pubmed: future oncology
- A clinical evaluation of treatments that target cell cycle machinery in breast cancer.Related ArticlesA clinical evaluation of treatments that target cell cycle machinery in breast cancer. Expert Opin Pharmacother. 2019 Oct 14;:1-11 Authors: Fedele P, Sanna V, Fancellu A, Cinieri S Abstract Introduction: The dysregulation of cell cycle control can lead to cancer development. In breast cancer, cyclin D, CDK 4,6 and the retinoblastoma protein play a central role in the control of cell p
- Angiogenesis inhibition in non-small cell lung cancer: a critical appraisal, basic concepts and updates from American Society for Clinical Oncology 2019.Related ArticlesAngiogenesis inhibition in non-small cell lung cancer: a critical appraisal, basic concepts and updates from American Society for Clinical Oncology 2019. Curr Opin Oncol. 2019 Oct 11;: Authors: Cantelmo AR, Dejos C, Kocher F, Hilbe W, Wolf D, Pircher A Abstract PURPOSE OF REVIEW: Recently, the combination of antiangiogenic agents, chemotherapy and immunotherapy has shown synergistic a
- Applications of artificial intelligence in neuro-oncology.Related ArticlesApplications of artificial intelligence in neuro-oncology. Curr Opin Neurol. 2019 Oct 10;: Authors: Aneja S, Chang E, Omuro A Abstract PURPOSE OF REVIEW: To discuss recent applications of artificial intelligence within the field of neuro-oncology and highlight emerging challenges in integrating artificial intelligence within clinical practice. RECENT FINDINGS: In the field of
- Liquid biopsy in the clinical management of bladder cancer: current status and future developments.Related ArticlesLiquid biopsy in the clinical management of bladder cancer: current status and future developments. Expert Rev Mol Diagn. 2019 Oct 12;: Authors: Kouba E, Lopez-Beltran A, Montironi R, Massari F, Huang K, Santoni M, Chovanec M, Cheng M, Scarpelli M, Zhang J, Cimadamore A, Cheng L Abstract INTRODUCTION: The use of liquid biopsy on the blood from solid malignancies provides a convenient
- Portal Vein Embolization for Future Liver Remnant Enhancement and Combined Modality Treatment for the Management of Post-hepatic Resection Biliary Fistula in an 18-Month Old Child With Hepatoblastoma.Related ArticlesPortal Vein Embolization for Future Liver Remnant Enhancement and Combined Modality Treatment for the Management of Post-hepatic Resection Biliary Fistula in an 18-Month Old Child With Hepatoblastoma. Front Surg. 2019;6:54 Authors: Kannappan O, Keditsu K, Bhagat M, Shrimal A, Polnaya A, Kulkarni S, Qureshi SS Abstract Hepatic resection is the mainstay of treatment for hepatoblastoma.
- Checkpoint inhibitors plus chemotherapy for first-line treatment of advanced non-small cell lung cancer: a systematic review and meta-analysis of randomized controlled trials.Related ArticlesCheckpoint inhibitors plus chemotherapy for first-line treatment of advanced non-small cell lung cancer: a systematic review and meta-analysis of randomized controlled trials. Future Sci OA. 2019 Sep 25;5(9):FSO421 Authors: Tun AM, Thein KZ, Thein WL, Guevara E Abstract Background: We conducted a meta-analysis to evaluate the efficacy and safety of upfront add-on immunotherapy for adv
- Managing growing teratoma syndrome: new insights and clinical applications.Related ArticlesManaging growing teratoma syndrome: new insights and clinical applications. Future Sci OA. 2019 Oct 10;5(9):FSO419 Authors: Saso S, Galazis N, Iacovou C, Kappatou K, Tzafetas M, Jones B, Yazbek J, Lathouras K, Anderson J, Jiao LR, Smith RJ Abstract Although a recognized condition, growing teratoma syndrome (GTS) has no guidelines for management, and patients diagnosed with the conditi
- Impact of serum levels of IL-18 and soluble IL-2 receptor on the clinical outcome of patients with diffuse large B-cell lymphoma treated with R-CHOP regimen.Related ArticlesImpact of serum levels of IL-18 and soluble IL-2 receptor on the clinical outcome of patients with diffuse large B-cell lymphoma treated with R-CHOP regimen. Future Sci OA. 2019 Aug 28;5(9):FSO414 Authors: Khaled HM, Abdelhamid TM, Abu-Taleb FM, El-Hifnawi NM, Waley AB Abstract Aim & methods: To assess the impact of pretreatment serum levels of IL-18 and soluble IL-2 receptor (sIL-2R)
- Cryoablation and Immunotherapy: An Enthralling Synergy to Confront the Tumors.Related ArticlesCryoablation and Immunotherapy: An Enthralling Synergy to Confront the Tumors. Front Immunol. 2019;10:2283 Authors: Yakkala C, Chiang CL, Kandalaft L, Denys A, Duran R Abstract Treatment of solid tumors by ablation techniques has gained momentum in the recent years due to their technical simplicity and reduced morbidity as juxtaposed to surgery. Cryoablation is one of such techniques,
