibular disorder Publication date: Available online 26 November 2019 Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology Author(s): Camila Maria Bastos Machado de Resende, Laura Géssica Dantas da Silva Rocha, Raissa Pinheiro de Paiva, Camila da Silva Cavalcanti, Erika Oliveira de Almeida, Angelo Giuseppe Roncalli, Gustavo Augusto Seabra Barbosa Objectives The aim of this study was to evaluate the relationship between anxiety, quality of life (QL), and sociodemographic aspects and temporomandibular disorders (TMDs) and to assess the predisposition to TMDs in patients with low QL and anxiety. Study Design In total, 120 patients (60 TMD/60 non-TMD) were screened to assess QL (World Health Organization Quality of Life Brief Version [WHOQOL]); anxiety (Beck Anxiety Inventory [BAI]; the State-Trait Anxiety Inventory[STAI-S and -T]; the Hospital Anxiety and Depression Scale [HADS]); and TMD (Research Diagnostic Criteria for Temporomandibular Disorders-RDC/TMD). Pearson's χ2 test, the Student t test, odds ratio (OR) analysis, and nonconditional logistic regression analysis were performed. Results Among patients with TMD, 60% were women (P = .002), 65.1% were single (P = .009), and 71.4% were employed (P = .008). Most of the anxious individuals had TMD, according to HADS, 75% (P < .001); STAI-S, 55.6% (P = .035); STAI-T, 54.9% (P = .011); and BAI, 63.9% (P = .002). WHOQOL showed higher QL for non-TMD participants (P < .001). Sociodemographic data showed an association with TMD: gender (OR = 3.5), professional status (OR = 3.3), and marital status (OR = 2.8). WHOQOL presented higher association strength (OR = 9.2), followed by HADS (OR = 5.0). Conclusions A relationship exists between sociodemographic aspects, anxiety, and QL and TMD. Patients with TMD have higher anxiety levels and lower QL, and this can interfere with treatment, reinforcing the need for therapies that consider the various factors of the disorder.

Application of diffusion-weighted magnetic resonance imaging in the diagnosis of odontogenic lesions: a systematic review Publication date: Available online 22 November 2019 Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology Author(s): Luciana Munhoz, Danielle Ayumi Nishimura, Miki Hisatomi, Yoshinobu Yanagi, Junich Asaumi, Emiko Saito Arita ABSTRACT Objectives This systematic literature review addresses the use of diffusion-weighted magnetic resonance imaging (DWI) and apparent diffusion coefficient (ADC) for the evaluation of benign maxillomandibular odontogenic lesions. Study Design Databases were searched and original research studies or case report manuscripts up to April 2019 were included using the keyword "diffusion" combined with the keywords “maxillofacial pathology”, “oral pathology”, “odontogenic tumors”, “dental tissue neoplasms”, “odontogenic cysts”, and the histological denomination of benign odontogenic lesions according to the World Health Organization classification. Only English language manuscripts and studies pertaining to DWI were selected. Results Fifteen investigations (11 original articles and 4 case reports) regarding distinct benign odontogenic lesions were included. Most studies did not include exclusively odontogenic lesions in their samples. Conclusions It is too early to reach a conclusion that DWI and ADC can provide useful information in the differentiation of the histological type of some benign odontogenic lesions based on the available data in the literature.

Evaluation of P16 as a surrogate marker for transcriptionally active HPV status of Oropharyngeal Squamous Cell Carcinoma in an eastern Chinese population Publication date: Available online 21 November 2019 Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology Author(s): Shengming Xu, Bao Sun, Rong Zhou, Chaoji Shi, Yong Han, Jiayi Li, Jingjing Sun, Zhen Tian, Zhiyuan Zhang, Jiang Li Abstract Objectives: To characterize the clinicopathological features of Oropharyngeal Squamous Cell Carcinoma (OPSCC) patients from an eastern Chinese population and evaluate the diagnostic validity of P16 immunochemistry (IHC) for HPV status detection in OPSCC. Study Design: A total of 257 paraffin-embedded primary OPSCC specimens were collected from 2014 to 2019. HPV RNA In-Situ-Hybridization (ISH) was conducted as the gold standard for the detection of transcriptionally active HPV status and HPV DNA PCR, P16 IHC, next-generation-sequencing for TP53 exons were also performed and analyzed for comparison. Results: The overall HPV infection rate was 18.29% (47/257) and the TP53 mutation frequency was 13.16% (5/38) and 94.74% (18/19) in HPV-positive and HPV-negative OPSCC patients respectively (P<0.001). P16 IHC had the worst diagnostic ability and prognosis prediction value (Disease-specific-survival, DSS, P=0.405) when compared with HPV DNA PCR as well as combination of P16 IHC and HPV DNA PCR. However, the diagnostic ability of P16 IHC was better in OPSCC without tobacco or alcohol exposure. Conclusion: Solitary P16 IHC is insufficient for HPV status detection for OPSCC patients with tobacco and/or alcohol exposure but perform better for those without exposure, and additional HPV DNA specific testing may be necessary for accurate HPV status determination.

A SOLITARY, RED, PAPILLARY-VERRUCOUS LESION ON THE MANDIBULAR ALVEOLAR MUCOSA Publication date: Available online 15 November 2019 Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology Author(s): Konstantinos I. Tosios, Eleni-Marina Kalogirou, Nikolaos G. Nikitakis

Application of a fully deep convolutional neural network to the automation of tooth segmentation on panoramic radiographs Publication date: Available online 15 November 2019 Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology Author(s): Jeong-Hee Lee, Sang-Sun Han, Young Hyun Kim, Chena Lee, Inhyeok Kim Abstract Objectives To evaluate a fully deep learning mask region-based convolutional neural network (R-CNN) method for automated tooth segmentation using individual annotation of panoramic radiographs. Materials and Methods In total, 846 images with tooth annotations from 30 panoramic radiographs were used for training, and 20 panoramic images as the validation and test sets. An oral radiologist manually performed individual tooth annotation on the panoramic radiographs to generate the ground truth of each tooth structure. We used the augmentation technique to reduce overfitting and obtained 1024 training samples from 846 original data points. A fully deep learning method using the mask R-CNN model was implemented through a fine-tuning process to detect and localize the tooth structures. For performance evaluation, the F1-score, mean intersection over union (IoU), and visual analysis were utilized. Results The proposed method produced an F1-score of 0.875 (precision: 0.858, recall: 0.893) and a mean IoU of 0.877. A visual evaluation of the segmentation method showed a close resemblance to the ground truth. Conclusion The method achieved high performance for automation of tooth segmentation on dental panoramic images. The proposed method might be applied in the first step of diagnosis automation and in forensic identification, which involves similar segmentation tasks.