Antibiotics, Vol. 8, Pages 211: The Remarkable Effect of Potassium Iodide in Eosin and Rose Bengal Photodynamic Action against Salmonella Typhimurium and Staphylococcus aureus Antibiotics doi: 10.3390/antibiotics8040211 Authors: Adriele R. Santos Andréia F. P. Batista Ana T. P. C. Gomes Maria da Graça P. M. S. Neves Maria Amparo F. Faustino Adelaide Almeida Noboru Hioka Jane M. G. Mikcha Antimicrobial photodynamic therapy (aPDT) has been shown as a promising technique...
Tue Nov 05, 2019 02:00
Antibodies, Vol. 8, Pages 54: Antibody-Drug Conjugates Targeting the Urokinase Receptor (uPAR) as a Possible Treatment of Aggressive Breast Cancer Antibodies doi: 10.3390/antib8040054 Authors: Efrat T. Harel Penelope M. Drake Robyn M. Barfield Irene Lui Shauna Farr-Jones Laura Van’t Veer Zev J. Gartner Evan M. Green André Luiz Lourenço Yifan Cheng Byron C. Hann David Rabuka Charles S. Craik A promising molecular target for aggressive cancers is the...
Tue Nov 05, 2019 02:00
Antibodies, Vol. 8, Pages 53: Engineering a Novel Antibody-Peptide Bispecific Fusion Protein Against MERS-CoV Antibodies doi: 10.3390/antib8040053 Authors: Lili Wang Jiyan Xu Yu Kong Ruiying Liang Wei Li Jinyao Li Jun Lu Dimiter S. Dimitrov Fei Yu Yanling Wu Tianlei Ying In recent years, tremendous efforts have been made in the engineering of bispecific or multi-specific antibody-based therapeutics by combining two or more functional antigen-recognizing...
Mon Nov 04, 2019 02:00
Antioxidants, Vol. 8, Pages 527: Enhancement of Minor Ginsenosides Contents and Antioxidant Capacity of American and Canadian Ginsengs (Panax quinquefolius) by Puffing Antioxidants doi: 10.3390/antiox8110527 Authors: Min-Soo Kim Sung-Joon Jeon So Jung Youn Hyungjae Lee Young-Joon Park Dae-Ok Kim Byung-Yong Kim Wooki Kim Moo-Yeol Baik The effects of puffing on ginsenosides content and antioxidant activities of American and Canadian ginsengs, Panax quinquefolius,...
Tue Nov 05, 2019 02:00
Antioxidants, Vol. 8, Pages 526: Dietary EPA Increases Rat Mortality in Diabetes Mellitus, A Phenomenon Which Is Compensated by Green Tea Extract Antioxidants doi: 10.3390/antiox8110526 Authors: Leger He Azarnoush Jouve Rigaudiere Joffre Bouvier Sapin Pereira Demaison : Diabetes is characterized by a high mortality rate which is often associated with heart failure. Green tea and eicosapentaenoic acid (EPA) are known to lessen some of the harmful impacts...
Mon Nov 04, 2019 02:00
Arts, Vol. 8, Pages 148: Siyosapa: At the Edge of Art Arts doi: 10.3390/arts8040148 Authors: Penney The art history of Native North America built its corpus through considerations of “art-by-appropriation,” referring to selections of historically produced objects reconsidered as art, due to their artful properties, in addition to “art-by-intention,” referring to the work by known artists intended for the art market. The work of Siyosapa, a Hunkpapa/Yanktonai...
Tue Nov 05, 2019 02:00
Atmosphere, Vol. 10, Pages 679: Parallel Comparison of Major Sudden Stratospheric Warming Events in CESM1-WACCM and CESM2-WACCM Atmosphere doi: 10.3390/atmos10110679 Authors: Si-Ming Liu Yuan-Hao Chen Jian Rao Can Cao Si-Yu Li Mu-Han Ma Yao-Bin Wang After the recent release of the historical runs by community Earth system model version 2–the whole atmosphere community climate model (CESM2-WACCM), the major sudden stratospheric warming (SSW) events in this...