- Radiotherapy in India: History, current scenario and proposed solutions.Related ArticlesRadiotherapy in India: History, current scenario and proposed solutions. Indian J Cancer. 2019 Oct-Dec;56(4):359-363 Authors: Munshi A, Ganesh T, Mohanti BK Abstract The history and current status of a biomedical discipline in a country or region provide important health system indicators. During the last one hundred years, radiotherapy has established its position as a vital specialt
- Case Report: An Unusual Presentation of Bilateral Subclavian Stenosis in a Patient with Asymptomatic Hypotension.Related ArticlesCase Report: An Unusual Presentation of Bilateral Subclavian Stenosis in a Patient with Asymptomatic Hypotension. Am J Case Rep. 2019 Oct 14;20:1509-1514 Authors: Toh MR, Lee D, Damodharan K, Abdullah MA Abstract BACKGROUND Subclavian stenosis is an uncommon clinical condition associated with severe cardiovascular complications, usually presenting with claudication and subclavian stea
- A rare case of intranodal hemorrhagic spindle cell tumor with amianthoid fibers presenting as a suspicious lump in the groin.Related ArticlesA rare case of intranodal hemorrhagic spindle cell tumor with amianthoid fibers presenting as a suspicious lump in the groin. Int J Surg Case Rep. 2019 Oct 07;64:72-74 Authors: Nsour E, Al Khader A Abstract INTRODUCTION: Intranodal hemorrhagic spindle cell tumor with amianthoid fibers is extremely rare. PRESENTATION OF THE CASE: Herein, we present the case of a 58-year-old ma
- Total laparoscopic surgery for treatment of leiomyoma of the transverse colon in a patient with an abdominal mesh: A case report.Related ArticlesTotal laparoscopic surgery for treatment of leiomyoma of the transverse colon in a patient with an abdominal mesh: A case report. Int J Surg Case Rep. 2019 Oct 04;64:66-71 Authors: Fujimoto G, Osada S Abstract INTRODUCTION: Gastrointestinal stromal tumors are the most common mesenchymal tumors of the gastrointestinal tract; however, gastrointestinal leiomyomas are relatively rare. Sur
Gait & Posture
- Elongation differences between the sub-tendons of gastrocnemius medialis and lateralis during plantarflexion in different frontal plane position of the footPublication date: Available online 14 October 2019Source: Gait & PostureAuthor(s): Susann Wolfram, Emma F. Hodson-Tole, Christopher I. Morse, Keith L. Winwood, Islay M. McEwanAbstractBackgroundGastrocnemius medialis (GM) and lateralis (GL) act at the ankle complex in the sagittal and frontal planes and there is evidence that their actions can be somewhat uncoupled from each other. Some independence of GM and GL from each other could be advantageo
Latest Results for Journal of Anesthesia
- The protective effect of hydroxyethyl starch solution on the glycocalyx layer in an acute hemorrhage mouse modelAbstract Purpose Fluid therapy focused on glycocalyx (GCX) protection in hemorrhagic shock is a current focus of research. Hydroxyethyl starch (HES) solution is commonly used for fluid resuscitation; however, its effects on the GCX remain unclear. The primary aim of this study was to explore the protective effect of HES130 in maintaining GCX thickness and reducing plasma syndecan-1 exp
- Factors Contributing to the Preferred Method of Feeding in End-Stage Dementia: A Scoping ReviewAbstract Dementia is reported to be the overall fourth leading non-communicable cause of death, and accounted for almost two million deaths worldwide (3.5% of the total number) in 2016. Dysphagia and aspiration pneumonia secondary to dementia are the two most serious comorbidities. As the dementia progresses and the severity of an individual’s dysphagia increases, the question of whether to commence an artificial nutrition or a
- Changes in elastic properties of the nasal tip using Columellar strut graft versus tongue-in-groove method over one year after rhinoplastyAbstract Introduction In this study, we decided to investigate the changes in elasticity of the nasal tip using Columellar strut graft versus toung in groove method over a year after rhinoplasty. Materials and methods In this before-after randomized clinical trial study, 44 candidates for rhinoplasty were
Surgical Infections
