Conditions: Esophagogastric Cancer; Esophagus Cancer; Esophageal Cancer; Gastric Cancer; Gastric Adenocarcinoma; Gastroesophageal Junction Adenocarcinoma; Gastroesophageal Junction Squamous Cell CarcinomaInterventions: Drug: 18F-BMS-986229 Injection; Drug: IV 18F-BMS-986229; Diagnostic Test: PET/CT ScanSponsors: Memorial Sloan Kettering Cancer Center; Bristol-Myers SquibbRecruiting
Wed Nov 13, 2019 19:00
Conditions: Hypocalcemia; Thyroid; Postoperative Complications; Parathyroid Dysfunction; Hormone DisturbanceIntervention: Diagnostic Test: Immediate postoperative PTH serum sampling and cut-off value identificationSponsor: University Hospital "Sestre Milosrdnice"Recruiting
Wed Nov 13, 2019 19:00
Condition: Esophageal AdenocarcinomaInterventions: Drug: Durvalumab 50 MG/ML; Drug: TremelimumabSponsors: University of Cologne; AstraZenecaRecruiting
Mon Nov 11, 2019 19:00
Condition: Chronic Rhinosinusitis Without Nasal PolypsIntervention: Device: Vibration TherapySponsors: SynDermix AG; ISS AGNot yet recruiting
Mon Nov 11, 2019 19:00
Condition: Primary Axillary HyperhidrosisInterventions: Drug: WO3970; Drug: Qbrexza® (glycopyrronium) cloth, 2.4%, for topical useSponsors: Dr. August Wolff GmbH & Co. KG Arzneimittel; Therapeutics, Inc.Not yet recruiting
Mon Nov 11, 2019 19:00
Condition: Concussion, MildIntervention: Device: Top Spin 360Sponsors: Western University, Canada; TopSpin Technologies LtdNot yet recruiting
Mon Nov 11, 2019 19:00
Wed Nov 13, 2019 02:00
Abstract Purpose The aim of this national survey is to assess the current practice of functional septorhinoplasty (SRP) surgery in the UK and better inform future practice. Methods An ENT-UK approved questionnaire was sent out to all 135 consultant members of the British Society of Facial Plastic Surgery (BSFPS). Data was collected on numbers of functional...
Tue Nov 12, 2019 02:00
Abstract Purpose This study aimed to evaluate hearing results in patients with type 3 tympanoplasty using autologous cartilage grafts. Methods The study included patients treated with “stapes stabilizing cartilage graft” (SSCG) and Plastipore partial ossicular replacement prosthesis (PPORP) for hearing reconstruction. Hearing results and complications were...
Tue Nov 12, 2019 02:00
Abstract Purpose A randomized phase III trial demonstrated that gemcitabine plus cisplatin (GP) prolonged progression-free survival and overall survival compared with fluorouracil plus cisplatin (FP) as first-line chemotherapy in patients with metastatic nasopharyngeal carcinoma (NPC). The cost-effectiveness analysis was designed to identify the economic option for metastatic NPC from a Chinese societal perspective. ...
Tue Nov 12, 2019 02:00
Abstract Several cytokines signaling via Janus Kinase (JAK) proteins have been implicated in the pathogenesis of immune‐mediated inflammatory diseases, including psoriasis and rheumatoid arthritis (RA). Tofacitinib, a small JAK inhibitor, is approved for the treatment of RA and has demonstrated good efficacy in psoriasis phase‐III clinical trials. In this work, we analyzed the in vitro effects of tofacitinib on the functions of human dendritic cells (DCs) and macrophages. When assessing the effects...
Tue Nov 12, 2019 19:56
Tue Nov 12, 2019 20:18
Tue Nov 12, 2019 20:12
Abstract Sinus histiocytosis with massive lymphadenopathy, or Rosai-Dorfman disease, is a rare, benign type of non-Langerhans cell histiocytosis. The radiological findings are often nonspecific, potentially mimicking malignancies. The diagnosis is ultimately made based on pathology, in which the lymph nodes are characterized by a dilated subcapsular sinus filled with histiocytes that can exhibit emperipolesis. Immunohistochemically, the histiocytes are variably CD68 positive...
