The Journal of Physiology
- Shaw and Shal voltage‐gated potassium channels mediate circadian changes in Drosophila clock neuron excitabilityAbstract Like in mammals, Drosophila circadian clock neurons display rhythms of activity with higher action potential firing rates and more positive resting membrane potentials during the day. This rhythmic excitability has been widely observed but, critically, its regulation remains unresolved. We have characterized and modeled the changes underlying these electrical activity rhythms in the lateral ventral clock neurons (LNvs). We show that cur
- Changing perspectives on how the permeation pathway through potassium channels is regulatedAbstract The primary means by which ion permeation through potassium channels is controlled, and the key to selective intervention in a range of pathophysiological conditions, is the process by which channels switch between non‐conducting and conducting states. Conventionally, this has been explained by a steric mechanism in which the pore alternates between two conformations: a ‘closed’ state in which the conduction pathway is occluded and an ‘
Anthropology-News
- Anti Latinu/Anti Spanish Attacks and Anthro-Political LinguisticsThis article marks the final piece in a three-part series on language policing which has appeared in the Society for Linguistic Anthropology section news column over the summer. Recent reports about racially fueled mass murders and the increasing number of hate crimes targeting Latinus (the universal “u” is gender neutral, while respecting Spanish phonology) other immigrants, and people of color in general, have walked a thin line concerning the
Japanese Journal of Clinical Oncology - current issue
- Fusobacterium nucleatum facilitates ulcerative colitis through activating IL‐17F signaling to NF‐κB via the upregulation of CARD3 expressionAbstract Accumulating evidence links Fusobacterium nucleatum (F. nucleatum) with ulcerative colitis (UC). The mechanism by which F. nucleatum promotes intestinal inflammation in UC remains poorly defined. Here, we first examined the abundance and impact of F. nucleatum on disease activity in UC tissues. Next, we isolated a strain of F. nucleatum from UC tissues and explored whether F. nucleatum aggravates the intestinal inflammatory response in
- Mesenchymal stromal cells in cancer: A review of their immunomodulatory functions and dual effects on tumor progressionAbstract Mesenchymal stem or stromal cells (MSCs) are pluripotent cells implicated in a broad range of physiological events, including organogenesis and maintenance of tissue homeostasis as well as tissue regeneration and repair. Because their current definition is somewhat loose – based primarily on their ability to differentiate into a variety of mesenchymal tissues, adhere to plastic and express, or lack, a handful of cell surface markers – M
Evolutionary Biology News -- ScienceDaily
- Sperm and egg cell 'immune response' protects koala DNADiscovery of a type of immunity that protects koalas' DNA from viruses has importance for the survival of koalas and our fundamental understanding of evolution. A team of scientists are studying tissue samples from koalas to understand how a unique type of cell responds to retrovirus infections, which cause diseases such as chlamydia and cancer.
- Taming the wild cheese fungusThe flavors of fermented foods are heavily shaped by the fungi that grow on them, but the evolutionary origins of those fungi aren't well understood. Experimental findings offer microbiologists a new view on how those molds evolve from wild strains into the domesticated ones used in food production.
Clinical Cancer Research Online First Articles
- High Intensity Focused Ultrasound (HIFU) Triggers Immune Sensitization of Refractory Murine Neuroblastoma to Checkpoint Inhibitor TherapyPurpose: Immunotherapy promises unprecedented benefits to cancer patients. However, the majority of cancer types, including high-risk neuroblastoma remain immunologically unresponsive. High intensity focused ultrasound (HIFU) is a non-invasive technique that can mechanically fractionate tumors, transforming immunologically 'cold' tumors into responsive 'hot' tumors. Experimental Design:We treated <2% of tumor volume in previously unresponsive, la
- Submucosal saline injection followed by endoscopic ultrasound versus endoscopic ultrasound only for distinguishing between T1a and T1b esophageal cancerPurpose: To examine whether submucosal saline injection (SSI) can improve traditional endoscopic ultrasound's (EUS) accuracy in distinguishing between T1a and T1b stage esophageal squamous cell carcinoma (ESCC). Experimental Design: 180 T1N0M0 stage ESCC patients aged 18-85 years old were enrolled between February 14, 2012 to June 4, 2018 at Sun Yat-sen University Cancer Center in China. They were randomly assigned (1:1) to receive either EUS ex
- Potent cell cycle inhibition and upregulation of immune response with abemaciclib and anastrozole in neoMONARCH, Phase 2 neoadjuvant study in HR+/HER2- breast cancerPurpose: neoMONARCH assessed the biological effects of abemaciclib in combination with anastrozole in the neoadjuvant setting. Experimental Design: Postmenopausal women with stage I-IIIB HR+/HER2- breast cancer were randomized to a 2-week lead-in of abemaciclib, anastrozole, or abemaciclib plus anastrozole followed by 14 weeks of the combination. The primary objective evaluated change in Ki67 from baseline to 2 weeks of treatment. Additional ob