Tue Nov 05, 2019 02:00
Atmosphere, Vol. 10, Pages 678: Application of the Passive Sampler Developed for Atmospheric Mercury and Its Limitation Atmosphere doi: 10.3390/atmos10110678 Authors: Ji-Won Jeon Young-Ji Han Seung-Hwan Cha Pyung-Rae Kim Young-Hee Kim Hyuk Kim Gwang-Seol Seok Seam Noh In this study, a passive sampler for gaseous elemental mercury (GEM) was developed and applied to field monitoring. Three Radiello® diffusive bodies with gold-coated beads as Hg adsorbent were...
Tue Nov 05, 2019 02:00
Behavioral Sciences, Vol. 9, Pages 112: A Neuroimaging Study of Personality Traits and Self-Reflection Behavioral Sciences doi: 10.3390/bs9110112 Authors: Joseph Ciorciari John Gountas Patrick Johnston David Crewther Matthew Hughes This study examines the blood-oxygen level dependent (BOLD) activation of the brain associated with the four distinctive thinking styles associated with the four personality orientations of the Gountas Personality Orientations (GPO) survey: Emotion/Feeling-Action,...
Tue Nov 05, 2019 02:00
Behavioral Sciences, Vol. 9, Pages 111: Redesign Me: Virtual Reality Experience of the Line of Life and Its Connection to a Healthier Self Behavioral Sciences doi: 10.3390/bs9110111 Authors: Iva Georgieva Georgi V. Georgiev Virtual Reality is used in various ways for creating a storytelling experience. It gives us the opportunity to imagine one’s life events as a story, and in settings that are intended to aid the self, such as treatment of trauma, anxiety, phobia, etc....
Tue Nov 05, 2019 02:00
Biology, Vol. 8, Pages 83: Understanding the Effect of Structural Diversity in WRKY Transcription Factors on DNA Binding Efficiency through Molecular Dynamics Simulation Biology doi: 10.3390/biology8040083 Authors: Akshay Singh Ajay Kumar Sharma Nagendra Kumar Singh Humira Sonah Rupesh Deshmukh Tilak Raj Sharma A precise understanding of the molecular mechanism involved in stress conditions has great importance for crop improvement. Biomolecules, such as WRKY proteins,...
Mon Nov 04, 2019 02:00
Biomolecules, Vol. 9, Pages 706: Dynamical Rearrangement of Human Epidermal Growth Factor Receptor 2 upon Antibody Binding: Effects on the Dimerization Biomolecules doi: 10.3390/biom9110706 Authors: Magalhães Machuqueiro Almeida Melo D. S. Cordeiro Verde Gümüş Moreira D. G. Correia Melo Human epidermal growth factor 2 (HER2) is a ligand-free tyrosine kinase receptor of the HER family that is overexpressed in some of the most aggressive tumours. Although...
Tue Nov 05, 2019 02:00
Biomolecules, Vol. 9, Pages 705: Conformation and Aggregation of Human Serum Albumin in the Presence of Green Tea Polyphenol (EGCg) and/or Palmitic Acid Biomolecules doi: 10.3390/biom9110705 Authors: Sun Ferguson Hagerman Polyphenols such as epigallocatechin gallate (EGCg) may have roles in preventing some chronic diseases when they are ingested as components of plant-based foods and beverages. Human serum albumin (HSA) is a multi-domain protein that binds various ligands and...
Tue Nov 05, 2019 02:00
Biomolecules, Vol. 9, Pages 704: Molecular Characterization of a Novel Cold-Active Hormone-Sensitive Lipase (HaHSL) from Halocynthiibacter Arcticus Biomolecules doi: 10.3390/biom9110704 Authors: Ly Thi Huong Luu Le Wanki Yoo Changwoo Lee Ying Wang Sangeun Jeon Kyeong Kyu Kim Jun Hyuck Lee T. Doohun Kim Bacterial hormone-sensitive lipases (bHSLs), which are homologous to the catalytic domains of human HSLs, have received great interest due to their uses in the preparation...
Tue Nov 05, 2019 02:00
Biomolecules, Vol. 9, Pages 703: Curcumin Ameliorates Lead-Induced Hepatotoxicity by Suppressing Oxidative Stress and Inflammation, and Modulating Akt/GSK-3β Signaling Pathway Biomolecules doi: 10.3390/biom9110703 Authors: Ahlam Alhusaini Laila Fadda Iman H. Hasan Enas Zakaria Abeer M. Alenazi Ayman M. Mahmoud Lead (Pb) is a toxic heavy metal pollutant with adverse effects on the liver and other body organs. Curcumin (CUR) is the principal curcuminoid of turmeric and possesses...
