Cancers, Vol. 11, Pages 1788: Consensus Procedures in Oncological Imaging: The Case of Prostate Cancer Cancers doi: 10.3390/cancers11111788 Authors: Stefano Fanti Wim Oyen Elisabetta Lalumera Recently, there has been increasing interest in methodological aspects of advanced imaging, including the role of guidelines, recommendations, and experts’ consensus, the practice of self-referral, and the risk of diagnostic procedure overuse. In a recent Delphi study of the European...
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Cancers, Vol. 11, Pages 1787: Cell Surface GRP78 as a Death Receptor and an Anticancer Drug Target Cancers doi: 10.3390/cancers11111787 Authors: Ge Kao Cell surface GRP78 (csGRP78, glucose-regulated protein 78 kDa) is preferentially overexpressed in aggressive, metastatic, and chemo-resistant cancers. GRP78 is best studied as a chaperone protein in the lumen of endoplasmic reticulum (ER), facilitating folding and secretion of the newly synthesized proteins and regulating protein...
Wed Nov 13, 2019 02:00
Cancers, Vol. 11, Pages 1784: Is there an Exposure–Response Relationship for Nivolumab in Real-World NSCLC Patients? Cancers doi: 10.3390/cancers11111784 Authors: Bellesoeur Ollier Allard Hirsch Boudou-Rouquette Arrondeau Thomas-Schoemann Tiako Khoudour Chapron Giraud Wislez Damotte Lupo Vidal Alexandre Goldwasser Tod Blanchet Pharmacokinetic/pharmacodynamic data from real-world cohort are sparse in non small–cell...
Wed Nov 13, 2019 02:00
Cancers, Vol. 11, Pages 1785: Histone Demethylase KDM4C Stimulates the Proliferation of Prostate Cancer Cells via Activation of AKT and c-Myc Cancers doi: 10.3390/cancers11111785 Authors: Lin Wang Chen Tseng Jiang Tsai Shen Yuh Sie Wang Kung Chuu Our three-dimensional organotypic culture revealed that human histone demethylase (KDM) 4C, a histone lysine demethylase, hindered the acini morphogenesis of RWPE-1 prostate cells, suggesting its...
Wed Nov 13, 2019 02:00
Cancers, Vol. 11, Pages 1786: Therapeutic Inducers of Apoptosis in Ovarian Cancer Cancers doi: 10.3390/cancers11111786 Authors: Mudra Binju Monica Angelica Amaya-Padilla Graeme Wan Hendra Gunosewoyo Yohan Suryo Rahmanto Yu Yu Ovarian cancers remain one of the most common causes of gynecologic cancer-related death in women worldwide. The standard treatment comprises platinum-based chemotherapy, and most tumors develop resistance to therapeutic drugs. One mechanism of developing...
Wed Nov 13, 2019 02:00
Cancers, Vol. 11, Pages 1783: Targeting Integrins in Cancer Nanomedicine: Applications in Cancer Diagnosis and Therapy Cancers doi: 10.3390/cancers11111783 Authors: Ping-Hsiu Wu Abayomi Emmanuel Opadele Yasuhito Onodera Jin-Min Nam Due to advancements in nanotechnology, the application of nanosized materials (nanomaterials) in cancer diagnostics and therapeutics has become a leading area in cancer research. The decoration of nanomaterial surfaces with biological ligands is a...
Wed Nov 13, 2019 02:00
Cancers, Vol. 11, Pages 1782: A Review on Curability of Cancers: More Efforts for Novel Therapeutic Options Are Needed Cancers doi: 10.3390/cancers11111782 Authors: Shuncong Wang Yewei Liu Yuanbo Feng Jian Zhang Johan Swinnen Yue Li Yicheng Ni Cancer remains a major cause of death globally. Given its relapsing and fatal features, curing cancer seems to be something hardly possible for the majority of patients. In view of the development in cancer therapies, this article...