- Immune cell PD-L1 co-localizes with macrophages and is associated with outcome in PD-1 pathway blockade therapyBackground: PD-L1 is expressed in tumor cells and immune cells and both have been associated with response to anti-PD-1 axis immunotherapy. Here, we examine the expression of PD-L1 to determine which cell type carries the predictive value of the test. Methods: We measured the expression of PD-L1 in multiple immune cells with two platforms and confocal microscopy on three retrospective Yale NSCLC cohorts (425 non-immunotherapy-treated cases and 6
- Genomic profiling identifies association of IDH1/IDH2 mutation with longer relapse free and metastasis free survival in high-grade chondrosarcomaPurpose: Chondrosarcomas are the second most common primary malignant bone tumors. While histologic grade is the most important factor predicting the clinical outcome of chondrosarcoma, it is subject to interobserver variability. IDH1 and IDH2 hotspot mutations were recently found to be frequently mutated in central chondrosarcomas. However, a few published articles have been controversial regarding the association between IDH1/IDH2 mutation stat
- Phosphoproteomic and Kinomic Signature of Clinically Aggressive Grade I (1.5) Meningiomas Reveals Rb1 signaling as a Novel Mediator and BiomarkerPurpose: Most WHO Grade I meningiomas carry a favorable prognosis. Some become clinically aggressive with recurrence, invasion, and resistance to conventional therapies (grade 1.5; recurrent/progressive WHO grade I tumors requiring further treatment within 10 years). We aimed to identify biomarker signatures in grade 1.5 meningiomas where histopathology and genetic evaluation has fallen short. Experimental Design: MS-based phosphoproteomics and
- Mogamulizumab Forecast: Clearer patients, with a slight chance of immune mayhemMogamulizumab, approved by the FDA for relapsed or refractory mycosis fungoides and Sézary syndrome, improves progression-free survival compared to vorinostat in the largest trial to date in cutaneous T-cell lymphoma, with particular efficacy in leukemic disease, but carries a risk of immune-mediated toxicities with concomitant depletion of regulatory T-cells.
- Molecular changes during progression from non‐muscle invasive to advanced urothelial carcinomaMolecular changes occurring during invasion and clinical progression of cancer are difficult to study longitudinally in patient derived material. A unique feature of urothelial bladder cancer (UBC) is that patients frequently develop multiple non muscle‐invasive tumors, some of which may eventually progress to invade the muscle of the bladder wall. Here, we use a cohort of 73 patients that experienced a total of 357 UBC diagnoses to study the st
- NO•/RUNX3/Kynurenine Metabolic Signaling Enhances Disease Aggressiveness in Pancreatic CancerPancreatic ductal adenocarcinoma (PDAC) is a lethal malignancy and is refractory to available treatments. Delineating the regulatory mechanisms of metabolic reprogramming, a key event in pancreatic cancer progression, may identify candidate targets with potential therapeutic significance. We hypothesized that inflammatory signaling pathways regulate metabolic adaptations in pancreatic cancer. Metabolic profiling of tumors from PDAC patients with
- Mycophenolic Acid is a Drug with the Potential to be Repurposed for Suppressing Tumour Growth and Metastasis in Osteosarcoma TreatmentOur previous review of proteomics data showed that in osteosarcoma, some overexpressed proteins were targets of FDA‐approved immunosuppressive and anti‐arrhythmic drugs, including mycophenolate mofetil (MMF), ribavirin, leflunomide, azathioprine, and digoxin. Here, these drugs were screened for growth inhibitory effects in human osteosarcoma cell lines, including MNNG/HOS, U2OS, SaOS‐2, MG‐63 and 143B cells. Only mycophenolic acid (MPA), an activ
- Platinum‐Based Regimens Versus Cetuximab in Definitive Chemoradiation for Human Papillomavirus‐Unrelated Head and Neck CancerPatients ineligible for cisplatin with definitive radiotherapy (CP‐CRT) for locally advanced head and neck squamous cell carcinoma (LA‐HNSCC), concurrent cetuximab (C225‐RT) is a popular substitute. Carboplatin‐based chemoradiation (CB‐CRT) is another option, however relative efficacies of CP‐CRT, CB‐CRT and C225‐RT are unclear, particularly in the human papillomavirus (HPV)‐unrelated population. We identified 316 patients with stage III‐IVB can
- Interval Breast Cancer Risk Associations with Breast Density, Family History, and Breast Tissue AgeingInterval breast cancers (those diagnosed between recommended mammography screens) generally have poorer outcomes and are more common among women with dense breasts. We aimed to develop a risk model for interval breast cancer. We conducted a nested case–control study within the Melbourne Collaborative Cohort Study involving 168 interval breast cancer patients and 498 matched control subjects. We measured breast density using the CUMULUS software.
