Related ArticlesAn Experimental Paradigm for Measuring the Effects of Ageing on Sentence Processing. J Vis Exp. 2019 Oct 25;(152): Authors: Liu X, Wang H, Xie A, Mao X Abstract Previous studies have found that older adults have greater difficulties in processing syntactically complex sentences than younger adults. However, the exact regions where the difficulties arise have not been fully identified. In this study, a maze task was implemented to investigate...
Tue Nov 12, 2019 16:33
Related ArticlesSilencing the Spark: CRISPR/Cas9 Genome Editing in Weakly Electric Fish. J Vis Exp. 2019 Oct 27;(152): Authors: Constantinou SJ, Nguyen L, Kirschbaum F, Salazar VL, Gallant JR Abstract Electroreception and electrogenesis have changed in the evolutionary history of vertebrates. There is a striking degree of convergence in these independently derived phenotypes, which share a common genetic architecture. This is perhaps best exemplified...
Tue Nov 12, 2019 16:33
Related ArticlesProstate Organoid Cultures as Tools to Translate Genotypes and Mutational Profiles to Pharmacological Responses. J Vis Exp. 2019 Oct 24;(152): Authors: Pappas KJ, Choi D, Sawyers CL, Karthaus WR Abstract Presented here is a protocol to study pharmacodynamics, stem cell potential, and cancer differentiation in prostate epithelial organoids. Prostate organoids are androgen responsive, three-dimensional (3D) cultures grown in a defined medium...
Tue Nov 12, 2019 16:33
Related ArticlesRadiotracer Administration for High Temporal Resolution Positron Emission Tomography of the Human Brain: Application to FDG-fPET. J Vis Exp. 2019 Oct 22;(152): Authors: Jamadar SD, Ward PGD, Carey A, McIntyre R, Parkes L, Sasan D, Fallon J, Orchard E, Li S, Chen Z, Egan GF Abstract Functional positron emission tomography (fPET) provides a method to track molecular targets in the human brain. With a radioactively-labelled glucose analogue,...
Tue Nov 12, 2019 16:33
Related ArticlesBulk Droplet Vitrification for Primary Hepatocyte Preservation. J Vis Exp. 2019 Oct 25;(152): Authors: de Vries RJ, Banik PD, Nagpal S, Weng L, Ozer S, van Gulik TM, Toner M, Tessier SN, Uygun K Abstract Vitrification is a promising ice-free alternative for classic slow-freezing (at approximately 1 °C/min) cryopreservation of biological samples. Vitrification requires extremely fast cooling rates to achieve transition of water into the...
Tue Nov 12, 2019 16:33
Related ArticlesSolid Phase 11C-Methylation, Purification and Formulation for the Production of PET Tracers. J Vis Exp. 2019 Oct 24;(152): Authors: Singleton TA, Boudjemeline M, Hopewell R, Jolly D, Bdair H, Kostikov A Abstract Routine production of radiotracers used in positron emission tomography (PET) mostly relies on wet chemistry where the radioactive synthon reacts with a non-radioactive precursor in solution. This approach necessitates purification...
Tue Nov 12, 2019 16:33
Related ArticlesAbsolute Quantification of Cell-Free Protein Synthesis Metabolism by Reversed-Phase Liquid Chromatography-Mass Spectrometry. J Vis Exp. 2019 Oct 25;(152): Authors: Vilkhovoy M, Dai D, Vadhin S, Adhikari A, Varner JD Abstract Cell-free protein synthesis (CFPS) is an emerging technology in systems and synthetic biology for the in vitro production of proteins. However, if CFPS is going to move beyond the laboratory and become a widespread...
Tue Nov 12, 2019 16:33
Related ArticlesExperimental Approach to Examine Leptin Signaling in the Carotid Bodies and its Effects on Control of Breathing. J Vis Exp. 2019 Oct 25;(152): Authors: Shin MK, Kim LJ, Caballero-Eraso C, Polotsky VY Abstract An adipocyte-produced hormone leptin is a potent respiratory stimulant, which may play an important role in defending respiratory function in obesity. The carotid bodies (CB), a key organ of peripheral hypoxic sensitivity, express...
Tue Nov 12, 2019 16:33
Related Articles3D Imaging of Soft-Tissue Samples using an X-ray Specific Staining Method and Nanoscopic Computed Tomography. J Vis Exp. 2019 Oct 24;(152): Authors: Busse M, Müller M, Kimm MA, Ferstl S, Allner S, Achterhold K, Herzen J, Pfeiffer F Abstract We demonstrate a laboratory-based method combining X-ray microCT and nanoCT with a specific X-ray stain, which targets the cell cytoplasm. The described protocol is easy to apply, fast and suitable...
