• Clinical and translational oncology
• Role of novel hormonal therapies in the management of non-metastatic castration-resistant prostate cancer: a literature-based meta-analysis of randomized trials

  Abstract Background Novel hormonal therapies have been recently investigated in non-metastatic castration-resistant prostate cancer (CRPC). We performed a meta-analysis to assess the efficacy and safety of novel hormonal therapies in non-metastatic CRPC. Materials and methods The primary outcome was metas

  Clinical and translational oncology

  Mon Oct 14, 2019 17:00
• Clinical Neurology and Neurosurgery
• The effects of vitamin D supplementation on expanded disability status scalein people with multiple sclerosis: a critical, systematic review and metaanalysis of randomized controlled trials

  Publication date: Available online 14 October 2019Source: Clinical Neurology and NeurosurgeryAuthor(s): Amin Doosti-Irani, Omid Reza Tamtaji, Mohammad Ali Mansournia, Majid Ghayour- Mobarhan, Gordon Ferns, Reza Daneshvar Kakhaki, Arash Rezaei Shahmirzadi, Zatollah AsemiAbstractIn this meta-analysis of randomized controlled trials (RCTs), the effects of vitamin D supplementation on the scores for the expanded disability status scale (EDSS) in peop

  Clinical Neurology and Neurosurgery

  Tue Oct 15, 2019 05:26
• Leuprolide acetate pseudomenopause therapy as a cause of reversible cerebral vasoconstriction syndrome

  Publication date: Available online 14 October 2019Source: Clinical Neurology and NeurosurgeryAuthor(s): Hiroki Yamada, Ryogo Kikuchi, Akiyoshi Nakamura, Hiromichi Miyazaki

  Clinical Neurology and Neurosurgery

  Tue Oct 15, 2019 05:26
• Investigative Radiology - Current Issue
• Transcranial Shear Wave Elastography of Neonatal and Infant Brains for Quantitative Evaluation of Increased Intracranial Pressure

  Objectives Increased intracranial pressure (ICP) in neonates and infants is a severe disease state that requires adequate diagnosis and, depending on the clinical situation and whether it is increasing, a rapid and efficient therapy. Clinical evaluation, B-mode ultrasound, and Doppler ultrasound give rise to a basic noninvasive diagnosis of increased ICP. The purpose of this prospective study was 2-fold: first, to analyze the technical feasibi

  Investigative Radiology - Current Issue

  Tue Oct 15, 2019 00:09
• Modulating Diffusion-Weighted Magnetic Resonance Imaging for Screening in Oncologic Tertiary Prevention: A Prospective Ex Vivo and In Vivo Study

  Introduction Diffusion-weighted imaging (DWI) is an important part of oncological magnetic resonance imaging (MRI) examinations, especially for tertiary cancer prevention in terms of early detection of recurrent disease. However, abdominal studies can be challenged by motion artifacts, poor signal-to-noise ratios, and visibility of retroperitoneal structures, which necessitates sequence optimization depending on the investigated region. This s

  Investigative Radiology - Current Issue

  Tue Oct 15, 2019 00:09
• Magnetization Transfer Imaging Is Unaffected by Decreases in Renal Perfusion in Swine

  Objectives Multiparametric renal magnetic resonance imaging (MRI), including diffusion-weighted imaging, magnetic resonance elastography, and magnetization transfer imaging (MTI), is valuable in the noninvasive assessment of renal fibrosis. However, hemodynamic changes in diseased kidneys may impede their ability to measure renal fibrosis. Because MTI assesses directly tissue content of macromolecules, we test the hypothesis that MTI would be

  Investigative Radiology - Current Issue

  Tue Oct 15, 2019 00:09
• Ultrasound Time-Harmonic Elastography of the Aorta: Effect of Age and Hypertension on Aortic Stiffness

  Objectives The aim of this study was to investigate ultrasound time-harmonic elastography for quantifying aortic stiffness in vivo in the context of aging and arterial hypertension. Materials and Methods Seventy-four participants (50 healthy participants and 24 participants with long-standing hypertension) were prospectively included between January 2018 and October 2018, and underwent ultrasound time-harmonic elastography of the upper ab

