Medgadget
- Deep Learning Spots Organs on CT Scans to Prevent Radiation DamageRadiotherapy is a well established method for attacking tumors within the body. There are a number of techniques that are used to administer radiation to a lesion, but they all come with the risk of injuring nearby tissues and organs. Gamma beams and other directed high energy devices result in the exposure of all the tissues that are on the way to and on the other side of a target, which is a serious problem. Knowing where the important organs a
Analytical Chemistry
- [ASAP] Pseudo-Multiple Reaction Monitoring (Pseudo-MRM) Mode on the “Brick” Mass Spectrometer, Using the Grid-SWIFT WaveformAnalytical ChemistryDOI: 10.1021/acs.analchem.9b03315
- [ASAP] Tandem Ion Mobility Spectrometry for the Detection of Traces of Explosives in Cargo at Concentrations of Parts Per QuadrillionAnalytical ChemistryDOI: 10.1021/acs.analchem.9b03589
- [ASAP] Rapid Characterization of Multiple-Contact Miscibility: Toward a Slim-Tube on a ChipAnalytical ChemistryDOI: 10.1021/acs.analchem.9b02893
- [ASAP] Single-Molecule Topochemical Analyses for Large-Scale Multiplexing TasksAnalytical ChemistryDOI: 10.1021/acs.analchem.9b02483
- [ASAP] Quantification of Analyte Concentration in the Single Molecule Regime Using Convolutional Neural NetworksAnalytical ChemistryDOI: 10.1021/acs.analchem.9b03599
Radiation Molecular Biology.
- A multicentre phase II study of hypofractionated stereostatic boost in intermediate risk prostate carcinoma: a 5-year analysis of the CKNO-PRO trialPublication date: Available online 8 October 2019Source: International Journal of Radiation Oncology*Biology*PhysicsAuthor(s): David Pasquier, Didier Peiffert, Philippe Nickers, Philippe Maingon, Pascal Pommier, Thomas Lacornerie, Geoffrey Martinage, Emmanuelle Tresch, Eric LartigauAbstractBackgroundThe aim of this analysis was to assess the 5-year tolerance and survival in patients undergoing hypofractionated stereotactic boost after external be
Royal Society of Chemistry (Great Britain) Society for Analytical Chemistry Society of Public Analysts (Great Britain)
- Differential Presentation of a Single Antimicrobial Peptide is Sufficient to Identify LPS from Distinct Bacterial SamplesAnalyst, 2019, Accepted ManuscriptDOI: 10.1039/C9AN01781J, PaperTimothy Reichart, Joshua R. Uzarski, Charlene MelloRapid detection and identification of bacteria is important for human health, biodefense, and food safety. Small arrays of different antimicrobial peptides (AMPs) enable identification of lipopolysaccharide (LPS) samples from a...The content of this RSS Feed (c) The Royal Society of Chemistry
- Quantitative and specific detection of cancer-related microRNAs in living cells using surface-enhanced Raman scattering imaging based on hairpin DNA-functionalized gold nanocagesAnalyst, 2019, Accepted ManuscriptDOI: 10.1039/C9AN01579E, PaperZhenyu Wang, Jin Xue, Caili Bi, Heng Xin, Youwei Wang, Xiaowei CaoVariations in the intracellular expression level of cancer-related miroRNAs (miRNAs) were connected with worsening tumor progression. A simple, accurate, and sensitive analytical method for imaging and detection of intracellular miRNA...The content of this RSS Feed (c) The Royal Society of Chemistry
- Expression pattern of androgen receptors, AR-V7 and AR-567es, in circulating tumor cells and paired plasma-derived extracellular vesicles in metastatic castration resistant prostate cancerAnalyst, 2019, Advance ArticleDOI: 10.1039/C9AN00999J, PaperAreti Strati, Martha Zavridou, Evangelos Bournakis, Sophia Mastoraki, Evi LianidouAndrogen-receptor splice variant 7 (AR-V7) is a highly promising liquid biopsy predictive biomarker showing primary or acquired resistance to novel androgen receptor signaling inhibitors in metastatic castration resistant prostate cancer (mCRPC).To cite this article before page numbers are assigned, use the