Tue Nov 12, 2019 16:33
Related ArticlesSubcellular Fractionation of Primary Chronic Lymphocytic Leukemia Cells to Monitor Nuclear/Cytoplasmic Protein Trafficking. J Vis Exp. 2019 Oct 23;(152): Authors: Hay J, Moles MW, Cassels J, Michie AM Abstract Nuclear export of macromolecules is often deregulated in cancer cells. Tumor suppressor proteins, such as p53, can be rendered inactive due to aberrant cellular localization disrupting their mechanism of action. The survival of...
Tue Nov 12, 2019 16:33
Related ArticlesClonal Genetic Tracing using the Confetti Mouse to Study Mineralized Tissues. J Vis Exp. 2019 Oct 23;(152): Authors: Zhou B, Kaucka M, Chagin AS, Newton PT Abstract Labeling an individual cell in the body to monitor which cell types it can give rise to and track its migration through the organism or determine its longevity can be a powerful way to reveal mechanisms of tissue development and maintenance. One of the most important tools...
Tue Nov 12, 2019 16:33
Related ArticlesInvasive Hemodynamic Assessment for the Right Ventricular System and Hypoxia-Induced Pulmonary Arterial Hypertension in Mice. J Vis Exp. 2019 Oct 24;(152): Authors: Luo F, Wang X, Luo X, Li B, Zhu D, Sun H, Tang Y Abstract Pulmonary arterial hypertension (PAH) is a chronic and severe cardiopulmonary disorder. Mice are a popular animal model used to mimic this disease. However, the evaluation of right ventricular pressure (RVP) and pulmonary...
Tue Nov 12, 2019 16:33
Related ArticlesIn Vivo Assessment of Alveolar Macrophage Efferocytosis Following Ozone Exposure. J Vis Exp. 2019 Oct 22;(152): Authors: Hodge MX, Reece SW, Madenspacher JH, Gowdy KM Abstract Ozone (O3) is a criteria air pollutant that exacerbates and increases the incidence of chronic pulmonary diseases. O3 exposure is known to induce pulmonary inflammation, but little is known regarding how exposure alters processes important to the resolution of inflammation....
Tue Nov 12, 2019 16:33
Related ArticlesIdentification of Host Pathways Targeted by Bacterial Effector Proteins using Yeast Toxicity and Suppressor Screens. J Vis Exp. 2019 Oct 25;(152): Authors: Faris R, Weber MM Abstract Intracellular bacteria secrete virulence factors called effector proteins into the host cytosol that act to subvert host proteins and/or their associated biological pathways to the benefit of the bacterium. Identification of putative bacterial effector proteins...
Tue Nov 12, 2019 16:33
Related ArticlesLaser-Induced Fluorescence Emission (L.I.F.E.) as Novel Non-Invasive Tool for In-Situ Measurements of Biomarkers in Cryospheric Habitats. J Vis Exp. 2019 Oct 26;(152): Authors: Weisleitner K, Hunger L, Kohstall C, Frisch A, Storrie-Lombardi MC, Sattler B Abstract Global warming affects microbial communities in a variety of ecosystems, especially cryospheric habitats. However, little is known about microbial-mediated carbon fluxes in extreme...
Tue Nov 12, 2019 16:33
Related ArticlesImmunofluorescence Staining Using IBA1 and TMEM119 for Microglial Density, Morphology and Peripheral Myeloid Cell Infiltration Analysis in Mouse Brain. J Vis Exp. 2019 Oct 27;(152): Authors: González Ibanez F, Picard K, Bordelau M, Sharma K, Bisht K, Tremblay MÈ Abstract This is a protocol for the dual visualization of microglia and infiltrating macrophages in mouse brain tissue. TMEM119 (which labels microglia selectively), when combined...
Tue Nov 12, 2019 16:33
Related ArticlesSingle Cell Micro-aspiration as an Alternative Strategy to Fluorescence-activated Cell Sorting for Giant Virus Mixture Separation. J Vis Exp. 2019 Oct 27;(152): Authors: Sahmi-Bounsiar D, Boratto PVM, Oliveira GP, Bou Khalil JY, La Scola B, Andreani J Abstract During the amoeba co-culture process, more than one virus may be isolated in a single well. We previously solved this issue by end point dilution and/or fluorescence activated cell...