- Influence of neurovascular mechanisms on response to tDCS: an exploratory studyAbstract The beneficial effects of transcranial direct current stimulation (tDCS) for stroke rehabilitation are limited by the variability in changes in corticomotor excitability (CME) after tDCS. Neuronal activity is closely related to cerebral blood flow; however, the cerebral hemodynamics of neuromodulation in relation to neural effects have been less explored. In this study, we examined the effects of tDCS on cerebral blo
- A single high-intensity exercise bout during early consolidation does not influence retention or relearning of sensorimotor locomotor long-term memoriesAbstract A single exercise bout has been found to improve the retention of a skill-based upper extremity motor task up to a week post-practice. This effect is the greatest when exercise intensity is high and exercise is administered immediately after motor practice (i.e., early in consolidation). Whether exercise can affect other motor learning types (e.g., sensorimotor adaptation) and tasks (e.g., walking) is still unclear a
- Learning and long-term retention of dynamic self-stabilization skillsAbstract In earlier studies, we had subjects use a joystick to balance themselves when seated in a device programmed to behave like an inverted pendulum. Subjects tested in a vertically oriented roll plane showed rapid learning for dynamically stabilizing themselves about the direction of balance when it corresponded with the direction of gravity. Subjects tested in a horizontally oriented roll plane, unlike the vertical roll
- The effects of risk magnitude training on mapping risks on spaceAbstract Risk perception has recently been shown to reveal a mental spatial representation, with people responding faster to low-risk items on the left side, and high-risk items on the right side. Subjective risk perception has a stronger spatial representation than objective risk perception; however, both reveal small effect sizes. With risk magnitude being a new domain within spatial mapping literature, we sought to explore
- Event-related potentials to single-cycle binaural beats of a pure tone, a click train, and a noiseAbstract There are only few electrophysiological studies on a phenomenon called “binaural beats” (BBs), which is experienced when two tones with frequencies close to each other are dichotically presented to the ears. And, there is no study in which the electrical responses of the brain to BBs of complex sounds are recorded and analyzed. Owing to a recent method based on single-cycle BB stimulation with sub-threshold temporary
- Effects of single-session cathodal transcranial direct current stimulation on tic symptoms in Tourette’s syndromeAbstract Tourette syndrome is a neurodevelopmental disorder characterised by motor and phonic tics. For some, tics can be managed using medication and/or forms of behavioural therapy; however, adverse side effects and access to specialist resources can be barriers to treatment. In this sham-controlled brain stimulation study, we investigated the effects of transcranial direct current stimulation (tDCS) on the occurrence of ti
- The development of visually guided steppingAbstract Adults use vision during stepping and walking to fine-tune foot placement. However, the developmental profile of visually guided stepping is unclear. We asked (1) whether children use online vision to fine-tune precise steps and (2) whether precision stepping develops as part of broader visuomotor development, alongside other fundamental motor skills like reaching. With 6-(N = 11), 7-(N = 11), 8-(N = 11)-year-olds an
- Prefrontal cortex activity induced by periodontal afferent inputs downregulates occlusal forceAbstract The prefrontal cortex (PFC) plays an important role in several cognitive functions, such as planning, decision making, and social behavior. We previously reported that periodontal sensory input significantly increases PFC activity during the motor task of maintaining occlusal (biting) force. However, the relationships between periodontal sensation, PFC activity, and the performance of motor tasks have not been evalua
- Bilateral subthalamic nucleus deep brain stimulation increases fixational saccades during movement preparation: evidence for impaired preparatory setAbstract People with Parkinson’s disease (PD) exhibit an increase in fixational saccades during the preparatory period prior to target onset in the antisaccade task and this increase is related to an increase in prosaccade errors in the antisaccade task. It was previously shown that bilateral, but not unilateral, subthalamic nucleus deep brain stimulation (STN DBS) in people with PD further increases the prosaccade error rate
- Interfacing Soft and Hard: A Spring Reinforced ActuatorSoft Robotics, Ahead of Print.
