European Review » Neurology
- MicroRNA-132 promotes neurons cell apoptosis and activates Tau phosphorylation by targeting GTDC-1 in Alzheimer’s diseaseOBJECTIVE: Alzheimer’s disease (AD) is a neurodegenerative disorder with limited success in the prognosis of patients worldwide. The microRNA (miRNA) technology shows an encouraging trend in the therapeutics of AD. The study aimed to investigate the role of miR-132 and its underlying mechanism involving neuronal apoptosis and Tau phosphorylation in the pathophysiology of AD. MATERIALS AND METHODS: Frozen human postmortem brain samples and neuron
- Plasma concentration of ZCCHC14 contributes to prognostic efficacy in intracerebral hemorrhage patientsOBJECTIVE: Intracerebral hemorrhage (ICH) is a devastating cerebrovascular disease of the central nervous system. In this study, we aimed to investigate plasma ZCCHC14 expression and its correlation with the diagnosis, prognosis, and clinical features of ICH. PATIENTS AND METHODS: The plasma levels of ZCCHC14, TNF-α, IL-6, and IL-10 were dynamically detected among 130 ICH patients and 60 corresponding healthy subjects. A receiver operating chara
- MicroRNA-421 promotes inflammatory response of fibroblast-like synoviocytes in rheumatoid arthritis by targeting SPRY1OBJECTIVE: The aim of this study was to investigate whether microRNA-421 could participate in the proliferative, migratory and inflammatory changes of fibroblast-like synoviocytes (FLS) in rheumatoid arthritis by targeting SPRY1. PATIENTS AND METHODS: The expressions of microRNA-421 and SPRY1 in synovial tissues and FLS were detected by quantitative Real Time-Polymerase Chain Reaction (qRT-PCR) and Western blot, respectively. The binding conditi
Clinical Oral Investigations
- Correction to: Effect of Er:YAG laser etching on topography, microstructure, compressive strength, and bond strength of a universal adhesive to calcium silicate cementsFigure 2 was incorrect in the original published version of this article. Correct figure in presented here. The original article has been corrected.
- Are combined bleaching techniques better than their sole application? A systematic review and meta-analysisAbstract Objectives A systematic review and meta-analysis were performed to answer this research question: “Does combined in-office (IO) and at-home (AH) bleaching produce improved color change and lower tooth sensitivity (TS) better than solely AH or IO bleaching in adults?” Material and methods
- Experimental mucositis/gingivitis in persons aged 70 or over: microbiological findings and prediction of clinical outcomeAbstract Objectives To assess in persons aged 70 years or older the microbiological alterations occurring around implants and natural teeth during and after 3 weeks of undisturbed plaque accumulation. Furthermore, to test the predictive value of several markers at baseline for the extent of inflammation around implants and teeth after this period.
