Journal of Cutaneous Medicine and Surgery, Ahead of Print. BackgroundPenile invasive squamous cell carcinoma (SCC) is a rare disease with several known risk factors. However, few studies have assessed its incidence, mortality, and temporal trends.ObjectiveOur objectives are to analyze the epidemiology of penile SCC in Canada and to examine patient distribution with this cancer across Canada in order to elucidate population risk factors.MethodsThree independent cancer registries were used to retrospectively...
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Background. Thrombin could elicit degranulation of mast cells involved in numerous physiologic and pathologic processes; however, the detailed scrutiny of this procedure and further research of possible cell signaling pathways are lacking. Methods. P815 mouse mast cells were exposed to various concentrations of thrombin for 16 h. Expression of protease-activated receptor (PAR)1, PAR2, PAR3, and PAR4 mRNA in P815 was analyzed by quantitative real-time PCR (qRT-PCR) and the fittest concentration of...
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Journal Name: Clinical Chemistry and Laboratory Medicine (CCLM)Issue: Ahead of print
Tue Nov 12, 2019 23:11
Journal Name: Clinical Chemistry and Laboratory Medicine (CCLM)Issue: Ahead of print
Tue Nov 12, 2019 23:11
Journal Name: Clinical Chemistry and Laboratory Medicine (CCLM)Issue: Ahead of print
Tue Nov 12, 2019 23:11
Journal Name: Clinical Chemistry and Laboratory Medicine (CCLM)Issue: Ahead of print
Tue Nov 12, 2019 23:11
Journal Name: Clinical Chemistry and Laboratory Medicine (CCLM)Issue: Ahead of print
Tue Nov 12, 2019 23:11
Journal Name: Clinical Chemistry and Laboratory Medicine (CCLM)Issue: Ahead of print
Tue Nov 12, 2019 23:11
Journal Name: Clinical Chemistry and Laboratory Medicine (CCLM)Issue: Ahead of print
Tue Nov 12, 2019 23:11
Objective: To evaluate resonance frequency (RF) values via dehydration effects in the inner ear caused by the glycerol test, which is used as a diagnostic method for Ménière’s disease (MD). Methods: Twenty adult patients with unilateral MD were included in the study. Before, and then at 1, 2, and 3 h after administration of glycerol (1 g/kg), pure-tone hearing levels (125–8,000 kHz) and multifrequency tympanometry tests were performed. As a control, the RF values of the ears of 25 healthy subjects...
Tue Nov 12, 2019 16:56
British Journal of Nursing, Volume 28, Issue 20, Page 1292-1298, November 2019.
Tue Nov 12, 2019 07:22
British Journal of Nursing, Volume 28, Issue 20, Page S21-S26, November 2019.
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British Journal of Nursing, Volume 28, Issue 20, Page 1332-1334, November 2019.
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British Journal of Nursing, Volume 28, Issue 20, Page 1338-1339, November 2019.
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British Journal of Nursing, Volume 28, Issue 20, Page 1336-1336, November 2019.
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British Journal of Nursing, Volume 28, Issue 20, Page 1337-1337, November 2019.
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British Journal of Nursing, Volume 28, Issue 20, Page 1335-1335, November 2019.
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British Journal of Nursing, Volume 28, Issue 20, Page 1279-1279, November 2019.
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British Journal of Nursing, Volume 28, Issue 20, Page 1316-1324, November 2019.
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British Journal of Nursing, Volume 28, Issue 20, Page S10-S18, November 2019.
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British Journal of Nursing, Volume 28, Issue 20, Page S28-S32, November 2019.
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British Journal of Nursing, Volume 28, Issue 20, Page 1308-1314, November 2019.
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British Journal of Nursing, Volume 28, Issue 20, Page 1282-1287, November 2019.
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British Journal of Nursing, Volume 28, Issue 20, Page S4-S8, November 2019.
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British Journal of Nursing, Volume 28, Issue 20, Page S38-S42, November 2019.
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British Journal of Nursing, Volume 28, Issue 20, Page 1300-1306, November 2019.
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British Journal of Nursing, Volume 28, Issue 20, Page 1280-1280, November 2019.
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British Journal of Nursing, Volume 28, Issue 20, Page S3-S3, November 2019.
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British Journal of Nursing, Volume 28, Issue 20, Page S34-S37, November 2019.
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British Journal of Nursing, Volume 28, Issue 20, Page 1288-1290, November 2019.
Tue Nov 12, 2019 07:22
British Journal of Nursing, Volume 28, Issue 20, Page 1340-1341, November 2019.