- A hairpin DNAs-fueled nanoflare for simultaneous illuminating two microRNAs in drug-induced nephrotoxic cells with target catalytic recycling amplificationAnalyst, 2019, Accepted ManuscriptDOI: 10.1039/C9AN01902B, PaperHan Gao, Jiwei Li, Yuran Jia, xie-an Yu, Jin Qi, Jiangwei Tian, Bo-Yang YuThe detection of specific extracellular microRNAs (miRNAs) is beneficial for the prediction of drug-induced kidney injury. Here, a novel hairpin DNAs-fueled nanoflare has been developed for simultaneous detection of drug-induced...The content of this RSS Feed (c) The Royal Society of Chemistry
- Model-Based High-Definition Dynamic Contrast Enhanced MRI for Concurrent Estimation of Perfusion and Microvascular PermeabilityPublication date: Available online 8 October 2019Source: Medical Image AnalysisAuthor(s): Joon Sik Park, Eunji Lim, Seung-Hong Choi, Chul-Ho Sohn, Joonyeol Lee, Jaeseok ParkAbstractThis work introduces a model-based, high-definition dynamic contrast enhanced (DCE) MRI for concurrent estimation of perfusion and microvascular permeability over the whole brain. A time series of reference-subtracted signals is decomposed into one component that refle
- REFUGE Challenge: A Unified Framework for Evaluating Automated Methods for Glaucoma Assessment from Fundus PhotographsPublication date: Available online 8 October 2019Source: Medical Image AnalysisAuthor(s): José Ignacio Orlando, Huazhu Fu, João Barbossa Breda, Karel van Keer, Deepti R. Bathula, Andrés Diaz-Pinto, Ruogu Fang, Pheng-Ann Heng, Jeyoung Kim, JoonHo Lee, Joonseok Lee, Xiaoxiao Li, Peng Liu, Shuai Lu, Balamurali Murugesan, Valery Naranjo, Sai Samarth R. Phaye, Sharath M. Shankaranarayana, Apoorva Sikka, Jaemin SonAbstractGlaucoma is one of the leading
- Expression of co-inhibitory molecules B7-H4 and B7-H1 in Epstein-Barr Virus positive Diffuse Large B-Cell Lymphoma and their roles in tumor invasionPublication date: Available online 7 October 2019Source: Pathology - Research and PracticeAuthor(s): Ying Jiang, Jun Lin, Jing Zhang, Shasha Lu, Chun Wang, Yin TongAbstractTo investigate the relationship between immunoregulatory molecules B7-H4 and B7-H1 in Epstein-Barr positive diffuse large B-cell lymphoma (EBV+DLBCL). Immunohistochemistry was used to detect the expression of B7-H4 and B7-H1 in tumor tissues of 13 patients with EBV+DLBCL. The e
- The Jewish Pathologist Carl Julius Rothberger (1871-1945) and the gradual deprivation of his rights in the Third ReichPublication date: Available online 7 October 2019Source: Pathology - Research and PracticeAuthor(s): Dominik Gross, Christina LaursAbstractThe Jewish pathologist Carl Julius Rothberger (1871-1945) is undoubtedly one of the most important representatives of his field. His studies on atrial fibrillation, the bundle branch block and arrhythmia perpetua in particular secured him a place in medical history. Rothberger also gave the name to an agar use
Journal of Biophotonics
- Spatially‐resolved diffuse imaging for high‐speed depth estimation of jet injectionAbstract We investigate the use of spatially‐resolved diffuse imaging to track a fluid jet delivered at high speed into skin tissue. A jet injector with a short needle to deliver drugs beneath the dermis, is modified to incorporate a laser beam into the jet, which is ejected into ex vivo porcine tissue. The diffuse light emitted from the side and top of the tissue sample is recorded using high‐speed videography. Similar experiments, using a dept
Journal of Medical Case Reports - Latest Articles
- Acute inferior ST-elevation myocardial infarction due to delirium tremens: a case reportDelirium tremens is a severe form of alcohol withdrawal syndrome. Literature documenting acute coronary events in the setting of alcohol withdrawal remains scarce. An accepted hypothesis for the underlying pro...