- Nuclear morphological changes in gingival epithelial cells of patients with periodontitisAbstract Objectives This study assessed the frequency of nuclear morphological changes in gingival epithelial cells, as a biomarker for DNA damage, in individuals with periodontitis, before and after implementation of periodontal therapy, and compared the morphology to those with healthy periodontal tissues. Mater
- Radiographic pattern of underlying dentin lesions (ICDAS 4) in permanent teethAbstract Objective To assess the radiographic pattern of underlying dentine shadows (UDS) in the occlusal surfaces of permanent teeth. Methods A total of 282 permanent posterior teeth pertaining to 91 individuals, 142 UDS and 140 non-cavitated enamel lesions (NCEL), were included for compari
- Changes in the oral health-related quality of life in adult patients with intellectual disabilities after dental treatment under general anesthesiaAbstract Objectives This study aimed to assess self- and proxy-rated changes in the oral health-related quality of life (OHRQoL) in adult patients with intellectual disabilities after dental treatment in general anesthesia. Methods The OHRQoL in 52 adult patients with intellectual and develo
- Dental caries are positively associated with periodontal disease severityAbstract Objectives To examine associations between periodontal disease severity and clinical and microbiological measures of caries in adults. Materials and methods A cross-sectional study of 94 healthy adults ((mean ± SD) 55.4 ± 13.0 years) was conducted. Data were collected by means of qu
- Influence of buffy coat–derived putative endothelial progenitor cells on tumor growth and neovascularization in oral squamous cell carcinoma xenograftsAbstract Objectives The aim of this murine in vivo study was to investigate whether buffy coat–derived putative endothelial progenitor cells (BCEPC) alter tumor growth and neovascularization in oral squamous cell carcinomas (OSCC). Materials and methods A murine xenograft model using the PCI
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- Reappraising Neurosurgical Residency in Nepal-Stepping Stone for Paradigm Shift from Its Current Perspectives.Related ArticlesReappraising Neurosurgical Residency in Nepal-Stepping Stone for Paradigm Shift from Its Current Perspectives. World Neurosurg. 2019 Sep 12;133:8-9 Authors: Munakomi S, Bajracharya A Abstract BACKGROUND: Nepal has a critical shortage of health workers for achieving its projected sustainable development goals pertaining to its health sector. METHODS: To counteract this crisis
- Sumo-associated traumatic vertebral artery dissection precipitating subarachnoid hemorrhage in association with bifid origins of the posterior inferior cerebellar artery.Related ArticlesSumo-associated traumatic vertebral artery dissection precipitating subarachnoid hemorrhage in association with bifid origins of the posterior inferior cerebellar artery. World Neurosurg. 2019 Oct 11;: Authors: Hoda H, Takami H, Graffeo CS, Hanakawa K, Komiyama M, Murao M, Ide T Abstract Traumatic vertebral artery dissection (tVAD) is frequently accompanied by cerebellar infarction, b
- A rare intracranial recurrent meningioma with unique co-existing atypical, papillary and lipomatous component - A case report with review of literature.Related ArticlesA rare intracranial recurrent meningioma with unique co-existing atypical, papillary and lipomatous component - A case report with review of literature. World Neurosurg. 2019 Oct 11;: Authors: Sadiya N, Halbe S, Ghosh M, Ghosh S Abstract BACKGROUND: Meningiomas are common Central Nervous System tumors with wide range of morphological variants, the pathogenesis being its complex embryo
- Negative Regulation of mTOR Signaling Restricts Cell Proliferation in the Floor Plate.Related ArticlesNegative Regulation of mTOR Signaling Restricts Cell Proliferation in the Floor Plate. Front Neurosci. 2019;13:1022 Authors: Kadoya M, Sasai N Abstract The neural tube is composed of a number of neural progenitors and postmitotic neurons distributed in a quantitatively and spatially precise manner. The floor plate, located in the ventral-most region of the neural tube, has a lot of un