- Functional Characterization of a Candidate Tumor Suppressor Gene, Mirror Image Polydactyly 1, in Nasopharyngeal CarcinomaMirror Image Polydactyl 1 (MIPOL1) is generally associated with congenital anomalies. However, its role in cancer development is poorly understood. Previously, by utilizing the functional complementation approach, microcell‐mediated chromosome transfer (MMCT), a tumor suppressor gene, MIPOL1, was identified. MIPOL1 was confirmed to be down‐regulated in nasopharyngeal carcinoma (NPC) cells and tumor tissues, and re‐expression of MIPOL1 induced tum
Journal of Medical Case Reports - Latest Articles
- Treatment of lumbar vertebra epithelioid hemangioma with radiation therapy: a case reportAlthough epithelioid hemangiomas involving bone have been described in previous case reports and case series, the effects of radiation therapy on vertebral epithelioid hemangioma has not been fully reported. H...
Behavioural Brain Research
- Reward and punishment learning in schizophrenia and bipolar disorderPublication date: Available online 14 October 2019Source: Behavioural Brain ResearchAuthor(s): Eid Abohamza, Thomas Weickert, Manal Ali, Ahmed A. MoustafaAbstractPrior studies on reward learning deficits in psychiatric disorders have used probabilistic learning tasks, making it unclear whether impairment is due to the probabilistic nature of the task rather than reward processing. In this study, we tested probabilistic vs. deterministic reward an
- Intraventricular murine Aβ infusion elicits hippocampal inflammation and disrupts the consolidation, but not retrieval, of conditioned fear in C57BL6/J micePublication date: Available online 14 October 2019Source: Behavioural Brain ResearchAuthor(s): J.D. White, C.M. Urbano, J.O. Taylor, J.L. Peterman, M. Cooksey, M. Eimerbrink, M.D. Eriksson, B.G. Cooper, M.J. Chumley, G.W. BoehmAbstractAlthough one of the defining characteristics of Alzheimer’s disease is the presence of amyloid-beta (Aβ) plaques, the early accumulation of soluble Aβ oligomers (AβOs) may disrupt synaptic function and trigger cogni
Oncogenesis - nature.com science feeds
- LncRNA HOXA-AS3 confers cisplatin resistance by interacting with HOXA3 in non-small-cell lung carcinoma cellsOncogenesis, Published online: 15 October 2019; doi:10.1038/s41389-019-0170-yLncRNA HOXA-AS3 confers cisplatin resistance by interacting with HOXA3 in non-small-cell lung carcinoma cells
- Drug‐induced sarcoidosis: an overview of the WHO pharmacovigilance databaseAbstract Background There is a documented association between drug exposure and sarcoidosis‐like reactions. In this study, we used the largest pharmacovigilance database to describe drug‐induced sarcoidosis. Methods Data were collected from the World Health Organization (WHO) pharmacovigilance database (VigiBase). We excluded steroids and vaccines from the analysis. The primary endpoint was the lower endpoint of the 95% credibility inte
- The value of bronchoalveolar lavage for discrimination between healthy and diseased individualsAbstract Background Bronchoalveolar lavage (BAL) is standard diagnostic procedure. Procedural recommendations have been made by pneumological societies including normal values for interpretation of BAL cytology. These normal values derive from small studies in healthy volunteers and have never been analysed for their sensitivity and specificity. Objectives This study aims to analyse sensitivity and specificity of these normal values by
- Hospitalization, Alzheimer's and Related Neuropathologies, and Cognitive DeclineABSTRACT Objective To test the hypothesis that Alzheimer's disease and related neuropathologies contribute to the association between hospitalization and cognitive decline in old age. Methods As part of a longitudinal clinical‐pathologic cohort study, 526 older persons (mean age at death=90.9, 71% female) without dementia at baseline completed annual cognitive testing and were autopsied at death. Hospitalization information was obtained
