IJERPH, Vol. 16, Pages 4601: Examining the Mental Well-Being of Australian Sport Coaches International Journal of Environmental Research and Public Health doi: 10.3390/ijerph16234601 Authors: Fraser Carson Mary Malakellis Julia Walsh Luana C. Main Peter Kremer Background: Research has highlighted the multitude of factors that are negatively associated with coach mental well-being but has failed to investigate how the determinants of mental well-being can affect the coach...
Wed Nov 20, 2019 02:00
IJERPH, Vol. 16, Pages 4592: Impacts of Built Environment on Urban Vitality: Regression Analyses of Beijing and Chengdu, China International Journal of Environmental Research and Public Health doi: 10.3390/ijerph16234592 Authors: Shiwei Lu Chaoyang Shi Xiping Yang The loss of urban vitality is an important problem in the development of urban central areas. Analyzing the correlation between urban built environment and urban vitality supports urban planning and design. However, current...
Wed Nov 20, 2019 02:00
IJERPH, Vol. 16, Pages 4593: Rapid Biodegradation of the Organophosphorus Insecticide Chlorpyrifos by Cupriavidus nantongensis X1T International Journal of Environmental Research and Public Health doi: 10.3390/ijerph16234593 Authors: Shi Fang Qin Chen Wu Hua Chlorpyrifos was one of the most widely used organophosphorus insecticides and the neurotoxicity and genotoxicity of chlorpyrifos to mammals, aquatic organisms and other non-target organisms have caused much...
Wed Nov 20, 2019 02:00
IJERPH, Vol. 16, Pages 4589: Pyruvate Kinase M2 Expression: A Potential Metabolic Biomarker to Differentiate Endometrial Precancer and Cancer That Is Associated with Poor Outcomes in Endometrial Carcinoma International Journal of Environmental Research and Public Health doi: 10.3390/ijerph16234589 Authors: Lai Chou Lin Yu Ou Chu Wu Wang Chao Background: Pyruvate kinase M2 (PKM2) is a regulator of the processes of glycolysis and oxidative phosphorylation,...
Wed Nov 20, 2019 02:00
IJERPH, Vol. 16, Pages 4591: Heartburn-Related Internet Searches and Trends of Interest across Six Western Countries: A Four-Year Retrospective Analysis Using Google Ads Keyword Planner International Journal of Environmental Research and Public Health doi: 10.3390/ijerph16234591 Authors: Kamiński Łoniewski Misera Marlicz The internet is becoming the main source of health-related information. We aimed to investigate data regarding heartburn-related searches made by Google...
Wed Nov 20, 2019 02:00
IJERPH, Vol. 16, Pages 4590: Examining the Factor Structure of the Pittsburgh Sleep Quality Index in a Multi-Ethnic Working Population in Singapore International Journal of Environmental Research and Public Health doi: 10.3390/ijerph16234590 Authors: Dunleavy Bajpai Tonon Chua Cheung Soh Christopoulos Vries Car The Pittsburgh Sleep Quality Index (PSQI) is a widely used measure for assessing sleep impairment. Although it was developed as a unidimensional...
Wed Nov 20, 2019 02:00
IJERPH, Vol. 16, Pages 4595: Perceived Stress among Different Occupational Groups and the Interaction with Sedentary Behaviour International Journal of Environmental Research and Public Health doi: 10.3390/ijerph16234595 Authors: Dėdelė Miškinytė Andrušaitytė Bartkutė Sedentary lifestyle and low physical activity are associated with health issues, including both physical and mental health, non-communicable diseases, overweight, obesity and reduced quality of life. This study...
Wed Nov 20, 2019 02:00
IJMS, Vol. 20, Pages 5840: Recent Insights into Long Bone Development: Central Role of Hedgehog Signaling Pathway in Regulating Growth Plate International Journal of Molecular Sciences doi: 10.3390/ijms20235840 Authors: Haraguchi Kitazawa Kohara Ikedo Imai Kitazawa The longitudinal growth of long bone, regulated by an epiphyseal cartilaginous component known as the “growth plate”, is generated by epiphyseal chondrocytes. The growth plate provides...