Tue Nov 12, 2019 07:22
British Journal of Nursing, Volume 28, Issue 20, Page 1326-1330, November 2019.
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British Journal of Nursing, Volume 28, Issue 20, Page 1349-1349, November 2019.
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British Journal of Nursing, Volume 28, Issue 20, Page 1342-1343, November 2019.
Tue Nov 12, 2019 07:22
Abstract Purpose Type 2 diabetes frequently remains undiagnosed for years, whereas early detection of affected individuals would facilitate the implementation of timely and cost-effective therapies, hence decreasing morbidity. With the intention of identifying novel diagnostic biomarkers, we characterized the miRNA profile of microvesicles isolated from retroactive serum samples of normoglycemic individuals and two groups of subjects with...
Tue Nov 12, 2019 02:00
Abstract Purpose The “block-and-replace” (BR) method involves the use of a high dose of antithyroid drugs (ATD) with levothyroxine (L-T4). Its use in the management of Graves’ disease (GD) is still debated mainly because the frequency of side effects of ATD is dose dependent. We retrospectively studied the effect of medium dose of ATD with L-T4 versus monotherapy with ATD in pediatric patients with unstable GD. ...
Tue Nov 12, 2019 02:00
Publication date: Available online 11 November 2019Source: Revue des Maladies RespiratoiresAuthor(s): E. Lorentz, T. Despreaux, A. Quignette, T. Chinet, A. DescathaRésuméIntroductionDans un contexte de sous-déclaration des maladies professionnelles, l’objectif a été d’évaluer la validité de matrices emplois-expositions silice et amiante pour le dépistage des expositions professionnelles dans le domaine de l’oncologie thoracique.MéthodesCinquante patients hospitalisés pour cancer bronchopulmonaire...
Tue Nov 12, 2019 18:26
Publication date: Available online 11 November 2019Source: Revue des Maladies RespiratoiresAuthor(s): A. Tiotiu, Y. Billon, P. Vaillant, O. Menard, P. Hofman, C. MascauxRésuméEnviron 5 % des cancers bronchiques non à petites cellules (CBNPC) sont porteurs du réarrangement ALK accessible aux thérapies ciblées de type inhibiteur de tyrosine kinase ALK (ITK ALK). À l’heure actuelle, plusieurs produits sont disponibles en première ligne thérapeutique (crizotinib, céritinib, alectinib) après avoir démontré...
Tue Nov 12, 2019 18:26
Publication date: Available online 11 November 2019Source: Revue des Maladies RespiratoiresAuthor(s): F. Vandenbos, C. Nicolaï
Tue Nov 12, 2019 18:26
Publication date: Available online 11 November 2019Source: Revue des Maladies RespiratoiresAuthor(s): O. Brun, D. Caillaud, D. Charpin, J.-C. Dalphin
Tue Nov 12, 2019 18:26
Publication date: Available online 11 November 2019Source: Sleep MedicineAuthor(s): Eva Feketeova, Maria Tormasiova, Katarina Klobučníková, Peter Durdik, Dominika Jarcuskova, Miroslav Benca, Marianna VitkovaAbstractObjectiveAn increase in the incidence of narcolepsy after the pandemic influenza with the H1N1 vaccination in 2009 resulted in an interest in narcolepsy epidemiology. The aim of the study was to examine the incidence and prevalence rates of narcolepsy and to describe the associated characteristics...
Tue Nov 12, 2019 17:54
Publication date: Available online 11 November 2019Source: Pathology - Research and PracticeAuthor(s): Fu-neng Jiang, Li-jun Dai, Sheng-bang Yang, Yong-ding Wu, Yu-xiang Liang, Xiao-li Yin, Cui-yun Zou, Wei-de ZhongAbstractBackgroundFK506 binding protein 9 (FKBP9) has been reported and identified for a long time, but its relationship with cancer is rarely studied. For example, the role of FK506 binding protein 9 in prostate cancer (PCa) is still unclear. Therefore, we decided to detect the expression...
Tue Nov 12, 2019 17:49
Publication date: Available online 11 November 2019Source: Pathology - Research and PracticeAuthor(s): Jianjun Gao, Wei Qin, Pengcheng Kang, Yi Xu, Kaiming Leng, Zhenglong Li, Lining Huang, Yunfu Cui, Xiangyu ZhongAbstractObjectiveLINC00261 plays a vital role in tumorigenesis and metastasis of digestive system cancer. However, an influence of LINC00261 on cholangiocarcinoma has a little research. There, we investigated clinical role and molecular mechanisms of LINC00261 in cholangiocarcinoma.MethodsThe...