- Mapping Holmes' tremor circuit using the human brain connectomeAbstract Objective Holmes' tremor is a debilitating movement disorder with limited treatment options. Lesions causing Holmes' tremor can occur in multiple different brain locations, leaving the neuroanatomical substrate unclear. Here we test whether lesion locations that cause Holmes' tremor map to a connected brain circuit and whether this circuit might serve as a useful therapeutic target. Methods Case reports of Holmes' tremor caused
- Use OF NBI for the assessment of clinical signs of rhino-pharyngo-laryngeal reflux in pediatric age: Preliminary resultsPublication date: Available online 15 October 2019Source: International Journal of Pediatric OtorhinolaryngologyAuthor(s): J. Galli, D. Meucci, G. Salonna, R. Anzivino, V. Giorgio, M. Trozzi, S. Settimi, M.L. Tropiano, G. Paludetti, S. BotteroAbstractObjectivesLaryngopharyngeal reflux (LPR) is a complex problem in pediatric population: diagnosis and clinical presentation are still controversial.Classic white light endoscopy shows some pathognomon
- Audiological benefit and subjective satisfaction of children with the ADHEAR audio processor and adhesive adapterPublication date: Available online 15 October 2019Source: International Journal of Pediatric OtorhinolaryngologyAuthor(s): Amelia Favoreel, Emilie Heuninck, Anne-Laure MansbachAbstractObjectivesThe main objective of this study was to evaluate the audiological benefit of the ADHEAR system in a group of children with a uni- or bilateral conductive hearing loss (CHL) during a short-term exposure of three weeks, and to compare it to a conventional bo
- TSLP contributes to allergic airway inflammation induced by diesel exhaust particle exposure in an experimental model of severe asthmaAbstract Numerous epidemiologic studies have reported associations between exposure to air pollutant and increased risk of allergic diseases, with a recent study estimating that 8–20% of asthma emergency room visits worldwide could be attributed to ozone exposure and 4–9% to exposure to particulate matter smaller than 2.5µm (PM2.5). Traffic pollution derived diesel particles represent a major source of PM2.5 in large urban centers and have been
Folia Phoniatrica et Logopaedica
- ContentsFolia Phoniatr Logop 2019;71:I–IV
- Author Index/Subject IndexFolia Phoniatr Logop 2019;71:323
- Acknowledgement to ReviewersFolia Phoniatr Logop 2019;71:321–322
- PrelimsFolia Phoniatr Logop 2019;71:197–200
- Hypertonic saline and seawater solutions damage sinonasal epithelial cell air‐liquid interface culturesBackground Nasal irrigation (NI) is commonly used to treat several sinonasal diseases, including chronic rhinosinusitis with nasal polyps (CRSwNP); however, the effects of NI on the sinonasal epithelium are not fully known. The aim of this study was to investigate the effects of commonly used NI solutions on epithelial mucociliary and barrier functionality in primary cultured human nasal epithelial cells (HNECs). Methods HNECs from control
- A preliminary report on the effect of gabapentin pretreatment on periprocedural pain during in‐office posterior nasal nerve cryoablationBackground Posterior nasal nerve (PNN) cryoablation is a novel surgical technique to address allergic and nonallergic rhinitis. Periprocedural pain has been reported after PNN cryoablation and there are no standardized protocols for optimal in‐office local anesthesia. This study sought to evaluate the effect of gabapentin on patient discomfort following in‐office PNN cryoablation. Methods Multi‐institutional prospective analysis of patient
- Predictors of efficacy for combination oral and topical corticosteroids to treat patients with chronic rhinosinusitis with nasal polypsBackground A short‐course oral corticosteroid taper and topical intranasal corticosteroids may be used to maximize the success of medical management for chronic rhinosinusitis with nasal polyps (CRSwNP). In this study, we sought to identify characteristics that would be predictive of efficacy for this combination regimen. Methods Sixty‐four patients with CRS, bilateral polyps, a polyp score of at least 3, and a 22‐item Sino‐Nasal Outcome T
otol rhinol
