Abstract The potential anti-cariogenic effect of blue light was evaluated using an oral biofilm model. Two species, Streptococcus mutans and Streptococcus sanguinis, were cultivated ex vivo on bovine enamel blocks for 24 h, either separately or mixed together, then exposed to blue light (wavelengths 400–500 nm) using 112 J/cm2. Twenty four or 48 h after exposure to light the biofilm structure and biomass were characterized and quantified using SEM and qPCR, respectively. Bacterial...
Tue Nov 12, 2019 02:00
Abstract The anatomy of the prostate is reviewed in the context of discussing the staging of prostate cancer and patterns of tumor spread. The utility of prostate magnetic resonance imaging along with new advancements in tumor staging are discussed specifically in locally advanced disease. What should be included in the radiology report carries a substantial weight to formulate the urologist’s decision in regards to the selection of surgical candidates, preoperative planning and...
Wed Nov 13, 2019 02:00
Abstract Purpose To review available prostate cancer biomarkers and their performance in a clinical order, from prostate cancer detection, to treatment of localized and advanced disease. Methods We used an electronic literature search of the PubMed database using the key words “prostate biomarkers,” “genomic markers,” and “prostate cancer screening,” as well...
Wed Nov 13, 2019 02:00
Abstract Purpose The physical examination and pelvic imaging with MRI are often used in the pre-operative evaluation of pelvic organ prolapse. The objective of this study was to compare grading of prolapse on defecography phase of dynamic magnetic resonance imaging (dMRI) with physical examination (PE) grading using both the Pelvic Organ Prolapse Quantification (POP-Q) staging and Baden–Walker (BW) grading systems in the evaluation of...
Tue Nov 12, 2019 02:00
Abstract Purpose To evaluate the reproducibility of hepatic MRE under various combinations of settings of field strength, pulse sequence, scan interval, and reader in non-alcoholic fatty liver disease (NAFLD) patients. Methods Adult NAFLD patients were prospectively enrolled for serial hepatic MRE with 1.5 T using 2D GRE sequence and 3.0 T using 2D SE-EPI...
Tue Nov 12, 2019 02:00
Abstract The pelvic floor is composed of a network of muscles, ligaments, and fasciae, which provide active and passive support for the pelvic organs. Impairment of these pelvic floor elements can result in a variety of functional abnormalities and single or multicompartment organ prolapse. Knowledge of normal pelvic floor anatomy can aid the radiologist in understanding the complex nature of pelvic floor dysfunction and is important for comprehensive image interpretation. This...
Tue Nov 12, 2019 02:00
Abstract Background The extent to which the composition and diversity of the oral microbiome varies with age is not clearly understood. Methods The 16S rRNA gene of subgingival plaque in 1219 women, aged 53–81 years, was sequenced and its taxonomy annotated against the Human Oral Microbiome Database (v.14.5). Composition of the subgingival microbiome...
Wed Nov 13, 2019 02:00
Abstract Background Smoking is a major risk factor for periodontitis and tooth loss. Smoking cessation has a positive impact in periodontal treatment. However, so far, no systematic review has evaluated the effect of smoking cessation on tooth loss. Therefore, this review aimed to evaluate if smoking cessation reduces the risk of tooth loss. Methods ...
Tue Nov 12, 2019 02:00
Abstract Background To develop an Italian version of the Craniofacial Pain Disability Inventory (CFPDI-I) and investigate its psychometric abilities in patients with temporomandibular disorders (TMD). Methods The CFPDI was translated following international standards. The psychometric analyses included reliability by internal consistency (Cronbach’s...
Tue Nov 12, 2019 02:00
Abstract Parasporal inclusion protein of Bacillus thuringiensis-LDC-501 (Bt-LDC-501) exhibits selective cytocidal action towards human colon cancer cells. The yield of this parasporal protein was minimum in the normal culture. In order to increase the yield of protein from Bt-LDC-501 various agro-based cost-efficient nutrient sources such as corn steep liquor (CSL), sesame oil cake extract (SOC), groundnut oil cake extract (GOC), neem oil cake extract (NOC), rice bran extract (RB),...
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Abstract The generation of genomic data from microorganisms has revolutionized our abilities to understand their biology, but it is still challenging to obtain complete genome sequences of microbes in an automated high-throughput and cost-effective manner. While the advent of second-generation sequencing technologies provided significantly higher throughput, their shorter lengths and more pronounced sequence-context bias led to a shift towards resequencing applications. Recently,...
Wed Nov 13, 2019 02:00
Abstract Surfactin is a promising microbial lipopeptide with wide applications in food, environmental, agricultural, and pharmaceutical fields. However, its high cost caused by low productivity largely limits the commercial application. In this study, genome shuffling was employed to improve surfactin production in Bacillus velezensis strain LM3403 via recursive protoplast fusion. RT-qPCR analysis was employed to evaluate the transcriptional variance of surfactin synthase genes...