- Propranolol Accelerats Hemangioma Stem Cell Transformation Into Adipocyte.Related ArticlesPropranolol Accelerats Hemangioma Stem Cell Transformation Into Adipocyte. Ann Plast Surg. 2019 Nov;83(5):e5-e13 Authors: Li HH, Lou Y, Zhang RR, Xie J, Cao DS Abstract BACKGROUND: Infantile hemangioma (IH) is the most common childhood benign vascular tumor. Recently, propranolol has been found to be an effective therapy for IH, but its mechanism of action is not yet understood. Heman
- Herpetic Corneal Keratopathy Management Using Ipsilateral Supratrochlear Nerve Transfer for Corneal Neurotization.Related ArticlesHerpetic Corneal Keratopathy Management Using Ipsilateral Supratrochlear Nerve Transfer for Corneal Neurotization. Ann Plast Surg. 2019 Nov;83(5):553-557 Authors: Lin CH, Lai LJ Abstract BACKGROUND: Neurotrophic keratopathy (NK) is a potentially sight-threatening condition caused by impairment in the trigeminal corneal innervations with decrease or loss of corneal sensitivity. This pr
- A Modification of the Posterior Perichondrio-Adipo-Dermal Flap for Protruding Ear Correction: A Customized Technique.Related ArticlesA Modification of the Posterior Perichondrio-Adipo-Dermal Flap for Protruding Ear Correction: A Customized Technique. Ann Plast Surg. 2019 Nov;83(5):500-506 Authors: Ersen B Abstract Prominent ear deformity is a common congenital deformity of the external ear affecting 5% of the general population. Because of the deformity's displeasing nature, corrective prominent ear surgery is wide
- The Facilitator.Related ArticlesThe Facilitator. Ann Plast Surg. 2019 Nov;83(5):491-492 Authors: Hallock GG PMID: 31609803 [PubMed - in process]
- Hyaluronic Acid Filler Injections for Nasolabial Folds in Asian Patients: A Treatment Plan Based on a Practical Nasolabial Assessment Method.Related ArticlesHyaluronic Acid Filler Injections for Nasolabial Folds in Asian Patients: A Treatment Plan Based on a Practical Nasolabial Assessment Method. Ann Plast Surg. 2019 Oct 10;: Authors: Zhao M, Cai L, Li F, Han X Abstract BACKGROUND: There are multiple techniques used to inject hyaluronic acid to minimize the appearance of nasolabial folds. These techniques vary in accordance with the etio
- Surgical Reconstruction of Complex Distal Foot Defects With Vascularized Fascia Lata.Related ArticlesSurgical Reconstruction of Complex Distal Foot Defects With Vascularized Fascia Lata. Ann Plast Surg. 2019 Oct 11;: Authors: Liu M, Yang Y, Zhang Y, Yang X, Hu D Abstract BACKGROUND: Reconstruction of distal foot defect remains a challenge in plastic surgery. The purpose of this report is to present a new procedure that repairs these defects in severe burn patients. Results of applica
- Review of epiglottitis in the post Haemophilus influenzae type-b vaccine era.Related ArticlesReview of epiglottitis in the post Haemophilus influenzae type-b vaccine era. ANZ J Surg. 2018 11;88(11):1135-1140 Authors: Baird SM, Marsh PA, Padiglione A, Trubiano J, Lyons B, Hays A, Campbell MC, Phillips D Abstract BACKGROUND: This study reviewed the demographics, presentation, management, complications and outcomes of acute epiglottitis post Haemophilus influenzae type-b vaccine
- Defining the shape of the scapulothoracic gliding surfaceAbstract Purpose The aim of the study is to evaluate the difference in shape of the upper part and lower part of the Scapulothoracic Gliding Surface (STGS). Methods 3D-CT images of the thoracic cage of 50 patients were created in MIMICS ®. Three anatomical landmarks (insertion m. serratus anterior on 5th
- Os odontoideum: diagnosis and role of imagingAbstract Objective To elucidate the imaging manifestations of os odontoideum, establish the diagnosis and guide surgical therapy. Methods Clinical and imaging data, including X-ray, CT and MR of 24 patients with os odontoideum, were retrieved and reviewed retrospectively.
