Cross-sectional analysis of cognitive function using multivariate normative comparisons in men with HIV diseaseBackground: Prevalence estimates of cognitive impairment in HIV disease vary widely. Here we used multivariate normative comparison (MNC) with identify individuals with impaired cognition, and to compare the results with those using the Frascati and Gisslén criteria. Methods: The current project used data collected before October 2014 from bisexual/gay men from the Multicenter AIDS Cohort...
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Brainstem Functions and ReflexesNo abstract availableOcular Motor and Vestibular Disorders in Brainstem DiseaseSummary: The brainstem contains ocular motor and vestibular structures that, when damaged, produce specific eye movement disorders. In this review, we will discuss three brainstem syndromes with characteristic ocular motor and vestibular findings that can be highly localizing. First, we will discuss the lateral medullary (Wallenberg) syndrome, focusing on ocular lateropulsion, saccadic dysmetria,...
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Left atrium: a forgotten biomarker and a potential target in cardiovascular medicineEmerging evidence shows the clinical usefulness of left atrium analysis in different fields of cardiovascular medicine in terms of diagnosis, prognosis and as a potential target for medical treatment. Left atrium structural and functional remodeling has been shown to be a sensitive marker able to detect high-risk individuals in the general population and in subjects with known cardiovascular diseases such as atrial...
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The Utility of FDG-PET in the Treatment of Hodgkin LymphomaNo abstract availableBreast Cancer at ESMO: Gaudy & GaudiNo abstract availableASH 2019: What to Know About This Year's ConferenceNo abstract availableASCO President's Thoughts on Conquering Cancer: UniteNo abstract availableValuesNo abstract availableView From the Other Side of the Stethoscope: Empowering Patient HandoutsNo abstract availableDriving Change in Small Bowel AdenocarcinomaNo abstract availableJournal Snapshot: An Assortment...
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Treatment of First-time Patellar Dislocations and Evaluation of Risk Factors for Recurrent Patellar InstabilityApproximately one-third of skeletally mature patients with primary patellar dislocation will experience recurrent patellar instability over time. Because of the multifactorial combination of features contributing to overall stability of the patellofemoral joint, first-time patella dislocation presents a challenge to the treating physician. A detailed patient history, focused physical examination,...
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Pulsed Electromagnetic Fields Reduce Interleukin-6 Expression in Intervertebral Disc Cells Via Nuclear Factor-κβ and Mitogen-Activated Protein Kinase p38 PathwaysStudy Design. This is an in vitro study of bovine disc cells exposed to pulsed electromagnetic fields. Objective. The purpose of the present study was to investigate whether pulsed electromagnetic fields (PEMF) effects on the expression of interleukin-6 (IL-6) expression is mediated by two known inflammation regulators, nuclear factor-κB...
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Effects of different strategies on high thrombus burden in patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary catheterizationObjective This study aimed at evaluating efficacy and safety of thrombus aspiration and intracoronary-targeted thrombolysis on coronary thrombus burden in ST-elevation myocardial infarction (STEMI) patients undergoing primary percutaneous catheterization, comparing their effects on myocardial perfusion through index of microcirculatory...
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Safety of in-office laryngology proceduresPurpose of review A wide range of diagnostic and therapeutic laryngology procedures are currently performed in an office setting. In-office laryngology procedures (IOLP) are increasingly seen as standard-of-care, and while generally considered safe, high-quality evidence supporting the latter statement is lacking. This review aims to summarize recent literature regarding the safety of IOLP. Recent findings There is a paucity of guidelines and standardized...
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Silencing of Mig-7 expression inhibits in-vitro invasiveness and vasculogenic mimicry of human glioma U87 CellsGliomas are the most common malignant primary brain tumors with poor prognosis. The migration-inducing gene-7 (Mig-7) protein is a cysteine-rich protein. Vasculogenic mimicry can replace endothelium-dependent blood vessels and supply blood to tumors, thus promoting tumor invasion and metastasis. They have also been shown to play critical roles in the development and progression of various...