Tue Nov 12, 2019 16:33
Related ArticlesPrimary Culture of Neurons Isolated from Embryonic Mouse Cerebellum. J Vis Exp. 2019 Oct 26;(152): Authors: Shabanipour S, Dalvand A, Jiao X, Rahimi Balaei M, Chung SH, Kong J, Del Bigio MR, Marzban H Abstract The use of primary cell cultures has become one of the major tools to study the nervous system in vitro. The ultimate goal of using this simplified model system is to provide a controlled microenvironment and maintain the high survival...
Tue Nov 12, 2019 16:33
Related ArticlesA Training and Testing System for Performing Vascular Reconstruction In Vitro. J Vis Exp. 2019 Oct 26;(152): Authors: Wang Y, Mu L, Zhang W, Chen H, Li Q, Shi A, Tang B, Zhang X, Dong D, Lv Y Abstract Manual vascular reconstruction training is essential for a beginner surgeon. However, an optimal training system for vascular reconstruction in vitro has yet to be developed. In this study, we introduce an in vitro training and testing system...
Tue Nov 12, 2019 16:33
Related ArticlessiRNA Electroporation to Modulate Autophagy in Herpes Simplex Virus Type 1-Infected Monocyte-Derived Dendritic Cells. J Vis Exp. 2019 Oct 28;(152): Authors: Düthorn A, Turan A, Draßner C, Mühl-Zürbes P, Heilingloh CS, Steinkasserer A, Grosche L Abstract Herpes simplex virus type-1 (HSV-1) induces autophagy in both, immature dendritic cells (iDCs) as well as mature dendritic cells (mDCs), whereas autophagic flux is only observed in iDCs....
Tue Nov 12, 2019 16:33
Related ArticlesHow to Obtain Reliable Visual Event-related Potentials in Newborns. J Vis Exp. 2019 Oct 24;(152): Authors: Cubero-Rego L, Ricardo-Garcell J, Harmony T, Corsi-Cabrera M Abstract The present study discusses the characteristics of visual event-related potentials (VEPs) and outlines methodological steps for obtaining reliable measurements in newborns. Obtaining high-quality, reliable VEPs is crucial for the early detection of abnormal development...
Tue Nov 12, 2019 16:33
Related ArticlesSimple Surgical Induction of Conductive Hearing Loss with Verification Using Otoscope Visualization and Behavioral Clap Startle Response in Rat. J Vis Exp. 2019 Oct 26;(152): Authors: Manno FAM, Manno SHC, Ma V, Barrios FA, Cho WC, Cheng SH, Lau C Abstract Conductive hearing loss (CHL) is a prevalent hearing impairment in humans. The goal of the protocol is to describe a simple surgical procedure for inducing CHL in rodents. The protocol...
Tue Nov 12, 2019 16:33
Related ArticlesUsing Human Induced Pluripotent Stem Cells for the Generation of Tumor Antigen-specific T Cells. J Vis Exp. 2019 Oct 24;(152): Authors: Good ML, Vizcardo R, Maeda T, Tamaoki N, Malekzadeh P, Kawamoto H, Restifo NP Abstract The generation and expansion of functional T cells in vitro can lead to a broad range of clinical applications. One such use is for the treatment of patients with advanced cancer. Adoptive T cell transfer (ACT) of highly...
Tue Nov 12, 2019 16:33
Related ArticlesKinase Inhibitor Screening In Self-assembled Human Protein Microarrays. J Vis Exp. 2019 Oct 23;(152): Authors: Festa F, Labaer J Abstract The screening of kinase inhibitors is crucial for better understanding properties of a drug and for the identification of potentially new targets with clinical implications. Several methodologies have been reported to accomplish such screening. However, each has its own limitations (e.g., the screening...
Tue Nov 12, 2019 16:33
Related ArticlesTissue Collection of Bats for -Omics Analyses and Primary Cell Culture. J Vis Exp. 2019 Oct 23;(152): Authors: Yohe LR, Devanna P, Davies KTJ, Potter JHT, Rossiter SJ, Teeling EC, Vernes SC, Dávalos LM Abstract As high-throughput sequencing technologies advance, standardized methods for high quality tissue acquisition and preservation allow for the extension of these methods to non-model organisms. A series of protocols to optimize tissue...
Tue Nov 12, 2019 16:33
Related ArticlesLaminectomy and Spinal Cord Window Implantation in the Mouse. J Vis Exp. 2019 Oct 23;(152): Authors: Pietruczyk EA, Stephen TKL, Alford S, Lutz SE Abstract This protocol describes a method for spinal cord laminectomy and glass window implantation for in vivo imaging of the mouse spinal cord. An integrated digital vaporizer is utilized to achieve a stable plane of anesthesia at a low-flow rate of isoflurane. A single vertebral spine is...