Case Reports in Pediatrics
- An Isolated Hypogonadotropic Hypogonadism due to a L102P Inactivating Mutation of KISS1R/GPR54 in a Large FamilyKISS1R (GPR54) mutations have been reported in several patients with congenital normosmic idiopathic hypogonadotropic hypogonadism (nIHH). We aim to describe in detail nIHH patients with KISS1R (GPR54) mutations belonging to one related extended family and to review the literature. A homozygous mutation (T305C) leading to a leucine substitution with proline (L102P) was found in three affected kindred (2 males and 1 female) from a consanguineous S
- In Response to RE: Uniformed Services University Women's Enrollment and Career Choices in Military Medicine: A Retrospective Descriptive Analysis.Related ArticlesIn Response to RE: Uniformed Services University Women's Enrollment and Career Choices in Military Medicine: A Retrospective Descriptive Analysis. Mil Med. 2019 Oct 11;: Authors: Cervero RM, Battista A, Schreiber-Gregory DN, Konopasky A, Torre D, Maggio LA, Boulet JR, Reamy BV, Durning SJ PMID: 31608382 [PubMed - as supplied by publisher]
- Time-restricted feeding in rest phase alters IgE/mast cell–mediated allergic reaction in micePublication date: Available online 14 October 2019Source: Allergology InternationalAuthor(s): Yuki Nakamura, Kayoko Ishimaru, Atsuhito Nakao
- Targeted Antibody Blocking by a Dual-Functional Conjugate of Antigenic Peptide and Fc-III Mimetics (DCAF).Related ArticlesTargeted Antibody Blocking by a Dual-Functional Conjugate of Antigenic Peptide and Fc-III Mimetics (DCAF). J Vis Exp. 2019 Sep 17;(151): Authors: Bai X, Zhang L, Hu J, Zhao X, Pan J, Deng H, Feng S Abstract Elimination of harmful antibodies from organisms is a valuable approach for the intervention of antibody-associated diseases, such as Dengue hemorrhagic fever and autoimmune diseas
- Stem Cell-Derived Viral Ag-Specific T Lymphocytes Suppress HBV Replication in Mice.Related ArticlesStem Cell-Derived Viral Ag-Specific T Lymphocytes Suppress HBV Replication in Mice. J Vis Exp. 2019 Sep 25;(151): Authors: Xiong X, Lei F, Haque M, Song J Abstract Hepatitis B virus (HBV) infection is a global health issue. With over 350 million people affected worldwide, HBV infection remains the leading cause of liver cancer. This is a major concern, especially in developing countri
- Single-Molecule Förster Resonance Energy Transfer Methods for Real-Time Investigation of the Holliday Junction Resolution by GEN1.Related ArticlesSingle-Molecule Förster Resonance Energy Transfer Methods for Real-Time Investigation of the Holliday Junction Resolution by GEN1. J Vis Exp. 2019 Sep 18;(151): Authors: Sobhy MA, Bralić A, Raducanu VS, Tehseen M, Ouyang Y, Takahashi M, Rashid F, Zaher MS, Hamdan SM Abstract Bulk methods measure the ensemble behavior of molecules, in which individual reaction rates of the underlying s
- Providing Meaningful Environmental Enrichment and Measuring Saliva Cortisol in Pigs Housed on Slatted Flooring.Related ArticlesProviding Meaningful Environmental Enrichment and Measuring Saliva Cortisol in Pigs Housed on Slatted Flooring. J Vis Exp. 2019 Sep 30;(151): Authors: Morgan L, Raz T Abstract As pork is the most consumed meat worldwide, the welfare of animals in the swine industry has increasingly become a major public concern, which imposes a substantial pressure coming from customers, legislators a
- Applying an eMASS Customization Program as a Research Tool to Evaluate Consumer Benefits.Related ArticlesApplying an eMASS Customization Program as a Research Tool to Evaluate Consumer Benefits. J Vis Exp. 2019 Sep 27;(151): Authors: Park M, Yoo J Abstract As many scholars and practitioners study personalization and relationship marketing, it is important to provide personalization such as mass customization through marketing technology. The purpose of this study is to examine how to con
- Establishing Single-Cell Based Co-Cultures in a Deterministic Manner with a Microfluidic Chip.Related ArticlesEstablishing Single-Cell Based Co-Cultures in a Deterministic Manner with a Microfluidic Chip. J Vis Exp. 2019 Sep 27;(151): Authors: He CK, Chen YW, Wang SH, Hsu CH Abstract Cell co-culture assays have been widely used for studying cell-cell interactions between different cell types to better understand the biology of diseases including cancer. However, it is challenging to clarify t