Tue Nov 12, 2019 17:49
Publication date: Available online 11 November 2019Source: Pathology - Research and PracticeAuthor(s): Anne K. Braczynski, David Capper, David T.W. Jones, Jens Schittenhelm, Damian Stichel, Andreas von Deimling, Patrick N. Harter, Michel MittelbronnAbstractAimMGMT promoter methylation status is an important biomarker predicting survival and response to chemotherapy in patients suffering from glioblastoma. Since new diagnostic methods such as methylome-based classification of brain tumors are more...
Tue Nov 12, 2019 17:49
Publication date: Available online 11 November 2019Source: Pathology - Research and PracticeAuthor(s): Pablo Igor Ribeiro Francoa, Arthur Perillo Rodrigues, Liliana Borges de Menezes Leite, Marina Pacheco MiguelAbstractCancer is a disease that affects millions of individuals worldwide and has a great impact on public health. Therefore, the study of tumor biology and an understanding of how the components of the tumor microenvironment behave and interact is extremely important for cancer research....
Tue Nov 12, 2019 17:49
Publication date: Available online 11 November 2019Source: Pathology - Research and PracticeAuthor(s): Nenggang Zhang, Asis K. Sarkar, Debananda PatiAbstractSepin-1 is a small compound that inhibits enzymatic activity of Separase and growth of cancer cells. As part of the IND-enabling studies to develop Sepin-1 as a chemotherapeutic agent, herein we have profiled the toxicity of Sepin-1 in Sprague-Dawley rats in a good laboratory practice (GLP) setting. The maximum tolerated dose (MTD) of Sepin-1...
Tue Nov 12, 2019 17:49
Publication date: Available online 11 November 2019Source: Pathology - Research and PracticeAuthor(s): Jie Mei, Bujie Xu, Leiyu Hao, Zhuang Xiao, Yan Liu, Ting Yan, Yichao ZhuAbstractRecent studies have reported that dishevelled-associated activator of morphogenesis 1 (DAAM1) is remarkably essential for mediating cell migration and invasion in breast cancer (BrCa). Nonetheless, the definite expression profile of DAAM1 in BrCa patients and the impact on metastasis of BrCa in vivo have not been explored...
Tue Nov 12, 2019 17:49
Publication date: Available online 11 November 2019Source: Pathology - Research and PracticeAuthor(s): Can Yi, Chao Huang, Huan Wang, Chen Wang, Lijuan Dong, Xiuli Gu, Xianhong Feng, Bifeng ChenAbstractCYP24A1, an essential gene in regulation of vitamin D, has been reported to play an important role in enhancing immune activity and inhibiting tumorigenesis. Previous studies proposed that rs2585428, rs4809960, rs6022999 and rs6068816 in CYP24A1 gene might be greatly associated with cancer risk. To...
Tue Nov 12, 2019 17:49
Publication date: Available online 11 November 2019Source: Pathology - Research and PracticeAuthor(s): Weijie Dai, Jiajie Zhou, Han Wang, Menghui Zhang, Xiaozhong Yang, Wei SongAbstractBackgroundColorectal cancer (CRC) is one of the most common malignancies worldwide usually diagnosed at advanced stages which causes poor prognosis of patients. Therefore, novel diagnostic biomarkers and therapeutic targets are urgently needed.Materials and methodsmiR-424-5p was identified through integrated analysis...
Tue Nov 12, 2019 17:49
Publication date: Available online 11 November 2019Source: Pathology - Research and PracticeAuthor(s): Heejin Bang, Soomin Ahn, Eun Ji Kim, Seung Tae Kim, Ha Young Park, Jeeyun Lee, Kyoung-Mee KimABSTRACTRapamycin-insensitive companion of mTOR (RICTOR) is a key component of mammalian target of rapamycin (mTOR) complex 2 (mTORC2), and promotes cellular proliferation and survival through the activation of downstream AGC kinase family members. The amplification of RICTOR has been proposed as a therapeutically...
Tue Nov 12, 2019 17:49
Publication date: Available online 11 November 2019Source: Pathology - Research and PracticeAuthor(s): Bin Wang, Hao Li, Xuchao Wang, Xinguo ZhuAbstractColorectal carcinoma (CRC) is one of the most common malignancies worldwide, and except for surgery, treatments effects are limited. Recently, NLRP3 has been reported as an activator in the tumorigenesis of CRC. However, the function and mechanism of NLRP3 in CRC remains elusive. In this study, we revealed that NLRP3 was elevated in CRC tissues and...