Wed Nov 13, 2019 02:00
Cancers, Vol. 11, Pages 1781: Radiation and Stemness Phenotype May Influence Individual Breast Cancer Outcomes: The Crucial Role of MMPs and Microenvironment Cancers doi: 10.3390/cancers11111781 Authors: María Auxiliadora Olivares-Urbano Carmen Griñán-Lisón Sandra Ríos-Arrabal Francisco Artacho-Cordón Ana Isabel Torralbo Elena López-Ruiz Juan Antonio Marchal María Isabel Núñez Breast cancer is the most common cancer in women. Radiotherapy (RT) is one of the mainstay...
Tue Nov 12, 2019 02:00
Cancers, Vol. 11, Pages 1780: Prognostic Factors in a Large Nationwide Cohort of Histologically Confirmed Primary and Secondary Angiosarcomas Cancers doi: 10.3390/cancers11111780 Authors: Marije E. Weidema Uta E. Flucke Winette T.A. van der Graaf Vincent K.Y. Ho Melissa H.S. Hillebrandt-Roeffen Dutch Nationwide Network and Registry of Histo- and Cytopathology (PALGA)-Group Dutch Nationwide Network and Registry of Histo- and Cytopathology (PALGA)-Group Yvonne M.H. Versleijen-Jonkers...
Tue Nov 12, 2019 02:00
A 73-year-old woman who had a smoking history of 30 pack-years presented to the dermatology clinic with pruritic and painful lesions on the palms of her hands that had first appeared 9 months earlier. She reported a cough that had been present for 1 year and a weight loss of 5 kg over the past 4…
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A 44-year-old man with a family history of glaucoma presented to the ophthalmology clinic to reestablish care after relocating. He had previously started using timolol, brimonidine, and brinzolamide, which had been prescribed because of increased intraocular pressure. The measured pressure was 21…
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There is an error in the original publication of this paper. Figures 1 and 2 have been interchanged. The corrected version of these figures is shown below:
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Abstract Enzyme engineering has been widely employed to tailor the substrate specificity and enantioselectivity of enzymes. In this study, we mutated Trp288, an unconserved residue in the small binding pocket of an acetophenone reductase from Geotrichum candidum NBRC 4597 (GcAPRD). Trp288 mutants showed substrate specificity expansion towards bulky-bulky ketones and enantioselectivity alteration which was highly dependent on the substrate substituent length. In aliphatic ketone...
Wed Nov 13, 2019 02:00
Abstract There is a renewed interest in acetone-butanol-ethanol (ABE) fermentation from renewable substrates for the sustainable and environment-friendly production of biofuel and platform chemicals. However, the ABE fermentation is associated with several challenges due to the presence of heterogeneous components in the renewable substrates and the intrinsic characteristics of ABE fermentation process. Hence, there is a need to select optimal substrates and modify their characteristics...
Wed Nov 13, 2019 02:00
Abstract Microalgae are versatile sources of bioproducts, a solution for many environmental problems. However, and despite its importance, one of the main problems in large-scale cultures—the presence of contaminants—is rarely systematically approached. Contamination, or the presence of undesirable organisms in a culture, is deleterious for the culture and frequently leads to culture crashes. To avoid contamination, closed systems can be used; however, for very large-scale open...
Wed Nov 13, 2019 02:00
Abstract Aspergillus flavus is the main cause of postharvest agricultural commodity loss. In this study, puroindoline A (PINA) protein was expressed in Escherichia coli, purified, and its antifungal properties against A. flavus were characterized. Sodium dodecyl sulfate polyacrylamide gel electrophoresis showed that the molecular weight of the recombinant PINA protein was approximately 44 kDa. PINA exerted a powerful antifungal effect against A. flavus at 42.42 μg/mL on potato...
Tue Nov 12, 2019 02:00
Abstract The liver is an important digestive gland, and acute liver failure results in high mortality. Probiotics are considered potential adjuvant therapies for liver disease. This study aimed to investigate the beneficial effects of Lactobacillus helveticus R0052 on acute liver injury and the underlying mechanisms. Sprague-Dawley rats were gavaged with L. helveticus R0052 suspensions (3 × 109 CFU) for 1 week. Subsequently, acute liver injury was induced by intraperitoneal d-galactosamine...