Wed Nov 20, 2019 02:00
IJMS, Vol. 20, Pages 5838: Cytosolic Acidification Is the First Transduction Signal of Lactoferrin-induced Regulated Cell Death Pathway International Journal of Molecular Sciences doi: 10.3390/ijms20235838 Authors: Andrés Acosta-Zaldívar González-Seisdedos Fierro In yeast, we reported the critical role of K+-efflux for the progress of the regulated cell death (RCD) induced by human lactoferrin (hLf), an antimicrobial protein of the innate immune system that blocks Pma1p...
Wed Nov 20, 2019 02:00
IJMS, Vol. 20, Pages 5839: Nucleoplasmic Reticulum Formation in Human Endometrial Cells is Steroid Hormone Responsive and Recruits Nascent Components International Journal of Molecular Sciences doi: 10.3390/ijms20235839 Authors: Pytowski Drozdz Jiang Hernandez Kumar Knott Vaux The nuclei of cells may exhibit invaginations of the nuclear envelope under a variety of conditions. These invaginations form a branched network termed the nucleoplasmic reticulum (NR),...
Wed Nov 20, 2019 02:00
IJMS, Vol. 20, Pages 5837: Stay-Green Trait: A Prospective Approach for Yield Potential, and Drought and Heat Stress Adaptation in Globally Important Cereals International Journal of Molecular Sciences doi: 10.3390/ijms20235837 Authors: Kamal Alnor Gorafi Abdelrahman Abdellatef Tsujimoto The yield losses in cereal crops because of abiotic stress and the expected huge losses from climate change indicate our urgent need for useful traits to achieve food security. The stay-green...
Wed Nov 20, 2019 02:00
IJMS, Vol. 20, Pages 5835: Near-Infrared Photoimmunotherapy Using a Small Protein Mimetic for HER2-Overexpressing Breast Cancer International Journal of Molecular Sciences doi: 10.3390/ijms20235835 Authors: Yamaguchi Pantarat Suzuki Evdokiou Near-infrared photoimmunotherapy (NIR-PIT) is a new and promising cancer therapy based on a monoclonal antibody conjugated to a photosensitizer which is activated by near-infrared light irradiation, causing cell death. We investigated...
Wed Nov 20, 2019 02:00
IJMS, Vol. 20, Pages 5836: Telomere Maintenance in Pediatric Cancer International Journal of Molecular Sciences doi: 10.3390/ijms20235836 Authors: Ackermann Fischer Telomere length has been proposed as a biomarker of biological age and a risk factor for age-related diseases and cancer. Substantial progress has been made in recent decades in understanding the complex molecular relationships in this research field. However, the majority of telomere studies have been conducted in adults....
Wed Nov 20, 2019 02:00
IJMS, Vol. 20, Pages 5834: Virtual Screening Using Pharmacophore Models Retrieved from Molecular Dynamic Simulations International Journal of Molecular Sciences doi: 10.3390/ijms20235834 Authors: Pavel Polishchuk Alina Kutlushina Dayana Bashirova Olena Mokshyna Timur Madzhidov Pharmacophore models are widely used for the identification of promising primary hits in compound large libraries. Recent studies have demonstrated that pharmacophores retrieved from protein-ligand...
Wed Nov 20, 2019 02:00
IJMS, Vol. 20, Pages 5833: Significant Benefits of Nanoparticles Containing a Necrosis Inhibitor on Mice Testicular Tissue Autografts Outcomes International Journal of Molecular Sciences doi: 10.3390/ijms20235833 Authors: Federico Del Vento Maxime Vermeulen Bernard Ucakar Jonathan Poels Anne des Rieux Christine Wyns Fertility preservation for prepubertal boys relies exclusively on cryopreservation of immature testicular tissue (ITT) containing spermatogonia as the only...
Wed Nov 20, 2019 02:00
IJMS, Vol. 20, Pages 5832: Suppression of 6-Hydroxydopamine-Induced Oxidative Stress by Hyperoside Via Activation of Nrf2/HO-1 Signaling in Dopaminergic Neurons International Journal of Molecular Sciences doi: 10.3390/ijms20235832 Authors: Kwon Lee Park Ra Lee Pang Kim In our ongoing research to discover natural products with neuroprotective effects, hyperoside (quercetin 3-O-galactoside) was isolated from Acer tegmentosum, which has been used in Korean traditional...
