Related ArticlesHemangiopericytoma of supraglottis: A rare case report and review of literature. J Cancer Res Ther. 2019 Jul-Sep;15(3):729-732 Authors: Kendre P, Kataria P, Patel AA, Gaurav L, Dalsaniya S Abstract In 1942, Stout and Murray first used the term hemangiopericytoma to describe a tumor which is distinguished histologically from other types of vascular neoplasm characterized by proliferation of pericytes. It is a rare neoplasm that was originally...
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Related ArticlesRare case of an angiectatic sinonasal polyp feigning malignancy. J Cancer Res Ther. 2019 Jul-Sep;15(3):733-736 Authors: Guntur S, Shenoy VS, Kshithi K, Domah HA, Chaithra GV Abstract Angiectatic sinonasal polyps are uncommon. However, riveting nature of this polyp lies in its clinical presentation mimicking a neoplasm. It is radiologically very challenging to pick up this lesion in spite of its characteristic findings on imaging. Histopathology...
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Related ArticlesSynchronous double malignancy of lip and submandibular salivary gland with rare histology. J Cancer Res Ther. 2019 Jul-Sep;15(3):737-738 Authors: Darlington CD, Joseph SC, Anitha GFS Abstract In the modern era, there is an increase in the incidence of double malignancies owing to the remarkable improvement in cancer diagnostics and patient survival. Double malignancies can be either synchronous or metachronous. Synchronous double malignancy...
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Related ArticlesCase report of parathyroid carcinoma in a pediatric patient. Int J Pediatr Otorhinolaryngol. 2019 Sep;124:120-123 Authors: Zivaljevic VR, Jovanovic MD, Djordjevic MS, Diklic AD, Paunovic IR Abstract Parathyroid carcinoma is extremely rare in pediatric population. The authors report a case of 15-year-old girl with extremely elevated serum calcium (4.1 mmol/L) and parathyroid hormone (1170 pg/mL), with palpable neck mass. After en bloc...
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Related ArticlesRapidly progressing myofibroma of the gingiva - a rare occurrence. Br J Oral Maxillofac Surg. 2019 09;57(7):707-708 Authors: Srinivasan B, Al-Asaadi Z, Anand R, Brennan PA PMID: 31208789 [PubMed - indexed for MEDLINE]
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Related ArticlesMedulloblastomas in cerebellopontine angle: Epidemiology, clinical manifestations, imaging features, molecular analysis and surgical outcome. J Clin Neurosci. 2019 Sep;67:93-98 Authors: Xia H, Zhong D, Wu X, Li J, Yang Y, Sun X Abstract Cerebellopontine angle (CPA) medulloblastoma is rare and short of system description. We attempted to clarify its epidemiology, clinical manifestations, imaging features, pathological and molecular types,...
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Related ArticlesCutaneous Bone Formation Associated With Melanocytic Nevus. J Craniofac Surg. 2019 Oct;30(7):e688-e691 Authors: Erinanc H, Turk E Abstract AIM: Cutaneous bone formation is an uncommon lesion of the skin. It may be primary or secondary. Secondary lesions are mostly associated with melanocytic nevi. Although many different theories have been proposed to explain the etiology, extraskeletal bone formation is complex and poorly understood...
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Related ArticlesProspective observation of Clostridium histolyticum collagenase for the treatment of Dupuytren's disease in 788 patients: the Austrian register. Arch Orthop Trauma Surg. 2019 Sep;139(9):1315-1321 Authors: Rohit A, Peter A, Paul A, Anja B, Christian D, Renate D, Stefan G, Dietmar H, Johannes J, Peter K, Marco K, Martin L, Maximilian N, Christoph P, Gernot S, Gerald S, Tobias S, Matthias W, Armin Z, Markus G Abstract INTRODUCTION: Since...