Tue Nov 12, 2019 17:49
Publication date: November 2019Source: Journal of Phonetics, Volume 77Author(s): Miran Oh, Dani ByrdAbstractIn producing linguistic prominence, certain linguistic elements are highlighted relative to others in a given domain; focus is an instance of prominence in which speakers highlight new or important information. This study investigates prominence modulation at the sub-syllable level using a corrective focus task, examining acoustic duration and pitch with particular attention to the gestural...
Tue Nov 12, 2019 17:38
Publication date: December 2019Source: Biomedicine & Pharmacotherapy, Volume 120Author(s): Chen Huang, Qianshun Chen, Xunyu Xu, Xu WuAbstractBackgroundMiR-195 plays an important role in metastasis and invasion of esophageal cancer (EC). However, the specific mechanism is not clear. The aim of this study was to explore the pathways how miR-195 controls EC cell proliferation.MethodQuantitative reverse transcription polymerase chain reaction (qRT-PCR) was applied to detect theexpression of miR-195...
Tue Nov 12, 2019 17:35
Publication date: December 2019Source: Biomedicine & Pharmacotherapy, Volume 120Author(s): Zi-Cheng Zhang, Yi-Lin Yang, Bo Li, Xu-Ce Hu, Shuai Xu, Fei Wang, Ming Li, Xiao-Yi Zhou, Xian-Zhao WeiAbstractBackgroundSpinal fusion is considered the gold standard procedure for treating spinal degeneration, tumors, and trauma. An inflammatory response is an important part of bone repair. We investigated the polarization change of inflammatory macrophages (M1) and resident macrophages (M2) during low-intensity...
Tue Nov 12, 2019 17:35
New Findings What is the central question of this study? Characterize the time courses of blood flow in the brachial artery and microvascular beds of the skin and skeletal muscle following transient ischemia. What is the main finding and its importance? Skeletal muscle blood flow was significantly slower than the transient increase in the cutaneous tissue, suggesting mechanistic differences between cutaneous and muscular blood flow distribution after transient ischemia. These results challenge...
Tue Nov 12, 2019 12:07
New Findings •What is the central question of this study? Quantitative values of shear rate‐specific blood viscosity and shear stress in the human macrovasculature in response to exercise hyperaemia are unknown. •What is the main finding and its importance? Using the handgrip exercise model, we show that an increase in brachial artery shear rate led to a decrease in blood viscosity, despite concomitant haemoconcentration. This shear‐thinning behaviour of blood, secondary to increased erythrocyte...
Mon Nov 11, 2019 20:03
Publication date: Available online 11 November 2019Source: Gait & PostureAuthor(s): Alessandro Picelli, Giorgio Sandrini, Carlo Cisari, Stefano Paolucci, Nicola Smania, Alessio Baricich
Tue Nov 12, 2019 17:01
Publication date: Available online 11 November 2019Source: Gait & PostureAuthor(s): Lindsey Brown, Jordan Wilson, Michael McNally, Jennifer Perry, Rebecca D Jackson, Timothy E Hewett, John Ryan, Michael V Knopp, Jason E Payne, Stephanie Di StasiAbstractBackgroundSuboptimal patient-reported function and movement impairments often persist after hip arthroscopy for femoroacetabular impingement syndrome(FAIS). Individuals with FAIS with preoperative cartilage pathology (ie. chondropathy) demonstrate...
Tue Nov 12, 2019 17:01
Publication date: Available online 12 November 2019Source: Dental MaterialsAuthor(s): Marina R. Kaizer, Nantawan Kolakarnprasert, Camila Rodrigues, Herzl Chai, Yu ZhangAbstractObjectivesThe rapidly increasing use of zirconia-based CAD/CAM multi-layer structures in dentistry calls for a thorough evaluation of their mechanical integrity. This work examines the effect of the multi-layering architecture as well as variations in composition and inclusion of pigments among the layers on the flexural strength...
Tue Nov 12, 2019 16:47
Publication date: Available online 12 November 2019Source: Dental MaterialsAuthor(s): Fei Zhang, Benedikt C. Spies, Jef Vleugels, Helen Reveron, Christian Wesemann, Wolf-Dieter Müller, Bart van Meerbeek, Jérôme ChevalierAbstractObjectivesTo evaluate two-body wear of three zirconia ceramics stabilized with 3, 4 and 5 mol% yttria and to compare their wear behavior with that of a lithium-disilicate glass-ceramic.MethodsSixteen rectangular-shaped specimens made from three grades of zirconia ceramics...