- Autologous Fat Injection Pharyngoplasty in Adults with Velopharyngeal Insufficiency.Related ArticlesAutologous Fat Injection Pharyngoplasty in Adults with Velopharyngeal Insufficiency. Ann Otol Rhinol Laryngol. 2019 Oct 14;:3489419882063 Authors: Contrera KJ, Tierney WS, Bryson PC Abstract OBJECTIVES: Understand the utility and technique of injection pharyngoplasty with autologous fat for the treatment of mild to moderate velopharyngeal insufficiency in adults without a history of c
- Somatic copy number alterations in pleomorphic adenoma and recurrent pleomorphic adenoma.Related ArticlesSomatic copy number alterations in pleomorphic adenoma and recurrent pleomorphic adenoma. Oral Surg Oral Med Oral Pathol Oral Radiol. 2019 Sep 02;: Authors: Mariano FV, Fidalgo F, Casarim ALM, Martins AS, Scarini JF, de Lima Souza RA, Egal ES, Kowalski LP, Krepischi ACV, Altemani A Abstract OBJECTIVE: As the genetic changes in recurrent pleomorphic adenoma (RPA) have not yet been inve
- A Spectrotemporal Correlate of Language Impairment in Autism Spectrum Disorder.Related ArticlesA Spectrotemporal Correlate of Language Impairment in Autism Spectrum Disorder. J Autism Dev Disord. 2019 Aug;49(8):3181-3190 Authors: Bloy L, Shwayder K, Blaskey L, Roberts TPL, Embick D Abstract This study introduces an objective neurophysiological marker of language ability, the integral of event-related desynchronization in the 5-20 Hz band during 0.2-1 seconds post auditory stimu
- Cortical Processing of Frequency Changes Reflected by the Acoustic Change Complex in Adult Cochlear Implant Users.Related ArticlesCortical Processing of Frequency Changes Reflected by the Acoustic Change Complex in Adult Cochlear Implant Users. Audiol Neurootol. 2018;23(3):152-164 Authors: Liang C, Houston LM, Samy RN, Abedelrehim LMI, Zhang F Abstract The purpose of this study was to examine neural substrates of frequency change detection in cochlear implant (CI) recipients using the acoustic change complex (AC
- Not All Predictions Are Equal: "What" and "When" Predictions Modulate Activity in Auditory Cortex through Different Mechanisms.Related ArticlesNot All Predictions Are Equal: "What" and "When" Predictions Modulate Activity in Auditory Cortex through Different Mechanisms. J Neurosci. 2018 10 03;38(40):8680-8693 Authors: Auksztulewicz R, Schwiedrzik CM, Thesen T, Doyle W, Devinsky O, Nobre AC, Schroeder CE, Friston KJ, Melloni L Abstract Using predictions based on environmental regularities is fundamental for adaptive behavior.
- Predictors of In-Laboratory Polysomnography Attendance in a Cohort of Patients with Stroke or TIAPublication date: Available online 14 October 2019Source: Sleep MedicineAuthor(s): Alex A. MacDonald, Phavalan Rajendram, Maneesha Kamra, Brian J. Murray, Penny A. MacDonald, Mark I. BoulosAbstractStudy ObjectivesAfter cerebrovascular events, obstructive sleep apnea (OSA) is associated with poor functional outcomes, an increased risk of recurrent stroke, and mortality. Although the significant under-diagnosis of OSA is likely multifactorial in na
Cancers
- Cancers, Vol. 11, Pages 1570: Technological and Therapeutic Advances in Advanced Small Cell Lung CancerCancers, Vol. 11, Pages 1570: Technological and Therapeutic Advances in Advanced Small Cell Lung Cancer Cancers doi: 10.3390/cancers11101570 Authors: Lum Alamgeer Small cell lung cancer (SCLC) accounts for approximately 10–15% of all lung cancers. The prognosis is poor with median survival in the advanced stage remaining at around 12 months. Despite applying every known therapeutic approach, no major breakthrough has impro
- Cancers, Vol. 11, Pages 1569: Breast Cancer Stem Cells as Drivers of Tumor Chemoresistance, Dormancy and Relapse: New Challenges and Therapeutic OpportunitiesCancers, Vol. 11, Pages 1569: Breast Cancer Stem Cells as Drivers of Tumor Chemoresistance, Dormancy and Relapse: New Challenges and Therapeutic Opportunities Cancers doi: 10.3390/cancers11101569 Authors: De Angelis Francescangeli Zeuner Breast cancer is the most frequent cancer among women worldwide. Therapeutic strategies to prevent or treat metastatic disease are still inadequate although great progress has been made in t