Tue Nov 12, 2019 16:33
Related ArticlesAtom Probe Tomography Analysis of Exsolved Mineral Phases. J Vis Exp. 2019 Oct 25;(152): Authors: Genareau K, Perez-Huerta A, Laiginhas F Abstract Element diffusion rates and temperature/pressure control a range of fundamental volcanic and metamorphic processes. Such processes are often recorded in lamellae exsolved from host mineral phases. Thus, the analysis of the orientation, size, morphology, composition and spacing of exsolution...
Tue Nov 12, 2019 16:33
Related ArticlesComparing Bibliometric Analysis Using PubMed, Scopus, and Web of Science Databases. J Vis Exp. 2019 Oct 24;(152): Authors: AlRyalat SAS, Malkawi LW, Momani SM Abstract Literature databases (i.e., PubMed, Scopus, and Web of Science) differ in terms of their coverage, focus, and the tool they provide. PubMed focuses mainly on life sciences and biomedical disciplines, whereas Scopus and Web of Science are multidisciplinary. The protocol...
Tue Nov 12, 2019 16:33
Using micro-computed tomography to examine the larynx in cases of suspected strangulation-a comparison of case findings and control images. Int J Legal Med. 2019 Nov 12;: Authors: Baier W, Burnett BA, Payne M, Warnett JM, Williams MA Abstract The examination of strangulation is one of the most challenging causes of death diagnoses encountered in forensic pathology. The injuries are often subtle and difficult to detect, especially in cases that lack superficial...
Wed Nov 13, 2019 20:20
Related ArticlesSimultaneous electromagnetic articulography and electroglottography data acquisition of natural speech. J Acoust Soc Am. 2018 11;144(5):EL380 Authors: Harper S, Lee S, Goldstein L, Byrd D Abstract This paper reports on the concurrent use of electroglottography (EGG) and electromagnetic articulography (EMA) in the acquisition of EMA trajectory data for running speech. Static and dynamic intersensor distances, standard deviations, and...
Wed Nov 13, 2019 20:20
Related ArticlesImportance of glottis landmarks for the assessment of cleft lip and palate speech intelligibility. J Acoust Soc Am. 2018 11;144(5):2656 Authors: Kalita S, Mahadeva Prasanna SR, Dandapat S Abstract The present work explores the acoustic characteristics of articulatory deviations near g(lottis) landmarks to derive the correlates of cleft lip and palate speech intelligibility. The speech region around the g landmark is used to compute two...
Wed Nov 13, 2019 20:20
Related ArticlesInflammation-induced upregulation of P2X4 expression augments mucin secretion in airway epithelia. Am J Physiol Lung Cell Mol Physiol. 2019 01 01;316(1):L58-L70 Authors: Winkelmann VE, Thompson KE, Neuland K, Jaramillo AM, Fois G, Schmidt H, Wittekindt OH, Han W, Tuvim MJ, Dickey BF, Dietl P, Frick M Abstract Mucus clearance provides an essential innate defense mechanism to keep the airways and lungs free of particles and pathogens....
Wed Nov 13, 2019 20:20
Related ArticlesEffects of Submental Surface Electrical Stimulation on Swallowing Kinematics in Healthy Adults: An Error-Based Learning Paradigm. Am J Speech Lang Pathol. 2018 11 21;27(4):1375-1384 Authors: Serel Arslan S, Azola A, Sunday K, Vose A, Plowman E, Tabor L, Singer M, Robison R, Humbert IA Abstract Purpose: Hyoid bone and laryngeal approximation aid airway protection (laryngeal vestibule closure) while moving toward their peak superior and...
Wed Nov 13, 2019 20:20
Related ArticlesImpact of recurrent laryngeal nerve lesion on oropharyngeal muscle activity and sensorimotor integration in an infant pig model. J Appl Physiol (1985). 2018 07 01;125(1):159-166 Authors: DeLozier KR, Gould FDH, Ohlemacher J, Thexton AJ, German RZ Abstract The successful performance of a swallow requires dynamic integration between a wide range of sensory inputs and muscle activities to produce the coordinated kinematics of oropharyngeal...