Wed Nov 20, 2019 02:00
IJMS, Vol. 20, Pages 5831: Renal Benefits of SGLT 2 Inhibitors and GLP-1 Receptor Agonists: Evidence Supporting a Paradigm Shift in the Medical Management of Type 2 Diabetes International Journal of Molecular Sciences doi: 10.3390/ijms20235831 Authors: Vjera Ninčević Tea Omanović Kolarić Hrvoje Roguljić Tomislav Kizivat Martina Smolić Ines Bilić Ćurčić Diabetic nephropathy (DN) is one of the most perilous side effects of diabetes mellitus type 1 and type 2 (T1DM and T2DM).)....
Wed Nov 20, 2019 02:00
IJMS, Vol. 20, Pages 5830: Radiation-Stimulated Translocation of CD166 and CRYAB to the Endothelial Surface Provides Potential Vascular Targets on Irradiated Brain Arteriovenous Malformations International Journal of Molecular Sciences doi: 10.3390/ijms20235830 Authors: McRobb McKay Gauden Lee Subramanian Thomas Wiedmann Moutrie Grace Zhao Molloy Stoodley Vascular targeting with pro-thrombotic antibody-conjugates is a promising biological...
Wed Nov 20, 2019 02:00
IJMS, Vol. 20, Pages 5828: Altered Genome-Wide DNA Methylation in Peripheral Blood of South African Women with Gestational Diabetes Mellitus International Journal of Molecular Sciences doi: 10.3390/ijms20235828 Authors: Stephanie Dias Sumaiya Adam Paul Rheeder Johan Louw Carmen Pheiffer Increasing evidence implicate altered DNA methylation in the pathophysiology of gestational diabetes mellitus (GDM). This exploratory study probed the association between GDM and peripheral...
Wed Nov 20, 2019 02:00
IJMS, Vol. 20, Pages 5827: Metabolically Active Brown Adipose Tissue Is Found in Adult Subjects with Type 1 Diabetes International Journal of Molecular Sciences doi: 10.3390/ijms20235827 Authors: Eriksson Selvaraju Berglund Espes Type 1 diabetes (T1D) is characterized by the loss of insulin-producing cells and hence insulin secretion and metabolic control. In addition to insulin, there are a number of hormones and cytokines that influence metabolism, and many of these can...
Wed Nov 20, 2019 02:00
IJMS, Vol. 20, Pages 5825: In Silico Approach for the Definition of radiomiRNomic Signatures for Breast Cancer Differential Diagnosis International Journal of Molecular Sciences doi: 10.3390/ijms20235825 Authors: Francesca Gallivanone Claudia Cava Fabio Corsi Gloria Bertoli Isabella Castiglioni Personalized medicine relies on the integration and consideration of specific characteristics of the patient, such as tumor phenotypic and genotypic profiling. Background: Radiogenomics...
Wed Nov 20, 2019 02:00
IJMS, Vol. 20, Pages 5829: Autophagy in the Central Nervous System and Effects of Chloroquine in Mucopolysaccharidosis Type II Mice International Journal of Molecular Sciences doi: 10.3390/ijms20235829 Authors: Mitsuyo Maeda Toshiyuki Seto Chiho Kadono Hideto Morimoto Sachiho Kida Mitsuo Suga Motohiro Nakamura Yosky Kataoka Takashi Hamazaki Haruo Shintaku Mucopolysaccharidosis type II (MPS II) is a rare lysosomal storage disease (LSD) involving a genetic error...
Wed Nov 20, 2019 02:00
IJMS, Vol. 20, Pages 5824: Molecular Interactions between Pathogens and the Circadian Clock International Journal of Molecular Sciences doi: 10.3390/ijms20235824 Authors: Sailen Barik The daily periodicity of the Earth’s rotation around the Sun, referred to as circadian (Latin “circa” = about, and “diem” = day), is also mirrored in the behavior and metabolism of living beings. The discovery that dedicated cellular genes control various...
Wed Nov 20, 2019 02:00
IJMS, Vol. 20, Pages 5826: CGRP Signaling via CALCRL Increases Chemotherapy Resistance and Stem Cell Properties in Acute Myeloid Leukemia International Journal of Molecular Sciences doi: 10.3390/ijms20235826 Authors: Tobias Gluexam Alexander M. Grandits Angela Schlerka Chi Huu Nguyen Julia Etzler Thomas Finkes Michael Fuchs Christoph Scheid Gerwin Heller Hubert Hackl Nathalie Harrer Heinz Sill Elisabeth Koller Dagmar Stoiber Wolfgang Sommergruber Rotraud...
