Metabolites, Vol. 9, Pages 283: The Application of Metabolomic Techniques in Research Investigating Neurodegenerative Diseases Metabolites doi: 10.3390/metabo9120283 Authors: Brian D. Green We live in a world posing many new and different challenges for human health, and one such challenge is the rapidly expanding number of cases of human neurodegenerative disease [...]
Wed Nov 20, 2019 02:00
Metabolites, Vol. 9, Pages 282: Glucose-6 Phosphate, A Central Hub for Liver Carbohydrate Metabolism
Metabolites, Vol. 9, Pages 282: Glucose-6 Phosphate, A Central Hub for Liver Carbohydrate Metabolism Metabolites doi: 10.3390/metabo9120282 Authors: Rajas Gautier-Stein Mithieux : Cells efficiently adjust their metabolism according to the abundance of nutrients and energy. The ability to switch cellular metabolism between anabolic and catabolic processes is critical for cell growth. Glucose-6 phosphate is the first intermediate of glucose metabolism and plays a central role...
Wed Nov 20, 2019 02:00
MPs, Vol. 2, Pages 87: Transferring Grains from Single-Grain Luminescence Discs to SEM Specimen Stubs Methods and Protocols doi: 10.3390/mps2040087 Authors: Doverbratt Alexanderson The grain transfer protocol presents a step-by-step guide on how to successfully transfer positioned grains from a single-grain luminescence disc to a scanning electron microscope (SEM) specimen stub and how to transport them between laboratories. Single-grain luminescence analysis allows the determination...
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Microorganisms, Vol. 7, Pages 592: A Mesophilic Aeromonas salmonicida Strain Isolated from an Unsuspected Host, the Migratory Bird Pied AvocetMicroorganisms doi: 10.3390/microorganisms7120592Authors: Vincent Bernatchez Frey CharetteAeromonas salmonicida is a Gram-negative bacterium, known as a fish pathogen since its discovery. Although the species was initially considered psychrophilic, a mesophilic subspecies (pectinolytica) and many other mesophilic strains still not attributed to subspecies have...
Wed Nov 20, 2019 02:00
Microorganisms, Vol. 7, Pages 590: The Degradative Capabilities of New Amycolatopsis Isolates on Polylactic AcidMicroorganisms doi: 10.3390/microorganisms7120590Authors: Decorosi Exana Pini Adessi Messini Giovannetti VitiPolylactic acid (PLA), a bioplastic synthesized from lactic acid, has a broad range of applications owing to its excellent proprieties such as a high melting point, good mechanical strength, transparency, and ease of fabrication. However, the safe disposal of PLA is an emerging environmental...
Wed Nov 20, 2019 02:00
Microorganisms, Vol. 7, Pages 591: Performance of an Immunochromatographic Test (ICT) in Comparison to Some Commonly Used Serological Tests for the Diagnosis of Brucellosis in Dromedary Camels (Camelus dromedarius)Microorganisms doi: 10.3390/microorganisms7120591Authors: Serhan Khan Gasim Alketbi De Massis Calistri Giovannini Al Hosani Al Jaberi Al Mansoori Al Ketbi Khalafalla AlmuhairiSerological tests may represent an essential tool for the diagnosis of camel brucellosis; however, concerns arise...
Wed Nov 20, 2019 02:00
Microorganisms, Vol. 7, Pages 586: Root-Associated Fungal Communities in Two Populations of the Fully Mycoheterotrophic Plant Arachnitis uniflora Phil. (Corsiaceae) in Southern ChileMicroorganisms doi: 10.3390/microorganisms7120586Authors: Herrera Soto de Bashan Sampedro ArriagadaThe microbiological interactions of the roots of non-photosynthetic plants in South America have been scarcely explored. This study analyzes culturable fungal diversity associated with the mycoheterotrophic plant Arachnitis...
Wed Nov 20, 2019 02:00
Microorganisms, Vol. 7, Pages 588: Marek’s Disease Virus Infection of Natural Killer CellsMicroorganisms doi: 10.3390/microorganisms7120588Authors: Bertzbach van Haarlem Härtle Kaufer JansenNatural killer (NK) cells are key players in the innate immune response. They kill virus-infected cells and are crucial for the induction of adaptive immune responses. Marek's disease virus (MDV) is a highly contagious alphaherpesvirus that causes deadly T cell lymphomas in chickens. Host resistance to MDV is...