- Generation of Defined Genomic Modifications Using CRISPR-CAS9 in Human Pluripotent Stem Cells.Related ArticlesGeneration of Defined Genomic Modifications Using CRISPR-CAS9 in Human Pluripotent Stem Cells. J Vis Exp. 2019 Sep 25;(151): Authors: Cardenas-Diaz FL, Maguire JA, Gadue P, French DL Abstract Human pluripotent stem cells offer a powerful system to study gene function and model specific mutations relevant to disease. The generation of precise heterozygous genetic modifications is chall
- Quantification of Coenzyme A in Cells and Tissues.Related ArticlesQuantification of Coenzyme A in Cells and Tissues. J Vis Exp. 2019 Sep 27;(151): Authors: Frank MW, Subramanian C, Rock CO, Jackowski S Abstract Emerging research has revealed that the cellular coenzyme A (CoA) supply can become limiting with a detrimental impact on growth, metabolism and survival. Measurement of cellular CoA is a challenge due to its relatively low abundance and the
- Measuring Diurnal Rhythms in Autophagic and Proteasomal Flux.Related ArticlesMeasuring Diurnal Rhythms in Autophagic and Proteasomal Flux. J Vis Exp. 2019 Sep 17;(151): Authors: Ryzhikov M, Eubanks A, Haspel JA Abstract Cells employ several methods for recycling unwanted proteins and other material, including lysosomal and non-lysosomal pathways. The main lysosome-dependent pathway is called autophagy, while the primary non-lysosomal method for protein catabol
- Three-dimensional Angiogenesis Assay System using Co-culture Spheroids Formed by Endothelial Colony Forming Cells and Mesenchymal Stem Cells.Related ArticlesThree-dimensional Angiogenesis Assay System using Co-culture Spheroids Formed by Endothelial Colony Forming Cells and Mesenchymal Stem Cells. J Vis Exp. 2019 Sep 18;(151): Authors: Shah S, Lee H, Park YH, Jeon E, Chung HK, Lee ES, Shim JH, Kang KT Abstract Studies in the field of angiogenesis have been aggressively growing in the last few decades with the recognition that angiogenesis
- Stereotaxic Surgery for Implantation of Microelectrode Arrays in the Common Marmoset (Callithrix jacchus).Related ArticlesStereotaxic Surgery for Implantation of Microelectrode Arrays in the Common Marmoset (Callithrix jacchus). J Vis Exp. 2019 Sep 29;(151): Authors: Budoff SA, Rodrigues Neto JF, Arboés V, Nascimento MSL, Kunicki CB, Araújo MFP Abstract Marmosets (Callithrix jacchus) are small non-human primates that are gaining popularity in biomedical and preclinical research, including the neuroscienc
- Assay for Blood-brain Barrier Integrity in Drosophila melanogaster.Related ArticlesAssay for Blood-brain Barrier Integrity in Drosophila melanogaster. J Vis Exp. 2019 Sep 18;(151): Authors: Davis MJ, Talbot D, Jemc J Abstract Proper nervous system development includes the formation of the blood-brain barrier, the diffusion barrier that tightly regulates access to the nervous system and protects neural tissue from toxins and pathogens. Defects in the formation of thi
- Nanoscopic Imaging of Human Tissue Sections via Physical and Isotropic Expansion.Related ArticlesNanoscopic Imaging of Human Tissue Sections via Physical and Isotropic Expansion. J Vis Exp. 2019 Sep 25;(151): Authors: Klimas A, Bucur O, Njeri B, Zhao Y Abstract In modern pathology, optical microscopy plays an important role in disease diagnosis by revealing microscopic structures of clinical specimens. However, the fundamental physical diffraction limit prevents interrogation of
- Resolving Water, Proteins, and Lipids from In Vivo Confocal Raman Spectra of Stratum Corneum through a Chemometric Approach.Related ArticlesResolving Water, Proteins, and Lipids from In Vivo Confocal Raman Spectra of Stratum Corneum through a Chemometric Approach. J Vis Exp. 2019 Sep 26;(151): Authors: Zhang L, Cambron T, Niu Y, Xu Z, Su N, Zheng H, Wei K, Ray P Abstract Development of this in vivo confocal Raman spectroscopic method enables the direct measurement of water, proteins, and lipids with depth resolution in hu
- Cell Type-specific Gene Expression Profiling in the Mouse Liver.Related ArticlesCell Type-specific Gene Expression Profiling in the Mouse Liver. J Vis Exp. 2019 Sep 17;(151): Authors: Wang AW, Zahm AM, Wangensteen KJ Abstract Liver repopulation after injury is a crucial feature of mammals which prevents immediate organ failure and death after exposure of environmental toxins. A deeper understanding of the changes in gene expression that occur during repopulation