  Investigative Radiology - Current Issue

  Tue Oct 15, 2019 00:09
• Measuring Dynamic CT Perfusion Based on Time-Resolved Quantitative DECT Iodine Maps: Comparison to Conventional Perfusion at 80 kVp for Pancreatic Carcinoma

  Objectives Using dual-energy computed tomography (DECT) for quantifying iodine content after injection of contrast agent could provide a quantitative basis for dynamic computed tomography (CT) perfusion measurements by means of established mathematical models of contrast agent kinetics, thus improving results by combining the strength of both techniques, which was investigated in this study. Materials and Methods A dynamic DECT acquisitio

  Investigative Radiology - Current Issue

  Tue Oct 15, 2019 00:09
• Three Tesla 3D High-Resolution Vessel Wall MRI of the Orbit may Differentiate Arteritic From Nonarteritic Anterior Ischemic Optic Neuropathy

  Background Anterior ischemic optic neuropathy (AION) is the most common cause of acute optic neuropathy in older patients. Distinguishing between arteritic AION (A-AION) and nonarteritic (NA-AION) is paramount for improved patient management. Purpose The aim of this study was to evaluate 3-dimensional high-resolution vessel wall (HR-VW) magnetic resonance imaging (MRI) at 3 T to discriminate A-AION from NA-AION. Materials and Methods

  Investigative Radiology - Current Issue

  Tue Oct 15, 2019 00:09
• Tumor Contrast Enhancement and Whole-Body Elimination of the Manganese-Based Magnetic Resonance Imaging Contrast Agent Mn-PyC3A

  Objectives The goals of this study were to compare the efficacy of the new manganese-based magnetic resonance imaging (MRI) contrast agent Mn-PyC3A to the commercial gadolinium-based agents Gd-DOTA and to Gd-EOB-DTPA to detect tumors in murine models of breast cancer and metastatic liver disease, respectively, and to quantify the fractional excretion and elimination of Mn-PyC3A in rats. Methods T1-weighted contrast-enhanced MRI with 0.1 m

  Investigative Radiology - Current Issue

  Tue Oct 15, 2019 00:09
• Free-Breathing Dynamic Contrast-Enhanced Imaging of the Upper Abdomen Using a Cartesian Compressed-Sensing Sequence With Hard-Gated and Motion-State-Resolved Reconstruction

  Objectives The aim of this study was to compare a compressed-sensing free-breathing VIBE (fbVIBE) with a conventional breath-hold VIBE (bhVIBE) for dynamic contrast-enhanced imaging of the upper abdomen. Materials and Methods In total, 70 datasets (bhVIBE, n = 30; fbVIBE n = 40; hard-gated [hg] reconstruction, n = 30; motion-state-resolved [mr] reconstruction, n = 10) were assessed by 2 experienced readers. Both sequences were performed o

  Investigative Radiology - Current Issue

  Tue Oct 15, 2019 00:09
• Journal of Experimental & Clinical Cancer Research - Latest Articles
• Correction to: FAK-ERK activation in cell/matrix adhesion induced by the loss of apolipoprotein E stimulates the malignant progression of ovarian cancer

  In the original publication of this manuscript [1], Fig. 5E lower panel was incorrect due to an error in the preparation of these figures for publication. It was noticed that in the lower panel of Fig. 5E, one...

  Journal of Experimental & Clinical Cancer Research - Latest Articles

  Mon Oct 14, 2019 17:00
• G3: .Genes, Genomes, Genetics Mission - Online First Articles
• Ectopic Expression of Litsea cubeba LcMADS20 Modifies Silique Architecture

  Litsea cubeba (Lour.) Pers. (mountain pepper, Lauraceae) is an important woody essential oil crop that produces fragrant oils in its fruits, especially in its peels. Identification of genes involved in the regulation of fruits and peel architecture is of economic significance for L. cubeba industry. It has been well known that the MADS-box genes are essential transcription factors that control flowers and fruits development. Here, we obtained 33

  G3: .Genes, Genomes, Genetics Mission - Online First Articles

  Tue Oct 15, 2019 15:56
• Psychophysiology
• Circadian misalignment impairs ability to suppress visual distractions