Tue Nov 12, 2019 02:00
Abstract Mutations in the gelsolin protein are responsible for a rare conformational disease known as AGel amyloidosis. Four of these mutations are hosted by the second domain of the protein (G2): D187N/Y, G167R and N184K. The impact of the latter has been so far evaluated only by studies on the isolated G2. Here we report the characterization of full-length gelsolin carrying the N184K mutation and compare the findings with those obtained on the wild type and the other variants....
Wed Nov 13, 2019 02:00
Abstract Fungi are considered model organisms for the analysis of important phenomena of eukaryotes. For example, some of them have been described as models to understand the phenomenon of multicellularity acquisition by different unicellular organisms phylogenetically distant. Interestingly, in this work, we describe the multicellular development in the model fungus S. reilianum. We observed that Sporisorium reilianum, a Basidiomycota cereal pathogen that at neutral pH grows with...
Wed Nov 13, 2019 02:00
Abstract Rationale Exposure to chronic constant light (CCL) has a detrimental impact on circadian rhythms of motor activity and sleep/wake cycles. Agomelatine is an atypical antidepressant showing a chronotropic activity. Objectives In this study, we explored the role of melatonin (MT) receptors and brain-derived neurotrophic factor (BDNF) in the brain in...
Wed Nov 13, 2019 02:00
Abstract Rationale Studies point out a higher prevalence of posttraumatic stress disorder (PTSD) in individuals with diabetes mellitus. It is known that glucocorticoid (GR) and mineralocorticoid (MR) receptors are implicated in fear memory processes and PTSD. However, there is no preclinical studies addressing the involvement of these receptors on abnormal fear memories related to diabetic condition. ...
Tue Nov 12, 2019 02:00
Abstract Neuromuscular fatigue (NMF) is usually assessed non-invasively in healthy, athletic or clinical populations with the combination of voluntary and evoked contractions. Although it might appear relatively straightforward to magnetically or electrically stimulate at different levels (cortical/spinal/muscle) and to measure mechanical and electromyographic responses to quantify neuromuscular adjustments due to sustained/repeated muscle contractions, there are drawbacks that...
Tue Nov 12, 2019 02:00
Enhancement of FK520 production in Streptomyces hygroscopicus by combining traditional mutagenesis with metabolic engineering. Appl Microbiol Biotechnol. 2019 Nov 12;: Authors: Yu Z, Lv H, Wu Y, Wei T, Yang S, Ju D, Chen S Abstract FK520 (ascomycin), a 23-membered macrolide with immunosuppressive activity, is produced by Streptomyces hygroscopicus. The problem of low yield and high impurities (mainly FK523) limits the industrialized production of FK520....
Wed Nov 13, 2019 21:39
Publication date: Available online 13 November 2019Source: Magnetic Resonance ImagingAuthor(s): Jose Bernal, Maria del C. Valdés-Hernández, Javier Escudero, Linda Viksne, Anna K. Heye, Paul A. Armitage, Stephen Makin, Rhian M. Touyz, Joanna M. WardlawAbstractCerebral small vessel disease (SVD) comprises various pathological processes affecting small brain vessels and damaging white and grey matter. In this paper, we propose a framework comprising region of interest sampling, dynamic spectral and...
Wed Nov 13, 2019 13:53
Publication date: Available online 13 November 2019Source: Magnetic Resonance ImagingAuthor(s): Simon Schmidt, Sebastian Flassbeck, Peter Bachert, Mark E. Ladd, Sebastian SchmitterAbstractPurposeTo investigate velocity encoded and velocity compensated variants of multi-spoke RF pulses that can be used for flip-angle homogenization at ultra-high fields (UHF). Attention is paid to the velocity encoding for each individual spoke pulse and to displacement artifacts that arise in Fourier transform imaging...
Wed Nov 13, 2019 13:53
Publication date: Available online 12 November 2019Source: Magnetic Resonance ImagingAuthor(s): Mustapha Bouhrara, Abinand C. Rejimon, Luis E. Cortina, Nikkita Khattar, Richard G. SpencerAbstractChanges in longitudinal relaxation time (T1) and proton density (PD) are sensitive indicators of microstructural alterations associated with various central nervous system diseases as well as brain maturation and aging. In this work, we introduce a new approach for rapid and accurate high-resolution (HR)...