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Related ArticlesGiant Cell Tumor of Soft Tissue: A Rare Entity. Orthopedics. 2019 Jul 01;42(4):e364-e369 Authors: Mavrogenis AF, Tsukamoto S, Antoniadou T, Righi A, Errani C Abstract Giant cell tumor (GCT) of the soft tissue (GCT-ST) is a rare, unusual primary soft tissue tumor that is completely distinct from, and should not be confused with, any giant cell-rich tumor of bone or soft tissue. Currently, GCT-ST is included in the group of so-called fibrohistiocytic...
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Related ArticlesAn evaluation of masitinib for treating systemic mastocytosis. Expert Opin Pharmacother. 2019 Sep;20(13):1539-1550 Authors: Laforgia M, Marech I, Nardulli P, Calabrò C, Gadaleta CD, Ranieri G Abstract Introduction: Systemic Mastocytosis (SM) is a complex family of rare diseases, against which pharmacological therapies are still very few. It is a c-kit driven disease, whose disregulation leads to uncontrolled activation and proliferation...
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Related ArticlesPrimary central nervous system small lymphocytic lymphoma in the bilateral ventricles: two case reports. BMC Neurol. 2019 Aug 19;19(1):200 Authors: Guo R, Zhang X, Niu C, Xi Y, Yin H, Lin H, Chang T Abstract BACKGROUND: Primary central nervous system (CNS) small lymphocytic lymphoma (SLL), as a type of low-grade lymphoma, is extremely rare. The diagnosis of CNS SLL is challenging due to its variable clinical and radiological features,...
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Related ArticlesTagraxofusp, the first CD123-targeted therapy and first targeted treatment for blastic plasmacytoid dendritic cell neoplasm. Expert Rev Clin Pharmacol. 2019 Oct;12(10):941-946 Authors: Economides MP, McCue D, Lane AA, Pemmaraju N Abstract Introduction: CD123 or interleukin 3 receptor alpha is overexpressed in multiple hematologic malignancies. Tagraxofusp is an intravenously administered CD123-directed cytotoxin consisting of the fusion...
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Related ArticlesSuprasellar Cysticercosis Cyst with Optic Nerve Compression Masquerading as an Arachnoid Cyst. Middle East Afr J Ophthalmol. 2019 Apr-Jun;26(2):114-116 Authors: Musara A, Soko N, Shamu S Abstract Cysticercosis is a parasitic infection caused by the larvae of the cestode Taenia solium. Ocular parasitosis in humans is well recognized; however, cysticercosis of the optic nerve is rare. Here, we report a case of an adult male who presented...
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Related ArticlesEukaryotic translation initiation factor 6 overexpression plays a major role in the translational control of gallbladder cancer. J Cancer Res Clin Oncol. 2019 Nov;145(11):2699-2711 Authors: Golob-Schwarzl N, Wodlej C, Kleinegger F, Gogg-Kamerer M, Birkl-Toeglhofer AM, Petzold J, Aigelsreiter A, Thalhammer M, Park YN, Haybaeck J Abstract BACKGROUND: Gallbladder cancer (GBC) is a rare neoplasia of the biliary tract with high mortality...
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Related ArticlesA rare case of pituicytoma presenting with severe Cushing disease: A case report and review of literature. Medicine (Baltimore). 2019 Nov;98(44):e17772 Authors: Li X, Liu Y, Miao Y, Wang J, Wang L, Wang EH Abstract RATIONALE: Pituicytomas are exceptional rare tumors in the sellar and suprasellar regions with clinical manifestations, such as headache, visual disturbance, hypopituitarism, and decreased libido. Unlike that of common pituitary...
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Related ArticlesTreatment of Bing-Neel syndrome with first line sequential chemoimmunotherapy: A case report. Medicine (Baltimore). 2019 Nov;98(44):e17794 Authors: Gavriatopoulou M, Ntanasis-Stathopoulos I, Moulopoulos LA, Manaios A, Fotiou D, Eleutherakis-Papaiakovou E, Migkou M, Bourgioti C, Terpos E, Kastritis E, Dimopoulos MA Abstract RATIONALE: Bing-Neel syndrome (BNS) is a rare manifestation of Waldenström macroglobulinemia (WM) with <200 cases...
