Cancers, Vol. 11, Pages 1716: Balancing STAT Activity as a Therapeutic Strategy Cancers doi: 10.3390/cancers11111716 Authors: Polak Chernosky Smigiel Tamagno Jackson Driven by dysregulated IL-6 family member cytokine signaling in the tumor microenvironment (TME), aberrant signal transducer and activator of transcription (STAT3) and (STAT5) activation have been identified as key contributors to tumorigenesis. Following transformation, persistent STAT3 activation drives...
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Abstract Aims The role of mismatch repair (MMR) testing has evolved from identifying Lynch syndrome patients to predicting response to immune checkpoint inhibitors. This has led to requests from clinicians to retest recurrences of MMR proficient primary tumours in the hope that the recurrence may show a different MMR status and qualify the patient for treatment. We aimed to determine whether repeat testing is warranted. Methods and results We evaluated recurrent tumours (local recurrences...
Sat Nov 02, 2019 12:30
Abstract Aims The hallmarks of type 2 diabetes (T2D) are hyperglycemia and insulin resistance. These factors, at the cellular level, are associated with mitochondrial dysfunction and increased glucose uptake. Such events are poorly explored in the context of the salivary glands. In this study, we present a series of eight cases of a distinct salivary gland lesion characterized by multiple oncocytic cysts, and we provide new pathologic insights regarding its pathogenesis. Methods and Results...
Sat Nov 02, 2019 12:29
Abstract T‐cell prolymphocytic leukemia (T‐PLL) is an aggressive tumor with leukemic presentation of mature T‐lymphocytes. Here, we aimed at characterizing the initial events in the molecular pathogenesis of T‐PLL and particularly, at determining the point in T‐cell differentiation when the hallmark oncogenic events, that is, inv (14)(q11q32)/t(14;14)(q11;q32) and t(X;14)(q28;q11) occur. To this end, we mined whole genome and transcriptome sequencing data of 17 and 11 T‐PLL cases, respectively....
Sat Nov 02, 2019 10:53
Summary The role of immune checkpoint inhibitors in metastatic lung cancer has been established in recent year and the pre‐therapeutic profiles of the tumor microenvironment in responders have been increasingly reported. The role of salvage surgery and the immune profiles of the post‐therapeutic specimens in patients achieving an objective response have rarely been studied. We report a case of metastatic lung cancer treated by anti‐PD‐1 antibody followed by surgical resection. The immune status...
Sat Nov 02, 2019 17:14
Abstract The tripartite motif containing 23 (TRIM23) gene is a member of the tripartite motif (TRIM) family that participate in many pathophysiological processes. However, the role of TRIM23 in lung adenocarcinoma (LUAD) remains unclear. In the present study, TRIM23 was firstly screened by next‐generation sequencing between cisplatin (DDP)‐resistant A549/DDP cell line and parental A549 cell line, combined with integrated analysis of the Gene Expression Omnibus (GEO) data (E‐GEOD‐43493 and E‐GEOD‐43494)....
Sat Nov 02, 2019 12:14
The long non-coding RNA (lncRNA) urothelial carcinoma-associated 1 (UCA1) is involved in various cancers and often functions through microRNAs. The pro-survival protein PTP1B is known to play important roles i...
Fri Nov 01, 2019 02:00
Abstract Introduction Risk stratification tools provide valuable information to inform treatment decisions. Existing algorithms for patients with multiple myeloma (MM) were based on patients with newly diagnosed disease, and these have not been validated in the relapsed setting or in routine clinical practice. We developed a risk stratification algorithm (RSA) for patients with MM at initiation of second-line (2L) treatment, based on data...
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The methods traditionally used to identify a posteriori dietary patterns are principal components, factor and cluster analysis. The aim of this study is to assess the relation between dietary patterns derived with latent class analysis and oral/pharyngeal cancer risk (OPC), highlighting the strengths of this method compared to traditional ones. We analysed data from an Italian multicentric case‐control study on OPC including 946 cases and 2492 hospital controls. Dietary patterns were derived using...
Sat Nov 02, 2019 11:08
Obesity is known to be associated with primary liver cancer (PLC), but the separate effects of excess abdominal and gluteofemoral size are unclear. Thus, we examined the association between waist and hip circumference with risk of PLC overall and by histologic type – hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC). The Liver Cancer Pooling Project is a consortium of prospective cohort studies that includes data from 1,167,244 individuals (PLC n=2,208, HCC n=1,154, ICC n=335)....
Sat Nov 02, 2019 10:57
Abstract Introduction Although the standard treatment for stromal tumours is surgery, in locally advanced forms, it is often necessary to achieve tumour downstaging to improve surgical outcomes. Neoadjuvant treatment in gastrointestinal stromal tumours (GISTs) with tyrosine kinase inhibitors, including imatinib, has been shown to be effective in several studies, but the duration of this treatment is still a subject of debate. ...