Tue Nov 05, 2019 02:00
Biomolecules, Vol. 9, Pages 698: 2-Hydroxy-N-phenylbenzamides and Their Esters Inhibit Acetylcholinesterase and Butyrylcholinesterase Biomolecules doi: 10.3390/biom9110698 Authors: Martin Krátký Šárka Štěpánková Neto-Honorius Houngbedji Rudolf Vosátka Katarína Vorčáková Jarmila Vinšová The development of novel inhibitors of acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) represents a viable approach to alleviate Alzheimer’s disease. Thirty-six halogenated...
Tue Nov 05, 2019 02:00
Biomolecules, Vol. 9, Pages 702: Cytokinin Detection during the Dictyostelium discoideum Life Cycle: Profiles Are Dynamic and Affect Cell Growth and Spore Germination Biomolecules doi: 10.3390/biom9110702 Authors: Megan M. Aoki Anna B. Kisiala Shaojun Li Naomi L. Stock Craig R. Brunetti Robert J. Huber R. J. Neil Emery Cytokinins (CKs) are a family of evolutionarily conserved growth regulating hormones. While CKs are well-characterized in plant systems, these N6-substituted...
Tue Nov 05, 2019 02:00
Biomolecules, Vol. 9, Pages 700: Uncoupling of Carbonic Anhydrase from Na-H exchanger-1 in Experimental Colitis: A Possible Mechanistic Link with Na-H Exchanger Biomolecules doi: 10.3390/biom9110700 Authors: Islam Khan Khalid Khan In this study, we investigated a mechanistic link between Na–H exchanger-1 (NHE-1) and carbonic anhydrase (CA) in experimental colitis induced in the rats by intrarectal administration of trinitrobenzenesulphonic acid (TNBS). Western blot analysis...
Tue Nov 05, 2019 02:00
Biomolecules, Vol. 9, Pages 701: Lignin Accumulation in Three Pumelo Cultivars in Association with Sucrose and Energy Depletion Biomolecules doi: 10.3390/biom9110701 Authors: Juan Liu Qinghua Huang Peizi Kang Lei Liang Junjia Chen Lignification, which occurs in many horticultural fruit and vegetables, brings about undesirable texture and unfavorable consumer preference. However, this problem has rarely been studied. In this work, three pumelo cultivars cvs “Hongroumiyou”...
Tue Nov 05, 2019 02:00
Biomolecules, Vol. 9, Pages 699: Dithiocarbamate as a Valuable Scaffold for the Inhibition of Metallo-β-Lactmases Biomolecules doi: 10.3390/biom9110699 Authors: Ying Ge Li-Wei Xu Ya Liu Le-Yun Sun Han Gao Jia-Qi Li Kewu Yang The ‘superbug’ infection caused by metallo-β-lactamases (MβLs) has grown into an emergent health threat. Given the clinical importance of MβLs, a novel scaffold, dithiocarbamate, was constructed. The...
Tue Nov 05, 2019 02:00
Biomolecules, Vol. 9, Pages 697: Chamaejasmine Isolated from Wikstroemia dolichantha Diels Suppresses 2,4-Dinitrofluoro-benzene-Induced Atopic Dermatitis in SKH-1 Hairless Mice Biomolecules doi: 10.3390/biom9110697 Authors: Tae-Young Kim No-June Park Jonghwan Jegal Sangho Choi Sang Woo Lee Jin Hang Su-Nam Kim Min Hye Yang Plants of the genus Wikstroemia have long been used as traditional medicines to treat diseases like pneumonia, rheumatism, and bronchitis. This...
Tue Nov 05, 2019 02:00
Biomolecules, Vol. 9, Pages 695: Transcriptome Mechanism of Utilizing Corn Steep Liquor as the Sole Nitrogen Resource for Lipid and DHA Biosynthesis in Marine Oleaginous Protist Aurantiochytrium sp. Biomolecules doi: 10.3390/biom9110695 Authors: Wang Yu Zhu Wang Li Wang In the current study, corn steep liquor (CSL) is evaluated as an ideal raw agro-material for efficient lipid and docosahexaenoic acid DHA production by Aurantiochytrium sp. Low CSL level in medium...