Wed Nov 13, 2019 10:56
Zusammenfassung Die Kehlkopfentfernung (Laryngektomie) bietet für Patienten mit fortgeschrittenen Larynx- und Hypopharynxkarzinomen ohne Fernmetastasen einen kurativen Ansatz. Insbesondere bei Vorliegen eines cT4a-Karzinoms ist die Laryngektomie der primären Radio(chemo)therapie prognostisch (retrospektiv) überlegen. Weitere wichtige Indikationen für eine Laryngektomie stellen eine tumorbedingte Larynxdysfunktion wie Schluckunfähigkeit bzw. Aspirationsneigung und ein Rezidiv nach...
Tue Nov 12, 2019 02:00
Zusammenfassung Hintergrund Die Tonsillektomie zählt zu den häufigen Eingriffen in Deutschland, deren Anzahl durch demografische Veränderungen, das Aufkommen der Tonsillotomie und der Leitlinie zur Tonsillitistherapie beeinflusst sein könnte. Ziel Die Zahl der jährlich in den Bundesländern ausgeführten Tonsillektomien, Adenotonsillektomien und Tonsillotomien...
Tue Nov 12, 2019 02:00
Zusammenfassung Der Artikel geht zunächst auf die Rahmenbedingungen ein, die für die Durchführung der Facharztprüfung in den Weiterbildungsordnungen der Landesärztekammern festgelegt sind. Es werden konkrete Vorschläge unterbreitet, wie sich der Weiterbildungsassistent bei der Auswahl der von ihm zu bearbeitenden Fachliteratur und der Zeiteinteilung des von ihm zu bewältigenden Lernstoffs verhalten kann. Zur Ausgestaltung günstiger Umgebungsbedingungen in den letzten Stunden vor...
Tue Nov 12, 2019 02:00
Related ArticlesRisk factors of pharyngocutaneous fistula after total laryngectomy: a systematic review and meta-analysis. Eur Arch Otorhinolaryngol. 2019 Nov 11;: Authors: Wang M, Xun Y, Wang K, Lu L, Yu A, Guan B, Yu C Abstract OBJECTIVE: The purpose of this study was to systematically evaluate the risk factors of pharyngocutaneous fistula (PCF) after total laryngectomy. METHODS: We systematically searched Pubmed, Web of Science, Cochrane...
Wed Nov 13, 2019 19:31
Transoral robotic and laser surgery is rising in popularity due to the increasing incidence of Human Papilloma Virus (HPV) related oropharyngeal cancer. However, adequate exposure of the tongue base remains a ...
Tue Nov 12, 2019 02:00
Thyroid, Ahead of Print.
Wed Nov 13, 2019 10:00
Introduction: Otitis media is a frequent condition among children with high morbidity. Orofacial clefts are undoubtedly one of the most well-established risk factors for otitis media during childhood. The clinical spectrum of disease in orofacial clefting is broad according to the subtype of malformation. This study aims to correlate the occurrence of otitis media among lip and/or palate cleft children with clinical and epidemiological parameters, in particular with the subtypes of malformation diagnosed....
Wed Nov 13, 2019 17:48
Publication date: Available online 11 November 2019Source: Operative Techniques in Otolaryngology-Head and Neck SurgeryAuthor(s): Shivani Shah-BeckerMost benign tumors of the larynx are epithelial in origin, with nearly 85% being laryngeal papilloma. Nonepithelial laryngeal tumors are uncommon and more than 50% of these are malignant. Therefore, benign nonepithelial solid tumors of the larynx are quite rare. The management of these tumors varies based on the site of origin, specific pathology, tumor...
Tue Nov 12, 2019 12:17
Publication date: Available online 13 November 2019Source: European Annals of Otorhinolaryngology, Head and Neck DiseasesAuthor(s): A. Ghio, L. Giusti, E. Blanc, S. PintoAbstractObjectivesSpeech intelligibility can be defined as “the degree to which a speaker's intended message is recovered by a listener”. Loss of intelligibility is one of the most frequent complaints in patients suffering from speech disorder, impairing communication. Measurement of intelligibility is therefore an important parameter...