Sat Nov 02, 2019 02:00
Michelia maudiae Dunn is one of the important ornamental plants in the Magnoliaceae family, and the color of its flowers usually appears naturally pure white. The discovery of a rubellis flower named M. maudiae Dunn var. rubicunda provides an opportunity to reveal the metabolism of the flavonoids and anthocyanins of this “early angiosperm” plant. Combined metabolome and transcriptome analyses were applied using white and rubellis mutant tepals. Seven stages have been divided for flower development,...
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Abstract The use of dose coefficients (DCs) based on the reference phantoms recommended by the International Commission on Radiological Protection (ICRP) with a fixed body size may produce errors to the estimated organ/tissue doses to be used, for example, for epidemiologic studies depending on the body size of cohort members. A set of percentile-specific computational phantoms that represent 10th, 50th, and 90th percentile standing heights and body masses in adult male and female...
Sat Nov 02, 2019 02:00
Abstract Introduction Pelvic lymphadenectomy (pLA) in prostate cancer (PCa) is one of the most common uro-oncologic surgical procedures. An increased complication rate is accompanied by unproven oncologic benefit. Extent of pLA and mechanisms of metastasis are discussed controversially. We aimed to explore evidence and knowledge gaps in pLA and mechanisms of metastasis in PCa and to develop further steps to clarify oncologic benefits through...
Sat Nov 02, 2019 02:00
Abstract Purpose Glioblastoma is an aggressive malignant cancer of the central nervous system, with disease progression associated with deterioration of neurocognitive function and quality of life (QoL). As such, maintenance of QoL is an important treatment goal. This analysis presents time to deterioration (TtD) of QoL in patients with recurrent glioblastoma receiving Asunercept plus reirradiation (rRT) or rRT alone. ...
Sat Nov 02, 2019 02:00
Abstract Purpose Neoadjuvant chemotherapy (NACT) is employed in patients with breast cancer (BC) with the aim of reducing tumor burden and improving surgical outcomes. We evaluated the levels of energy metabolites pre- and post-radiotherapy (RT) in breast cancer (BC) patients who previously received NACT and investigated the alterations of these metabolites in relation to the patient achieving a pathologic complete response to NACT. ...
Sat Nov 02, 2019 02:00
Patients treated with radiotherapy for head and neck (H&N) cancer often experience anatomical changes. The potential compromises to Planning Target Volume (PTV) coverage or Organ at Risk (OAR) sparing has prom...
Fri Nov 01, 2019 02:00
Publication date: Available online 2 November 2019Source: Practical Radiation OncologyAuthor(s): Brian P. Quaranta
Sat Nov 02, 2019 18:09
Publication date: Available online 2 November 2019Source: European Journal of Surgical OncologyAuthor(s): Jüri Teras, Hidde M. Kroon, John F. Thompson, Marina Teras, Pille Pata, Andrus Mägi, Roland M. Teras, Sirje Rüütel BoudinotAbstractBackgroundIsolated limb infusion (ILI) with cytotoxic agents is a simple and effective treatment option for patients with melanoma in-transit metastases (ITMs) confined to an extremity. Data for ILIs performed in Europe are sparse and to date no Eastern European ILI...
Sat Nov 02, 2019 17:45
Publication date: Available online 2 November 2019Source: Critical Reviews in Oncology/HematologyAuthor(s): Francesco Meani, Simona Di Lascio, Wiebke Wandschneider, Giacomo Montagna, Valerio Vitale, Sabine Zehbe, Yves Harder, Sandra Leoni Parvex, Paolo Spina, Claudia Canonica, Daniele Generali, Olivia PaganiGraphical abstract
Sat Nov 02, 2019 16:29
Publication date: Available online 1 November 2019Source: Critical Reviews in Oncology/HematologyAuthor(s): Choo-Yuen Ting, Liew Su-May, Amy Price, Gin-Gin Gan, Diana Bee-Lan Ong, Soo-Yong Tan, Ping-Chong BeeAbstractThe clinical significance of aberrantly expressed microRNAs in predicting treatment response to chemotherapy in diffuse large B-cell lymphoma patients (DLBCL) remains uncertain. Feasibility of microRNA testing to predict treatment outcome was evaluated. Twenty-two types of aberrantly...
Sat Nov 02, 2019 16:29
Publication date: Available online 1 November 2019Source: Critical Reviews in Oncology/HematologyAuthor(s): Massimiliano Salati, Cinzia Baldessari, Luca Reggiani Bonetti, Carlo Messina, Valeria Merz, Bruna Cerbelli, Andrea BotticelliAbstractNMC is a recently recognized cancer type hallmarked by chromosomal translocation involving the NUT gene, a catastrophic event leading to fusion oncoprotein responsible for malignant transformation and tumor progression. The aggressiveness of disease together with...