Tue Nov 12, 2019 02:00
Abstract α-Glucosidase, Agl2, from Xanthomonas campestris was successfully overexpressed in Escherichia coli BL21(DE3) cells and purified with Ni columns. The enzyme exhibits glycosylation abilities towards a wide range of phenolic substrates, including phenol, vanillin, and ethyl vanillin, with maltose as the glycosyl donor. The catalytic properties of the purified enzyme were further investigated. It was observed that the synthesized glycosides started to degrade with prolonged...
Tue Nov 12, 2019 02:00
Abstract (2R,3S)-isocitric acid has long been used only as a specific biochemical reagent. However, there is ever increasing evidence that it can also be used as an original promising substance for prevention and treatment of some diseases. The review considers the results of longtime research in our laboratory and the data of other researchers related to microbial synthesis of (2R,3S)-isocitric acid, derivation and selection of active microbial producers, development of their...
Tue Nov 12, 2019 02:00
Abstract The present paper describes the generation of derivatives from the hybrid peptide called Ent35-MccV, active against Gram-positive and Gram-negative bacteria. This peptide has a triple glycine hinge region between enterocin CRL35 and microcin V. In order to obtain variants of Ent35-MccV with greater biotechnological potential, a saturation mutagenesis was carried out in the hinge region. As a result, we obtained a bank of E. coli strains expressing different mutated hybrid...
Tue Nov 12, 2019 02:00
Abstract A metagenome from an enrichment culture of a hydrothermal vent sample taken at Vulcano Island (Italy) was sequenced and an endoglucanase-encoding gene (vul_cel5A) was identified in a previous work. Vul_Cel5A with maximal activity at 115 °C was characterized as the most heat-active endoglucanase to date. Based on metagenome sequences, genomes were binned and bin4 included vul_cel5A as well as a putative GH1 β-glycosidase-encoding gene (vul_bgl1A) with highest identities...
Tue Nov 12, 2019 02:00
Abstract Mycobacterium tuberculosis is able to transition into a dormant state, causing a latent state of tuberculosis. Dormant mycobacteria acquire phenotypic resistance to all known antibacterial drugs; they are also able to maintain vitality in the host for decades and become active, causing the active form of the disease. In order to cure latent tuberculosis, new approaches should be developed. Earlier, we discovered accumulation in significant concentrations of porphyrins...
Tue Nov 12, 2019 02:00
Abstract FK520 (ascomycin), a 23-membered macrolide with immunosuppressive activity, is produced by Streptomyces hygroscopicus. The problem of low yield and high impurities (mainly FK523) limits the industrialized production of FK520. In this study, the FK520 yield was significantly improved by strain mutagenesis and genetic engineering. First, a FK520 high-producing strain SFK-6-33 (2432.2 mg/L) was obtained from SFK-36 (1588.4 mg/L) through ultraviolet radiation mutation coupled...
Tue Nov 12, 2019 02:00
Abstract 1-Deoxynojirimycin (DNJ), a representative iminopyranose, is widely used in anti-diabetic, antioxidant, anti-inflammatory, and anti-obesity applications. It naturally exists in plants, insects, and the culture broth of some microbes as a secondary metabolite product. However, the content of DNJ in plants and insects is relatively low, which is an obstacle to investigating DNJ in terms of structure–function relationships and restricts large-scale industrial production....
Tue Nov 12, 2019 02:00
Abstract Brain computer interfaces (BCI) represent an alternative for patients whose cognitive functions are preserved, but are unable to communicate via conventional means. A commonly used BCI paradigm is based on the detection of event-related potentials, particularly the P300, immersed in the electroencephalogram (EEG). In order to transfer laboratory-tested BCIs into systems that can be used by at homes, it is relevant to investigate if it is possible to select a limited set...