Wed Nov 13, 2019 13:53
Publication date: Available online 12 November 2019Source: European Annals of Otorhinolaryngology, Head and Neck DiseasesAuthor(s): A. Holm, A. Allard, I. Eriksson, G. Laurell, K. Nylander, K. OlofssonAbstractObjectivesSinonasal inverted papilloma (SIP) is a relatively rare disease, and its etiology is not understood. It is characterized by locally aggressive growth and a strong tendency to recur despite its benign histology.AimsThe aim of this study was to identify the presence of human papilloma...
Wed Nov 13, 2019 13:53
Publication date: Available online 12 November 2019Source: European Annals of Otorhinolaryngology, Head and Neck DiseasesAuthor(s): M. Fieux, V. Darrouzet, S. Tringali
Wed Nov 13, 2019 13:53
Publication date: Available online 11 November 2019Source: European Annals of Otorhinolaryngology, Head and Neck DiseasesAuthor(s): A. Cakır Cetın, E.A. Gunerı
Tue Nov 12, 2019 17:48
Publication date: Available online 11 November 2019Source: European Annals of Otorhinolaryngology, Head and Neck DiseasesAuthor(s): E. Chabrillac, G. De Bonnecaze, M. Rives, V. Lubrano, E. Serrano, S. VergezAbstractIntroductionIn old and frail patients, oncologic anterior skull-base surgery through an endonasal endoscopic approach avoids the morbidity incurred by transfacial and transcranial approaches, sometimes considered unreasonable, although surgery remains the gold standard treatment for sinonasal...
Tue Nov 12, 2019 17:48
Publication date: Available online 12 November 2019Source: International Journal of Pediatric OtorhinolaryngologyAuthor(s): Annina Lyly, Antti Kontturi, Eeva Salo, Tea Nieminen, Johanna Nokso-KoivistoAbstractObjectiveCervicofacial lymphadenitis caused by nontuberculous mycobacteria (NTM) is commonly treated with surgery or antimicrobial therapy. The aim of this study was to analyze the utility of our new blood-based diagnostic method and the treatment protocol, surgery or observation alone, in NTM...
Tue Nov 12, 2019 17:04
Publication date: Available online 12 November 2019Source: International Journal of Pediatric OtorhinolaryngologyAuthor(s): Nadia Vilela, Seisse Gabriela Gandolfi Sanches, Renata Mota Mamede CarvalloAbstractObjectiveThe aim of this study was to determine whether the auditory skills presented by five-year-old children can predict their performance in auditory processing (AP) tests at seven years old.DesignThirty-five children were evaluated for AP at two different times. At evaluation 1, the children...
Tue Nov 12, 2019 17:04
Abstract Background Current soft endoscope intervention mainly depends on the skills of endoscopists, especially for the orientation of the endoscope within the human tortuous lumen. This dependence causes inefficient and time consuming surgery. Methods A human‐robot cooperation navigation strategy is proposed to perform the intervention of soft endoscope. The navigation strategy firstly detects the cavity center by processing the image of endoscope, then an auto‐orienting strategy is presented...
Tue Nov 12, 2019 14:45
Abstract Background Various techniques have been proposed in the literature for phase and tool recognition from laparoscopic videos. In comparison, research in multi‐label annotation of still frames is limited. Methods We describe a framework for multi‐label annotation of images extracted from laparoscopic cholecystectomy (LC) videos based on multi‐instance multiple‐label learning. The image is considered as a bag of features extracted from local regions after coarse segmentation. A method...
Mon Nov 11, 2019 20:49
Abstract Background Although many techniques are used to treat the Acromioclavicular (AC) joint dislocations, minimal invasive or arthroscopic coracoclavicular ligament reconstructions became popular recently. In this study authors compared the biomechanical results of double versus triple button reconstruction techniques. Methods Three‐dimensional solid modeling of the shoulder girdle was carried out using virtual finite element modeling. AC joint dislocation was applied to the reference...