Wed Nov 20, 2019 02:00
IJMS, Vol. 20, Pages 5822: Transforming Growth Factor-β Signaling Pathway in Colorectal Cancer and Its Tumor Microenvironment International Journal of Molecular Sciences doi: 10.3390/ijms20235822 Authors: Yoshiro Itatani Kenji Kawada Yoshiharu Sakai Transforming growth factor-beta (TGF-β) signaling is one of the important cellular pathways that play key roles for tissue maintenance. In particular, it is important in the context of inflammation and tumorigenesis by modulating...
Wed Nov 20, 2019 02:00
IJMS, Vol. 20, Pages 5823: Heat Shock Cognate 70 Functions as A Chaperone for the Stability of Kinetochore Protein CENP-N in Holocentric Insect Silkworms International Journal of Molecular Sciences doi: 10.3390/ijms20235823 Authors: Bingqian Li Zhiqing Li Chenchen Lu Li Chang Dongchao Zhao Guanwang Shen Takahiro Kusakabe Qingyou Xia Ping Zhao The centromere, in which kinetochore proteins are assembled, plays an important role in the accurate congression and segregation...
Wed Nov 20, 2019 02:00
IJMS, Vol. 20, Pages 5821: Beyond the Cell Surface: Targeting Intracellular Negative Regulators to Enhance T cell Anti-Tumor Activity International Journal of Molecular Sciences doi: 10.3390/ijms20235821 Authors: Sitaram Uyemura Malarkannan Riese It is well established that extracellular proteins that negatively regulate T cell function, such as Cytotoxic T-Lymphocyte-Associated protein 4 (CTLA-4) and Programmed Cell Death protein 1 (PD-1), can be effectively targeted to...
Wed Nov 20, 2019 02:00
IJMS, Vol. 20, Pages 5820: Exploring Frequencies of Circulating Specific Th17 Cells against Myeloperoxidase and Proteinase 3 in ANCA Associated Vasculitis International Journal of Molecular Sciences doi: 10.3390/ijms20235820 Authors: Martinez Valenzuela Draibe Quero Fulladosa Cruzado Bestard Torras : Background: The role of the T helper 17 (Th17) cell subset in anti-neutrophil cytoplasm antibodies (ANCA) associated vasculitis (AAV) is controversial. We hypothesized...
Wed Nov 20, 2019 02:00
JCM, Vol. 8, Pages 2031: Regorafenib CSF Penetration, Efficacy, and MRI Patterns in Recurrent Malignant Glioma Patients Journal of Clinical Medicine doi: 10.3390/jcm8122031 Authors: Zeiner Kinzig Divé Maurer Filipski Harter Senft Bähr Hattingen Steinbach Sörgel Voss Steidl Ronellenfitsch (1) Background: The phase 2 Regorafenib in Relapsed Glioblastoma (REGOMA) trial indicated a survival benefit for patients with first recurrence of...
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JCM, Vol. 8, Pages 2030: Insights into the Regulation of Tumor Angiogenesis by Micro-RNAs Journal of Clinical Medicine doi: 10.3390/jcm8122030 Authors: Leone Buonavoglia Fasano Solimando De Re Cicco Vacca Racanelli One of the hallmarks of cancer is angiogenesis, a series of events leading to the formation of the abnormal vascular network required for tumor growth, development, progression, and metastasis. MicroRNAs (miRNAs) are short, single-stranded, non-coding...
Wed Nov 20, 2019 02:00
JCM, Vol. 8, Pages 2027: Clinical Inference of Serum and Bone Sclerostin Levels in Patients with End-Stage Kidney Disease Journal of Clinical Medicine doi: 10.3390/jcm8122027 Authors: Maré Verhulst Cavalier Delanaye Behets Meijers Kuypers D’Haese Evenepoel Mounting evidence indicates that sclerostin, a well-known inhibitor of bone formation, may qualify as a clinically relevant biomarker of chronic kidney disease-related mineral and bone disorder (CKD-MBD),...