- Technical Detail for Robot Assisted Pancreaticoduodenectomy.Related ArticlesTechnical Detail for Robot Assisted Pancreaticoduodenectomy. J Vis Exp. 2019 Sep 28;(151): Authors: Kim AC, Rist RC, Zureikat AH Abstract Since its first report in 2003, robotic pancreaticoduodenectomy (RPD) has gained popularity among pancreatic surgeons. Inherent advantages of the robotic platform, including three-dimensional vision, wristed instruments, and improved ergonomics, all
- Enrichment of Pachytene Spermatocytes and Spermatids from Mouse Testes Using Standard Laboratory Equipment.Related ArticlesEnrichment of Pachytene Spermatocytes and Spermatids from Mouse Testes Using Standard Laboratory Equipment. J Vis Exp. 2019 Sep 17;(151): Authors: Da Ros M, Lehtiniemi T, Olotu O, Meikar O, Kotaja N Abstract To characterize each step of spermatogenesis, researchers must separate different subpopulations of germ cells from testes. However, isolating discrete populations is challenging,
- Purification of Human S100A12 and Its Ion-induced Oligomers for Immune Cell Stimulation.Related ArticlesPurification of Human S100A12 and Its Ion-induced Oligomers for Immune Cell Stimulation. J Vis Exp. 2019 Sep 29;(151): Authors: Fuehner S, Foell D, Kessel C Abstract In this protocol, we describe a method to purify human calcium-binding protein S100A12 and its ion-induced oligomers from Escherichia coli culture for immune cell stimulations. This protocol is based on a two-step chromat
- Light Spot-Based Assay for Analysis of Drosophila Larval Phototaxis.Related ArticlesLight Spot-Based Assay for Analysis of Drosophila Larval Phototaxis. J Vis Exp. 2019 Sep 27;(151): Authors: Sun Y, Zhou P, Zhao Q, Gong Z Abstract The larvae of Drosophila melanogaster show obvious light-avoiding behavior during the foraging stage. Drosophila larval phototaxis can be used as a model to study animal avoidance behavior. This protocol introduces a light-spot assay to inv
- Analyzing Satellite Cell Function During Skeletal Muscle Regeneration by Cardiotoxin Injury and Injection of Self-delivering siRNA In Vivo.Related ArticlesAnalyzing Satellite Cell Function During Skeletal Muscle Regeneration by Cardiotoxin Injury and Injection of Self-delivering siRNA In Vivo. J Vis Exp. 2019 Sep 18;(151): Authors: Ahrens HE, Henze H, Schüler SC, Schmidt M, Hüttner SS, von Maltzahn J Abstract Skeletal muscle possesses an enormous capacity to regenerate after injury. This process is mainly driven by muscle stem cells, al
- Screening and Identification of Small Peptides Targeting Fibroblast Growth Factor Receptor2 using a Phage Display Peptide Library.Related ArticlesScreening and Identification of Small Peptides Targeting Fibroblast Growth Factor Receptor2 using a Phage Display Peptide Library. J Vis Exp. 2019 Sep 30;(151): Authors: Zhao Y, Wang Q, Hong A, Chen X Abstract The human Fibroblast Growth Factor Receptor (FGFR) family comprises four members, namely, FGFR1, FGFR2, FGFR3, and FGFR4, that are involved in various biological activities incl
- Using Cholesky Decomposition to Explore Individual Differences in Longitudinal Relations between Reading Skills.Related ArticlesUsing Cholesky Decomposition to Explore Individual Differences in Longitudinal Relations between Reading Skills. J Vis Exp. 2019 Sep 17;(151): Authors: Erbeli F, Campbell AR, Hart SA Abstract The Cholesky decomposition method is the gold standard used in the field of behavioral genetics. The method is popular because it is easy to program and solve. Using this method, researchers can
- Characterizing the Relationship Between Eye Movement Parameters and Cognitive Functions in Non-demented Parkinson's Disease Patients with Eye Tracking.Related ArticlesCharacterizing the Relationship Between Eye Movement Parameters and Cognitive Functions in Non-demented Parkinson's Disease Patients with Eye Tracking. J Vis Exp. 2019 Sep 26;(151): Authors: Wong OWH, Fung GPC, Chan S Abstract Cognitive impairment is a common phenomenon in Parkinson's disease that has implications on the prognosis. A simple, noninvasive and objective proxy measurement
- Generation of Heterogeneous Drug Gradients Across Cancer Populations on a Microfluidic Evolution Accelerator for Real-Time Observation.Related ArticlesGeneration of Heterogeneous Drug Gradients Across Cancer Populations on a Microfluidic Evolution Accelerator for Real-Time Observation. J Vis Exp. 2019 Sep 19;(151): Authors: Lin KC, Torga G, Sun Y, Pienta KJ, Sturm JC, Austin RH Abstract Conventional cell culture remains the most frequently used preclinical model, despite its proven limited ability to predict clinical results in canc