Tue Nov 12, 2019 16:47
Publication date: Available online 12 November 2019Source: Dental MaterialsAuthor(s): David LeesonAbstractObjectiveSignificant technological advances are occurring in the dental industry that are complementary to the introduction of monolithic restorative materials. Glidewell Laboratories has been at the forefront of innovation of these developments and these internal developments may be instructive of future trends in dentistry.MethodsThis paper examines internal Glidewell data from 2010 to 2019...
Tue Nov 12, 2019 16:47
Publication date: Available online 12 November 2019Source: Dental MaterialsAuthor(s): Toshiki Takamizawa, Arisa Imai, Eizo Hirokane, Akimasa Tsujimoto, Wayne W. Barkmeier, Robert L. Erickson, Mark A. Latta, Masashi MiyazakiAbstractObjectiveThe aim of this study was to observe the resin/dentin interfaces of universal adhesives by using scanning electron microscopy (SEM), and to compare their morphologies with conventional etch & rinse (ER) and self-etch (SE) adhesive systems.MethodsTwo three-step...
Tue Nov 12, 2019 16:47
Publication date: Available online 12 November 2019Source: Dental MaterialsAuthor(s): Andreas Kessler, Marcel Reymus, Reinhard Hickel, Karl-Hein KunzelmannAbstractObjectiveThe aim of this study was to investigate the three-body wear of different additively manufactured temporary materials, one temporary PMMA material for CAD/CAM milling and one resin-based composite for direct restorations as a control group by using an ACTA machine.MethodsSpecimens (n = 8) of the 3D printing materials 3Delta temp,...
Tue Nov 12, 2019 16:47
Optical coherence tomography can differentiate brain regions with intrinsic contrast and at a micron scale resolution. Such a device can be particularly useful as a realtime neurosurgical guidance tool. We present, to our knowledge, the first full‐field swept‐source optical coherence tomography system operating near a wavelength of 1310 nm. The proof‐of‐concept system was integrated with an endoscopic probe tip, that is compatible with deep brain stimulation keyhole neurosurgery. Neuroimaging experiments...
Mon Nov 11, 2019 20:49
Abstract In the current clinical care practice, Gleason grading system is one of the most powerful prognostic predictors for prostate cancer (PCa). The grading system is based on the architectural pattern of cancerous epithelium in histological images. However, the standard procedure of histological examination often involves complicated tissue fixation and staining, which are time‐consuming and may delay the diagnosis and surgery. In this study, label‐free multiphoton microscopy (MPM) was used...
Mon Nov 11, 2019 20:29
Abstract Incomplete surgical resection of head and neck squamous cell carcinoma (HNSCC) is the most common cause of local HNSCC recurrence. Currently, surgeons rely on pre‐operative imaging, direct visualization, palpation, and frozen section to determine the extent of tissue resection. It has been demonstrated that optical coherence tomography (OCT), a minimally invasive, non‐ionizing near infrared mesoscopic imaging modality can resolve subsurface differences between normal and abnormal head and...
Mon Nov 11, 2019 20:26
Abstract Understanding and quantifying the temporal acquisition of host cell molecules by intracellular pathogens is fundamentally important in biology. In this study, a recently developed holographic optical trapping (HOT)‐based Raman micro‐spectroscopy (RMS) instrument is applied to detect, characterize and monitor in real time the molecular trafficking of a specific molecular species (isotope‐labelled phenylalanine (L‐Phe(D8)) at the single cell level. This approach enables simultaneous measurement...
Mon Nov 11, 2019 20:25
Virtual cast of a human carotid canal that passes the internal carotid artery. We used measurements at five locations in the canal to show that the size of the artery is fairly constant and close to the size of the outer opening. Abstract Some blood vessels enter bones through foramina, leaving the size of the foramen as a gauge for estimating the rate of blood flow and hence the metabolic rate of the supplied tissues. Foramen dimensions have been measured using varied methods in previous foramen...
Tue Nov 12, 2019 15:57
The size of the most studied skeletal traits was largely determined by body mass. Shapes of skull, sternum and pelvis covary by the standard PLS, but only covariation of skull and pelvis remained after correction for phylogeny. Covariation was mainly influenced by body mass and dietary preferences. Abstract Morphological integration of the bird skeleton is of great interest because it relates to issues of specialization, plasticity, and rate of evolutionary transformations of a skeleton as a whole...
