Objective: Our previous studies have confirmed that α2δ1 has the potential to function as a cancer stem cell marker, and CACNA2D1 is the coding gene of α2δ1. But it is unclear how microRNAs regulate the expression of the CACNA2D1 gene in laryngeal cancer cells. Methods: We detected the expressions of α2δ1 protein, microRNA-107, and CACNA2D1 in 40 pairs of laryngeal cancer tissues and adjacent normal tissues. Laryngeal squamous cell carcinoma cells, TU212 and TU686, were cultured and transfected...
Fri Nov 08, 2019 02:00
The relatively low toxicity profile of nab-paclitaxel plus carboplatin and its feasibility as an adjuvant administration was reported previously. This study aimed to evaluate the survival efficacy for completely resected patients with stage IB, II, and IIIA nonsmall cell lung cancer (NSCLC). Twenty-nine eligible patients with NSCLC who received surgical resection for pathological stage IB, II, or IIIA, followed by postoperative adjuvant chemotherapy with modified 3-week cycles of either nab-paclitaxel...
Fri Nov 08, 2019 02:00
Rhabdomyosarcoma is the most common soft tissue sarcoma that typically occurs in children and adolescents and is rare in adults. Furthermore, as cardiac tumor is rare, adult cardiac rhabdomyosarcoma is a very rare entity. Here, we report the case of a 68-year-old woman with cardiac rhabdomyosarcoma who was successfully treated with eribulin. She presented with sudden loss of consciousness, which was attributed to the cardiac tumor. The tumor was resected by emergency surgery and was diagnosed as...
Fri Nov 08, 2019 02:00
Background Health insurance plays a critical role in the accessibility to and quality of health care for patients with melanoma in the United States. Current knowledge regarding the association between insurance status and stage of melanoma is limited because few studies to date have simultaneously controlled for factors known to influence the risk of diagnosis of late‐stage melanoma. The current study was conducted to examine the association between health insurance status and stage of melanoma...
Tue Nov 12, 2019 16:30
Background High levels of sedentary behavior may negatively affect health outcomes in cancer survivors. A systematic review and meta‐analysis was performed to clarify whether postdiagnosis sedentary behavior is related to survival, patient‐reported outcomes, and anthropometric outcomes in cancer survivors. Methods The Ovid MEDLINE, EMBASE, CINAHL (The Cumulative Index to Nursing and Allied Health Literature), and SPORTDiscus databases were searched from study inception to June 2019. Studies...
Tue Nov 12, 2019 16:30
Background Early detection of ovarian cancer could significantly improve patient outcomes. Cancer antigen 125 (CA 125) is elevated in sera from approximately 60% of patients with early‐stage (I/II) disease. Sensitivity might be improved through the combination of CA 125 with other biomarkers. Among potential biomarkers, antigen‐autoantibody (Ag‐AAb) complexes have received relatively little attention. Methods Luminex‐based immunoassays were used to measure human epididymis protein 4 (HE4),...
Tue Nov 12, 2019 16:28
BACKGROUND Greater than one‐half of children who are treated for acute lymphoblastic leukemia (ALL) develop ≥1 treatment‐related medical conditions in their lifetime, many of which are known risk factors for diabetes mellitus. In the current study, the authors evaluated the prevalence and risk factors of diabetes mellitus among clinically assessed adult survivors of childhood ALL METHODS The authors performed a retrospective evaluation of data from survivors of ALL and community controls who...
Tue Nov 12, 2019 16:27
Background The incidence of neuroendocrine tumors (NETs) is rapidly rising. There are very few studies investigating the role of sociodemographic factors in NETs. This study was aimed at examining how geographic and sociodemographic characteristics shape outcomes in the NET population. Methods A retrospective analysis using the Surveillance, Epidemiology, and End Results database was performed, and the NET patient population from 1973 to 2015 was studied. Univariate and multivariable analyses...