Wed Nov 13, 2019 13:53
Publication date: Available online 11 November 2019Source: Magnetic Resonance ImagingAuthor(s): Ali Fatehi Hassanabad, Fiona Burns, Michael S. Bristow, Carmen Lydell, Andrew G. Howarth, Bobak Heydari, Xuexin Gao, Paul W.M. Fedak, James A. White, Julio GarciaAbstractBackgroundThe influence of complex bicuspid aortic valve (BAV) flow patterns on net intraluminal aortic pressure, both among patients with and without significant aortic stenosis, is unknown. Pressure drop (PD), as estimated by 4D Flow...
Tue Nov 12, 2019 17:27
Publication date: Available online 11 November 2019Source: Magnetic Resonance ImagingAuthor(s): Mehran Azimbagirad, Fabrício H. Simozo, Antonio C.S. Senra Filho, Luiz O. Murta JuniorAbstractQuantifying the intracranial tissue volume changes in magnetic resonance imaging (MRI) assists specialists to analyze the effects of natural or pathological changes. Since these changes can be subtle, the accuracy of the automatic compartmentalization method is always criticized by specialists. We propose and...
Tue Nov 12, 2019 17:27
Publication date: Available online 11 November 2019Source: Magnetic Resonance ImagingAuthor(s): Ze Wang, Di Cui, Jian Zhang, Ed.X. Wu, Edward S. HuiAbstractIn magnetic resonance fingerprinting (MRF), tissue parameters are determined by finding the best-match to the acquired MR signal from a predefined signal dictionary. This dictionary searching (DS) process is generally performed in an exhaustive manner, which requires a large predefined dictionary and long searching time. A fast MRF DS algorithm,...
Tue Nov 12, 2019 17:27
Many pathologies that modify the shell geometry and ornamentation of ammonoids are known from the fossil record. Since they may reflect the developmental response of the organism to a perturbation (usually a s...
Wed Nov 13, 2019 02:00
Various apolipoproteins widely distributed among vertebrata play key roles in lipid metabolism and have a direct correlation with human diseases as diagnostic markers. However, the evolutionary progress of apo...
Wed Nov 13, 2019 02:00
Mucosal Immunology, Published online: 13 November 2019; doi:10.1038/s41385-019-0224-7Pulmonary monocytes interact with effector T cells in the lung tissue to drive TRM differentiation following viral infection
Wed Nov 13, 2019 02:00
Mucosal Immunology, Published online: 13 November 2019; doi:10.1038/s41385-019-0221-xDespite early antiretroviral therapy effector memory and follicular helper CD4 T cells are major reservoirs in visceral lymphoid tissues of SIV-infected macaques
Wed Nov 13, 2019 02:00
Wed Nov 13, 2019 02:00
Wed Nov 13, 2019 02:00
Alpha-hemolysin of uropathogenic <i>Escherichia coli</i> induces GM-CSF-mediated acute kidney injury
Mucosal Immunology, Published online: 12 November 2019; doi:10.1038/s41385-019-0225-6Alpha-hemolysin of uropathogenic Escherichia coli induces GM-CSF-mediated acute kidney injury
Tue Nov 12, 2019 02:00
Mucosal Immunology, Published online: 12 November 2019; doi:10.1038/s41385-019-0223-8Anti-commensal Ig—from enormous diversity to clear function
Tue Nov 12, 2019 02:00
Alpha-hemolysin of uropathogenic <i>Escherichia coli</i> induces GM-CSF-mediated acute kidney injury
Tue Nov 12, 2019 02:00
Nature Chemistry, Published online: 13 November 2019; doi:10.1038/s41557-019-0382-yHydrogen-bonded organic frameworks can readily encapsulate native enzymes and keep them active beyond biological conditions.
Wed Nov 13, 2019 02:00
Nature Chemistry, Published online: 12 November 2019; doi:10.1038/s41557-019-0383-xAddendum: Synthesis and reactivity of precolibactin 886
Tue Nov 12, 2019 02:00
Abstract The aim of this study was to investigate the frequency of consumption of snack products, as well as the association between snacking and restorative treatment need, and associated factors among a healthy Finnish male population. Approximately 8500 conscripts answered a computer-based questionnaire covering their snacking habits and other health behaviours. Restorative treatment need and history (DT, DMFT) were examined by trained and calibrated dentists. Cross-tabulations...
Tue Nov 12, 2019 02:00
Abstract Periodontitis is an inflammatory disease that causes bone resorption. This study used a ligature‐induced experimental periodontitis model to observe the kinetic process of microstructural changes in alveolar bone and introduced star volume analysis as a new methodology to assess microstructural changes. Thirty Wistar rats were used. To induce experimental periodontitis, ligatures were placed around the maxillary first molar. Rats were euthanized on days 0, 1, 3, 7, 14,...
Tue Nov 12, 2019 02:00
Pediatric Allergy, Immunology, and Pulmonology, Ahead of Print.