Mon Nov 04, 2019 02:00
Biomolecules, Vol. 9, Pages 696: Natural Bis-Benzylisoquinoline Alkaloids-Tetrandrine, Fangchinoline, and Cepharanthine, Inhibit Human Coronavirus OC43 Infection of MRC-5 Human Lung Cells Biomolecules doi: 10.3390/biom9110696 Authors: Kim Min Jang Lee Shin Song Kim Kim Jin Kwon Stephania tetrandra and other related species of Menispermaceae are the major sources of the bis-benzylisoquinoline alkaloids tetrandrine (TET), fangchinoline (FAN), and cepharanthine...
Mon Nov 04, 2019 02:00
Biomolecules, Vol. 9, Pages 694: Two Novel Amyloid Proteins, RopA and RopB, from the Root Nodule Bacterium Rhizobium leguminosarum Biomolecules doi: 10.3390/biom9110694 Authors: Kosolapova Belousov Sulatskaya Belousova Sulatsky Antonets Volkov Lykholay Shtark Vasileva Zhukov Ivanova Zykin Kuznetsova Turoverov Tikhonovich Nizhnikov Amyloids represent protein fibrils with a highly ordered spatial structure, which not only...
Mon Nov 04, 2019 02:00
Biomolecules, Vol. 9, Pages 693: Combination of Gemcitabine with Cell-Penetrating Peptides: A Pharmacokinetic Approach Using In Silico Tools Biomolecules doi: 10.3390/biom9110693 Authors: Ferreira Lapa Vale Gemcitabine is an anticancer drug used to treat a wide range of solid tumors and is a first line treatment for pancreatic cancer. Our group has previously developed novel conjugates of gemcitabine with cell-penetrating peptides (CPP), and here we report some preliminary...
Mon Nov 04, 2019 02:00
Biomolecules, Vol. 9, Pages 692: Notch Signaling in Kidney Development, Maintenance, and Disease Biomolecules doi: 10.3390/biom9110692 Authors: Malini Mukherjee Eric Fogarty Madhusudhana Janga Kameswaran Surendran Kidney development involves formation of nephrons intricately aligned with the vasculature and connected to a branched network of collecting ducts. Notch signaling plays multiple roles during kidney development involving the formation of nephrons composed of diverse...
Mon Nov 04, 2019 02:00
Biosensors, Vol. 9, Pages 131: Fully Automated Microsystem for Unmediated Electrochemical Characterization, Visualization and Monitoring of Bacteria on Solid Media; E. coli K-12: A Case Study Biosensors doi: 10.3390/bios9040131 Authors: Cesar A. Hernandez Valerio Beni Johann F. Osma In this paper, we present a non-fluidic microsystem for the simultaneous visualization and electrochemical evaluation of confined, growing bacteria on solid media. Using a completely automated platform,...
Mon Nov 04, 2019 02:00
Brain Sciences, Vol. 9, Pages 309: Manifold Learning of Dynamic Functional Connectivity Reliably Identifies Functionally Consistent Coupling Patterns in Human Brains Brain Sciences doi: 10.3390/brainsci9110309 Authors: Yuyuan Yang Lubin Wang Yu Lei Yuyang Zhu Hui Shen Most previous work on dynamic functional connectivity (dFC) has focused on analyzing temporal traits of functional connectivity (similar coupling patterns at different timepoints), dividing them into functional...
Mon Nov 04, 2019 02:00
Cancers, Vol. 11, Pages 1735: Lenalidomide Maintenance with or without Prednisone in Newly Diagnosed Myeloma Patients: A Pooled Analysis Cancers doi: 10.3390/cancers11111735 Authors: Bonello Pulini Ballanti Gentile Spada Annibali Omedé Ronconi Cangialosi Podda Palmas Malfitano Rivoli Belotti Ciambelli Vincelli Cafro Innao Palumbo Sonneveld Spencer Hájek Boccadoro Gay : We conducted a pooled analysis...
Tue Nov 05, 2019 02:00
Cancers, Vol. 11, Pages 1736: ADAM17 Activity and IL-6 Trans-Signaling in Inflammation and Cancer Cancers doi: 10.3390/cancers11111736 Authors: Schumacher Rose-John All ligands of the epidermal growth factor receptor (EGF-R) are transmembrane proteins, which need to be proteolytically cleaved in order to be systemically active. The major protease responsible for this cleavage is the membrane metalloprotease ADAM17, which also has been implicated in cleavage of TNFα and...