Tue Nov 12, 2019 16:26
Background Poly(adenosine diphosphate ribose) polymerase (PARP) inhibitors exhibit promising activity against ovarian cancers, but their efficacy can be limited by acquired drug resistance. This study explores the role of autophagy in regulating the sensitivity of ovarian cancer cells to PARP inhibitors. Methods Induction of autophagy was detected by punctate LC3 fluorescence staining, LC3I to LC3II conversion on Western blot analysis, and electron microscopy. Enhanced growth inhibition and...
Tue Nov 12, 2019 16:25
Background Prior studies in oncology have shown that a higher annual facility patient volume is associated with reduced mortality. Because classic Hodgkin lymphoma is uncommon but highly curable, this study used the National Cancer Database (2003‐2014) to analyze whether such a relationship exists for this disease. Methods The facilities were classified by quartiles, and random intercepts were used to account for clustering of patients within facilities. A Cox regression model was used to...
Tue Nov 12, 2019 16:24
Background Pain is a common problem, especially in the first few years of breast cancer survivorship. Asian American survivors of breast cancer reportedly have inadequate cancer pain management, and subsequently report a lower quality of life compared with other racial/ethnic groups. Technology‐based programs could improve the cancer pain management process. The purpose of the current study was to examine the efficacy of a technology‐based information and coaching/support program on cancer pain...
Tue Nov 12, 2019 16:22
Background The thoracic radiotherapy (TRT) target volume for limited‐stage small‐cell lung cancer (SCLC) has been controversial for decades. In this report, the final results of a prospective randomized trial on the TRT target volume before and after induction chemotherapy are presented. Methods After 2 cycles of etoposide and cisplatin, patients arm were randomized to receive TRT to the postchemotherapy or prechemotherapy tumor volume in a study arm and a control arm. Involved‐field radiotherapy...
Tue Nov 12, 2019 16:20
Background An increased risk of metabolic syndrome has been reported for childhood cancer survivors and for adult survivors with certain cancer types. One previous study reported on the risk for diseases in the metabolic syndrome specifically among survivors of adolescent and young adult cancers. Methods The study comprised 11,822 five‐year survivors of adolescent and young adult cancer (ages 15‐39 years at diagnosis) who were diagnosed during the period from 1994 through 2009 in Denmark and...
Tue Nov 12, 2019 16:18
Background The objective of this study was to conduct the first systematic evaluation of the long‐term economic impact of arsenic trioxide (ATO) plus all‐trans retinoic acid (ATRA) for the treatment of patients with newly diagnosed acute promyelocytic leukemia (APL) from the perspective of the Chinese health care system. Methods On the basis of clinical data from a randomized phase 3 trial, a time‐dependent Markov model with 4 health states (complete remission, relapse or treatment failure,...
Tue Nov 12, 2019 16:15
Tue Nov 12, 2019 16:14
British Journal of Cancer, Published online: 13 November 2019; doi:10.1038/s41416-019-0619-yImpact of breast cancer molecular subtypes on the incidence, kinetics and prognosis of central nervous system metastases in a large multicentre real-life cohort
Wed Nov 13, 2019 02:00
British Journal of Cancer, Published online: 13 November 2019; doi:10.1038/s41416-019-0632-1Survival after cancer in children, adolescents and young adults in the Nordic countries from 1980 to 2013
Wed Nov 13, 2019 02:00
British Journal of Cancer, Published online: 13 November 2019; doi:10.1038/s41416-019-0611-6Overall and progression-free survival with cabazitaxel in metastatic castration-resistant prostate cancer in routine clinical practice: the FUJI cohort
Wed Nov 13, 2019 02:00
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Abstract Immune checkpoint inhibition suggests promising progress for the treatment of advanced hepatocellular carcinoma (HCC). However, the underlying cellular mechanisms remain unclear because liver cancer cells apparently do not upregulate inhibitory checkpoint molecules. Here, we analysed whether regulatory T cells (Tregs) can alternatively trigger checkpoint inhibition pathways in HCC. Using flow cytometry we analysed expression of checkpoint molecules (PD-1, PD-L1, CTLA-4,...