Wed Nov 13, 2019 20:20
Related ArticlesSevere late dysphagia after multimodal treatment of stage III/IV laryngeal and hypopharyngeal cancer. Jpn J Clin Oncol. 2019 Nov 11;: Authors: Huh G, Ahn SH, Suk JG, Lee MH, Kim WS, Kwon SK, Ock CY, Keam B, Heo DS, Kim JH, Wu HG Abstract BACKGROUND: Long-term side effects after radiotherapy for organ preservation 'could deteriorate' the laryngeal function. This study intended to identify the incidence of severe late dysphagia following...
Tue Nov 12, 2019 16:29
Related ArticlesIn-home auditory training using audiovisual stimuli on a tablet computer: Feasibility and preliminary results. Auris Nasus Larynx. 2019 Nov 07;: Authors: Sato T, Yabushita T, Sakamoto S, Katori Y, Kawase T Abstract OBJECTIVE: To examine the feasibility and possible effects of in-home auditory training using audiovisual speech stimuli on a tablet computer for patients with hearing loss using a hearing aid (HA) or a cochlear implant (CI)....
Tue Nov 12, 2019 14:30
Related ArticlesRetention of cricothyrotomy skills by paramedics using a wire guided technique. Am J Emerg Med. 2019 03;37(3):407-410 Authors: March JA, Kiemeney MJ, De Guzman J, Ferguson JD Abstract INTRODUCTION: Cricothyrotomy may be necessary for airway management when a patient's airway cannot be maintained through standard techniques such as oral airway placement, blind insertion airway device, or endotracheal intubation. Wire-guided cricothyrotomy...
Tue Nov 12, 2019 14:30
Related ArticlesLaryngeal Dysfunction in Cough Hypersensitivity Syndrome: A Cross-Sectional Observational Study. J Allergy Clin Immunol Pract. 2018 Nov - Dec;6(6):2087-2095 Authors: Vertigan AE, Kapela SM, Kearney EK, Gibson PG Abstract BACKGROUND: Chronic refractory cough (CRC), a phenotype of cough hypersensitivity syndrome (CHS), is a disabling problem. Laryngeal dysfunction may be important in CRC and CHS because laryngeal symptoms are common; however,...
Tue Nov 12, 2019 14:30
Related ArticlesUnusual Clinical Manifestation of Laryngeal Edema in a Case of DRESS Syndrome. J Allergy Clin Immunol Pract. 2018 Nov - Dec;6(6):2108-2109 Authors: Sim DW, Koh YI PMID: 29574127 [PubMed - indexed for MEDLINE]
Tue Nov 12, 2019 14:30
Related ArticlesStreptococcus Oralis meningitis from right sphenoid Meningoencephalocele and cerebrospinal fluid leak. BMC Infect Dis. 2019 Nov 11;19(1):960 Authors: Patel K, Memon Z, Prince A, Park C, Sajan A, Ilyas N Abstract BACKGROUND: Streptococcus oralis belongs to the Streptococcus mitis group and is part of the normal flora of the nasal and oropharynx (Koneman et al., The Gram-positive cocci part II: streptococci, enterococci and the 'Streptococcus-like'...
Wed Nov 13, 2019 20:25
Related ArticlesComparison of two fetoscopic open neural tube defect (ONTD) repair techniques: Single-layer vs three-layer closure. Ultrasound Obstet Gynecol. 2019 Nov 11;: Authors: Belfort MA, Whitehead WE, Shamshirsaz AA, Espinoza J, Nassr AA, Lee TC, Olutoye OO, Keswani SG, Cortes MS Abstract OBJECTIVES: We previously reported on a fetoscopic repair for open neural tube defect (ONTD) using a single layer closure (SLC). Because of a high rate of cerebrospinal...
Tue Nov 12, 2019 13:29
Related ArticlesEndoscopic endonasal versus transcranial approach to resection of olfactory groove meningiomas: a systematic review. Neurosurg Rev. 2019 Nov 10;: Authors: Purohit A, Jha R, Khalafallah AM, Price C, Rowan NR, Mukherjee D Abstract Despite the increasing utility of the endoscopic endonasal approach (EEA) for management of anterior skull base (ASB) pathologies, the optimal treatment strategy for olfactory groove meningiomas (OGM) remains...
Tue Nov 12, 2019 13:29
Retrospective evaluation of the patients with urinary tract infections due to carbapenemase producing Enterobacteriaceae. J Chemother. 2019 Nov 12;:1-6 Authors: Önal U, Sipahi OR, Pullukçu H, Yamazhan T, Arda B, Ulusoy S, Aydemir Ş, Taşbakan MI Abstract In this study, we aimed to investigate retrospectively the patients with carbapenem-resistant Enterobacteriaceae urinary tract infections (UTIs) in the terms of demographic findings, antibiotic sensitivity...