Tue Nov 05, 2019 02:00
Cancers, Vol. 11, Pages 1733: Development and Mechanistic Insight into the Enhanced Cytotoxic Potential of Parvifloron D Albumin Nanoparticles in EGFR-Overexpressing Pancreatic Cancer Cells Cancers doi: 10.3390/cancers11111733 Authors: Ana Santos-Rebelo Pradeep Kumar Viness Pillay Yahya E. Choonara Carla Eleutério Mariana Figueira Ana S. Viana Lia Ascensão Jesús Molpeceres Patrícia Rijo Isabel Correia Joana Amaral Susana Solá Cecília M. P. Rodrigues Maria...
Tue Nov 05, 2019 02:00
Cancers, Vol. 11, Pages 1732: Population-Based Brain Tumor Survival Analysis via Spatial- and Temporal-Smoothing Cancers doi: 10.3390/cancers11111732 Authors: Chenjin Ma Yuan Xue Shuangge Ma In cancer research, population-based survival analysis has played an important role. In this article, we conduct survival analysis on patients with brain tumors using the SEER (Surveillance, Epidemiology, and End Results) database from the NCI (National Cancer Institute). It has been recognized...
Tue Nov 05, 2019 02:00
Cancers, Vol. 11, Pages 1734: Enriching Personalized Endometrial Cancer Research with the Harmonization of Biobanking Standards Cancers doi: 10.3390/cancers11111734 Authors: Adishesh Hapangama Endometrial cancer is the commonest gynecological cancer, with an incidence predicted to escalate by a further 50–100% before 2025, due to the rapid rise in risk factors such as obesity and increased life expectancy. Endometrial cancer associated mortality is also rising, depicting...
Tue Nov 05, 2019 02:00
Cancers, Vol. 11, Pages 1731: Carcinogenesis and Metastasis in Liver: Cell Physiological Basis Cancers doi: 10.3390/cancers11111731 Authors: Anna Rossetto Valli De Re Agostino Steffan Matteo Ravaioli Gianmaria Miolo Patrizia Leone Vito Racanelli Alessandro Uzzau Umberto Baccarani Matteo Cescon Hepatocellular carcinoma (HCC) incidence is rising. This paper summarises the current state of knowledge and recent discoveries in the cellular and physiological mechanisms...
Tue Nov 05, 2019 02:00
Cancers, Vol. 11, Pages 1730: The Prognostic Role of CD8+ T Lymphocytes in Childhood Adrenocortical Carcinomas Compared to Ki-67, PD-1, PD-L1, and the Weiss Score Cancers doi: 10.3390/cancers11111730 Authors: Ivy Zortéa S. Parise Guilherme A. Parise Lúcia Noronha Mirvat Surakhy Thiago Demetrius Woiski Denise B. Silva Tatiana EI-Jaick B. Costa Maria Helena C. P. Del-Valle Heloisa Komechen Roberto Rosati Melyssa Grignet Ribeiro Marilza Leal Nascimento José...
Tue Nov 05, 2019 02:00
Cancers, Vol. 11, Pages 1728: TYK2: An Upstream Kinase of STATs in Cancer Cancers doi: 10.3390/cancers11111728 Authors: Katharina Wöss Natalija Simonović Birgit Strobl Sabine Macho-Maschler Mathias Müller In this review we concentrate on the recent findings describing the oncogenic potential of the protein tyrosine kinase 2 (TYK2). The overview on the current understanding of TYK2 functions in cytokine responses and carcinogenesis focusses on the activation of the signal...
Tue Nov 05, 2019 02:00
Cancers, Vol. 11, Pages 1729: Characterization of HMGB1/2 Interactome in Prostate Cancer by Yeast Two Hybrid Approach: Potential Pathobiological Implications Cancers doi: 10.3390/cancers11111729 Authors: Aida Barreiro-Alonso María Cámara-Quílez Martín Salamini-Montemurri Mónica Lamas-Maceiras Ángel Vizoso-Vázquez Esther Rodríguez-Belmonte María Quindós-Varela Olaia Martínez-Iglesias Angélica Figueroa María-Esperanza Cerdán High mobility group box B (HMGB) proteins...