Wed Nov 20, 2019 02:00
Microorganisms, Vol. 7, Pages 584: Structural and Functional Dynamics of Staphylococcus aureus Biofilms and Biofilm Matrix Proteins on Different Clinical MaterialsMicroorganisms doi: 10.3390/microorganisms7120584Authors: Hiltunen Savijoki Nyman Miettinen Ihalainen Peltonen FallareroMedical device-associated staphylococcal infections are a common and challenging problem. However, detailed knowledge of staphylococcal biofilm dynamics on clinically relevant surfaces is still limited. In the present...
Wed Nov 20, 2019 02:00
Microorganisms, Vol. 7, Pages 587: Variation in Soil Fungal Composition Associated with the Invasion of Stellera chamaejasme L. in Qinghai–Tibet Plateau GrasslandMicroorganisms doi: 10.3390/microorganisms7120587Authors: He Detheridge Liu Wang Wei Griffith Scullion WeiStellera chamaejasme L. is the most problematic weed in China’s grasslands. Its root exudates affect co-occurring plants and thus may also affect soil fungi. Soils (0–20 cm depth) on two adjacent sites, one invaded...
Wed Nov 20, 2019 02:00
Microorganisms, Vol. 7, Pages 585: First Insights into the Microbiome of a Mangrove Tree Reveal Significant Differences in Taxonomic and Functional Composition among Plant and Soil CompartmentsMicroorganisms doi: 10.3390/microorganisms7120585Authors: Purahong Sadubsarn Tanunchai Wahdan Sansupa Noll Wu BuscotMangrove forest trees play important ecological functions at the interface between terrestrial and marine ecosystems. However, despite playing crucial roles in plant health and productivity, there...
Wed Nov 20, 2019 02:00
Microorganisms, Vol. 7, Pages 589: DNA Methylation Profile of β-1,3-Glucanase and Chitinase Genes in Flax Shows Specificity Towards Fusarium Oxysporum Strains Differing in PathogenicityMicroorganisms doi: 10.3390/microorganisms7120589Authors: Wojtasik Boba Preisner Kostyn Szopa KulmaMost losses in flax (Linum usitatissimum L.) crops are caused by fungal infections. The new epigenetic approach to improve plant resistance requires broadening the knowledge about the influence of pathogenic and non-pathogenic...
Wed Nov 20, 2019 02:00
Microorganisms, Vol. 7, Pages 583: The Th17/Treg Cell Balance: A Gut Microbiota-Modulated StoryMicroorganisms doi: 10.3390/microorganisms7120583Authors: Cheng Guan Chen MaThe intestinal tract of vertebrates is normally colonized with a remarkable number of commensal microorganisms that are collectively referred to as gut microbiota. Gut microbiota has been demonstrated to interact with immune cells and to modulate specific signaling pathways involving both innate and adaptive immune processes. Accumulated...
Wed Nov 20, 2019 02:00
Molbank, Vol. 2019, Article M1093: 2,2’-((1,4-Dimethoxy-1,4-dioxobutane-2,3-diylidene)bis(azanylylidene))bis(quinoline-3-carboxylic acid) Molbank doi: 10.3390/M1093 Authors: Fedorowicz Gzella Wiśniewska Sączewski The title compound, 2,2’-((1,4-dimethoxy-1,4-dioxobutane-2,3-diylidene)bis(azanylylidene))bis(quinoline-3-carboxylic acid) was synthesized from isoxazolo[3,4-b]quinolin-3(1H)-one and dimethyl acetylenedicarboxylate (DMAD) via a double aza-Michael addition...
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Molbank, Vol. 2019, Article M1092: 1,1,4,7-Tetramethyldecahydro-1H-cyclopropa[e]azulen-7-ol from the Stembark Chisocheton pentandrus Molbank doi: 10.3390/M1092 Authors: Fareza Nurlelasari Supratman Katja Husna Awang A new aromadendrane-type sesquiterpenoid, namely dehydrosphatulenol (1), has been isolated from the stembark of Chisocheton pentandrus. The chemical structure of 1 was characterized on the basis of spectroscopic evidences including mainly one dimension...
Wed Nov 20, 2019 02:00
Molecules, Vol. 24, Pages 4229: Aptamers: A Review of Their Chemical Properties and Modifications for Therapeutic Application Molecules doi: 10.3390/molecules24234229 Authors: Adachi Nakamura Aptamers are short, single-stranded oligonucleotides that bind to specific target molecules. The shape-forming feature of single-stranded oligonucleotides provides high affinity and excellent specificity toward targets. Hence, aptamers can be used as analogs of antibodies. In December 2004,...