- Stereological Analysis of Early Gene Expression Using Egr-1 Immunolabeling After Spreading Depression in the Rat Somatosensory Cortex.Related ArticlesStereological Analysis of Early Gene Expression Using Egr-1 Immunolabeling After Spreading Depression in the Rat Somatosensory Cortex. Front Neurosci. 2019;13:1020 Authors: Sosthenes MCK, Diniz DG, Roodselaar J, Abadie-Guedes R, de Siqueira Mendes FCC, Fernandes TN, Bittencourt JC, Diniz CWP, Anthony DC, Guedes RCA Abstract Early growth response-1 (Egr-1), defined as a zinc finger tra
- Somatosensation Evoked by Cortical Surface Stimulation of the Human Primary Somatosensory Cortex.Related ArticlesSomatosensation Evoked by Cortical Surface Stimulation of the Human Primary Somatosensory Cortex. Front Neurosci. 2019;13:1019 Authors: Kirin SC, Yanagisawa T, Oshino S, Edakawa K, Tanaka M, Kishima H, Nishimura Y Abstract Electrical stimulation of the primary somatosensory cortex using intracranial electrodes is crucial for the evocation of artificial somatosensations, typically tact
- Fluoxetine Exposure During Sexual Development Disrupts the Stress Axis and Results in Sex- and Time- Dependent Effects on the Exploratory Behavior in Adult Zebrafish Danio rerio.Related ArticlesFluoxetine Exposure During Sexual Development Disrupts the Stress Axis and Results in Sex- and Time- Dependent Effects on the Exploratory Behavior in Adult Zebrafish Danio rerio. Front Neurosci. 2019;13:1015 Authors: Vera-Chang MN, St-Jacques AD, Lu C, Moon TW, Trudeau VL Abstract The antidepressant fluoxetine (FLX), generally the first line of pharmacological treatment in adolescents
- Mutational Analysis of Sigma-1 Receptor's Role in Synaptic Stability.Related ArticlesMutational Analysis of Sigma-1 Receptor's Role in Synaptic Stability. Front Neurosci. 2019;13:1012 Authors: Ryskamp DA, Zhemkov V, Bezprozvanny I Abstract Sigma-1 receptor (S1R) is an endoplasmic reticulum (ER) resident transmembrane protein. In our previous experiments, we demonstrated neuroprotective effects of pridopidine, an agonist of S1R, in cellular and animal models of Hunting
- Disrupted Intraregional Brain Activity and Functional Connectivity in Unilateral Acute Tinnitus Patients With Hearing Loss.Related ArticlesDisrupted Intraregional Brain Activity and Functional Connectivity in Unilateral Acute Tinnitus Patients With Hearing Loss. Front Neurosci. 2019;13:1010 Authors: Zhou GP, Shi XY, Wei HL, Qu LJ, Yu YS, Zhou QQ, Yin X, Zhang H, Tao YJ Abstract Purpose: The present study combined fractional amplitude of low-frequency fluctuations (fALFF), regional homogeneity (ReHo), and functional conne
- Inflammation Induced Sensory Nerve Growth and Pain Hypersensitivity Requires the N-Type Calcium Channel Cav2.2.Related ArticlesInflammation Induced Sensory Nerve Growth and Pain Hypersensitivity Requires the N-Type Calcium Channel Cav2.2. Front Neurosci. 2019;13:1009 Authors: Pitake S, Middleton LJ, Abdus-Saboor I, Mishra SK Abstract Voltage-gated calcium channels (VGCCs) are important mediators of pain hypersensitivity during inflammatory states, but their role in sensory nerve growth remains underexplored.
- Conceptualization of a Parasympathetic Endocrine System.Related ArticlesConceptualization of a Parasympathetic Endocrine System. Front Neurosci. 2019;13:1008 Authors: Gorky J, Schwaber J Abstract We here propose a parasympathetic endocrine system (PES) comprised of circulating peptides released from secretory cells in the gut, significantly modulated by vagal projections from the dorsal motor nucleus of the vagus (DMV). While most of these gut peptides me
- Spatial Dynamic Functional Connectivity Analysis Identifies Distinctive Biomarkers in Schizophrenia.Related ArticlesSpatial Dynamic Functional Connectivity Analysis Identifies Distinctive Biomarkers in Schizophrenia. Front Neurosci. 2019;13:1006 Authors: Bhinge S, Long Q, Calhoun VD, Adali T Abstract Dynamic functional network connectivity (dFNC) analysis is a widely-used to study associations between dynamic functional correlations and cognitive abilities. Traditional methods analyze time-varying
- Brain Activity Correlates With Cognitive Performance Deterioration During Sleep Deprivation.Related ArticlesBrain Activity Correlates With Cognitive Performance Deterioration During Sleep Deprivation. Front Neurosci. 2019;13:1001 Authors: Posada-Quintero HF, Reljin N, Bolkhovsky JB, Orjuela-Cañón AD, Chon KH Abstract We studied the correlation between oscillatory brain activity and performance in healthy subjects performing the error awareness task (EAT) every 2 h, for 24 h. In the EAT, sub