Tue Nov 12, 2019 13:19
We described for the first time the development of the pectoral appendages of the living coelacanth Latimeria. The pectoral fin and girdle are form early in the development of the coelacanth. The pectoral fin shows a reorientation of its girdle and a proportional reduction of its proximal radial elements, rendering the external morphology of the fin more lobe-shaped. Abstract The monobasal pectoral fins of living coelacanths and lungfishes are homologous to the forelimbs of tetrapods...
Tue Nov 12, 2019 12:50
The surface areas of the skin of the foot in situ and of the foot's skeletal components are strongly correlated and thus should be predictable in terrestrial tetrapods. Skin surface area was approximately 1.67 times that of skeletal surface area (~ 2 times for manus, ~ 1.6 times for pes, if analysed separately). This trend was not affected by body mass and showed little evidence of being strongly affected by phylogeny. This predictability has potential in aiding with estimating the size and possible...
Tue Nov 12, 2019 12:40
This study showed that the amount of MCT2 was higher in cerebellum than cortex and hippocampus in wild‐type mice. Immunohistochemistry assay revealed the highest density of MCT2 in the CA3 of the hippocampus. The granular cell layer of the cerebellum contained more MCT2 than the molecular layer. The density of MCT2 on the end feet of astrocytes was low, but the postsynaptic densities (PSDs) of asymmetric synapses in the molecular layer of the cerebellum exhibited a high density using immunogold post‐embedding...
Mon Nov 11, 2019 20:38
Are prescribers not aware of cardiovascular contraindications for diclofenac? A claims data analysis
Abstract Objectives To compare diclofenac use before and after implementation of European risk minimization measures in 2013, focusing on diclofenac initiators and prevalence of congestive heart failure (NYHA class II–IV), ischaemic heart disease, peripheral arterial disease and cerebrovascular disease (new contraindications) in these patients in Germany. Methods We included adults with health insurance coverage on 1 January 2011 (cohort 2011) or 1 January 2014 (cohort 2014) and...
Mon Nov 11, 2019 20:34
Kidney is a highly ATP dependent organ in human body. Healthy and functional mitochondria are essential for normal kidney function. Clinical and genetic variability are the hallmarks of mitochondrial disorders. We report here the involvement of two MT‐ND5 pathogenic variants encoding for ND5 subunit of respiratory chain complex I, the m.13513G > A and the m.13514A > G, in adult‐onset kidney disease in three unrelated patients. The first patient had MELAS syndrome, left ventricular hypertrophy...
Tue Nov 12, 2019 13:53
Publication date: Available online 11 November 2019Source: Medical HypothesesAuthor(s): Rodrigo Núñez-Cortés, Carlos Cruz-Montecinos, Marcela Andrea Antúnez-Riveros, Sofía Pérez-AlendaAbstractBackgroundGrip and pinch strength are relevant functional variables for various activities of daily life and are related to the quality of life of patients with carpal tunnel syndrome (CTS).ObjectiveThe main aim was to analyze the relationship between grip and pinch strength and the educational level in women...
Tue Nov 12, 2019 13:07
Publication date: Available online 11 November 2019Source: Medical HypothesesAuthor(s): M.F. Elettreby, E. AhmedAbstractMultiple sclerosis is one of the most common autoimmune-related neurological disorders affecting the central nervous system. One of its main properties is dissemination of lesions in time and space. Here, we propose a simple mathematical model to describe the stages of disease progression with recurrence. We tried to find the steady states and evaluated their stability to identify...
Tue Nov 12, 2019 13:07
Publication date: Available online 11 November 2019Source: Medical HypothesesAuthor(s): Aydin Gülses, Yahya Açil, Jörg WiltfangAbstractCurrent paper aims to hypothesize that, oral surgical interventions such as tooth extractions, endosseous implant placement, subgingival curettage, etc. might result in widespread of fungal species via blood stream and can cause fungal contaminations of the cardiac valves. We hereby suggest that, an additional fungal endocarditis risk assessment and prevention protocol...
Tue Nov 12, 2019 13:07
Publication date: Available online 11 November 2019Source: Medical HypothesesAuthor(s): Orhan Yaman, Fatih Ertam, Turker TuncerAbstractParkinson's disease is one of the mostly seen neurological disease. It affects to nervous system and hinders people's vital activities. The majority of Parkinson's patients lose their ability to speak, write and balance. Many machine learning methods have been proposed to automatically diagnose Parkinson’s disease using acoustic, hand writing and gaits. In this study,...