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Molecules, Vol. 24, Pages 4230: Total Synthesis of the Proposed Structure of Paraphaeosphaeride C Molecules doi: 10.3390/molecules24234230 Authors: Kobayashi Kunimura Kogen Paraphaeosphaeride C is a demethoxy derivative of phaeosphaeride A and exhibits STAT3 inhibitory activity. Our previous papers reported the total synthesis of phaeosphaeride A using a diastereoselective vinyl anion aldol reaction as the key step to construct the dihydropyran ring. In this work, the first...
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Molecules, Vol. 24, Pages 4228: Correction: Liu, M., et al. Potent Effects of Flavonoid-Rich Extract from Rosa laevigata Michx Fruit against Hydrogen Peroxide-Induced Damage in PC12 Cells via Attenuation of Oxidative Stress, Inflammation and Apoptosis. Molecules 2014, 19, 11816–11832. Molecules doi: 10.3390/molecules24234228 Authors: Min Liu Youwei Xu Xu Han Chen Liang Lianhong Yin Lina Xu Yan Qi Yanyan Zhao Jinyong Peng Changkai Sun During the course of a...
Wed Nov 20, 2019 02:00
Molecules, Vol. 24, Pages 4226: Multifunctional and Environmentally Friendly TiO2–SiO2 Mesoporous Materials for Sustainable Green Buildings Molecules doi: 10.3390/molecules24234226 Authors: Ghedini Menegazzo Manzoli Di Michele Puglia Signoretto This work deals with the formulation of environmentally friendly, cheap, and readily-available materials for green building applications, providing the function of air purificator by improving the safety and the comfort of...
Wed Nov 20, 2019 02:00
Molecules, Vol. 24, Pages 4225: Composition of Sugars in Wild and Cultivated Lingonberries (Vaccinium vitis-idaea L.) Molecules doi: 10.3390/molecules24234225 Authors: Gabriele Vilkickyte Raimondas Raudonis Vida Motiekaityte Rimanta Vainoriene Deividas Burdulis Jonas Viskelis Lina Raudone Products of lingonberries are widely used in the human diet; they are also promising beauty and health therapeutic candidates in the cosmetic and pharmaceutical industries. It is important...
Wed Nov 20, 2019 02:00
Molecules, Vol. 24, Pages 4224: Michael Addition Reaction Catalyzed by Imidazolium Chloride to Protect Amino Groups and Construct Medium Ring Heterocycles Molecules doi: 10.3390/molecules24234224 Authors: Dai Tian Li Shang Luo Wang Li Zhang Li Yuan An effective approach for amino protection and construction of a seven-membered ring has been developed. The method uses imidazolium chloride to carry out the Michael addition reaction at low temperatures...
Wed Nov 20, 2019 02:00
Molecules, Vol. 24, Pages 4227: Synthesis of Aryl Propionamide Scaffold Containing a Pentafluorosulfanyl Moiety as SARMs Molecules doi: 10.3390/molecules24234227 Authors: Shao Zhou Yang Wang Lu Jin The pentafluorosulfane (SF5) group, as a more electronegative bioisostere than the trifluoromethyl (CF3) group, has been gaining greater attention and increasingly reported usage in medicinal chemistry. Ostarine is the selective androgen receptor modulators (SARMs) containing...
Wed Nov 20, 2019 02:00
Molecules, Vol. 24, Pages 4222: Bixa orellana L. (Bixaceae) and Dysphania ambrosioides (L.) Mosyakin & Clemants (Amaranthaceae) Essential Oils Formulated in Nanocochleates against Leishmania amazonensis Molecules doi: 10.3390/molecules24234222 Authors: Laura Machín Beatriz Tamargo Abel Piñón Regla C. Atíes Ramón Scull William N. Setzer Lianet Monzote Leishmaniasis is a group of neglected tropical diseases caused by protozoan parasites of the Leishmania genus. The...
Wed Nov 20, 2019 02:00
Molecules, Vol. 24, Pages 4223: The Frontiers of Nanomaterials (SnS, PbS and CuS) for Dye-Sensitized Solar Cell Applications: An Exciting New Infrared Material Molecules doi: 10.3390/molecules24234223 Authors: Meyer Mbese Agoro To date, extensive studies have been done on solar cells on how to harness the unpleasant climatic condition for the binary benefits of renewable energy sources and potential energy solutions. Photovoltaic (PV) is considered as, not only as the future...