Wed Nov 13, 2019 19:56
Immunotherapy and other systemic therapies for cutaneous SCC. Oral Oncol. 2019 Nov 09;99:104459 Authors: Guminski A, Stein B Abstract Contrary to the impression that non-melanoma skin cancer is a banal and relatively trivial malignancy it causes about 1% of all cancer deaths. Cutaneous Squamous Cell carcinoma (CuSCC) make up a significant part of these deaths either from incurable loco-regional disease or metastatic disease. As is typical of the disease...
Wed Nov 13, 2019 19:46
Cell free circulating tumor nucleic acids, a revolution in personalized cancer medicine. Crit Rev Oncol Hematol. 2019 Nov 02;144:102827 Authors: Kerachian MA, Poudineh A, Thiery JP Abstract Innovative diagnostics are becoming an essential component in personalized cancer medicine. These diagnostics are increasingly based on cell-free nucleic acids and membrane vesicles. Isolating and sequencing cell free circulating DNA (cfDNA) in plasma may progressively...
Wed Nov 13, 2019 19:46
Quantitative associations between health insurance and stage of melanoma at diagnosis among nonelderly adults in the United States. Cancer. 2019 Nov 12;: Authors: Abudu B, Cook KA, Gershenwald JE, Cohen PR, Geller AC Abstract BACKGROUND: Health insurance plays a critical role in the accessibility to and quality of health care for patients with melanoma in the United States. Current knowledge regarding the association between insurance status and stage...
Wed Nov 13, 2019 19:46
Salvage therapy for relapsed testicular cancer: a need for consensus. Future Oncol. 2019 Nov 12;: Authors: Agrawal V, Adra N PMID: 31714157 [PubMed - as supplied by publisher]
Wed Nov 13, 2019 19:46
An overview of radiological manifestations of acquired dental developmental disturbances in paediatric head and neck cancer survivors. Dentomaxillofac Radiol. 2019 Nov 12;:20190275 Authors: Hoogeveen RC, Hol MLF, Pieters BR, Balgobind BV, Berkhout EWER, Schoot RA, Smeele LE, Merks HJHM, Becking EAG Abstract OBJECTIVES: In paediatric cancer survivors treated with chemotherapy and radiotherapy therapy, late effects on dental development are quite common....
Wed Nov 13, 2019 19:46
Quantitative MRI for Assessment of Treatment Outcomes in a Rabbit VX2 Hepatic Tumor Model. J Magn Reson Imaging. 2019 Nov 12;: Authors: Keller S, Chapiro J, Brangsch J, Reimann C, Collettini F, Sack I, Savic LJ, Hamm B, Goldberg SN, Makowski M Abstract Globally, primary and secondary liver cancer is one of the most common cancer types, accounting 8.2% of deaths worldwide in 2018. One of the key strategies to improve the patient's prognosis is the early...
Wed Nov 13, 2019 19:46
HIV awareness: a kap study among students in Italy reveals that preventive campaigns still represent a public health priority. Ann Ig. 2020 Jan-Feb;32(1):56-64 Authors: Loconsole D, Metallo A, Bruno V, De Robertis AL, Morea A, Quarto M, Chironna M Abstract BACKGROUND: Improving knowledge about HIV/AIDS among young people is crucial for preventing new infections. The aim of the study was to investigate knowledge, attitudes and practices regarding HIV...
Wed Nov 13, 2019 19:46
Related ArticlesFeasibility and Acceptability of a Pilot Tailored Text Messaging Intervention for Adolescents and Young Adults Completing Cancer Treatment. Psychooncology. 2019 Nov 11;: Authors: Schwartz LA, Daniel LC, Henry-Moss D, Bonafide CP, Li Y, Psihogios AM, Butler ES, Szalda D, Ver Hoeve ES, Hobbie WL, Dowshen NL, Pierce L, Kersun LS, Barakat LP Abstract PURPOSE: Despite cure, adolescents and young adults (AYA) who complete cancer treatment remain...
Wed Nov 13, 2019 19:46
Related ArticlesHispanics/Latinos in the Bronx Have Improved Survival in Non-Small Cell Lung Cancer Compared with Non-Hispanic Whites. J Racial Ethn Health Disparities. 2019 Nov 11;: Authors: Klugman M, Xue X, Ginsberg M, Cheng H, Rohan T, Hosgood HD Abstract BACKGROUND: Hispanics/Latinos are a growing yet understudied population in the United States (US). Despite lower socioeconomic status, Hispanics/Latinos tend to have similar or better health outcomes...