Wed Nov 13, 2019 10:00
Medical Image Perception Research in the Emerging Age of Artificial Intelligence. Radiology. 2019 Nov 12;:192252 Authors: Jacobson FL PMID: 31714868 [PubMed - as supplied by publisher]
Wed Nov 13, 2019 19:15
Performing Diffusion Tensor and Functional MRI in Patients with Metallic Braces. Radiology. 2019 Nov 12;:192297 Authors: Dietrich O PMID: 31714867 [PubMed - as supplied by publisher]
Wed Nov 13, 2019 19:15
Editor's Recognition Awards. Radiology. 2019 Nov 12;:192134 Authors: Bluemke DA PMID: 31714195 [PubMed - as supplied by publisher]
Wed Nov 13, 2019 19:15
Deep Convolutional Neural Network-based Software Improves Radiologist Detection of Malignant Lung Nodules on Chest Radiographs. Radiology. 2019 Nov 12;:182465 Authors: Sim Y, Chung MJ, Kotter E, Yune S, Kim M, Do S, Han K, Kim H, Yang S, Lee DJ, Choi BW Abstract Background Multicenter studies are required to validate the added benefit of using deep convolutional neural network (DCNN) software for detecting malignant pulmonary nodules on chest radiographs....
Wed Nov 13, 2019 19:15
MRI and CT Identify Isocitrate Dehydrogenase (IDH)-Mutant Lower-Grade Gliomas Misclassified to 1p/19q Codeletion Status with Fluorescence in Situ Hybridization. Radiology. 2019 Nov 12;:191140 Authors: Patel SH, Batchala PP, Mrachek EKS, Lopes MS, Schiff D, Fadul CE, Patrie JT, Jain R, Druzgal TJ, Williams ES Abstract Background Fluorescence in situ hybridization (FISH) is a standard method for 1p/19q codeletion testing in diffuse gliomas but occasionally...
Wed Nov 13, 2019 19:15
Whole-Brain Functional and Diffusion Tensor MRI in Human Participants with Metallic Orthodontic Braces. Radiology. 2019 Nov 12;:190070 Authors: Miao X, Wu Y, Liu D, Jiang H, Woods D, Stern MT, Blair NIS, Airan RD, Bettegowda C, Rosch KS, Qin Q, van Zijl PCM, Pillai JJ, Hua J Abstract Background MRI performed with echo-planar imaging (EPI) sequences is sensitive to susceptibility artifacts in the presence of metallic objects, which presents a substantial...
Wed Nov 13, 2019 19:15
Pharmacokinetics of Ferumoxytol in the Abdomen and Pelvis: A Dosing Study with 1.5- and 3.0-T MRI Relaxometry. Radiology. 2019 Nov 12;:190489 Authors: Wells SA, Schubert T, Motosugi U, Sharma SD, Campo CA, Kinner S, Woo KM, Hernando D, Reeder SB Abstract Background The off-label use of ferumoxytol (FE), an intravenous iron preparation for iron deficiency anemia, as a contrast agent for MRI is increasing; therefore, it is critical to understand its pharmacokinetics....
Wed Nov 13, 2019 19:15
Three-dimensional Deep Convolutional Neural Networks for Automated Myocardial Scar Quantification in Hypertrophic Cardiomyopathy: A Multicenter Multivendor Study. Radiology. 2019 Nov 12;:190737 Authors: Fahmy AS, Neisius U, Chan RH, Rowin EJ, Manning WJ, Maron MS, Nezafat R Abstract Background Cardiac MRI late gadolinium enhancement (LGE) scar volume is an important marker for outcome prediction in patients with hypertrophic cardiomyopathy (HCM); however,...
Wed Nov 13, 2019 19:15
Technology in Cancer Research &Treatment, Volume 18, Issue , January-December 2019. Objective:To investigate role of microRNA-1/Golgi phosphoprotein 3/Foxo1 axis in bladder cancer.Methods:The expression of Golgi phosphoprotein 3 was determined in both bladder cancer tissues and cell lines using quantitative real-time polymerase chain reaction and Western blotting, respectively. Golgi phosphoprotein 3 was knocked down by small hairpin RNA. MicroRNA-1 was overexpressed or inhibited by microRNA-1...
Tue Nov 12, 2019 04:39
Journal of Investigative Medicine High Impact Case Reports, Volume 7, Issue , January-December 2019. Biliopancreatic diversion is a surgical procedure that causes weight loss via volume restriction and malabsorption. It is now rarely performed due to the risk of severe nutritional deficiencies including vitamin A. We report a case of severe vitamin A deficiency due to malabsorption from a biliopancreatic diversion procedure for weight loss. By the time the patient presented to our department, she...