Mon Nov 11, 2019 20:48
Objective To investigate the association between tumor volume and locoregional failure (LRF) after concurrent chemoradiation (CCRT) for locally advanced larynx cancer (LC). Methods This is a retrospective cohort study from 2009 to 2014 identified from an institutional review board–approved registry. Fifty‐nine of 68 patients with locally advanced larynx cancer treated with definitive CCRT who had available imaging for review were identified. The main endpoint to be assessed was the association...
Wed Nov 13, 2019 16:23
Objectives Obstructive sleep apnea (OSA) patients with breathing abnormalities only or mainly in the supine posture are designated positional patients (PPs), whereas nonpositional patients (NPPs) have many breathing abnormalities in both lateral and supine postures. Positional therapy (PT), the avoidance of the supine posture during sleep, is the obvious treatment for PPs. The stability over time of being PP and leading factors that are involved in converting a PP to an NPP are addressed. Methods...
Wed Nov 13, 2019 16:19
Objective The anterior commissure is considered a laryngeal subsite, but it is not taken into account in the current T‐staging system. The impact of anterior commissure involvement (ACI) on the oncologic outcomes of T1 glottic tumors has not been well defined and remains controversial. The aim of this study was to assess the influence of ACI in the prognosis of T1 glottic tumors. Methods A systematic review and meta‐analysis of observational studies was performed by including studies published...
Wed Nov 13, 2019 16:10
Objectives To investigate the prognostic impact of primary tumor‐specific growth rate (TSGR) on treatment outcomes after definitive radiation therapy (RT) for nonoropharyngeal squamous cell carcinoma (non‐OPSCC). Methods The diagnostic tumor and nodal volumes of 39 non‐OPSCC patients were contoured and compared to corresponding RT planning scan volumes to determine TSGR. Overall survival (OS), disease‐free survival (DFS), and local recurrence‐free survival were evaluated according to the Kaplan‐Meier...
Tue Nov 12, 2019 17:13
Objective To determine the natural history of vocal fold cysts, by undertaking a retrospective analysis of data from a single clinical institute. Methods All patients diagnosed with vocal fold cysts were identified from January 2006 to June 2018. A total of 87 patients that elected not to have surgery or who had an interval of observation greater than 90 days prior to surgical intervention were further analyzed. The primary outcome was whether the cyst enlarged, reduced in size, resolved or...
Tue Nov 12, 2019 17:10
Objectives/Hypothesis Patients are frequently advised to sneeze with an open mouth and avoid nose‐blowing following an endoscopic endonasal approache (EEA) to the skull base, despite a lack of quantitative evidence. This study applies computational fluid dynamics (CFD) to quantify sinus pressures along the skull base during sneezing. Study Design Case–control series. Methods Computed tomography or magnetic resonance imaging scans of four post‐EEA patients and four healthy controls were...
Tue Nov 12, 2019 17:05
Objective To estimate the diagnostic performance of Narrow Band Imaging (NBI) in patients with cervical metastasis from head and neck squamous cell carcinoma of unknown primary (SCCUP) origin. Methods PubMed, Embase, and Scopus databases were systematically scrutinized up to July 1, 2019, looking for studies that encompassed the NBI in the SCCUP diagnostic work up. The main inclusion criteria for eligible articles for the meta‐analysis were non‐evidence of primary tumor after physical examination...
Tue Nov 12, 2019 17:00
Objective Compare intraoperative and postoperative outcomes of endoscopic and microscopic stapes surgery to provide objective evidence on whether the former is a better alternative than the latter. Methods We performed a systematic review and meta‐analysis for studies that compared endoscopic stapes surgery with microscopic stapes surgery. Only studies that met predetermined criteria were selected and assessed for bias and quality. Primary outcomes were postoperative air–bone gap (ABG) and...
Tue Nov 12, 2019 17:00
Tue Nov 12, 2019 16:56
Objectives/Hypothesis To assess the face, content, construct, and concurrent validity of the PHACON Sinonasal Surgery Simulator (SNSS). Study Design Prospective cohort study. Methods A total of 12 otolaryngology residents were recruited to perform sinonasal surgery on the simulator followed by cadaveric heads. Resident performances were recorded and de‐identified. Face and content validities were evaluated based on 5‐point Likert scale questionnaires. The recordings were evaluated by...