Wed Nov 13, 2019 19:46
Related ArticlesIssues and Ethical Considerations in Pharmaco-oncogenomics. Adv Exp Med Biol. 2019;1168:91-101 Authors: Morgan G Abstract The rapid advancements of treatment modalities and vast amounts of information being generated through novel technologies, paint the picture of a very promising future, one that will allow for a more efficient and precise DNA sequencing and potentially more tailored cancer therapies for patients. However, with all...
Wed Nov 13, 2019 19:46
Related ArticlesDesign and Implementing Pharmacogenomics Study in Cancer. Adv Exp Med Biol. 2019;1168:43-77 Authors: Romero Lagunes ML, Vera Badillo FE Abstract The advances in technology has shifted healthcare from a "one size fits all" model to focus on personalized therapy. Understanding the relationship of genome variations and its effect on drug response has led to individualized drug selection, maximizing drug efficacy and improving toxicity profile....
Wed Nov 13, 2019 19:46
Related ArticlesDelay in diagnosing patients with right-sided glioblastoma induced by hemispheric-specific clinical presentation. J Neurooncol. 2019 Nov 11;: Authors: Baumann C, Tichy J, Schaefer JH, Steinbach JP, Mittelbronn M, Wagner M, Foerch C Abstract PURPOSE: Cognitive functions are differentially represented in brain hemispheres. Aphasia is an "easy to recognize" symptom of diseases affecting the left side. In contrast, lesions in the right hemisphere...
Wed Nov 13, 2019 19:46
Related ArticlesImpact of the Hemostasis and Thrombosis Research Society trainee workshop in recruiting the next generation of nonmalignant hematologists. J Thromb Thrombolysis. 2019 Nov 11;: Authors: Lim MY, Blaszczyk K, Jacobsen-Tews L, Mott L, Sarode R, Ziegler J, Mahajerin A Abstract The United States is facing a shortage of physicians dedicated to nonmalignant hematology to meet future needs. The Hemostasis and Thrombosis Research Society (HTRS)...
Wed Nov 13, 2019 19:46
Related ArticlesDecreasing incidence of upper age restriction enrollment criteria among cancer clinical trials. J Geriatr Oncol. 2019 Nov 08;: Authors: Ludmir EB, Subbiah IM, Mainwaring W, Miller AB, Lin TA, Jethanandani A, Espinoza AF, Mandel JJ, Fang P, Smith BD, Smith GL, Pinnix CC, Sedrak MS, Kimmick GG, Stinchcombe TE, Jagsi R, Thomas CR, Fuller CD, VanderWalde NA Abstract BACKGROUND: Age disparities among cancer clinical trial participants are...
Wed Nov 13, 2019 19:46
Related ArticlesThe National Cancer Institute and Department of Veterans Affairs Interagency Group to Accelerate Trials Enrollment (NAVIGATE): A federal collaboration to improve cancer care. Semin Oncol. 2019 Oct 22;: Authors: Schiller SJ, Shannon C, Brophy MT, Denicoff AM, Good MJ, Prindiville SA, Huang GD Abstract Cancer clinical trials represent an important option for patients with a diagnosis of cancer and the clinician-investigators involved in...
Wed Nov 13, 2019 19:46
Related ArticlesWound monitoring of pH and oxygen in patients after radiation therapy. Radiat Oncol. 2019 Nov 11;14(1):199 Authors: Auerswald S, Schreml S, Meier R, Blancke Soares A, Niyazi M, Marschner S, Belka C, Canis M, Haubner F Abstract OBJECTIVES: Postradiogenic wound healing disorders are an important clinical problem. While a variety of treatment modalities are available, there is no strategy to objectively judge treatment success. The aim of...
Wed Nov 13, 2019 19:46
Related ArticlesNovel HDGF/HIF-1α/VEGF axis in oral cancer impacts disease prognosis. BMC Cancer. 2019 Nov 11;19(1):1083 Authors: Lin YW, Huang ST, Wu JC, Chu TH, Huang SC, Lee CC, Tai MH Abstract BACKGROUND: Hepatoma-derived growth factor (HDGF) participates in angiogenesis and represents a negative prognostic factor in oral cancer. The current study was designed to elucidate the regulatory mechanism between HDGF and vascular endothelial growth factor...