Tue Nov 12, 2019 13:07
Publication date: Available online 11 November 2019Source: Medical HypothesesAuthor(s): J. Tomasi, F. Le Bars, C. Shao, A. Lucas, M. Lederlin, P. Haigron, J.P. VerhoyeAbstractIntroductionRegular monitoring of uncomplicated type B aortic dissection is essential because 25 to 30% will progress to aneurysmal form. The predictive factors of this evolution are not clearly defined, but they seem to be correlated with hemodynamic data.HypothesisOur goal is to create a patient-specific and real-time model...
Tue Nov 12, 2019 13:07
Publication date: Available online 11 November 2019Source: Medical HypothesesAuthor(s): Mohammad- Hossein Mirzaii-Dizgah, Mohammad-Reza Mirzaii-Dizgah, Iraj Mirzaii-DizgahAbstractMultiple sclerosis (MS) is considered as motor and sensory function loss, which results from demyelination and following axonal lesion. Tau protein interferes in the construction and stabilization of microtubules that are needed for axonal transport. We hypothesize that the level of tau protein alters in MS, so we examined...
Tue Nov 12, 2019 13:07
Publication date: Available online 11 November 2019Source: Medical HypothesesAuthor(s): Alberto Spalice, Cristiana Alessia Guido, Francesco Nicita, Claudio Di Biasi, Anna Maria Zicari, Luigi GianniniAbstractHypothesisVirchow-Robin spaces (VRS) are perivascular spaces in the brain and can normally be visualized in Magnetic Resonance Imaging (MRI). Dilated VRS (dVRS) are defined on the basis of their shape, and can rarely be observed in healthy subjects, or found in various diseases. A judgement of...
Tue Nov 12, 2019 13:07
Publication date: Available online 11 November 2019Source: Medical HypothesesAuthor(s): Jose A. Adams, Arkady Uryash, Jose R. LopezAbstractNonsteroidal anti-inflammatory medications (NSAIDs) are one of the most commonly used analgesics in the world. NSAIDs decrease prostaglandin synthesis through cyclooxygenase inhibition (COX-1 or COX-2). The effects of NSAIDs on survival and outcomes from global ischemia reperfusion events and specifically from cardiac arrest (CA) remain controversial. We hypothesized...
Tue Nov 12, 2019 13:07
Publication date: Available online 11 November 2019Source: Medical HypothesesAuthor(s): DS RobertsonAbstractThe variables involved in the initiation and operation of the human immune system are considered. It is shown that the number of variations associated with disease and other detrimental conditions exceeds the number of lymphocyte cells available for control of these conditions. It is proposed that the immune system functions by changes in the ionic strength of metabolic fluids which in turn...
Tue Nov 12, 2019 13:07
Publication date: Available online 11 November 2019Source: Medical HypothesesAuthor(s): Sukanti bhattacharyya, Damodar Prasad Goswami, Arnab SenguptaAbstractVectorcardiogram (VCG) represents the trajectory of the tip of cardiac vectors in three dimensional space with varying time. It is a recurring, near-periodic pattern of cardiac dynamics that is constructed by drawing the instantaneous vectors from a zero reference point according to direction, magnitude and polarity in the space. Being a three...
Tue Nov 12, 2019 13:07
Publication date: Available online 11 November 2019Source: Clinical NeurophysiologyAuthor(s): Maurice Abou Jaoude, Jin Jing, Haoqi Sun, Claire S. Jacobs, Kyle R. Pellerin, M. Brandon Westover, Sydney S. Cash, Alice D. LamAbstractObjectiveDevelop a high-performing algorithm to detect mesial temporal lobe (mTL) epileptiform discharges on intracranial electrode recordings.MethodsAn epileptologist annotated 13,959 epileptiform discharges from a dataset of intracranial EEG recordings from 46 epilepsy...
Tue Nov 12, 2019 12:03
Publication date: Available online 11 November 2019Source: Clinical NeurophysiologyAuthor(s): Emel Oguz Akarsu, Nermin Gorkem Sirin, Elif Kocasoy Orhan, Bahar Erbas, Hava Ozlem Dede, Mehmet Baris Baslo, Halil Atilla Idrisoglu, Ali Emre OgeAbstractObjectiveTo extract insight about the mechanism of repeater F-waves (Frep) by exploring their correlation with electrophysiologic markers of upper and lower motor neuron dysfunction in amyotrophic lateral sclerosis (ALS).MethodsThe correlations of Frep parameters...