Sat Nov 02, 2019 16:29
Publication date: Available online 1 November 2019Source: Critical Reviews in Oncology/HematologyAuthor(s): Fausto Petrelli, Agostina De Stefani, Francesca Trevisan, Chiara Parati, Alessandro Inno, Barbara Merelli, Michele Ghidini, Lorenza Bruschieri, Elisabetta Vitali, Mary Cabiddu, Karen Borgonovo, Mara Ghilardi, Sandro Barni, Antonio GhidiniAbstractRadiotherapy (RT) represents a mainstay in the treatment of brain metastases (BMs) from solid tumors. Immunotherapy (IT) has improved survival of metastatic...
Sat Nov 02, 2019 16:29
Real‐world overall survival of patients with advanced BRAF mutant melanoma treated with front‐line BRAF/MEK inhibitors, anti‐PD‐1 antibodies, or nivolumab/ipilimumab. Abstract Background The optimal treatment sequence for patients with advanced BRAF V600 mutant melanoma is unknown. BRAF/MEK inhibition (BRAF/MEKi), single agent anti‐PD‐1 (aPD‐1) antibodies and combination immune checkpoint inhibition with nivolumab and ipilimumab (niv/ipi) are all approved; however, they have not been prospectively...
Sat Nov 02, 2019 10:37
Publication date: January 2020Source: Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Volume 1873, Issue 1Author(s): D. Farhat, H. LincetAbstractWe discuss how lipoic acid (LA), a natural antioxidant, induces apoptosis and inhibits proliferation, EMT, metastasis and stemness of cancer cells. Furthermore, owing to its ability to reduce chemotherapy-induced side effects and chemoresistance, LA appears to be a promising compound for cancer treatment.
Sat Nov 02, 2019 15:14
Publication date: December 2019Source: Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Volume 1872, Issue 2Author(s):
Sat Nov 02, 2019 15:14
Authors: Moreno I, Domínguez M, Toraño A Abstract We developed a two-step ELISA to determine the immunoreactive fraction of monoclonal antibodies in conditions of antigen excess. An antibody aliquot at limiting dilution was incubated in wells coated with increasing amounts of antigen up to concentrations that bind 100% of antibody. At equilibrium, a supernatant aliquot was transferred to a second plate coated with excess of antiglobulin, and the captured antibody was incubated with peroxidase-conjugated...
Sat Oct 26, 2019 00:00
CONCLUSION: Our results suggest that a specific IgG subclasses pattern together with raised levels of FLCs and VEGF could represent the biomarker "signature" of an inflammation multistage of acquired immune system. PMID: 31669506 [PubMed - as supplied by publisher] (Source: Journal of Immunological Methods)
Fri Oct 25, 2019 00:00
Cancers, Vol. 11, Pages 1715: Conversion Surgery with HIPEC for Peritoneal Oligometastatic Gastric Cancer Cancers doi: 10.3390/cancers11111715 Authors: Mielko Rawicz-Pruszyński Skórzewska Ciseł Pikuła Kwietniewska Gęca Sędłak Kurylcio Polkowski Peritoneal metastases (PM) of gastric cancer (GC) are characterized by a particularly poor prognosis, with median survival time of 6 months, and virtually no 5-year survival reported. Conversion therapy for...
Sat Nov 02, 2019 02:00
Cancers, Vol. 11, Pages 1714: Immunohistochemical and Molecular Features of Melanomas Exhibiting Intratumor and Intertumor Histomorphologic Heterogeneity Cancers doi: 10.3390/cancers11111714 Authors: Haider A. Mejbel Sri Krishna C. Arudra Dinesh Pradhan Carlos A. Torres-Cabala Priyadharsini Nagarajan Michael T. Tetzlaff Jonathan L. Curry Doina Ivan Dzifa Y. Duose Raja Luthra Victor G. Prieto Leomar Y. Ballester Phyu P. Aung Melanoma is a heterogeneous...
Sat Nov 02, 2019 02:00
Cancers, Vol. 11, Pages 1713: The Lung Immune Prognostic Index Discriminates Survival Outcomes in Patients with Solid Tumors Treated with Immune Checkpoint Inhibitors Cancers doi: 10.3390/cancers11111713 Authors: Meyers Stukalin Vallerand Lewinson Suo Dean North Pabani Cheng Heng Bebb Morris Immune checkpoint inhibitors (ICI) have revolutionized the treatment landscape of several solid tumor types. However, as patient outcomes are heterogeneous,...
Sat Nov 02, 2019 02:00
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