- Musical Sound Quality as a Function of the Number of Channels in Modern Cochlear Implant Recipients.Related ArticlesMusical Sound Quality as a Function of the Number of Channels in Modern Cochlear Implant Recipients. Front Neurosci. 2019;13:999 Authors: Berg K, Noble J, Dawant B, Dwyer R, Labadie R, Richards V, Gifford R Abstract Objectives: This study examined musical sound quality (SQ) in adult cochlear implant (CI) recipients. The study goals were to determine: the number of channels needed for
- PLS3 Overexpression Delays Ataxia in Chp1 Mutant Mice.Related ArticlesPLS3 Overexpression Delays Ataxia in Chp1 Mutant Mice. Front Neurosci. 2019;13:993 Authors: Janzen E, Wolff L, Mendoza-Ferreira N, Hupperich K, Delle Vedove A, Hosseinibarkooie S, Kye MJ, Wirth B Abstract Many neurodegenerative disorders share common pathogenic pathways such as endocytic defects, Ca2+ misregulation and defects in actin dynamics. Factors acting on these shared pathways
- Retinal Phenotype in the rd9 Mutant Mouse, a Model of X-Linked RP.Related ArticlesRetinal Phenotype in the rd9 Mutant Mouse, a Model of X-Linked RP. Front Neurosci. 2019;13:991 Authors: Falasconi A, Biagioni M, Novelli E, Piano I, Gargini C, Strettoi E Abstract Retinal degeneration 9 (rd9) mice carry a mutation in the retina specific "Retinitis Pigmentosa GTPase Regulator (RPGR)" Open Reading Frame (ORF) 15 gene, located on the X chromosome and represent a rare mod
- Adult Goat Retinal Neuronal Culture: Applications in Modeling Hyperglycemia.Related ArticlesAdult Goat Retinal Neuronal Culture: Applications in Modeling Hyperglycemia. Front Neurosci. 2019;13:983 Authors: Sharma S, Chakravarthy H, Suresh G, Devanathan V Abstract Culture of adult neurons of the central nervous system (CNS) can provide a unique model system to explore neurodegenerative diseases. The CNS includes neurons and glia of the brain, spinal cord and retina. Neurons i
- Apolipoprotein E-Mimetic Peptide COG1410 Enhances Retinal Ganglion Cell Survival by Attenuating Inflammation and Apoptosis Following TONI.Related ArticlesApolipoprotein E-Mimetic Peptide COG1410 Enhances Retinal Ganglion Cell Survival by Attenuating Inflammation and Apoptosis Following TONI. Front Neurosci. 2019;13:980 Authors: Kuai L, Peng J, Jiang Y, Zheng Z, Zhou X Abstract Vision loss after traumatic optic nerve injury (TONI) is considered irreversible because of the retrograde loss of retinal ganglion cells (RGCs), which undergo i
- Effect of Task and Attention on Neural Tracking of Speech.Related ArticlesEffect of Task and Attention on Neural Tracking of Speech. Front Neurosci. 2019;13:977 Authors: Vanthornhout J, Decruy L, Francart T Abstract EEG-based measures of neural tracking of natural running speech are becoming increasingly popular to investigate neural processing of speech and have applications in audiology. When the stimulus is a single speaker, it is usually assumed that th
- Exposure in vivo Induced Changes in Neural Circuitry for Pain-Related Fear: A Longitudinal fMRI Study in Chronic Low Back Pain.Related ArticlesExposure in vivo Induced Changes in Neural Circuitry for Pain-Related Fear: A Longitudinal fMRI Study in Chronic Low Back Pain. Front Neurosci. 2019;13:970 Authors: Timmers I, de Jong JR, Goossens M, Verbunt JA, Smeets RJ, Kaas AL Abstract Exposure in vivo (EXP) is a cognitive-behavioral treatment aimed at reducing pain-related fear in chronic pain, and has proven successful in reduci
- Five Novel Genes Related to the Pathogenesis and Progression of Pancreatic Neuroendocrine Tumors by Bioinformatics Analysis With RT-qPCR Verification.Related ArticlesFive Novel Genes Related to the Pathogenesis and Progression of Pancreatic Neuroendocrine Tumors by Bioinformatics Analysis With RT-qPCR Verification. Front Neurosci. 2019;13:937 Authors: Xiao Y, Yang Y, Wang Y, Li X, Wang W Abstract Objective: To explore novel related genes and potential biomarkers of pancreatic neuroendocrine tumors (PanNETs). Materials and Methods: Two dat
Progress in Orthodontics - Latest Articles
- A novel customized ceramic bracket for esthetic orthodontics: in vitro studyThis study aims to develop a novel process to establish a standardized manufacturing technique of customized esthetic ceramic bracket system (CCB) which could be endowed with individual color and shape to sati...