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Abstract Squamous cell carcinoma (SCC) is the most common and malignant laryngeal cancer. An early-stage diagnosis is of crucial importance to lower patient mortality and preserve both the laryngeal anatomy and vocal-fold function. However, this may be challenging as the initial larynx modifications, mainly concerning the mucosa vascular tree and the epithelium texture and color, are small and can pass unnoticed to the human eye. The primary goal of this paper was to investigate...
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Abstract Cancer classification is one of the crucial tasks in medical field. The gene expression of cells helps in identifying the cancer. The high dimensionality of gene expression data hinders the classification performance of any machine learning models. Therefore, we propose, in this paper a methodology to classify cancer using gene expression data. We employ a bio-inspired algorithm called binary bat algorithm for feature selection and extreme learning machine for classification...
Tue Nov 12, 2019 02:00
Objective. Noise-induced hearing loss (NIHL) is one of the most common occupational health risks in both developed and industrialized countries. It occurs as a result of interactions between genetic and environmental factors. Nevertheless, inherited genetic factors contributing to NIHL are not well understood. Therefore, we aim to investigate whether genetic mutations in three important base excision repair genes (OGG1, APEX1, and XRCC1) may influence susceptibility to NIHL. Methods. Three SNPs in...
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Background and Aim. Aspartate aminotransferase-to-platelet ratio index (APRI) is widely used in the assessment of fibrosis and cirrhosis, especially in patients with chronic hepatitis. However, the prognostic value of APRI in patients with chronic hepatitis with regard to the prediction of hepatocellular carcinoma (HCC) occurrence remains controversial. The objective of this meta-analysis is to investigate the association between APRI and HCC risk on the basis of cohort studies. Methods. We systematically...
Wed Nov 13, 2019 03:05
Abstract As rates of human papillomavirus (HPV)–related oropharyngeal cancer (OPC) continue to rise, the dental community’s role in primary prevention efforts related to HPV vaccination will become increasingly important. The aim of this study was to assess knowledge, beliefs, practices, and perceived barriers regarding HPV and HPV vaccine advocacy within the dental community. A sample of 266 dentists and dental hygienists completed an online survey, and responses were then analyzed...
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The original version of this article unfortunately contained a mistake. The name of “Maile Taualii” is now corrected in the author group of this article.
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Abstract Radiation training programs are designed to prepare graduates for independent practice, with metrics in place to assess appropriateness of clinical decision-making. Here, we investigated the self-assessed preparedness of US graduates during the transition to independent practice.An anonymous, Internet-based survey was distributed to recent graduates of radiation oncology residencies (2016–2017). A Likert scale was used to assess comfort with various aspects of practice,...
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Abstract To improve cancer disparities among under-represented minority (URM) populations, better representation of URM individuals in cancer research is needed. The San Diego State University and University of California San Diego Moores Cancer Center Partnership is addressing cancer disparities through an educational program targeting undergraduate URM students. The Partnership provides a paid intensive summer research internship enriched with year-round activities that include...
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Tue Nov 12, 2019 02:00
Chronic Respiratory Disease, Volume 16, Issue , January-December 2019. The majority of cases involving hypercalcemia in the setting of sarcoidosis are explained by the overproduction of calcitriol by activated macrophages. Vitamin D takes part in the regulation of granuloma formation. However, using vitamin D metabolites to assess the activity of the disease is still problematic, and its usefulness is disputable. In some cases, though, a calcium metabolism disorder could be a valuable tool (i.e....
Wed Nov 13, 2019 14:19
Gastric cancer is actually known as the sixth most frequent cancer and the second cancer-related cause of death worldwide. If studies giving an overview of current epidemiology of gastric cancer in Europe, Asi...
Wed Nov 13, 2019 02:00
Alcohol use disorder (AUD) is highly prevalent and accounts globally for 1.6% of disability-adjusted life years (DALYs) among females and 6.0% of DALYs among males. Effective treatments for AUDs are available ...
Wed Nov 13, 2019 02:00
Obesity in childhood is associated with adverse health outcomes and complications throughout the life-span of a child. Available evidence suggests a dramatic increase in childhood obesity in sub-Saharan Africa...
Wed Nov 13, 2019 02:00
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