Tue Nov 12, 2019 16:55
Tue Nov 12, 2019 17:03
Publication date: Available online 13 November 2019Source: American Journal of OtolaryngologyAuthor(s): Z. Jason Qian, Jennifer C. AlyonoAbstractObjectiveWhile some advocates have argued for marijuana as a treatment for tinnitus, the relationship between marijuana use and tinnitus is unknown. The objective of this study was to evaluate associations between marijuana use and the prevalence, severity, and rate of occurrence of tinnitus.Study designCross-sectional analysis of nationally representative...
Wed Nov 13, 2019 13:52
Publication date: Available online 12 November 2019Source: American Journal of OtolaryngologyAuthor(s): Hossein Ghazavi, Amir-Abbas Kargoshai, Mohammad Jamshidi-koohsariAbstractBackgroundDue to high prevalence of vitamin D deficiency and the possible association with Sudden Sensory-Neural Hearing Loss (SSNHL) finding the main causes and appropriate treatments are highly essential. This study aimed to investigate vitamin D levels in patients suffering SSNHL and its effect on response to treatment.Materials...
Wed Nov 13, 2019 13:52
Publication date: Available online 12 November 2019Source: American Journal of OtolaryngologyAuthor(s): Osama G. Abdel-Naby AwadAbstractPurposeRecurrent tonsillitis in children is a common disease affecting children quality of life and extends to their families. The aim of this study was to assess the effect of combined use of oral Azithromycin (AZT) plus Echinacea compared to exclusive use of AZT in children with recurrent tonsillitis.Material and methodsA prospective comparative study including...
Wed Nov 13, 2019 13:52
Publication date: Available online 12 November 2019Source: American Journal of OtolaryngologyAuthor(s): Thomas H. Fitzpatrick, Benjamin D. Lovin, Marcus J. Magister, Joshua D. Waltonen, James D. Browne, Christopher A. SullivanAbstractEagle Syndrome (ES) is a rare disorder that can present with symptoms ranging from globus sensation to otalgia that is attributed to an elongated styloid process and/or calcified stylohyoid ligament. No standardized treatment algorithm exists, and although various surgical...
Wed Nov 13, 2019 13:52
Publication date: Available online 12 November 2019Source: American Journal of OtolaryngologyAuthor(s): Nidal F. AL Deek
Tue Nov 12, 2019 17:53
Publication date: Available online 12 November 2019Source: American Journal of OtolaryngologyAuthor(s): Elizabeth O. Shay, Janki Shah, Blake Smith, Samantha AnneAbstractObjectivesRates of success with pediatric myringoplasty range from 35 to 95%. The objective of this study is to evaluate the impact of perforation size on successful closure of the tympanic membrane (TM) after gelfoam myringoplasty. We also aim to identify variables that affect perforation closure rates and define predictive factors...
Tue Nov 12, 2019 17:53
Publication date: Available online 11 November 2019Source: American Journal of OtolaryngologyAuthor(s): Michael J. EliasonAbstractPurposeEndoscopic sinus surgery (ESS) is the mainstay for chronic inflammatory and neoplastic sinonasal process and as a result many modalities have been studied to minimize blood loss and patient morbidity and to maximize intraoperative visualization. However, often conclusions of actual blood loss are based on surgeons' estimations without ever actually assessing the...
Tue Nov 12, 2019 17:53
Publication date: Available online 11 November 2019Source: American Journal of OtolaryngologyAuthor(s): Sarah L. Spaulding, Rebecca Ho, Sedef Everest, Raymond L. ChaiAbstractBackgroundMedullary thyroid carcinoma (MTC) is a somewhat rare, particularly aggressive form of thyroid cancer. The authors present what we believe to be the first case of MTC diagnosed solely on the basis of molecular testing, as well as a review of the literature concerning this topic and oncocytic variants of MTC.Case descriptionA...