Wed Nov 13, 2019 02:00
Abstract Histone deacetylase (HDAC) inhibitors impair tumor cell proliferation and alter gene expression. However, the impact of these changes on anti-tumor immunity is poorly understood. Here, we showed that the class I HDAC inhibitor, entinostat (ENT), promoted the expression of immune-modulatory molecules, including MHCII, costimulatory ligands, and chemokines on murine breast tumor cells in vitro and in vivo. ENT also impaired tumor growth in vivo—an effect that was dependent...
Tue Nov 12, 2019 02:00
Abstract Hepatitis B virus-associated hepatocellular carcinoma (HBV-HCC) is usually considered an inflammation-related cancer associated with chronic inflammation triggered by exposure to HBV and tumor antigens. T-cell exhaustion is implicated in immunosuppression of chronic infections and tumors. Although immunotherapies that enhance immune responses by targeting programmed cell death-1(PD-1)/PD-L1 are being applied to malignancies, these treatments have shown limited response...
Tue Nov 12, 2019 02:00
Abstract Purpose Tumor-associated macrophages (TAMs) exist as heterogeneous subsets and have dichotomous roles in cancer-immune evasion. This study aims to assess the clinical effects of Galectin-9+ tumor-associated macrophages (Gal-9+TAMs) in muscle-invasive bladder cancer (MIBC). Experimental design We identified Gal-9+TAMs by immunohistochemistry (IHC)...
Tue Nov 12, 2019 02:00
AbstractThe role of long non‐coding RNAs (lncRNAs) in the epithelial–mesenchymal transition (EMT) in pancreatic ductal adenocarcinoma (PDAC) is unclear. Some lncRNAs can be transferred by extracellular vesicles (EVs) and have potential as biomarkers. Here, we identify a lncRNA that could serve as a biomarker for PDAC and show the functional roles of the lncRNA. Expression profiling of lncRNAs revealed that HULC was highly expressed, and induced, by transforming growth factor‐β in PDAC cells and their...
Tue Nov 12, 2019 11:23
AbstractNeurogenic differentiation factor 1 (NeuroD1) is a transcription factor critical for promoting neuronal differentiation and maturation. NeuroD1 is involved in neuroblastoma and medulloblastoma, however, its molecular mechanism in promoting tumorigenesis remains unclear. Furthermore, the role of NeuroD1 in non‐neural malignancies has not been widely characterized. Here, we found that NeuroD1 is highly expressed in colorectal cancer. NeuroD1‐silencing induces the expression of p21, a master...
Tue Nov 12, 2019 11:13
Abstract This study was designed to evaluate the dynamic survival and recurrence of remnant gastric cancer (RGC) after radical resection and to provide a reference for the development of personalized follow‐up strategies. A total of 298 patients were analysed for their 3‐year conditional overall survival (COS3), 3‐year conditional disease‐specific survival (CDSS3), corresponding recurrence and pattern changes, and associated risk factors. The 5‐year OS and the 5‐year DSS of the entire cohort were...
Mon Nov 11, 2019 15:44
Purpose: We aimed to investigate genomic correlates underlying extremes of survivorship in metastatic colorectal cancer (CRC) and their applicability in informing survival in distinct subsets of metastatic CRC patients. Experimental Design: We examined differences in oncogenic somatic alterations between metastatic CRC cohorts demonstrating extremes of survivorship following complete metastasectomy: ≤2-year (n=17) and ≥10-year (n=18) survivors. Relevant genomic findings, and their association with...
Tue Nov 12, 2019 15:51
Purpose: A cryptic inv(16)(p13.3q24.3) encoding the CBFA2T3-GLIS2 fusion is associated with poor outcome in infants with acute megakaryocytic leukemia. We aimed to broaden our understanding of the pathogenesis of this fusion through transcriptome profiling. Experimental Design: Available RNA from children and young adults with de novo AML (N=1,049) underwent transcriptome sequencing (mRNA and miRNA). Transcriptome profiles for those with the CBFA2T3-GLIS2 fusion (N=24) and without (N=1,025) were...