Tue Nov 05, 2019 02:00
Cancers, Vol. 11, Pages 1727: AXL Receptor Tyrosine Kinase as a Therapeutic Target in Hematological Malignancies: Focus on Multiple Myeloma Cancers doi: 10.3390/cancers11111727 Authors: Siyang Yan Niels Vandewalle Nathan De Beule Sylvia Faict Ken Maes Elke De Bruyne Eline Menu Karin Vanderkerken Kim De Veirman AXL belongs to the TAM (TYRO3, AXL, and MERTK) receptor family, a unique subfamily of the receptor tyrosine kinases. Their common ligand is growth arrest-specific...
Tue Nov 05, 2019 02:00
Cancers, Vol. 11, Pages 1725: Comprehensive Outline of Whole Exome Sequencing Data Analysis Tools Available in Clinical Oncology Cancers doi: 10.3390/cancers11111725 Authors: Bartha Győrffy Whole exome sequencing (WES) enables the analysis of all protein coding sequences in the human genome. This technology enables the investigation of cancer-related genetic aberrations that are predominantly located in the exonic regions. WES delivers high-throughput results at a reasonable price....
Mon Nov 04, 2019 02:00
Cancers, Vol. 11, Pages 1726: STAT5A and STAT5B—Twins with Different Personalities in Hematopoiesis and Leukemia Cancers doi: 10.3390/cancers11111726 Authors: Maurer Kollmann Pickem Hoelbl-Kovacic Sexl The transcription factors STAT5A and STAT5B have essential roles in survival and proliferation of hematopoietic cells—which have been considered largely redundant. Mutations of upstream kinases, copy number gains, or activating mutations in STAT5A, or more frequently...
Mon Nov 04, 2019 02:00
Cancers, Vol. 11, Pages 1723: Progression-Free but No Overall Survival Benefit for Adult Patients with Bevacizumab Therapy for the Treatment of Newly Diagnosed Glioblastoma: A Systematic Review and Meta-Analysis Cancers doi: 10.3390/cancers11111723 Authors: Nagham Kaka Karim Hafazalla Haider Samawi Andrew Simpkin James Perry Arjun Sahgal Sunit Das Glioblastoma (GBM) is the most common high-grade primary brain tumor in adults. Standard multi-modality treatment of glioblastoma...
Mon Nov 04, 2019 02:00
Cancers, Vol. 11, Pages 1724: Coupled Genome-Wide DNA Methylation and Transcription Analysis Identified Rich Biomarkers and Drug Targets in Triple-Negative Breast Cancer Cancers doi: 10.3390/cancers11111724 Authors: Maoni Guo Siddharth Sinha San Ming Wang Triple-negative breast cancer (TNBC) has poor clinical prognosis. Lack of TNBC-specific biomarkers prevents active clinical intervention. We reasoned that TNBC must have its specific signature due to the lack of three key receptors...
Mon Nov 04, 2019 02:00
Cancers, Vol. 11, Pages 1721: Tumor Marker-Based Definition of the Transarterial Chemoembolization-Refractoriness in Intermediate-Stage Hepatocellular Carcinoma: A Multi-Cohort Study Cancers doi: 10.3390/cancers11111721 Authors: Jun Sik Yoon Dong Hyun Sinn Jeong-Hoon Lee Hwi Young Kim Cheol-Hyung Lee Sun Woong Kim Hyo Young Lee Joon Yeul Nam Young Chang Yun Bin Lee Eun Ju Cho Su Jong Yu Hyo-Cheol Kim Jin Wook Chung Yoon Jun Kim Jung-Hwan Yoon ...
Mon Nov 04, 2019 02:00
Cancers, Vol. 11, Pages 1722: Construction and Validation of an Immune-Related Prognostic Model Based on TP53 Status in Colorectal Cancer Cancers doi: 10.3390/cancers11111722 Authors: Xiaojuan Zhao Jianzhong Liu Shuzhen Liu Fangfang Yang Erfei Chen Growing evidence has indicated that prognostic biomarkers have a pivotal role in tumor and immunity biological processes. TP53 mutation can cause a range of changes in immune response, progression, and prognosis of colorectal cancer...
Mon Nov 04, 2019 02:00
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