Tue Nov 12, 2019 12:03
Publication date: Available online 11 November 2019Source: Clinical NeurophysiologyAuthor(s): Ha-Yeun Chung, Fabian Essig, Jonathan Wickel, Bianca Besteher, Hermann Neugebauer, Karl Georg Haeusler, Wolfgang Müllges, Matthias Schwab
Tue Nov 12, 2019 12:03
Publication date: Available online 11 November 2019Source: Clinical NeurophysiologyAuthor(s): Emilia Toth, Ganne Chaitanya, Sandipan Pati
Tue Nov 12, 2019 12:03
Publication date: Available online 11 November 2019Source: Clinical NeurophysiologyAuthor(s): Liberto Brage, Pedro Javier Pérez-Lorensu, Julio Plata-Bello, Ángel Saponaro-González, Luis Pérez-Orribo, Mario García-Conde, Pablo Febles-García, Héctor Roldán-Delgado, Víctor García-MarínAbstractObjectiveTo evaluate cylindrical depth electrodes in the interhemispheric fissure as an alternative to subdural strip electrodes for direct cortical stimulation (DCS) leg motor evoked potential (MEP) monitoring.MethodsA...
Tue Nov 12, 2019 12:03
Publication date: Available online 11 November 2019Source: Clinical NeurophysiologyAuthor(s): Cláudia S. Silva, Filipe B. Rodrigues, Gonçalo S. Duarte, João Costa, Mamede de CarvalhoAbstractObjectivesTo assess the prognostic value of phrenic nerve conduction (PNC) in amyotrophic lateral sclerosis (ALS).MethodsWe conducted a systematic review to identify studies reporting on PNC, and mortality and/or forced vital capacity (FVC) in patients with ALS. We searched Medline, EMBASE, and Web of Science....
Tue Nov 12, 2019 12:03
Publication date: Available online 11 November 2019Source: Clinical NeurophysiologyAuthor(s): P.A. Karthick, Hideaki Tanaka, Hui Ming Khoo, Jean GotmanAbstractObjectiveIntracranial EEG covers only a small fraction of brain volume and it is uncertain if a discharge represents a true seizure onset or results from spread. We therefore assessed if there are differences between characteristics of the ictal onset when we are likely to have a true onset, and characteristics of the discharge in regions of...
Tue Nov 12, 2019 12:03
Publication date: Available online 11 November 2019Source: Clinical NeurophysiologyAuthor(s): Shyam Sunder Tummanapalli, Tushar Issar, Natalie Kwai, Ann Poynten, Arun V. Krishnan, Mark Willcox, Maria MarkoulliAbstractObjectiveCorneal confocal microscopy (CCM) has been identified as a non-invasive technique to assess corneal nerve fiber morphology. It is not known how corneal nerve changes relate to measures of peripheral nerve function in diabetic peripheral neuropathy (DPN). The present study investigates...
Tue Nov 12, 2019 12:03
Abstract Purpose Sublingual hematoma is a rare complication seen in bleeding disorders, trauma, dental procedures, and the use of anticoagulants. Only a few publications have described idiopathic spontaneous sublingual hematoma, and all of them suspected severe hypertension as etiology. Our objective is to present a case of idiopathic spontaneous sublingual hematoma in a 48-year-old patient without any medical history of hypertension and...
Tue Nov 12, 2019 02:00
Abstract Purpose This study was to assess the efficiency of using a combination of one microplate and one miniplate for management of patients with parasymphyseal mandibular fractures versus two miniplates through measurement of the biting force. Patients and methods The study sample consisted of sixteen patients with an isolated mandibular fracture and randomly...
Tue Nov 12, 2019 02:00
Abstract Background Ultrasound (US) is used in the initial evaluation and surveillance of urinary tract dilation in children. Urinary tract dilation is diagnosed in 1–2% of all pregnancies during routine prenatal sonography with technological advances in US imaging. Urinary tract dilation classification systems, including the 2014 multidisciplinary consensus, assess anterior–posterior renal pelvic diameter and calyceal dilation. There...
Tue Nov 12, 2019 02:00
Fetus acardius amorphus is a rare congenital malformation characterized by the lack of a functional heart, the presence of a bivascular umbilical cord, as well as a developed and organized skeletal system and partially organized inner organs. Fetus acardii mostly occur in multiple gestations. The pathogenesis of this entity is not clarified yet. It has been hypothesized that, although formation of anastomosing vessels between the co-twin and the anomalous embryo as well as reverse directed blood...
Tue Nov 12, 2019 10:05
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