Tue Nov 12, 2019 15:51
Opinion statement As cancer care has evolved so has the awareness of the issues cancer patients, their caregivers and families face during and after treatment, giving rise to the cancer survivorship care initiative. The body of research pertaining to quality of life, health-related quality of life, and multidimensional symptom burden of neuro-oncology patients and their caregivers has grown significantly, yielding a wealth of data and information indicating interventions and...
Wed Nov 13, 2019 02:00
Publication date: Available online 12 November 2019Source: European Journal of Surgical OncologyAuthor(s): C. Morgan, T.D. Stringfellow, R. Rolph, T. Kovacs, A. Kothari, S.E. Pinder, H. Hamed, A.R. SeverAbstractIntroductionDetermining the extent of residual disease in the breast and axilla following neoadjuvant chemotherapy (NACT) is vital for surgical planning. Traditionally patients with incomplete radiological response in the breast after NACT undergo axillary node clearance, regardless of axillary...
Tue Nov 12, 2019 16:55
Publication date: Available online 11 November 2019Source: European Journal of Surgical OncologyAuthor(s): Marjolein De Cuypere, Pierre Lovinfosse, Frédéric Goffin, Christine Gennigens, Ramon Rovira Negre, Joan Duch Remon, Maxime Fastrez, Géraldine Gebhart, Jean Luc Squifflet, Mathieu Luyckx, Gabriel Charaf, Kurt Crener, Frédéric Buxant, Dario Bucella, Mathieu Jouret, Roland Hustinx, Frédéric KridelkaAbstractObjectiveExtended field chemoradiation is recommended for patients with locally advanced...
Tue Nov 12, 2019 16:55
Future Oncology, Ahead of Print.
Wed Nov 13, 2019 04:06
Future Oncology, Ahead of Print.
Wed Nov 13, 2019 04:06
Future Oncology, Ahead of Print.
Tue Nov 12, 2019 06:17
Salvage therapy for relapsed testicular cancer: a need for consensus. Future Oncol. 2019 Nov 12;: Authors: Agrawal V, Adra N PMID: 31714157 [PubMed - as supplied by publisher]
Wed Nov 13, 2019 20:48
Related ArticlesXRCC1 632 as a candidate for cancer predisposition via a complex interaction with genetic variants of base excision repair and double strand break repair genes. Future Oncol. 2019 Nov 11;: Authors: Singh A, Singh N, Behera D, Sharma S Abstract Aim: The DNA repair system safeguards integrity of DNA. Genetic alterations force the improper repair which in conjugation with other factors ultimately results in carcinogenesis. Materials &...
Tue Nov 12, 2019 17:42
Related ArticlesSurvival outcome of tyrosine kinase inhibitors beyond progression in association to radiotherapy in oligoprogressive EGFR-mutant non-small-cell lung cancer. Future Oncol. 2019 Nov 11;: Authors: Rossi S, Finocchiaro G, Noia VD, Bonomi M, Cerchiaro E, Rose F, Franceschini D, Navarria P, Ceresoli GL, Beretta GD, D'Argento E, Scorsetti M, Santoro A, Toschi L Abstract Aim: The association of tyrosine kinase inhibitors (TKIs) and local radiotherapy...
Tue Nov 12, 2019 17:42
Related ArticlesReal-world adverse events with niraparib 200 mg/day maintenance therapy in ovarian cancer: a retrospective study. Future Oncol. 2019 Nov 11;: Authors: Gallagher JR, Heap KJ, Carroll S, Travers K, Harrow B, Westin SN Abstract Aim: To assess real-world occurrence of common clinical trial-reported adverse events (AE) among patients with recurrent ovarian cancer initiating niraparib 200 mg/day. Materials & methods: This retrospective...