  Abstract Evening‐type individuals often perform poorly in the morning because of a mismatch between internal circadian time and external social time, a condition recognized as social jet lag. Performance impairments near the morning circadian (~24 hr) trough have been attributed to deficits in attention, but the nature of the impairment is unknown. Using electrophysiological indices of attentional selection (N2pc) and suppression (PD), we show t

  Psychophysiology

  Tue Oct 15, 2019 03:30
• Pathology International
• Multiple functions of S100A10, an important cancer promoter

  The S100 group of calcium binding proteins is composed of 21 members that exhibit tissue/cell specific expressions. These S100 proteins bind a diverse range of targets and regulate multiple cellular processes, including proliferation, migration and differentiation. S100A10, also known as p11, binds mainly to annexin A2 and mediates the conversion of plasminogen to an active protease, plasmin. Higher S100A10 expression has been reported to link to

  Pathology International

  Mon Oct 14, 2019 09:18
• Clinical Ophthalmology
• Keratograph 5M As A Useful And Objective Tool For Evaluating The Ocular Surface In Limbal Stem Cell Deficiency

  Clinical Ophthalmology

  Tue Oct 15, 2019 19:59
• Journal of Cancer Research and Clinical Oncology
• Preclinical rationale and clinical efficacy of antiangiogenic therapy and immune checkpoint blockade combination therapy in urogenital tumors

  Abstract Purpose In recent years, immune checkpoint blockade (ICB) therapies have shown good clinical responses in various solid cancers. However, a major challenge in the process of ICB treatment is when tumors do not have enough infiltrating T cells. Antiangiogenic drugs targeting vascular endothelial growth factor (VEGF) and its receptors have been approved for the treatment of vari

  Journal of Cancer Research and Clinical Oncology

  Mon Oct 14, 2019 17:00
• Correlations between microsatellite instability and the biological behaviour of tumours

  Abstract Purpose Microsatellites are widely distributed repetitive DNA motifs, accounting for approximately 3% of the genome. Due to mismatch repair system deficiency, insertion or deletion of repetitive units often occurs, leading to microsatellite instability. In this review, we aimed to explore the relationship between MSI and biological behaviour of colorectal carcinoma, gastric ca

  Journal of Cancer Research and Clinical Oncology

  Mon Oct 14, 2019 17:00
• Clinical significance of a pvrl 4 encoded gene Nectin-4 in metastasis and angiogenesis for tumor relapse

  Abstract Purpose In the present study, we have systematically examined the clinical significance of Nectin-4 (encoded by the PVRL-4 gene), a marker for breast cancer stem cells (CSCs), in cancer metastasis and angiogenesis using a variety of human specimens, including invasive duct carcinoma (IDC) with multiple grades, several types of primary tumors to local and distant relapses, lymp

  Journal of Cancer Research and Clinical Oncology

  Mon Oct 14, 2019 17:00
• OEM Online First
• Differential effect of Hurricane Sandy exposure on PTSD symptom severity: comparison of community members and responders

  ObjectivesTo evaluate whether the association between Hurricane Sandy exposures and post-traumatic stress disorder (PTSD) symptom severity was greater for exposed community members compared with responders.MethodsData were analysed from three existing studies with similar methodologies (N=1648): two community studies, Leaders in Gathering Hope Together (n=531) and Project Restoration (n=763); and the Sandy/World Trade Center Responders Study (n=3

  OEM Online First

  Mon Oct 14, 2019 22:33
• Accelerated lung function decline in an aluminium manufacturing industry cohort exposed to PM2.5: an application of the parametric g-formula

  ObjectiveOccupational dust exposure has been associated with accelerated lung function decline, which in turn is associated with overall morbidity and mortality. In the current study, we assess potential benefits on lung function of hypothetical interventions that would reduce occupational exposure to fine particulate matter (PM2.5) while adjusting for the healthy worker survivor effect.MethodsAnalyses were performed in a cohort of 6485 hourly ma

  OEM Online First

  Mon Oct 14, 2019 22:33
• International journal of basic and clinical endocrinology
• Thyroid hormone metabolites and analogues