- An Ectopic Chemokine Expression Model for Testing Macrophage Recruitment In Vivo.Related ArticlesAn Ectopic Chemokine Expression Model for Testing Macrophage Recruitment In Vivo. J Vis Exp. 2019 Sep 25;(151): Authors: Jiang Y, Chen J, Xu J Abstract Zebrafish are widely used in basic and biomedical research. Many zebrafish transgenic lines are currently available to label various types of cells. Owing to the transparent embryonic body of zebrafish, it is convenient for us to study
- Protocol to Create Chronic Wounds in Diabetic Mice.Related ArticlesProtocol to Create Chronic Wounds in Diabetic Mice. J Vis Exp. 2019 Sep 25;(151): Authors: Kim JH, Martins-Green M Abstract Chronic wounds develop as a result of defective regulation in one or more complex cellular and molecular processes involved in proper healing. They impact ~6.5M people and cost ~$40B/year in the US alone. Although a significant effort has been invested in underst
- Scratch Migration Assay and Dorsal Skinfold Chamber for In Vitro and In Vivo Analysis of Wound Healing.Related ArticlesScratch Migration Assay and Dorsal Skinfold Chamber for In Vitro and In Vivo Analysis of Wound Healing. J Vis Exp. 2019 Sep 26;(151): Authors: Belkacemi A, Laschke MW, Menger MD, Flockerzi V Abstract Impaired cutaneous wound healing is a major concern for patients suffering from diabetes and for elderly people, and there is a need for an effective treatment. Appropriate in vitro and i
- A Method for 3D Reconstruction and Virtual Reality Analysis of Glial and Neuronal Cells.Related ArticlesA Method for 3D Reconstruction and Virtual Reality Analysis of Glial and Neuronal Cells. J Vis Exp. 2019 Sep 28;(151): Authors: Calì C, Kare K, Agus M, Veloz Castillo MF, Boges D, Hadwiger M, Magistretti P Abstract Serial sectioning and subsequent high-resolution imaging of biological tissue using electron microscopy (EM) allow for the segmentation and reconstruction of high-resolutio
- Precision Measurements and Parametric Models of Vertebral Endplates.Related ArticlesPrecision Measurements and Parametric Models of Vertebral Endplates. J Vis Exp. 2019 Sep 17;(151): Authors: Feng H, Ziqi Z, Bin Y, Liu X, Duo S, Chaudhary SK, Tongde W, Li X, Ba Z, Wu D Abstract Detailed and comprehensive geometric data of vertebrae endplates is important and necessary to improve the fidelity of finite element models of the spine, design and ameliorate spinal implants
- Brain Infarct Segmentation and Registration on MRI or CT for Lesion-symptom Mapping.Related ArticlesBrain Infarct Segmentation and Registration on MRI or CT for Lesion-symptom Mapping. J Vis Exp. 2019 Sep 25;(151): Authors: Biesbroek JM, Kuijf HJ, Weaver NA, Zhao L, Duering M, Meta VCI Map Consortium, Biessels GJ Abstract In lesion-symptom mapping (LSM), brain function is inferred by relating the location of acquired brain lesions to behavioral or cognitive symptoms in a group of pa
- Isolation of Lamina Propria Mononuclear Cells from Murine Colon Using Collagenase E.Related ArticlesIsolation of Lamina Propria Mononuclear Cells from Murine Colon Using Collagenase E. J Vis Exp. 2019 Sep 26;(151): Authors: McManus D, Novaira HJ, Hamers AAJ, Pillai AB Abstract The intestine is the home to the largest number of immune cells in the body. The small and large intestinal immune systems police exposure to exogenous antigens and modulate responses to potent microbially der
- Investigating Alterations in Caecum Microbiota After Traumatic Brain Injury in Mice.Related ArticlesInvestigating Alterations in Caecum Microbiota After Traumatic Brain Injury in Mice. J Vis Exp. 2019 Sep 19;(151): Authors: Wen L, You W, Wang Y, Zhu Y, Wang H, Yang X Abstract Increasing evidence shows that the microbiota-gut-brain axis plays an important role in the pathogenesis of brain diseases. Several studies also demonstrate that traumatic brain injuries cause changes to the gu
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ΩτοΡινοΛαρυγγολόγος Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,
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Τρίτη 15 Οκτωβρίου 2019
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Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com,
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00302841026182,
00306932607174,
alsfakia@gmail.com,
Anapafseos 5 Agios Nikolaos 72100 Crete Greece,
Medicine by Alexandros G. Sfakianakis,
Telephone consultation 11855 int 1193
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