Tue Nov 12, 2019 13:48
Delayed time to chemotherapy (TTC) is associated with decreased outcomes of breast cancer patients. Recently, studies suggested that the association might be subtype‐dependent and that TTC within 30 days should be warranted in patients with triple‐negative breast cancer (TNBC). The aim of the current study is to determine if TTC beyond 30 days is associated with reduced 10‐year overall survival in TNBC patients. We identified all TNBC patients diagnosed between 2006 and 2014 who received adjuvant...
Tue Nov 12, 2019 19:18
RuvBL1 is an AAA+ ATPase whose expression in hepatocellular carcinoma (HCC) correlates with a poor prognosis. In vitro models suggest that targeting RuvBL1 could be an effective strategy against HCC. However, the role of RuvBL1 in the onset and progression of HCC is still unknown. To address this question, we developed a RuvBL1hep+/‐ mouse model and evaluated the outcome of DEN–induced liver carcinogenesis up to 12 months of progression. We found that RuvBL1 haploinsufficiency initially delayed the...
Tue Nov 12, 2019 19:08
Men with prostate cancer experience side effects for which a supportive social environment may be beneficial. We examined the association between four measures of social connectedness and mortality after prostate cancer diagnosis. Male participants in the Melbourne Collaborative Cohort Study in 1990‐94, who developed incident prostate cancer and attended follow‐up in 2003‐07, were eligible for the study. Information on social connectedness, collected at follow‐up, included: 1) living arrangement;...
Tue Nov 12, 2019 18:58
Immune checkpoint molecules have been identified as crucial regulators of the immune response, which motivated the emergence of immune checkpoint‐targeting therapeutic strategies. However, the prognostic significance of the immune checkpoint molecules PD‐1, CTLA4, TIM‐3 and LAG‐3 remains controversial. The aim of our study was to conduct a systematic assessment of the expression of these immune checkpoint molecules across different cancers in relation to treatment response, tumor‐infiltrating immune...
Tue Nov 12, 2019 18:56
Our aim was to describe HPV16E6 antibody kinetics prior to anal cancer in people living with HIV/AIDS (PLWHA) and evaluate the possible contribution of HPV16E6 serology to anal cancer risk prediction. For 91 persons diagnosed with anal cancer in the Swiss HIV Cohort Study (1989‐2017), serial serum/plasma samples were tested for HPV16E6 antibodies using multiplex serology, supplemented with samples from 1,356 participants without anal cancer. Anal cancer incidence was estimated for PLWHA from 40 years‐old...
Tue Nov 12, 2019 18:38
Endometrial cancers have high rates of phosphoinositide 3‐kinase (PI3K) pathway alterations. MK‐2206 is an allosteric inhibitor of AKT, an effector kinase of PI3K signals. We hypothesized patients with tumors harboring PIK3CA mutations would be more likely to benefit from MK‐2206 than those without PIK3CA mutation. A phase II study was performed in patients with recurrent endometrial cancer; all histologies except carcinosarcoma were eligible. Up to 2 prior chemotherapy lines were permitted, excluding...
Tue Nov 12, 2019 18:10
Abstract Purpose Growing solid tumors mostly outstrip blood supply and become hypoxic (low oxygen supply). To survive under this pathological milieu, tumors overexpress a potent oncogenic factor, hypoxia-inducible factor-1α (HIF-1α). HIF-1α up-regulate HIF-1 signaling pathways and subsequently activate genes that promote cancer growth even under hypoxia. Also, HIF-1 pathway activation leads to aggressive tumor growth, metastasis, therapy...
Wed Nov 13, 2019 02:00
Overexpressed PES1 promotes carcinogenesis in various types of malignant tumors. However, the biological role and clinical significance of PES1 in pancreatic cancer are still unexplored.
Tue Nov 12, 2019 02:00
Long non-coding RNAs (lncRNAs) are tumor-associated biological molecules and have been found to be implicated in the progression of colorectal cancer (CRC). This study aims to examine the effects of lncRNA RP1...