Wed Nov 20, 2019 02:00
Molecules, Vol. 24, Pages 4220: Contribution of Berry Polyphenols to the Human Metabolome Molecules doi: 10.3390/molecules24234220 Authors: Chandra Rathore Kay Everhart Curtis Burton-Freeman Cassidy Kay Diets rich in berries provide health benefits, however, the contribution of berry phytochemicals to the human metabolome is largely unknown. The present study aimed to establish the impact of berry phytochemicals on the human metabolome. A “systematic...
Wed Nov 20, 2019 02:00
Molecules, Vol. 24, Pages 4219: Effect of Forsythiaside A on the RLRs Signaling Pathway in the Lungs of Mice Infected with the Influenza A Virus FM1 Strain Molecules doi: 10.3390/molecules24234219 Authors: Xiao Zheng Yingjie Fu Shan-Shan Shi Sha Wu Yuqi Yan Liuyue Xu Yiwei Wang Zhenyou Jiang Forsythiaside A, a phenylethanoid glycoside monomer extracted from Forsythia suspensa, shows anti-inflammatory, anti-infective, anti-oxidative, and antiviral pharmacological...
Wed Nov 20, 2019 02:00
Molecules, Vol. 24, Pages 4221: Rutin, γ-Aminobutyric Acid, Gallic Acid, and Caffeine Negatively Affect the Sweet-Mellow Taste of Congou Black Tea Infusions Molecules doi: 10.3390/molecules24234221 Authors: Li Yao Wang Hua Wang Yang Dong Zhou Jiang Deng Yuan The sweet-mellow taste sensation is a unique and typical feature of premium congou black tea infusions. To explore the key taste-active compounds that influence the sweet-mellow taste, a sensory...
Wed Nov 20, 2019 02:00
Molecules, Vol. 24, Pages 4217: Discovery of Selective Butyrylcholinesterase (BChE) Inhibitors through a Combination of Computational Studies and Biological Evaluations Molecules doi: 10.3390/molecules24234217 Authors: Zhou Lu Yang Chen Wang Li Tang Cheng Yang Xu Xia As there are increased levels and activity of butyrylcholiesterase (BChE) in the late stage of Alzheimer’s disease (AD), development of selective BChE inhibitors is of vital...
Wed Nov 20, 2019 02:00
Molecules, Vol. 24, Pages 4216: Comprehensive Analysis of the Copper Exchange Implemented in Ammonia and Protonated Forms of Mordenite Using Microwave and Conventional Methods Molecules doi: 10.3390/molecules24234216 Authors: Shelyapina Krylova Zhukov Zvereva Rodriguez-Iznaga Petranovskii Fuentes-Moyado This article presents the results of a comprehensive study of copper-exchanged mordenite samples prepared from its ammonia and protonated forms (Si/Al = 10) using...
Wed Nov 20, 2019 02:00
Molecules, Vol. 24, Pages 4215: A Subcellular Quantitative Proteomic Analysis of Herpes Simplex Virus Type 1-Infected HEK 293T Cells Molecules doi: 10.3390/molecules24234215 Authors: Wan Wang Chen Zhu Shang Xiao Zhang Herpes simplex virus type 1 (HSV-1) is widespread double-stranded DNA (dsDNA) virus that establishes life-long latency and causes diverse severe symptoms. The mechanisms of HSV-1 infection and HSV-1’s interactions with various host cells...
Wed Nov 20, 2019 02:00
Molecules, Vol. 24, Pages 4214: Optimizing the Synthetic Route of Chromone-2-carboxylic Acids: A Step forward to Speed-Up the Discovery of Chromone-Based Multitarget-Directed Ligands Molecules doi: 10.3390/molecules24234214 Authors: Cagide Oliveira Reis Borges 6-Bromochromone-2-carboxylic acid (3) was synthesized by a microwave-assisted process. The optimization of the reaction was performed varying parameters, such as type of base/number of reagent equivalents, solvent,...