Wed Nov 20, 2019 02:00
JCM, Vol. 8, Pages 2028: Translational Insights into Extremely Low Frequency Pulsed Electromagnetic Fields (ELF-PEMFs) for Bone Regeneration after Trauma and Orthopedic Surgery Journal of Clinical Medicine doi: 10.3390/jcm8122028 Authors: Ehnert Schröter Aspera-Werz Eisler Falldorf Ronniger Nussler The finding that alterations in electrical potential play an important role in the mechanical stimulation of the bone provoked hype that noninvasive extremely low...
Wed Nov 20, 2019 02:00
JCM, Vol. 8, Pages 2026: Human Ovarian Granulosa Cells Isolated during an IVF Procedure Exhibit Differential Expression of Genes Regulating Cell Division and Mitotic Spindle Formation Journal of Clinical Medicine doi: 10.3390/jcm8122026 Authors: Brązert Kranc Chermuła Kowalska Jankowski Celichowski Jeseta Piotrowska-Kempisty Pawelczyk Zabel Mozdziak Kempisty Granulosa cells (GCs) are a population of somatic cells whose role after ovulation...
Wed Nov 20, 2019 02:00
JCM, Vol. 8, Pages 2029: A Novel Saliva-Based miRNA Signature for Colorectal Cancer Diagnosis Journal of Clinical Medicine doi: 10.3390/jcm8122029 Authors: Rapado-González Majem Álvarez-Castro Díaz-Peña Abalo Suárez-Cabrera Gil-Moreno Santamaría López-López Muinelo-Romay Suarez-Cunqueiro Salivary microRNAs (miRNAs) are of high interest as diagnostic biomarkers for non-oral cancer. However, little is known about their value for colorectal cancer...
Wed Nov 20, 2019 02:00
JCM, Vol. 8, Pages 2025: Fecal Eosinophil Cationic Protein Is a Diagnostic and Predictive Biomarker in Young Adults with Inflammatory Bowel Disease Journal of Clinical Medicine doi: 10.3390/jcm8122025 Authors: Nada Teresa Sandra Jessica Stefani Christian Konrad Gernot : Background and Aims: Fecal biomarkers are important non-invasive markers monitoring disease activity in inflammatory bowel disease (IBD). We compared the significance of fecal eosinophil cationic...
Wed Nov 20, 2019 02:00
JPM, Vol. 9, Pages 50: Feasibility of a mHealth Approach to Nutrition Counseling in an Appalachian State Journal of Personalized Medicine doi: 10.3390/jpm9040050 Authors: Olfert Barr Hagedorn Long Haggerty Weimer Golden Maurer Cochran Hendershot Whanger Mason Hodder West Virginia is a rural state with an aging population that may experience barriers to accessing nutritional and lifestyle counseling. This study examined feasibility of an...
Wed Nov 20, 2019 02:00
Medicina, Vol. 55, Pages 752: Perfusion Index Analysis in Patients Presenting to the Emergency Department Due to Synthetic Cannabinoid Use Medicina doi: 10.3390/medicina55120752 Authors: Yeniocak Background and objectives: The perfusion index (PI) indicates the ratio of pulsatile blood flow in peripheral tissue to non-pulsatile blood flow. This study was performed to examine the blood perfusion status of tissues and organs of patients using synthetic cannabinoids (SCs). Materials and...
Wed Nov 20, 2019 02:00
Medicina, Vol. 55, Pages 751: The MIR 2018 Exam: Psychometric Study and Comparison with the Previous Nine Years Medicina doi: 10.3390/medicina55120751 Authors: Baladrón Sánchez Lasheras Romeo Ladrero Villacampa Curbelo Jiménez Fonseca García Guerrero Background and Objectives: The aim of the present research is to study the questions used in the 2018 MIR exam (a test that allows access to specialized medical training in Spain), describe their psychometric properties,...
Wed Nov 20, 2019 02:00
Medicina, Vol. 55, Pages 753: The Role of C21orf91 in Herpes Simplex Virus Keratitis Medicina doi: 10.3390/medicina55120753 Authors: Danileviciene Zemaitiene Gintauskiene Nedzelskiene Zaliuniene Background and Objectives: This paper aims to describe the single nucleotide polymorphisms (SNPs) of C21orf91 rs1062202 and rs10446073 in patients with herpetic keratitis by evaluating corneal sub-basal nerves, as well as the density of Langerhans cells (LC) and endothelium cells...
Wed Nov 20, 2019 02:00
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