Tue Nov 12, 2019 08:53
Publication date: Available online 13 November 2019Source: Annals of Anatomy - Anatomischer AnzeigerAuthor(s): Erich Brenner
Wed Nov 13, 2019 17:46
Publication date: Available online 11 November 2019Source: Annals of Anatomy - Anatomischer AnzeigerAuthor(s): Robert Haładaj, Grzegorz Wysiadecki, R. Shane Tubbs, Mirosław TopolSummaryBackgroundThe levator palpebrae superioris muscle (LPS) acts as the upper eyelid's major elevator and retractor and is innervated by the oculomotor nerve. The muscle's paralysis is manifested by ptosis.Material and Methods70 orbits were dissected. After removing the orbital roof, the LPS’ shape and anatomical variations...
Tue Nov 12, 2019 18:55
Publication date: Available online 11 November 2019Source: Annals of Anatomy - Anatomischer AnzeigerAuthor(s): Shogo Hayashi, Hidetomo Hirouchi, Gen Murakami, Jőrg Wilting, Jose Francisco Rodríguez-Vázquez, Ji Jyun KimSummaryThe inferior pharyngeal constrictor (IPC) originates from the thyroid and cricoid cartilages and inserts to the pharyngeal raphe. In serial sagittal sections of 37 embryos and fetuses at 6-15 weeks (crown rump length 15-115 mm), we found 1) the IPC connecting to the sternothyroideus...
Tue Nov 12, 2019 18:55
Publication date: Available online 11 November 2019Source: Annals of Anatomy - Anatomischer AnzeigerAuthor(s): Christina Schmitt, Vivian Adamski, Florian Rasch, Rainer Adelung, Ralph Lucius, Michael Synowitz, Kirsten Hattermann, Janka Held-FeindtSummaryBackgroundThe treatment of glioblastomas (GBM) is still a clinical challenge. Current GBM therapeutic plans focus on the development of new strategies for local drug administration in the tumor cavity to realize an efficient long-term treatment with...
Tue Nov 12, 2019 18:55
Publication date: Available online 11 November 2019Source: Annals of Anatomy - Anatomischer AnzeigerAuthor(s): Agnieszka Przystańska, Artur Rewekant, Alicja Sroka, Tomasz Gedrange, Michał Ekkert, Katarzyna Jończyk-Potoczna, Agata Czajka-JakubowskaSummaryBackgroundIn the postnatal period, some sexual dimorphism is observed from the moment of birth, but it is most pronounced from puberty. The aim of the study based on CT images was to assess possible sexual dimorphism of the maxillary sinus in children...
Tue Nov 12, 2019 18:55
Abstract Purpose We present a case of a bilateral reversed palmaris longus muscle and a systematic review of the literature on this anatomical variation. Methods Routine dissection of a 90-year-old male cadaver revealed a rare bilateral reversed palmaris longus. This was documented photographically, and length and relation to anatomical landmarks were recorded....
Tue Nov 12, 2019 02:00
Related ArticlesRisk factors of pharyngocutaneous fistula after total laryngectomy: a systematic review and meta-analysis. Eur Arch Otorhinolaryngol. 2019 Nov 11;: Authors: Wang M, Xun Y, Wang K, Lu L, Yu A, Guan B, Yu C Abstract OBJECTIVE: The purpose of this study was to systematically evaluate the risk factors of pharyngocutaneous fistula (PCF) after total laryngectomy. METHODS: We systematically searched Pubmed, Web of Science, Cochrane...
Wed Nov 13, 2019 20:31
Related ArticlesThird or fourth branchial pouch sinus lesions: a case series and management algorithm. J Otolaryngol Head Neck Surg. 2019 Nov 11;48(1):61 Authors: Li Y, Lyu K, Wen Y, Xu Y, Wei F, Tang H, Chen S, Wang Z, Zhu X, Wen W, Lei W Abstract BACKGROUND: The purpose of this study was to develop an effective management algorithm for lesions of third or fourth branchial sinuses. STUDY DESIGN: Case series with chart review. METHODS:...
Wed Nov 13, 2019 20:31
Related ArticlesEvaluation of an Infant Temporal-Bone Model as Training Tool. Otol Neurotol. 2018 07;39(6):e448-e452 Authors: Probst R, Stump R, Mokosch M, Röösli C Abstract OBJECTIVE: Evaluation of the face validity of a new artificial model of an infant temporal bone (TB) suitable for surgical training, including cochlear implantation. SUBJECT: Micro-computer-tomography images were obtained from a TB specimen of a 1-year-old normal infant...