Wed Nov 20, 2019 02:00
Molecules, Vol. 24, Pages 4218: Electrophysiology and Behavioral Assessment of the New Molecule SMe1EC2M3 as a Representative of the Future Class of Triple Reuptake Inhibitors Molecules doi: 10.3390/molecules24234218 Authors: Koprdova Csatlosova Durisova Bogi Majekova Dremencov Mach SMe1EC2M3 is a pyridoindole derivative related to the neuroleptic drug carbidine. Based on the structural similarities of SMe1EC2M3 and known serotonin (5-HT), norepinephrine, and...
Wed Nov 20, 2019 02:00
Molecules, Vol. 24, Pages 4212: Recovery of Natural Antioxidants from Agro-Industrial Side Streams through Advanced Extraction Techniques Molecules doi: 10.3390/molecules24234212 Authors: Radu Claudiu Fierascu Irina Fierascu Sorin Marius Avramescu Elwira Sieniawska Large amounts of agro-industrial waste are being generated each year, leading to pollution and economic loss. At the same time, these side streams are rich source of active compounds including antioxidants. Recovered...
Wed Nov 20, 2019 02:00
Molecules, Vol. 24, Pages 4213: Accession-Level Differentiation of Urushiol Levels, and Identification of Cardanols in Nascent Emerged Poison Ivy Seedlings Molecules doi: 10.3390/molecules24234213 Authors: Aneirin A. Lott Emily R. Baklajian Christopher C. Dickinson Eva Collakova John G. Jelesko Poison ivy (Toxicodendron radicans (L.) Kuntze) shows accession-level differentiation in a variety of morphometric traits, suggesting local adaptation. To investigate whether the presumed...
Wed Nov 20, 2019 02:00
Molecules, Vol. 24, Pages 4210: Late-Stage Copper-Catalyzed Radiofluorination of an Arylboronic Ester Derivative of Atorvastatin Molecules doi: 10.3390/molecules24234210 Authors: Gonçalo S. Clemente Tryfon Zarganes-Tzitzikas Alexander Dömling Philip H. Elsinga There is an unmet need for late-stage 18F-fluorination strategies to label molecules with a wide range of relevant functionalities to medicinal chemistry, in particular (hetero)arenes, aiming to obtain unique in vivo information...
Wed Nov 20, 2019 02:00
Molecules, Vol. 24, Pages 4209: Nanoparticle Delivery Systems in the Treatment of Diabetes Complications Molecules doi: 10.3390/molecules24234209 Authors: Eliana B. Souto Selma B. Souto Joana R. Campos Patricia Severino Tatiana N. Pashirova Lucia Y. Zakharova Amélia M. Silva Alessandra Durazzo Massimo Lucarini Angelo A. Izzo Antonello Santini Diabetes mellitus, an incurable metabolic disease, is characterized by changes in the homeostasis of blood sugar...
Wed Nov 20, 2019 02:00
Molecules, Vol. 24, Pages 4211: A Novel pH- and Salt-Responsive N-Succinyl-Chitosan Hydrogel via a One-Step Hydrothermal Process Molecules doi: 10.3390/molecules24234211 Authors: Li Wang Li Ye Peng Deng Jiang In this study, we synthesized a series of pH-sensitive and salt-sensitive N-succinyl-chitosan hydrogels with N-succinyl-chitosan (NSCS) and the crosslinker glycidoxypropyltrimethoxysilane (GPTMS) via a one-step hydrothermal process. The structure and morphology...
Wed Nov 20, 2019 02:00
Molecules, Vol. 24, Pages 4208: Deficiency of Urokinase Plasminogen Activator May Impair β Cells Regeneration and Insulin Secretion in Type 2 Diabetes Mellitus Molecules doi: 10.3390/molecules24234208 Authors: Wu Ou Chang Lin Pei Chen : Background: The relationship between urokinase-type plasminogen activator (uPA) and the development of type 2 diabetes mellitus (T2DM) was investigated in the study by using mice and cell models, as well as patients with T2DM. Methods:...
Wed Nov 20, 2019 02:00
Molecules, Vol. 24, Pages 4207: Screening Effective Antifungal Substances from the Bark and Leaves of Zanthoxylum avicennae by the Bioactivity-Guided Isolation Method Molecules doi: 10.3390/molecules24234207 Authors: Xiong Huang Yao Zhao Zhu Wu Zhou Li Abstract: To find good antifungal substances by the bioactivity-guided isolation method, we tracked down the effective antifungal substances in the bark and leaves of Zanthoxylum avicennae, and isolated three...
Wed Nov 20, 2019 02:00
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