- Oxidation of proline from the cyclin-binding motif in maize CDKA;1 results in lower affinity with its cyclin regulatory subunit.Related ArticlesOxidation of proline from the cyclin-binding motif in maize CDKA;1 results in lower affinity with its cyclin regulatory subunit. Phytochemistry. 2019 Oct 11;169:112165 Authors: Méndez AAE, Pena LB, Curto LM, Fernández MM, Malchiodi EL, Garza-Aguilar SM, Vázquez-Ramos JM, Gallego SM Abstract Cyclin dependent kinase A; 1 (CDKA; 1) is essential in G1/S transition of cell cycle and its ox
- Non-SMC condensin I complex subunit D2 is a prognostic factor in triple-negative breast cancer for the ability to promote cell cycle and enhance invasion.Related ArticlesNon-SMC condensin I complex subunit D2 is a prognostic factor in triple-negative breast cancer for the ability to promote cell cycle and enhance invasion. Am J Pathol. 2019 Oct 11;: Authors: Zhang Y, Liu F, Zhang C, Ren M, Kuang M, Xiao T, Di X, Feng L, Fu L, Cheng S Abstract Triple-negative breast cancer (TNBC) is a heterogeneous disease with an unfavorable prognosis and no specific
- Circular RNA Pleiotrophin promotes carcinogenesis in glioma via regulation of microRNA-122/SRY-box transcription factor 6 axis.Related ArticlesCircular RNA Pleiotrophin promotes carcinogenesis in glioma via regulation of microRNA-122/SRY-box transcription factor 6 axis. Eur J Cancer Prev. 2019 Oct 11;: Authors: Chen C, Deng L, Nie DK, Jia F, Fu LS, Wan ZQ, Lan Q Abstract BACKGROUND: Circular RNAs (circRNAs) are recently identified as gene regulators in mammals and play important roles in carcinogenesis of cancer. For example
- Mycophenolic Acid is a Drug with the Potential to be Repurposed for Suppressing Tumour Growth and Metastasis in Osteosarcoma Treatment.Related ArticlesMycophenolic Acid is a Drug with the Potential to be Repurposed for Suppressing Tumour Growth and Metastasis in Osteosarcoma Treatment. Int J Cancer. 2019 Oct 14;: Authors: Klangjorhor J, Chaiyawat P, Teeyakasem P, Sirikaew N, Phanphaisarn A, Settakorn J, Lirdprapamongkol K, Yama S, Svasti J, Pruksakorn D Abstract Our previous review of proteomics data showed that in osteosarcoma, som
- In vivo acute toxicity evaluation and in vitro molecular mechanism study of antiproliferative activity of a novel indole Schiff base β-diiminato manganeseIII complex in hormone-dependent and triple negative breast cancer cells.Related ArticlesIn vivo acute toxicity evaluation and in vitro molecular mechanism study of antiproliferative activity of a novel indole Schiff base β-diiminato manganeseIII complex in hormone-dependent and triple negative breast cancer cells. PeerJ. 2019;7:e7686 Authors: Farghadani R, Seifaddinipour M, Rajarajeswaran J, Abdulla MA, Mohd Hashim NB, Khaing SL, Salehen NB Abstract Breast cancer is the
- Eupalinolide J Suppresses the Growth of Triple-Negative Breast Cancer Cells via Targeting STAT3 Signaling Pathway.Related ArticlesEupalinolide J Suppresses the Growth of Triple-Negative Breast Cancer Cells via Targeting STAT3 Signaling Pathway. Front Pharmacol. 2019;10:1071 Authors: Lou C, Chen Y, Zhang J, Yang B, Zhao H Abstract Persistent activation of STAT3 plays an important role in the development of triple-negative breast cancer (TNBC), and suppression of STAT3 is considered as a novel approach for cancer