Wed Nov 13, 2019 19:46
Related ArticlesCurrent and Future Aspects of Immunotherapy for Esophageal and Gastric Malignancies. Am Soc Clin Oncol Educ Book. 2019 Jan;39:237-247 Authors: De Mello RA, Lordick F, Muro K, Janjigian YY Abstract Esophagogastric (EG) cancer has a poor prognosis despite the use of standard therapies, such as chemotherapy and biologic agents. Recently, immune checkpoint inhibitors (ICIs) have been introduced as treatments for EG cancer; nivolumab and pembrolizumab...
Wed Nov 13, 2019 19:46
Related ArticlesThe Value and Future Developments of Multidisciplinary Team Cancer Care. Am Soc Clin Oncol Educ Book. 2019 Jan;39:332-340 Authors: Selby P, Popescu R, Lawler M, Butcher H, Costa A Abstract Multidisciplinary teams (MDTs) have been recommended as a key part of best cancer care for 25 years. Here, we set out the functions and approaches of MDTs and review their impact. Although the literature is patchy in quality, MDTs contribute to improving...
Wed Nov 13, 2019 19:46
Related ArticlesA Hypothesis-Generating Study Using Electrophysiology to Examine Cognitive Function in Colon Cancer Patients. Arch Clin Neuropsychol. 2019 Nov 11;: Authors: Hung SH, Mutti Jaswal S, Neil-Sztramko SE, Kam JWY, Niksirat N, C Handy T, Liu-Ambrose T, Lim HJ, Hayden S, Gill S, Campbell KL Abstract INTRODUCTION: The purpose of this study was to describe the trajectory of cognitive function using neuropsychological tests and electrophysiological...
Tue Nov 12, 2019 16:45
Related ArticlesCystic fibrosis in Turkey: First data from the national registry. Pediatr Pulmonol. 2019 Nov 11;: Authors: Dogru D, Çakır E, Şişmanlar T, Çobanoğlu N, Pekcan S, Cinel G, Yalçın E, Kiper N, Şen V, S Şen H, Ercan Ö, Keskin Ö, B Eltan S, Al Shadfan LM, Yazan H, Altıntaş DU, Şaşihüseyinoğlu Ş, Sapan N, Çekiç Ş, Çokuğraş H, A Kılınç A, R Gürsoy T, Aslan AT, Bingöl A, Başaran AE, Özdemir A, Köse M, Hangül M, Emiralioğlu N, Tuğcu G, Yüksel H, Yılmaz Ö, Orhan...
Tue Nov 12, 2019 16:45
Related ArticlesMyelofibrosis: best practices, controversies and 2019 update. Expert Rev Hematol. 2019 Nov 08;: Authors: Cruz NM, Gergis U, Silver RT Abstract Introduction: Recent advances in the prognostic scheme and treatment of primary and secondary myelofibrosis (MF) have resulted in an overwhelming amount of clinical information to assimilate. The authors believe a comprehensive review that summarizes the most recent published literature, could...
Tue Nov 12, 2019 16:45
Related ArticlesXRCC1 632 as a candidate for cancer predisposition via a complex interaction with genetic variants of base excision repair and double strand break repair genes. Future Oncol. 2019 Nov 11;: Authors: Singh A, Singh N, Behera D, Sharma S Abstract Aim: The DNA repair system safeguards integrity of DNA. Genetic alterations force the improper repair which in conjugation with other factors ultimately results in carcinogenesis. Materials &...
Tue Nov 12, 2019 16:45
Related ArticlesSurvival outcome of tyrosine kinase inhibitors beyond progression in association to radiotherapy in oligoprogressive EGFR-mutant non-small-cell lung cancer. Future Oncol. 2019 Nov 11;: Authors: Rossi S, Finocchiaro G, Noia VD, Bonomi M, Cerchiaro E, Rose F, Franceschini D, Navarria P, Ceresoli GL, Beretta GD, D'Argento E, Scorsetti M, Santoro A, Toschi L Abstract Aim: The association of tyrosine kinase inhibitors (TKIs) and local radiotherapy...
Tue Nov 12, 2019 16:45
Related ArticlesA summary of high quality online information resources for parents with cancer who have adolescent and young adult children: A scoping review. Psychooncology. 2019 Nov 11;: Authors: Weeks N, McDonald FEJ, Patterson P, Konings S, Coad J Abstract OBJECTIVE: Parents with cancer want information about maintaining family functioning despite cancer. This scoping review assesses what online information resources are available to help parents...
Tue Nov 12, 2019 13:22
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Tue Nov 12, 2019 13:22
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