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Related ArticlesPrimary epitheloid angiosarcoma of the pleura: an exceptional tumor location. Pan Afr Med J. 2019;33:327 Authors: Azzakhmam M, Elktaibi A, El Ochi MR, Allaoui M, Albouzidi A, Oukabli M Abstract Primary angiosarcoma of the pleura is an extremely rare tumour arising from arterial or venous pulmonary vessels of various size. It is characterized by an aggressive course and a poor prognosis. The early diagnosis is challenging due to diverse...
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Related ArticlesEwing-like sarcoma/undifferentiated round cell sarcoma in an infant with APC and MSH6 variation: A case report. Medicine (Baltimore). 2019 Nov;98(45):e17872 Authors: Xiong J, Zhu K, Mao J, Cai J, He M, Li L, Wang J, Wang L Abstract RATIONALE: Ewing-like sarcoma (ELS)/undifferentiated round cell sarcoma (URCS) is a rare type of soft tissue sarcomas (STS), especially in infants, with poor prognosis. It is a so-called "small round cell"...
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Related ArticlesClonal Evolution of MEK/MAPK Pathway Activating Mutations in a Metastatic Colorectal Cancer Case. Anticancer Res. 2019 Nov;39(11):5867-5877 Authors: Lehtomaki KI, Lahtinen LI, Rintanen N, Kuopio T, Kholova I, Makela R, Rantala JK, Kellokumpu-Lehtinen PL, Kononen J Abstract BACKGROUND/AIM: The aim of this study was to examine clonal heterogeneity, to test the utility of liquid biopsy in monitoring disease progression and to evaluate the...
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Related ArticlesAcral Lentiginous Melanoma of Foot and Ankle: A Clinicopathological Study of 7 Cases. Anticancer Res. 2019 Nov;39(11):6175-6181 Authors: Hao X, Yim J, Chang S, Schwartz E, Rubenstein S, Friske C, Shamim S, Masternick E, Mirkin G Abstract BACKGROUND/AIM: Acral lentiginous melanoma (ALM) is a rare entity on the foot. This study aimed to reveal its clinical presentations, histopathology and treatment options. MATERIALS AND METHODS:...
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Related ArticlesOutcome of Surgical Resection of Craniopharyngioma:Single Center 12 Years' Experience. Kathmandu Univ Med J (KUMJ). 2018 Oct.-Dec.;16(64):328-332 Authors: Bishokarma S, Shrestha S, Ranabhat K, Koirala S, Shrestha D, Panth R, Gongal DN Abstract Background Craniopharyngiomas (CPs) are rare epithelial tumors arising from the Rathke's pouch remnant located along the path of the craniopharyngeal duct accounting for 1.2-4% of all primary intracranial...
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Related ArticlesA Large Dermoid Cyst in the Floor of the Mouth. Kathmandu Univ Med J (KUMJ). 2018 Oct.-Dec.;16(64):348-350 Authors: Upadhyaya C, Paunju N, Chaurasia N, Srii R Abstract The dermoid cyst in the floor of mouth is considered to bea rare condition which comprises only 1.6 to 6.5% of all body dermoid cysts. Dermoid cyst in the floor of mouth may be congenital or acquired. The congenital form results from defective embryonic development and...
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Related ArticlesCholedochal Cyst of Cystic Duct in Children a Rare Entity. Kathmandu Univ Med J (KUMJ). 2018 Oct.-Dec.;16(64):354-358 Authors: Upadhyaya VD, Kumar B, Upadhyaya E, Neeyaz Z Abstract Choledochal cyst of the cystic duct is an uncommon entity which may occur as isolated disease or may be associated with choledochal cyst of the other part of the biliary tree. In most of the reported series it was diagnosed at time of operation but now days...