Tue Nov 12, 2019 02:00
Circular RNAs (circRNAs) have recently been shown to play important roles in different tumors. However, their detailed roles and regulatory mechanisms in pancreatic ductal adenocarcinoma (PDAC) are not well un...
Tue Nov 12, 2019 02:00
Prostate cancer (PCa) is a leading cause of cancer-related death in males worldwide. Exacerbated inflammation and angiogenesis have been largely demonstrated to contribute to PCa progression. Diverse naturally...
Tue Nov 12, 2019 02:00
We investigated the role of PD-L1 in the metabolic reprogramming of non-small cell lung cancer (NSCLC).
Tue Nov 12, 2019 02:00
Abstract Mps1/TTK plays an important role in development of many tumors. The purpose of the present study was designed to investigate the role of TTK in colon cancer. We analyzed TTK and colon cancer in the GEO database, colon cancer tissues and normal tissues were collected to verify the results by immunohistochemistry. We detected the TTK expression in the colon cancer cell lines, and overexpressed or silenced TTK expression in colon cancer cell lines. GEO database showed that...
Wed Nov 13, 2019 02:00
Abstract Fibrous sheath interacting protein 1 (FSIP1) is frequently activated in a variety of tumors including breast cancer. However, the clinical significance of FSIP1 in hormone receptor (HR)‐positive breast cancer is unclear. We analyzed the expression and clinical significance of FSIP1 in human breast cancer databases. A comprehensive analysis of 1094 gene expression profiles of breast cancer in The Cancer Genome Atlas revealed that FSIP1 overexpression correlated with decreased overall survival...
Tue Nov 12, 2019 11:55
Abstract The CREB‐binding protein (CBP) pathway plays an important role in transcription and activity of acetyltransferase that acetylates lysine residues of histones and nonhistone proteins. In the present study, we hypothesized that genetic variants in the CBP pathway genes played a role in survival of non‐small‐cell lung cancer (NSCLC). We tested this hypothesis using the genotyping data from the genome‐wide association study (GWAS) dataset from the Prostate, Lung, Colorectal, and Ovarian (PLCO)...
Tue Nov 12, 2019 11:53
Abstract Lung cancer is currently a leading cause of cancer-associated mortality worldwide. Despite the increasing evidences of variants that were associated with lung cancer risk, investigations of genetic factors and their roles in genetic susceptibility to lung cancer were limited. Here we systematically investigated the spectrum of pathogenic germline mutations in Chinese population with lung cancer. Genomic profiling of DNA was performed through next-generation sequencing...
Tue Nov 12, 2019 02:00
Abstract Objective Long‐term childhood cancer survivors (CCS) are less likely to become parents than their peers of the same age. Previous research has suggested that besides fertility, this outcome is shaped by psychosocial factors such as emotional motives toward having a child. Drawing from a sample of CCS with survival times >25 years, we present the validation of a questionnaire assessing cancer‐specific reproductive motives and concerns. Methods We evaluated the cancer‐specific...
Tue Nov 12, 2019 11:09
Abstract Objective Compassion fatigue – that is, secondary traumatic stress (STS) and burnout – is a traumatic emotional state experienced by healthcare providers and expressed in a reduced capacity to be interested in and empathic to the suffering of others. Compassion fatigue may be related to grief over patients’ loss. We examined the relation between grief and compassion fatigue among psycho‐oncologists while exploring the impact of social acknowledgment on this association. We hypothesized...
Tue Nov 12, 2019 11:07
Abstract Purpose Despite cure, adolescents and young adults (AYA) who complete cancer treatment remain at risk for numerous physical and psychological late effects. However, engagement in recommended follow‐up care, knowledge of cancer treatment history and risks, and adoption of health promoting behaviors are often suboptimal. The pilot randomized controlled trial assessed the feasibility and acceptability of a text messaging intervention (THRIVE; Texting Health Resources to Inform, motiVate,...