  Abstract Several metabolic products that derive from l-thyroxine (T4) and 3,3′5-l-triiodothyronine (T3), the main thyroid hormones secreted by the thyroid gland, possess biologic activities. Among these metabolites or derivatives showing physiological actions some have received greater attention: diiodothyronines, iodothyronamines, acetic acid analogues. It is known that increased thyroid hormone (T3 and T4) levels can improv

  International journal of basic and clinical endocrinology

  Mon Sep 30, 2019 17:00
• Thyroid hormone therapy in congenital hypothyroidism and pediatric hypothyroidism

  Abstract The evaluation and management of hypothyroidism in children are similar to adults, but there are important differences based on the dependence on normal thyroid function for neurocognitive and physical development. In the pediatric population, hypothyroidism is frequently categorized as congenital or acquired hypothyroidism, depending on the age of presentation and the underlying etiology. The evaluation and manageme

  International journal of basic and clinical endocrinology

  Mon Sep 30, 2019 17:00
• Novel uses of thyroid hormones in cardiovascular conditions

  Abstract Thyroid hormone levels are reduced in cardiovascular diseases and this phenomenon is associated with worse outcomes. It is unclear whether the changes in thyroid hormone bioavailability to the affected myocardium are beneficial or if this is a maladaptive response. Experimental studies from animal models of acute myocardial infarction (AMI) suggest that thyroid hormone treatment may be beneficial. There is limited da

  International journal of basic and clinical endocrinology

  Mon Sep 30, 2019 17:00
• Thyroid hormone therapy: past, present, and future

  International journal of basic and clinical endocrinology

  Mon Sep 30, 2019 17:00
• Thyroid hormone therapy for subclinical hypothyroidism

  Abstract Subclinical Hypothyroidism (SCH) is defined as a raised level of serum TSH level in the presence of normal circulating free thyroid hormones. SCH is a highly prevalent condition displaying some peculiarities, both in terms of the diagnostic and therapeutic approach, when specific population and/or concomitant diseases are taken into account. The debate upon whether LT4 therapy should be initiated or not in patients w

  International journal of basic and clinical endocrinology

  Mon Sep 30, 2019 17:00
• Thyroid hormone therapy of hypothyroidism in pregnancy

  Abstract Hypothyroidism is the most frequent pregnancy-related thyroid dysfunction, including overt and subclinical hypothyroidism. Studies show that even mild hypothyroidism may eventuate in adverse gestational outcomes and intellectual impairment of offspring. Women with overt hypothyroidism (OH) must be treated by levothyroxine (LT4) pre- and during pregnancy, however, it is controversial that when and how to initiate LT4

  International journal of basic and clinical endocrinology

  Mon Sep 30, 2019 17:00
• Neuro-Oncology
• Ecotropic viral integration site 1 regulates EGFR transcription in glioblastoma cells

  Abstract Purpose Ecotropic viral integration site-1 (EVI1) is a transcription factor that contributes to the unfavorable prognosis of leukemia, some epithelial cancers, and glial tumors. However, the biological function of EVI1 in glioblastoma multiforme (GBM) remains unclear. Based on microarray experiments, EVI1 has been reported to regulate epidermal growth factor receptor (EGFR) tr

  Neuro-Oncology

  Mon Oct 14, 2019 17:00
• Latest Results for BMC Oral Health
• Correction to: User satisfaction with public oral health services in the Brazilian unified health system

  Following publication of the original article [1], the authors have reported that there is an error in Table 2 - Distribution of users concerning satisfaction with oral health services: the categories ‘No’ and ‘Yes’ should swap places.

  Latest Results for BMC Oral Health

  Mon Oct 14, 2019 17:00
• Predisposing and enabling factors associated with public denture service utilization among older Thai people: a cross-sectional population-based study

  Abstract Backgrounds Tooth loss is one of the major oral health problems among older Thai people. However, there is the existence of socioeconomic-related inequalities in dental service utilization, especially denture service. The aim of this study was to assess the determinants associated with inequalities in denture service utilization among older Thai people using the Andersen

  Latest Results for BMC Oral Health

  Mon Oct 14, 2019 17:00
• Oral and Maxillofacial Surgery
• Successive re-implantation of dental implants into sites of previous failure