Wed Nov 13, 2019 20:31
Related ArticlesNon-thermal plasma treated solution with potential as a novel therapeutic agent for nasal mucosa regeneration. Sci Rep. 2018 09 13;8(1):13754 Authors: Won HR, Kang SU, Kim HJ, Jang JY, Shin YS, Kim CH Abstract Adequate and rapid mucosal regeneration is one of the most important factors in the healing process of nasal mucosa after surgery or trauma. In particular, delayed mucosal regeneration after surgery is an important cause of surgical...
Tue Nov 12, 2019 13:18
Related ArticlesRemote-access thyroid surgery-progress, assessment, and reflection. J Surg Oncol. 2018 09;118(3):388-389 Authors: Patel KN, Ganly I, Shaha AR PMID: 30176175 [PubMed - indexed for MEDLINE]
Tue Nov 12, 2019 13:18
Related ArticlesIn response to Double-blind, placebo-controlled study with alginate suspension for laryngopharyngeal reflux disease. Laryngoscope. 2018 10;128(10):E349-E350 Authors: Lechien JR, Karkos PD, Harmegnies B, Saussez S PMID: 29603239 [PubMed - indexed for MEDLINE]
Tue Nov 12, 2019 13:18
Vascular invasion has been identified as an informative risk factor for relapse in stage I testicular nonseminomas, used to tailor treatment. We investigated interobserver agreement in vascular invasion reporting and studied the potential additional value of immunohistochemistry for vascular markers for predicting relapse. Patients (n=52) with stage I testicular nonseminomas undergoing surveillance (1993-2006) were included (median follow-up of 66 mo). Two formalin-fixed paraffin-embedded blocks...
Wed Nov 13, 2019 09:50
Supratentorial extraventricular ependymomas (STEEs) are relatively rare ependymomas, and their pathologic and genetic characteristics are still poorly understood. The aim of this study was to determine the histologic, immunohistochemical, and RELA fusion features, as well as to clarify in more detail the clinical courses of STEEs. Data from a total of 43 patients with STEEs was analyzed retrospectively. The status of RELA fusion was evaluated using fluorescence in situ hybridization. The expression...
Wed Nov 13, 2019 09:50
Response classification after neoadjuvant chemotherapy in muscle-invasive bladder carcinoma is based on the TNM stage at radical cystectomy. We recently showed that histopathologic tumor regression grades (TRGs) add prognostic information to TNM. Our aim was to validate the prognostic significance of TRG in muscle-invasive bladder cancer in a multicenter setting. We enrolled 389 patients who underwent cisplatin-based chemotherapy before radical cystectomy in 8 centers between 2010 and 2016. Median...
Wed Nov 13, 2019 09:50
The PROMISE diagnostic algorithm, which uses p53, mismatch repair (MMR) protein immunohistochemistry, and DNA polymerase ε (POLE) exonuclease domain mutation testing, is a reliable surrogate of the molecular group in endometrial carcinoma. Its prognostic value has been validated in endometrial carcinoma and ovarian endometrioid carcinoma. Moreover, a similar prognostic grouping has been recently documented in endometrial clear cell carcinoma. Thus, we aimed to explore the role of these markers in...
Wed Nov 13, 2019 09:50
Chronic active Epstein-Barr virus (EBV) infection of T-cell and NK-cell type, systemic form (CAEBV-T/NK-S) is characterized by EBV+ T-cell and/or NK-cell proliferation with no changes suggesting malignancy. Therefore, when Hodgkin/Reed-Sternberg (HRS)-like cells are scattered in CAEBV-T/NK-S, it is more likely to be misdiagnosed as classic Hodgkin lymphoma. We encountered a case wherein the patient showed HRS-like cells with typical NK phenotype. Therefore, we further investigated 8 similar cases...
Wed Nov 13, 2019 09:50
Secretory carcinoma is a special-type breast carcinoma underpinned by a recurrent t(12;15)(p13;q25) translocation resulting in ETV6-NTRK3 gene fusion. Immunohistochemistry (IHC) using a pan-TRK antibody has been recently shown to help identify NTRK rearrangements in other tumor types. The purpose of this study was to assess the diagnostic utility of pan-TRK IHC in secretory carcinoma of the breast. Pan-TRK IHC was performed using a rabbit monoclonal antibody on whole sections of 24 breast secretory...
Wed Nov 13, 2019 09:50
ATF1, CREB1, and CREM constitute the CREB family of transcription factors. The genes encoding these factors are involved in gene fusion events in human tumors. EWSR1-ATF1 and EWSR1-CREB1 are the 2 most characterized fusions, whereas EWSR1-CREM has been less studied. To better understand the phenotypic spectrum of mesenchymal tumors associated with the EWSR1-CREM fusion, we investigated archival cases using fluorescence in situ hybridization and/or RNA sequencing. Among 33 clear cell sarcomas of soft...