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Related Articles[A Case of Micropapillary Carcinoma in the Sigmoid Colon]. Gan To Kagaku Ryoho. 2019 Nov;46(11):1787-1790 Authors: Konaka Y, Ueda M, Takenaka A, Yamada T, Nakano Y, Adachi Y Abstract In Japan, the number of the patients with colorectal carcinomas is increasing. Micropapillary carcinoma(MPC)is a rare adenocarcinoma that shows a characteristic histological feature. The first case of MPC was reported in 1993, which originated in the breast....
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Related ArticlesUnexpected diagnosis of an intramuscular myxoma arising from the masseter muscle. Br J Oral Maxillofac Surg. 2019 Nov 21;: Authors: Custódio M, Antunes ES, Alves GBM, Braz-Silva PH Abstract Intramuscular myxomas are myxoid neoplasms that mainly affect the muscles of the thigh, upper arm, and gluteus. In the head and neck region they are rare, and we know of only two reported cases in the masseter muscle. We think that this is the third....
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Related ArticlesNext-generation sequencing in salivary gland carcinoma: Targetable alterations lead to a therapeutic advantage-Multicenter experience. Head Neck. 2019 Nov 24;: Authors: Moore A, Bar Y, Maurice-Dror C, Ospovat I, Sarfaty M, Korzets Y, Goldvaser H, Gordon N, Billan S, Gutfeld O, Popovtzer A Abstract BACKGROUND: Salivary gland cancers (SGCs) are rare. The approach to metastatic patients is histology-dependent. There is little evidence on...
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A solitary fibrous tumor of the kidney. Urol Case Rep. 2020 Jan;28:101072 Authors: Kopel J, Sharma P, Warriach I Abstract Solitary fibrous tumors (SFTs) are rare mesenchymal neoplasms found areas lining the pleura. First reported in 1931, there have been a total of 55 cases of SFTs of the kidney worldwide. In most cases, SFTs presents with hematuria, flank pain, and enlarging abdominal mass. In this case, we report a case of a patient who underwent a...
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Genomic and Molecular Abnormalities in Gynecologic Clear Cell Carcinoma. Am J Clin Oncol. 2019 Nov 18;: Authors: Marks EI, Brown VS, Dizon DS Abstract Gynecologic clear cell carcinoma is a rare histology, accounting for ~5% of all ovarian and endometrial cancers in the United States. Compared to other types of gynecologic cancer, they are generally less responsive to standard therapy and have an overall worse prognosis. In addition, mounting evidence...
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Intracardiac metastasis from unknown uterine cervical cancer with severe thrombocytopenia. J Card Surg. 2019 Nov 25;: Authors: Kasai M, Osako M, Yamada T, Adachi M, Yamashita H, Hatano M, Yorozu A Abstract INTRODUCTION: Cardiac metastasis is relatively common in malignant neoplasms, such as lung cancers, breast cancers, melanomas, lymphomas, and leukemias. In contrast, cardiac metastasis of uterine cervical cancer, solitary metastasis to the heart, and...
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Risk of disease transformation and second primary solid tumors in patients with myeloproliferative neoplasms. Blood Adv. 2019 Nov 26;3(22):3700-3708 Authors: Hong J, Lee JH, Byun JM, Lee JY, Koh Y, Shin DY, Lee JO, Hwang SM, Choi HS, Kim I, Yoon SS, Bang SM Abstract This study aimed to elucidate patterns of disease transformation to secondary myelofibrosis (SMF) or secondary acute myeloid leukemia (SAML) and the development of second primary malignancies...
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Advances in Personalized Therapeutic Approaches in Myelodysplastic Syndromes. J Natl Compr Canc Netw. 2019 Nov;17(11.5):1444-1447 Authors: Bejar R Abstract Often unrecognized and underdiagnosed, myelodysplastic syndromes (MDS) are a rare group of cancers in which the bone marrow fails to produce sufficient healthy blood cells. Although patients with lower-risk MDS can live for >5 years, those with high-risk disease that evolves into acute myeloid...