  Publication date: Available online 13 October 2019Source: Journal of Oral and Maxillofacial SurgeryAuthor(s): Kimiko Agari, Bach LeAbstractPurposeTo evaluate the survival rates of dental implants re-implanted in sites of previous failure, including first, second, and third re-implantations, as well as to investigate the various factors that may affect re-implantation outcomes.Materials and MethodsAll dental implants placed in sites of previous im

  Oral and Maxillofacial Surgery

  Tue Oct 15, 2019 05:51
• Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
• Calcifications in the neck region of patients with carotid artery stenosis: A computed tomography angiography study of topographic anatomy

  Publication date: Available online 15 October 2019Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral RadiologyAuthor(s): Oya Barut, Jan Ahlqvist, Maria Garoff, Elias Johansson, Magnus Johansson, Per Wester, Eva Levring JäghagenAbstractObjectivesTo map the vertical locations of calcified carotid plaques (CCPs), osseous anatomical structures, and calcified soft tissues in the area of the carotid artery, determine to what extent CCPs are s

  Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology

  Tue Oct 15, 2019 07:27
• Modified in-continuity resection is advantageous in both prognosis and postoperative complications as a new surgical management for oral tongue cancer

  Publication date: Available online 14 October 2019Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral RadiologyAuthor(s): Bo Li, Chong Wang, Aoming Cheng, Kyojin Kim, Huan Liu, Mozi Li, Minghui Mao, Zhengxue Han, Zhien FengAbstractObjectiveTo explore the application value of modified in-continuity resection compared with traditional in-continuity resection and discontinuous resection for patients with cT2N0M0 oral tongue squamous cell ca

  Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology

  Tue Oct 15, 2019 07:27
• Surrogate Markers for High Risk Human Papillomavirus Infection in Oral Epithelial Dysplasia: A Comparison of p16, Ki-67 and ProExC

  Publication date: Available online 14 October 2019Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral RadiologyAuthor(s): Amr Alsabbagh, Terry L. Robins, Ariel Harriman, Linda Jackson-Boeters, Mark R. Darling, Zia A. Khan, Christina McCordObjectiveTo determine the utility of surrogate markers of human papillomavirus (HPV) infection in the diagnosis of HPV associated oral epithelial dysplasia (OED).Study designTwelve cases of oral dysplas

  Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology

  Tue Oct 15, 2019 07:27
• British Journal of Oral and Maxillofacial Surgery
• Changes in the position of the condyle after bilateral sagittal split ramus osteotomy in patients with mandibular retrusion and protrusion: a new condyle: fossa matching concept

  Publication date: Available online 14 October 2019Source: British Journal of Oral and Maxillofacial SurgeryAuthor(s): Q. Yin, R. Bi, B. Abotaleb, N. Jiang, Y. Li, S. ZhuAbstractThe purpose of this study was to compare the condylar positional changes after bilateral sagittal split ramus osteotomy (BSSRO) in patients with mandibular retrusion and those with mandibular prognathism. We also studied the correlation between the degree of matching of th

  British Journal of Oral and Maxillofacial Surgery

  Tue Oct 15, 2019 06:12
• The Journal of Prosthetic Dentistry
• Influence of various airborne-particle abrasion conditions on bonding between zirconia ceramics and an indirect composite resin material

  Publication date: Available online 15 October 2019Source: The Journal of Prosthetic DentistryAuthor(s): Saiji Shimoe, Tzu-Yu Peng, Mai Otaku, Nozomi Tsumura, Shogo Iwaguro, Takahiro SatodaAbstractStatement of problemIndirect composite resins (ICRs) have been suggested as veneering materials for implant-supported zirconia-based fixed dental prostheses; however, obtaining a durable bond between the zirconia ceramic and the ICR is a challenge.Purpos

  The Journal of Prosthetic Dentistry

  Tue Oct 15, 2019 05:12
• Effect of polyvinylphosphonic acid on resin-dentin bonds and the cytotoxicity of mouse dental papilla cell-23

  Publication date: Available online 15 October 2019Source: The Journal of Prosthetic DentistryAuthor(s): Yunyi Xie, Enbao He, Zeyuan Cao, Qianmin Ou, Yan WangAbstractStatement of problemPolyvinylphosphonic acid (PVPA) could be used as a biomimetic remineralization analog and a matrix metalloproteinases (MMPs) inhibitor. However, studies are lacking regarding the performance of PVPA in dental bonding systems for maintaining the durability of the re