Mon Nov 11, 2019 20:54
Abstract Objective Without an agreed‐upon set of characteristics that differentiate clinical from non‐clinical levels of fear of cancer recurrence (FCR), it is difficult to ensure that FCR severity is appropriately measured, and that those in need of intervention are identified. The objective of this study was to establish expert consensus on the defining features of clinical FCR. Method A three‐round Delphi was used to reach consensus on the defining features of clinical FCR. Sixty‐five...
Mon Nov 11, 2019 20:48
Abstract Objective Precision cancer medicine (PCM) aims at identifying tumor‐driving molecular characteristics to improve therapy. Despite early successes for some cancers, the approach faces manifold challenges. Patients undergoing extensive molecular diagnostics (MD) may hope for personal benefit although chances are small. In order to offer suitable support to this group, healthcare professionals need to gain insight into their experience. Thus, this study sought to explore the expectations...
Mon Nov 11, 2019 20:28
Abstract Objective Little attention has been paid to understanding how engaging in cancer‐related interpersonal exchanges via varying modes of communication influences psychological well‐being among young adults with cancer. This study explored the moderating role of communication mode on the relationship of relational processes of disclosure and responsiveness with psychological well‐being. Methods 61 young adults with cancer (M age = 34.59, SD = 4.82) completed a questionnaire about...
Mon Nov 11, 2019 19:03
Postradiogenic wound healing disorders are an important clinical problem. While a variety of treatment modalities are available, there is no strategy to objectively judge treatment success. The aim of this stu...
Mon Nov 11, 2019 02:00
Adjuvant (ART) and salvage radiotherapy (SRT) are two common concepts to enhance biochemical relapse free survival (BCRFS) in patients with prostate cancer (PC). We analyzed differences in outcome between ART ...
Mon Nov 11, 2019 02:00
Publication date: January–February 2020Source: Reports of Practical Oncology & Radiotherapy, Volume 25, Issue 1Author(s): Jan Stuk, Jaroslav Vanasek, Karel Odrazka, Martin Dolezel, Iveta Kolarova, Ales Hlavka, Martina Vitkova, Jan Vodicka, Karel PokornyAbstractIntroductionAt the present time, the skin tumors are among the most common cancers. Optimal therapy is based on the extent of the disease and the age of the patient. The need for radiotherapy occurs for inoperable locally advanced tumors...
Wed Nov 13, 2019 13:52
Publication date: January–February 2020Source: Reports of Practical Oncology & Radiotherapy, Volume 25, Issue 1Author(s): Neslihan Sarıgül, Fazlı Yağız Yedekçi, Mete Yeğiner, Fadıl Akyol, Haluk UtkuAbstractAimThe aim of this study was to determine the Inflection Points (IPs) of flattening filter free (FFF) CyberKnife dose profiles for cone-based streotactic radiotherapy. In addition, dosimetric field sizes were determined.BackgroundThe increased need for treatment in the early stages of cancer...
Wed Nov 13, 2019 13:52
The 3'-termini of tRNA are the point of amino acid linkage and thus crucial for their function in delivering amino acids to the ribosome and other enzymes. Therefore, to provide tRNA functionality, cells have to ensure the integrity of the 3'-terminal CCA-tail, which is generated during maturation by the 3'-trailer processing machinery and maintained by the CCA-adding enzyme. We developed a new tRNA sequencing method which is specifically tailored to assess the 3'-termini of E. coli tRNA. Intriguingly,...
Tue Nov 12, 2019 20:00
Abstract Purpose To describe the possibility of building a classifier for patients at risk of lymph node relapse and a predictive model for disease-specific survival in patients with early stage non-small cell lung cancer. Methods A cohort of 102 patients who received stereotactic body radiation treatment was retrospectively investigated. A set of 45 textural...
Wed Nov 13, 2019 02:00
Abstract Purpose Lymph node irradiation in breast cancer has gained complexity due to recently published studies and technical innovations which then led to changes in international guidelines. We sought to determine real-time variability in lymph node irradiation in clinical practice in German-speaking countries. Methods The Department of Radiation Oncology,...
Wed Nov 13, 2019 02:00
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