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Related ArticlesCUEDC2, a novel interacting partner of the SOCS1 protein, plays important roles in the leukaemogenesis of acute myeloid leukaemia. Cell Death Dis. 2018 07 10;9(7):774 Authors: Wu QY, Zhu YY, Liu Y, Wei F, Tong YX, Cao J, Zhou P, Niu MS, Li ZY, Zeng LY, Li F, Xu KL Abstract Downregulation of suppressor of cytokine signalling-1 (SOCS1) is one of the vital reasons for JAK1-STAT3 pathway activation in acute myeloid leukaemia (AML). CUE...
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Related ArticlesCREPT/RPRD1B associates with Aurora B to regulate Cyclin B1 expression for accelerating the G2/M transition in gastric cancer. Cell Death Dis. 2018 12 05;9(12):1172 Authors: Ding L, Yang L, He Y, Zhu B, Ren F, Fan X, Wang Y, Li M, Li J, Kuang Y, Liu S, Zhai W, Ma D, Ju Y, Liu Q, Jia B, Sheng J, Chang Z Abstract Gastric cancer, like most of other cancers, has an uncontrolled cell cycle regulated by cyclins and cyclin-dependent kinases...
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Related ArticlesThe Nup84 complex coordinates the DNA damage response to warrant genome integrity. Nucleic Acids Res. 2019 05 07;47(8):4054-4067 Authors: Gaillard H, Santos-Pereira JM, Aguilera A Abstract DNA lesions interfere with cellular processes such as transcription and replication and need to be adequately resolved to warrant genome integrity. Beyond their primary role in molecule transport, nuclear pore complexes (NPCs) function in other processes...
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Related ArticlesCyclin G1 drives maladaptive renal repair. Nat Rev Nephrol. 2019 04;15(4):191 Authors: Wang M PMID: 30770906 [PubMed - indexed for MEDLINE]
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Related ArticlesRNase H activities counteract a toxic effect of Polymerase η in cells replicating with depleted dNTP pools. Nucleic Acids Res. 2019 05 21;47(9):4612-4623 Authors: Meroni A, Nava GM, Bianco E, Grasso L, Galati E, Bosio MC, Delmastro D, Muzi-Falconi M, Lazzaro F Abstract RNA:DNA hybrids are transient physiological intermediates that arise during several cellular processes such as DNA replication. In pathological situations, they may stably...
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Related ArticlesStereoisomer-Specific Induction of G2/M Phase Arrest and Apoptosis by 9-(E,Z)-Hydroxyoctadecadienoic Acid in Mouse Lymphoma Cells. Biol Pharm Bull. 2019;42(6):937-943 Authors: Kodaka A, Hayakawa Y, AlSayegh RJ, Yasuhara T, Tomoda H, Oku T, Dan S, Tsuiji M, Tsuji T Abstract Hydroxyoctadecadienoic acids (HODEs) are generated by oxidation of linoleic acid in vivo and thought to mediate various pathophysiological responses. In this study,...
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Related ArticlesPTPN3 expressed in activated T lymphocytes is a candidate for a non-antibody-type immune checkpoint inhibitor. Cancer Immunol Immunother. 2019 Oct;68(10):1649-1660 Authors: Fujimura A, Nakayama K, Imaizumi A, Kawamoto M, Oyama Y, Ichimiya S, Umebayashi M, Koya N, Morisaki T, Nakagawa T, Onishi H Abstract It has been shown that protein tyrosine phosphatase non-receptor type (PTPN) 3 inhibits T-cell activation. However, there is no definitive...
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Related Articles[Progress of immune checkpoint inhibitors in neoadjuvant therapy of non-small cell lung cancer]. Zhonghua Wai Ke Za Zhi. 2019 Nov 01;57(11):872-877 Authors: Chen XY, Yang F Abstract Lung cancer carries the highest morbidity and mortality out of all malignancies in the world. About 85% of all cases are non-small cell lung cancer (NSCLC). Surgery is currently the optimal treatment for early-stage NSCLC, however, the postoperative recurrence...
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