Tue Nov 12, 2019 17:53
Publication date: November–December 2019Source: American Journal of Otolaryngology, Volume 40, Issue 6Author(s):
Tue Nov 12, 2019 17:53
Publication date: Available online 12 November 2019Source: Auris Nasus LarynxAuthor(s): Boo-Young Kim, Jung-Hae Cho, Do Hyun Kim, Sung Won Kim, Soo Whan Kim, Byung Guk Kim, Yong Jin ParkAbstractObjectiveTo determine whether combining acoustic pharyngometric parameters with cephalometric and clinical parameters could improve the predictive power for significant obstructive sleep apnea (OSA) in a Korean population.MethodsA total of 229 consecutive adult patients with suspected OSA were enrolled. The...
Wed Nov 13, 2019 14:16
Publication date: Available online 12 November 2019Source: Auris Nasus LarynxAuthor(s): Kazuhiro Omura, Kazuhiro Nomura, Satoshi Aoki, Yu Hosokawa, Yasuhiro Tanaka, Nobuyoshi Otori, Hiromi KojimaAbstractObjectiveSinonasal inverted papilloma can be resected endoscopically, but has a risk of recurrence. This risk can be minimized by identifying the pedicle of the tumor and ensuring complete resection. Intraoperative bleeding, particularly from the tumor, decreases endoscopic visualization and contributes...
Wed Nov 13, 2019 14:16
Condition: Athletic InjuriesInterventions: Other: Foam Rolling (FR); Other: Control Group (CG); Other: Orthopaedic Manual Physical Therapy Group (OMPT)Sponsor: University of ValenciaRecruiting
Wed Nov 13, 2019 19:00
Condition: Drug Safety ; Drug SpecificityIntervention: Drug: Cetuximab-IRDye800Sponsor: Fifth Affiliated Hospital, Sun Yat-Sen UniversityRecruiting
Wed Nov 13, 2019 19:00
Conditions: In Vitro Fertilization; Stress; Midazolam Adverse Reaction; Stress, EmotionalIntervention: Drug: Midazolam 7.5mgSponsor: University Hospital "Sestre Milosrdnice"Recruiting
Wed Nov 13, 2019 19:00
Conditions: Non Small Cell Lung Cancer; Medullary Thyroid Cancer; RET Gene Mutation; Metastatic Solid Tumor; Advanced Solid TumorIntervention: Drug: TPX-0046Sponsor: Turning Point Therapeutics, Inc.Not yet recruiting
Wed Nov 13, 2019 19:00
Conditions: Esophagogastric Cancer; Esophagus Cancer; Esophageal Cancer; Gastric Cancer; Gastric Adenocarcinoma; Gastroesophageal Junction Adenocarcinoma; Gastroesophageal Junction Squamous Cell CarcinomaInterventions: Drug: 18F-BMS-986229 Injection; Drug: IV 18F-BMS-986229; Diagnostic Test: PET/CT ScanSponsors: Memorial Sloan Kettering Cancer Center; Bristol-Myers SquibbRecruiting
Wed Nov 13, 2019 19:00
Conditions: Hypocalcemia; Thyroid; Postoperative Complications; Parathyroid Dysfunction; Hormone DisturbanceIntervention: Diagnostic Test: Immediate postoperative PTH serum sampling and cut-off value identificationSponsor: University Hospital "Sestre Milosrdnice"Recruiting
Wed Nov 13, 2019 19:00
Condition: Esophageal AdenocarcinomaInterventions: Drug: Durvalumab 50 MG/ML; Drug: TremelimumabSponsors: University of Cologne; AstraZenecaRecruiting
Mon Nov 11, 2019 19:00
Condition: Chronic Rhinosinusitis Without Nasal PolypsIntervention: Device: Vibration TherapySponsors: SynDermix AG; ISS AGNot yet recruiting
Mon Nov 11, 2019 19:00
Condition: Primary Axillary HyperhidrosisInterventions: Drug: WO3970; Drug: Qbrexza® (glycopyrronium) cloth, 2.4%, for topical useSponsors: Dr. August Wolff GmbH & Co. KG Arzneimittel; Therapeutics, Inc.Not yet recruiting
Mon Nov 11, 2019 19:00
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