Wed Nov 13, 2019 09:50
No abstract available
Wed Nov 13, 2019 09:50
Spitz melanoma is a rare variant of melanoma defined by distinct clinical, histologic, and genetic features and affecting patients of all ages. Half of these tumors are driven by fusion of kinase genes including ALK, NTRK1/3, ROS1, RET, MET, or BRAF. We recently reported recurrent fusion or truncation of the potentially targetable serine-threonine kinase gene MAP3K8 in 33% of Spitz melanomas. Here we describe the histologic features of these MAP3K8-rearranged tumors (16 pediatric Spitz melanomas;...
Wed Nov 13, 2019 09:50
Many gallbladder adenocarcinomas (ACs) are detected incidentally in routine cholecystectomy specimens, yet sampling practices vary when intestinal metaplasia (IM) or dysplasia are found via routine sampling. Our practice has been to submit 5 additional sections when IM is found, but cases with dysplasia are entirely submitted. We sought to determine an appropriate sampling protocol when encountering these findings. We retrospectively identified cholecystectomy specimens with these features over a...
Wed Nov 13, 2019 09:50
Although there are 5 well-described morphologic patterns of (nonglandular) urothelial carcinoma in situ (CIS), we have encountered a novel pattern of flat urothelial carcinoma with plasmacytoid features characterized by a triad of morphologic findings including abnormal architecture with cellular rounding, enlarged nuclei with eccentric nuclear localization, and dense globular eosinophilic cytoplasm. A total of 23 cases of plasmacytoid CIS (mean age: 74.1 y, range: 58 to 91 y) were collected and...
Wed Nov 13, 2019 09:50
The entity “pericytoma with t(7;12)” was described as a rare, distinct perivascular myoid neoplasm provisionally classified within the family of myopericytic tumors that demonstrates t(7;12)(p22;q13) translocation with resultant ACTB-GLI1 fusion and biologically was felt to behave in an indolent fashion. However, a recent study showed that tumors with this and similar translocations may have variable morphology and immunohistochemical phenotype with inconsistent myopericytic characteristics and a...
Wed Nov 13, 2019 09:50
Rosai-Dorfman disease (RDD) is a rare non-Langerhans cell histiocytic proliferation that occurs in nodal and extranodal sites. Rare examples of the disease involving the digestive system have been described. To characterize the digestive tract manifestations of this disease, 12 specimens from 11 patients with extranodal RDD affecting the digestive organs were analyzed. Hematoxylin and eosin sections and available immunohistochemical stains were reviewed, and the clinical information was obtained...
Wed Nov 13, 2019 09:50
Identifying tumor characteristics that correlate with metastasis and survival in patients with conjunctival melanoma can potentially lead to better outcomes through a better selection of patients for adjuvant treatments including potentially life-saving new melanoma therapy. The objective of this study was to validate the conjunctival melanoma staging criteria in the American Joint Committee on Cancer (AJCC) Cancer Staging Manual (8th edition) and explore the prognostic importance of tumor thickness,...
Wed Nov 13, 2019 09:50
Rosai-Dorfman disease (RDD) is an uncommon disorder, characterized by an atypical expansion of histiocytes which classically shows emperipolesis and immunoreactivity with S-100 protein. RDD affects the lymph nodes as well as extranodal sites; however, RDD of the breast is exceptionally rare. Herein, we describe the histopathologic features of 22 cases of RDD occurring in the breast, with an emphasis on the differential diagnosis. All cases were notable for an exuberant lymphocytic infiltrate with...
Wed Nov 13, 2019 09:50
Systemic high-grade B-cell lymphomas (HGBCLs) with MYC gene rearrangements are clinically aggressive. In situ lesions with indolent behavior have not been described to date. We have identified 2 cases of in situ B-cell neoplasms with MYC rearrangements (IS-BCN, MYC+) occurring, and focally confined to ≤4 lymphoid follicles in otherwise healthy individuals and without clinical progression despite minimal intervention (surgical only). Morphologically similar to systemic HGBCLs, the low power view of...
Wed Nov 13, 2019 09:50
Osteoblastoma and osteoid osteoma together are the most frequent benign bone-forming tumor, arbitrarily separated by size. In some instances, it can be difficult to differentiate osteoblastoma from osteosarcoma. Following our recent description of FOS gene rearrangement in these tumors, the aim of this study is to evaluate the value of immunohistochemistry in osteoid osteoma, osteoblastoma, and osteosarcoma for diagnostic purposes. A total of 337 cases were tested with antibodies against c-FOS: 84...
Wed Nov 13, 2019 09:50
No abstract available
Wed Nov 13, 2019 09:50
Abstract Medical conditions involving the hair are typically managed by a dermatologist. However, a significant psychosocial association has been found both in the development of hair conditions through primary pathologic involvement and as secondary co‐morbidity. Trichopsychodermatology is an emerging field aiming to better understand the psychiatric and psychosocial impact of disorders involving the hair. Trichotillomania or hair‐pulling disorder, alopecia areata, telegenic effluvium, anagen effluvium,...