- Cancers, Vol. 11, Pages 1566: PD-1-Associated Gene Expression Signature of Neoadjuvant Trastuzumab-Treated Tumors Correlates with Patient Survival in HER2-Positive Breast CancerCancers, Vol. 11, Pages 1566: PD-1-Associated Gene Expression Signature of Neoadjuvant Trastuzumab-Treated Tumors Correlates with Patient Survival in HER2-Positive Breast Cancer Cancers doi: 10.3390/cancers11101566 Authors: William P. D. Hendricks Natalia Briones Rebecca F. Halperin Salvatore Facista Paul R. Heaton Daruka Mahadevan Suwon Kim The therapeutic HER2-targeting antibody trastuzumab has been shown to elici
- Cancers, Vol. 11, Pages 1568: Platelets and Hepatocellular Cancer: Bridging the Bench to the ClinicsCancers, Vol. 11, Pages 1568: Platelets and Hepatocellular Cancer: Bridging the Bench to the Clinics Cancers doi: 10.3390/cancers11101568 Authors: Quirino Lai Alessandro Vitale Tommaso M. Manzia Francesco G. Foschi Giovanni B. Levi Sandri Martina Gambato Fabio Melandro Francesco P. Russo Luca Miele Luca Viganò Patrizia Burra Edoardo G. Giannini Growing interest is recently being focused on the role pl
- Cancers, Vol. 11, Pages 1565: Molecular Insights into Potential Contributions of Natural Polyphenols to Lung Cancer TreatmentCancers, Vol. 11, Pages 1565: Molecular Insights into Potential Contributions of Natural Polyphenols to Lung Cancer Treatment Cancers doi: 10.3390/cancers11101565 Authors: Zhou Pan Li Naturally occurring polyphenols are believed to have beneficial effects in the prevention and treatment of a myriad of disorders due to their anti-inflammatory, antioxidant, antineoplastic, cytotoxic, and immunomodulatory activities documented
- Cancers, Vol. 11, Pages 1567: Microsatellite Instability: Diagnosis, Heterogeneity, Discordance, and Clinical Impact in Colorectal CancerCancers, Vol. 11, Pages 1567: Microsatellite Instability: Diagnosis, Heterogeneity, Discordance, and Clinical Impact in Colorectal Cancer Cancers doi: 10.3390/cancers11101567 Authors: Evrard Tachon Randrian Karayan-Tapon Tougeron Tumor DNA mismatch repair (MMR) deficiency testing is important to the identification of Lynch syndrome and decision making regarding adjuvant chemotherapy in stage II colorectal cancer (CRC
- Cancers, Vol. 11, Pages 1563: Bioactive Compounds: Multi-Targeting Silver Bullets for Preventing and Treating Breast CancerCancers, Vol. 11, Pages 1563: Bioactive Compounds: Multi-Targeting Silver Bullets for Preventing and Treating Breast Cancer Cancers doi: 10.3390/cancers11101563 Authors: Nethaji Muniraj Sumit Siddharth Dipali Sharma Each cell in our body is designed with a self-destructive trigger, and if damaged, can happily sacrifice itself for the sake of the body. This process of self-destruction to safeguard the adjacent normal cells is kn
- Cancers, Vol. 11, Pages 1564: Genetic and Lineage Classification of Glioma-Initiating Cells Identifies a Clinically Relevant Glioblastoma ModelCancers, Vol. 11, Pages 1564: Genetic and Lineage Classification of Glioma-Initiating Cells Identifies a Clinically Relevant Glioblastoma Model Cancers doi: 10.3390/cancers11101564 Authors: Norihiko Saito Nozomi Hirai Kazuya Aoki Sho Sato Ryo Suzuki Yu Hiramoto Satoshi Fujita Haruo Nakayama Morito Hayashi Takatoshi Sakurai Satoshi Iwabuchi The Cancer Genome Atlas (TCGA) project described a robust gene ex
- Cancers, Vol. 11, Pages 1562: A Pan-Cancer Approach to Predict Responsiveness to Immune Checkpoint Inhibitors by Machine LearningCancers, Vol. 11, Pages 1562: A Pan-Cancer Approach to Predict Responsiveness to Immune Checkpoint Inhibitors by Machine Learning Cancers doi: 10.3390/cancers11101562 Authors: Maurizio Polano Marco Chierici Michele Dal Bo Davide Gentilini Federica Di Cintio Lorena Baboci David L. Gibbs Cesare Furlanello Giuseppe Toffoli Immunotherapy by using immune checkpoint inhibitors (ICI) has dramatically improved the tre
ΩτοΡινοΛαρυγγολόγος Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,
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00306932607174,
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