  The Journal of Prosthetic Dentistry

  Tue Oct 15, 2019 05:12
• bioRxiv Subject Collection: Evolutionary Biology
• Reconstructing the history of variation in effective population size along phylogenies. [NEW RESULTS]

  The nearly-neutral theory predicts specific relations between effective population size (Ne), and patterns of divergence and polymorphism, which depend on the shape of the distribution of fitness effects (DFE) of new mutations. However, testing these relations is not straightforward since Ne is difficult to estimate in practice. For that reason, indirect proxies for Ne have often been used to test the nearly-neutral theory, although with mixed re

  bioRxiv Subject Collection: Evolutionary Biology

  Mon Oct 14, 2019 17:00
• Parasite dispersal influences introgression rate [NEW RESULTS]

  Organisms vary in their dispersal abilities, and these differences can have important biological consequences, such as impacting the likelihood of hybridization events. However, the factors shaping the frequency of hybridization are still poorly understood, and therefore how dispersal ability affects the opportunities for hybridization is still unknown. Here, using the ecological replicate system of dove wing and body lice (Insecta: Phthiraptera)

  bioRxiv Subject Collection: Evolutionary Biology

  Mon Oct 14, 2019 17:00
• Evolutionary history of dimethylsulfoniopropionate (DMSP) demethylation enzyme DmdA in marine bacteria [NEW RESULTS]

  Dimethylsulfoniopropionate (DMSP), an osmolyte produced by oceanic phytoplankton, is predominantly degraded by bacteria belonging to the Roseobacter lineage and other marine Alphaproteobacteria via DMSP-dependent demethylase A protein (DmdA). To date, the evolutionary history of DmdA gene family is unclear. Some studies indicate a common ancestry between DmdA and GcvT gene families and a co-evolution between Roseobacter and the DMSP-producing-phy

  bioRxiv Subject Collection: Evolutionary Biology

  Mon Oct 14, 2019 17:00
• Fitness functions, genetic and non-genetic inheritance, and why ecological dynamics and evolution are inevitably linked [NEW RESULTS]

  Fitness functions are at the heart of ecology and evolution as they simultaneously determine both population dynamics and the strength of selection. We link the Breeders and Price equations with structured population models constructed from fitness functions to show how ecological and evolutionary dynamics are intimately linked, and to characterise all of the ways that environmental variation can influence selection and evolution. We show i) how

  bioRxiv Subject Collection: Evolutionary Biology

  Mon Oct 14, 2019 17:00
• Inference of population genetic structure from temporal samples of DNA [NEW RESULTS]

  The recent years have seen a growing number of studies investigating evolutionary questions using ancient DNA techniques and temporal samples of DNA. To address these questions, one of the most frequently-used algorithm is based on principal component analysis (PCA). When PCA is applied to temporal samples, the sample dates are, however, ignored during analysis, which could lead to some misinterpretations of the results. Here we introduce a new f

  bioRxiv Subject Collection: Evolutionary Biology

  Mon Oct 14, 2019 17:00
• Urbanization and market-integration have strong, non-linear effects on metabolic health in the Turkana [NEW RESULTS]

  Cardio-metabolic disease is a leading cause of death worldwide, with high prevalence in western, industrialized societies relative to developing nations and subsistence-level populations. This stark difference has been attributed to the dietary and lifestyle changes associated with industrialization, but current work has relied on health comparisons between separate, genetically distinct populations to draw conclusions. To more robustly determine

  bioRxiv Subject Collection: Evolutionary Biology

  Mon Oct 14, 2019 17:00
• Identifying the drivers of computationally detected correlated evolution among sites under antibiotic selection [NEW RESULTS]

  The ultimate causes of correlated evolution among sites in a genome remain difficult to tease apart. To address this problem directly, we performed a high-throughput search for correlated evolution among sites associated with resistance to a fluoroquinolone antibiotic using whole genome data from clinical strains of Pseudomonas aeruginosa, before validating our computational predictions experimentally. We show that for at least two sites, this co

  bioRxiv Subject Collection: Evolutionary Biology

  Mon Oct 14, 2019 17:00