Tue Nov 12, 2019 18:09
Abstract Background Itch is the most bothersome symptom in psoriasis, often leading to impaired quality of life. Treatment of psoriasis‐induced itch is frequently unsatisfactory as the various therapies employed have a delayed onset of effect. Histamine‐1 receptor (H1)‐antihistamines are not recommended in treatment guidelines as histamine is not considered a key mediator in psoriasis. However, patients using H1‐antihistamines frequently report benefits in questionnaire‐based studies. To address...
Tue Nov 12, 2019 18:04
Abstract Introduction Hori's nevus is a pigmentation disorder reported mainly in middle‐aged Asian women. There is no systematic review addressing its pharmacotherapy. Materials and methods The population for our systematic review was patients with a clinical/ histological diagnosis of Hori's nevus (both sex, any age group). We screened 5 literature databases using relevant keywords. All RCTs, observational studies and case series mentioning at least one intervention and outcome of that...
Tue Nov 12, 2019 18:03
Abstract The EFSA Panel on Plant Health performed a pest categorisation of Diabrotica virgifera zeae (Coleoptera: Chrysomelidae), the Mexican corn rootworm, for the EU. This is one of two subspecies of D. virgifera which occurs in Central America, Mexico and central southern parts of the USA (Texas, Oklahoma and New Mexico). The preferred larval host is maize (Zea mays) roots, although larvae can feed on the roots of sorghum and other grass species. Adults feed on the leaves, silks, immature seeds...
Tue Nov 12, 2019 14:03
Abstract The European Commission asked EFSA for a Scientific Opinion: to revise the state of knowledge about the differences between the chronic wasting disease (CWD) strains found in North America (NA) and Europe and within Europe; to review new scientific evidence on the zoonotic potential of CWD and to provide recommendations to address the potential risks and to identify risk factors for the spread of CWD in the European Union. Full characterisation of European isolates is being pursued, whereas...
Mon Nov 11, 2019 20:44
Abstract In recent years, research on animal personality has exploded within the field of behavioral ecology. Consistent individual differences in behavior exist in a wide range of species, and these differences can have fitness consequences and influence several aspects of a species' ecology. In comparison to studies of other animals, however, there has been relatively little research on the behavioral ecology of primate personality. This is surprising given the large body of research within psychology...
Wed Nov 13, 2019 13:26
המילה פיתה נראית כמילה עברית. רק דבר אחד מסגיר את מוצאהּ הלועזי – הטעמתה המלעילית, שאינה מתיישבת עם הטעמת המלרע של מילים בסיומת ־ָה ממין נקבה בעברית, דוגמת אישה, גינה, מלכה, משאלה. ואומנם המילה התגלגלה אלינו משפות הבלקן ומיוונית. משפות אלה נשאלה pita/pitta לשפתם של היהודים דוברי הספרדית היהודית (לאדינו), ועם עלייתם הם העשירו את העברית, בין היתר, לא רק בבּורֵקס (צורת רבים) אלא גם בשם לסוג הלחם הדק, העגול והאהוב. ואולם לאוזניים עבריות דמתה המילה פיתה למילה העברית פַּת ולמילה הארמית המקבילה לה פִּתָּא...
Wed Nov 13, 2019 16:09
מבחר מונחי משפט שאושרו באקדמיה בשנת תשע"ט The post למד לשונך 132 appeared first on האקדמיה ללשון העברית.
Tue Nov 12, 2019 13:28
מבחר מונחי משפט שאושרו באקדמיה בשנת תשע"ט The post למד לשונך 131 appeared first on האקדמיה ללשון העברית.
Tue Nov 12, 2019 13:24
תוכן העניינים ספר היובל לכבוד פרופ' חיים כהן, עורך המילון ההיסטורי, עמ' 1 מפעלו של פרופ' מורג: מהקלֶטֶת ועד למרשתת, עמ' 1 1,400 מונחים משפטיים חדשים, עמ' 1 אהרן ממן, העברית ולשונות היהודים, עמ' 2 גבריאל שלו, המינוח – נקודת המוצא לכל דיון משפטי, עמ' 3 קציעה כ"ץ, מורי שלמה מורג, עמ' 6 אירועים אחרונים, עמ' 6 לזכרו של ישראל בן־דוד (תרפ"ה–תשע"ט), עמ' 7 מן הארכיון: התפלה, המתקה או תפלול, עמ' 8 The post אקדם 65 appeared first on האקדמיה ללשון העברית.
Tue Nov 12, 2019 13:06
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