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Knowledge Is Power, Sympathy For The Ignorant: Forgiven, For They Do Not KnowNo abstract availableHow to Hold an Osteotome? Michelangelo GripNo abstract availableFacial Cleft in a Mayan FigurineNo abstract availableHumankind's Endless Quest for YouthNo abstract availableA Comparison of Surgical Outcomes of Two Combination Surgeries for Involutional Entropion: Fixing 3 vs 2 Pathologic ComponentsThe purpose of this study was to compare the surgical outcomes of two combinational surgeries for involutional...
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Pelvic Floor Muscle Performance, Hip Mobility, and Hip Strength in Women With and Without Self-Reported Stress Urinary IncontinenceObjective: To describe pelvic floor muscle (PFM) function, hip mobility, and hip strength profiles and compare measures between women with and without self-reported stress urinary incontinence (SUI). Study Design: Descriptive. Background: Women with SUI present with PFM and hip impairments; yet comparative data in asymptomatic women are lacking. Methods and Measures:...
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Article Summaries for November–December 2019 Psychosomatic Medicine, Volume 81, Issue 9No abstract availableThe Effect of Probiotic Supplementation on Depressive Symptoms and Quality of Life in Patients After Myocardial Infarction: Results of a Preliminary Double-Blind Clinical TrialObjective Evidence indicates that probiotic supplements may improve or prevent depression. Little is known about the effects of probiotic supplementation on symptoms of depression and quality of life (QOL) in patients...
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Toll like receptor 2 and 9 expression on circulating neutrophils is associated with increased mortality in critically ill patientsBackground: Toll-like receptors (TLRs) play an important role in inflammatory processes in critically ill patients by binding to pathogen-associated molecular patterns and danger-associated molecular patterns (DAMPs). Whether neutrophil or monocyte TLR expression patterns are associated with outcome in critical illness is unknown. Objectives: To answer this question, we...
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Achieving Sustainability in Reducing Unplanned Extubations in a Pediatric Cardiac ICUObjectives: To determine the incidence of unplanned extubations in a pediatric cardiac ICU in order to prove sustainability of our previously implemented quality improvement initiative. Additionally, we sought to identify risk factors associated with unplanned extubations as well as review the overall outcome of this patient population. Design: Retrospective chart review. Setting: Pediatric cardiac ICU at Children’s...
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Supporting the Use of Medications for Addiction Treatment in US Drug Courts: Opportunities for Health ProfessionalsDrug courts are specialty courts that offer treatment services as alternatives to incarceration for defendants struggling with problems related to substance use. These courts have become major access points in the United States for the treatment of substance use disorders, but drug court participants often have limited access to medications for addiction treatment (MAT). A growing chorus...
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Canalicular Incisional Approach for Recanalization of Punctum: A Modified Surgical Treatment for Acquired Complete Upper and Lower Punctum Occlusions as an Alternative to Bypass MethodsPurpose: To define the success of surgical technique used in the treatment of epiphora that is caused by bi-canalicular acquired complete punctum occlusion. Materials and Methods: The study is a retrospective consecutive case series, who underwent canalicular incisional approach for recanalization (CIAFOR) for acquired...
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Spontaneous coronary artery dissection managed with a conservative or revascularization approach: a meta-analysisBackground The optimal treatment approach for spontaneous coronary artery dissection (SCAD) remains unclear. Objectives The study aims to compare in-hospital and long-term clinical outcomes of SCAD patients initially managed with medical therapy (conservative approach) versus percutaneous coronary intervention or coronary artery bypass grafting (revascularization approach) based on published...