- [Expression Analysis and Epigenetics of MicroRNA-28-5p in Multiple Myeloma].Related Articles[Expression Analysis and Epigenetics of MicroRNA-28-5p in Multiple Myeloma]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2019 Oct;27(5):1540-1547 Authors: Gao YN, Ma YP Abstract OBJECTIVE: To investigate the expression, mechanism and methylation level of miR-28-5p in multiple myeloma (MM), so as to provide the expirement basis for searching new targeted therapy. METHODS: RT-PCR was u
- [Effect of Asparaginase on Diffuse Large B-Cell Lymphoma Cell Apoptosis and Its Related Mechanism].Related Articles[Effect of Asparaginase on Diffuse Large B-Cell Lymphoma Cell Apoptosis and Its Related Mechanism]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2019 Oct;27(5):1482-1489 Authors: Gao X, Jiao J, Liu MD, Qin YY, Xu LY, Sang W, Xu KL Abstract OBJECTIVE: To investigate the effects and its potential mechanism of asparaginase on proliferation, cell cycle and apoptosis of diffuse large B-cell lymphom
- [Effect of Quercetin on Wnt/β-Catenin Signal Pathway of K562 and K562R Cells].Related Articles[Effect of Quercetin on Wnt/β-Catenin Signal Pathway of K562 and K562R Cells]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2019 Oct;27(5):1409-1415 Authors: Li W, Zhao Y, Qiu L, Ma J Abstract OBJECTIVE: To investigate the effect of Quercetin (Qu) on cell proliferation, apoptosis and cell cycle, as well as the expression changes of Wnt/β-catenin signaling pathway, apoptosis and cell cycle regu
- Bub1 is not essential for the checkpoint response to unattached kinetochores in diploid human cells.Related ArticlesBub1 is not essential for the checkpoint response to unattached kinetochores in diploid human cells. Curr Biol. 2018 09 10;28(17):R929-R930 Authors: Currie CE, Mora-Santos M, Smith CA, McAinsh AD, Millar JBA Abstract Error-free chromosome segregation during mitosis depends on a functional spindle assembly checkpoint (SAC). The SAC is a multi-component signalling system that is recruit
- (-)-Gochnatiolide B, synthesized from dehydrocostuslactone, exhibits potent anti-bladder cancer activity in vitro and in vivo.Related Articles(-)-Gochnatiolide B, synthesized from dehydrocostuslactone, exhibits potent anti-bladder cancer activity in vitro and in vivo. Sci Rep. 2018 06 11;8(1):8807 Authors: Chen Y, Li W, Zeng Z, Tang Y Abstract With limited success achieved in bladder cancer patient management, novel agents are in urgent need for the purpose of therapy and prevention. As a sesquiterpenoid dimmer isolated fro
ΩτοΡινοΛαρυγγολόγος Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,
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Τρίτη 15 Οκτωβρίου 2019
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Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com,
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00302841026182,
00306932607174,
alsfakia@gmail.com,
Anapafseos 5 Agios Nikolaos 72100 Crete Greece,
Medicine by Alexandros G. Sfakianakis,
Telephone consultation 11855 int 1193
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