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Predicting postoperative complications with the respiratory exchange ratio after high-risk noncardiac surgery: A prospective cohort studyBACKGROUND The respiratory exchange ratio (RER), defined as the ratio of CO2 production (VCO2) to O2 consumption (VO2), is reported to be a noninvasive marker of anaerobic metabolism. The intubated, ventilated patient's inspired and expired fractions of O2 and CO2 (FiO2, FeO2, FiCO2 and FeCO2) are monitored in the operating room and can be used to calculate RER....
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Long and winding road: from infant wheeze to adult asthmaPurpose of review This review aims to recognize the multifactorial cause of asthma, from the influence of mother until adulthood, highlight the main characteristics of the disease at different ages and summarize the evidence of potential prevention strategies. Recent findings To date, regarding the prenatal period, the presence of specific genes, maternal asthma, drugs, and tobacco exposure are the most relevant predisposing features for an...
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Radiofrequency versus cryoballoon ablation for atrial fibrillation: an argument for a ‘cryo-first’ approachPurpose of review: Radiofrequency and cryoballoon ablation are the two most common modalities for catheter ablation of atrial fibrillation. Radiofrequency, being more prevalent and having existed for a longer period, is often utilized for patients’ first ablations, despite the efficiency and efficacy of the cryoballoon tool. Here we examine the advantages of the cryoballoon for its use in first-time...
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Ex-vivo lung perfusionPurpose of review Ex-vivo lung perfusion (EVLP) has been developed to expand the donor pool for lung transplantation recipients. The role of EVLP in organ preservation, evaluation and potential reconditioning is reviewed. Recent findings EVLP has been shown to significantly increase the utilization of donor lungs for transplantation. Evidence suggests that patient outcomes from EVLP lungs are comparable to standard procurement technique. Novel strategies are being developed...
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Asthma/obstructive pulmonary disease overlap: update on definition, biomarkers, and therapeuticsPurpose of review Asthma/chronic obstructive pulmonary disease overlap (ACO) continues to be a poorly understood condition. This review discusses newly proposed criteria and potential biomarkers in ACO, to aid in diagnosis and research studies, and prudent therapeutic approaches. Recent findings A global expert panel proposed an operational definition consisting of major and minor criteria as a step toward...
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Evaluation of biomarkers for monitoring thrombogenic potential of FXaI16LA zymogen-like activated factor X variant (FXaI16L) is being developed for treating acute bleeding conditions. Activated factor V is an essential cofactor to FXaI16L for activating prothrombin to thrombin. Thrombi/emboli formation was observed microscopically in FXaI16L toxicity studies in animals. The objective of this research was to evaluate candidate biomarkers for FXaI16L-induced thrombi/emboli formation to inform safety...
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Effects of elastic resistance exercise after total knee replacement on muscle mass and physical function in elderly women with osteoarthritis: A randomized controlled trialOBJECTIVE Knee osteoarthritis (KOA) and age are associated with high sarcopenia risk, especially in patients who have received total knee replacement (TKR). The purpose of this study was to identify the effects of elastic resistance exercise training (RET) after TKR on muscle mass and physical outcomes in older women with KOA....
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Altered monocyte phenotype and dysregulated innate cytokine responses among people living with HIV and opioid-use disorderBackground: Opioid-use disorders (OUD) and hepatitis C or B co-infection (HEP) are common among people living with HIV (PLHIV). The impact of OUD on innate and adaptive immunity among PLHIV with and without HEP is unknown. Objectives: To investigate the impact of OUD on monocyte and T-cell phenotypes, cytokine responses to lipopolysaccharide (LPS) and phytohemagglutinin (PHA),...
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Framework for Patient and Informal Caregiver Participation in Research (PAICPAIR): Part 1The term user involvement is frequently applied in research. Frameworks for patient and informal caregiver participation as coresearchers in studies concerning patients with life-threatening illness are however sparse. The PhD project Dying With Dignity—Dignity-Preserving Care for Older Women Living at Home With Incurable Cancer has implemented a thorough cooperation with patients and informal caregivers from...
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