- Myhre syndrome: A first familial recurrence and broadening of the phenotypic spectrumAbstract Myhre syndrome is a rare multisystem connective tissue disorder, characterized by short stature, facial dysmorphology, variable intellectual disability, skeletal abnormalities, arthropathy, cardiopathy, laryngotracheal anomalies, and stiff skin. So far, all molecularly confirmed cases harbored a de novo heterozygous gain‐of‐function mutation in SMAD4, encoding the SMAD4 transducer protein required for both transforming growth factor‐bet
- The brown bear as a translational model for sedentary lifestyle related diseasesAbstract Sedentary lifestyle accelerates biological aging, is a major risk factor for developing metabolic syndrome and is associated with cardiovascular disease, diabetes mellitus, kidney failure, sarcopenia and osteoporosis. In contrast to the linear path to worsening health in humans with metabolic syndrome, brown bears have developed a circular metabolic plasticity enabling these animals to tolerate obesity and a “sedentary lifestyle” during
G3: .Genes, Genomes, Genetics Mission - Online First Articles
- Targeted Forward Genetics: Population-Scale Analyses of Allele Replacements Spanning Thousands of Base Pairs in Fission YeastPrecise allele replacement (genome editing), without unwanted changes to the genome, provides a powerful tool to define the functions of DNA elements and encoded factors in their normal biological context. While CRISPR is now used extensively for gene targeting, its utility for precise allele replacement at population scale is limited because: (A) there is a strict requirement for a correctly positioned PAM motif to introduce recombinogenic dsDNA
- Inference of Selection from Genetic Time Series Using Various Parametric Approximations to the Wright-Fisher ModelDetecting genomic regions under selection is an important objective of population genetics. Typical analyses for this goal are based on exploiting genetic diversity patterns in present time data but rapid advances in DNA sequencing have increased the availability of time series genomic data. A common approach to analyze such data is to model the temporal evolution of an allele frequency as a Markov chain. Based on this principle, several methods
International journal of basic and clinical endocrinology
- Clinicopathological correlations of mesenteric fibrosis and evaluation of a novel biomarker for fibrosis detection in small bowel neuroendocrine neoplasmsAbstract Purpose Mesenteric fibrosis (MF) in small intestinal neuroendocrine neoplasms (SINENs) is often associated with significant morbidity and mortality. The detection of MF is usually based on radiological criteria, but no previous studies have attempted a prospective, multidimensional assessment of mesenteric desmoplasia to determine the accuracy of radiological measurements. The
- TLR4 knockout can improve dysfunction of β-cell by rebalancing proteomics disorders in pancreas of obese ratsAbstract Purpose Studies showed that TLR4 knockout (TLR4KO) could mitigate obesity and insulin resistance induced by high-fat diet in rats. In this study, we further investigated the effects of TLR4KO on islet function and pancreatic proteomics in obese rats by high-fat diet. Methods PA-induced lipotoxici
- CorrigendumPublication date: Available online 7 October 2019Source: Journal of Oral and Maxillofacial SurgeryAuthor(s):
- Clinicopathological features of peripheral ossifying fibroma in a series of 41 patientsPublication date: Available online 8 October 2019Source: British Journal of Oral and Maxillofacial SurgeryAuthor(s): H. Lázare, A. Peteiro, M. Pérez Sayáns, P. Gándara-Vila, J. Caneiro, A. García-García, I. Antón, J.M. Gándara-Rey, J.M. Suárez-PeñarandaAbstractPeripheral ossifying fibromas are benign mesenchymal lesions that usually arise in the anterior maxilla of young female patients. Histologically they consist of spindle cell proliferation w
- Re: adjuvant radiation in early oral cancers with isolated perineural invasionPublication date: Available online 8 October 2019Source: British Journal of Oral and Maxillofacial SurgeryAuthor(s): S.S. Shetty, A. Kudpaje, V. Rao, R. Jayaraj
- Repeat surgery after decompressive craniectomy for traumatic intracranial hemorrhage: outcomes and predictorsPublication date: Available online 8 October 2019Source: World NeurosurgeryAuthor(s): Matthews Lan, Robert J. Dambrino, Andrew Youssef, Aaron Yengo-Kahn, Michael C. Dewan, Jesse Ehrenfeld, Christopher M. Bonfield, Scott L. ZuckermanAbstractIntroductionRepeat surgery (RS) after decompressive craniectomy/craniotomy (DC) for traumatic intracranial hemorrhage (TICH) is a devastating complication. In patients undergoing DC for TICH, we sought to: a) d
- Cancer-associated fibroblasts in the tumor microenvironment of tongue carcinoma is a heterogeneous cell populationPublication date: Available online 8 October 2019Source: Acta HistochemicaAuthor(s): Marilena Vered, Anna Shnaiderman-Shapiro, Ayelet Zlotogorski-Hurvitz, Tuula Salo, Ran YahalomAbstractObjectivesTo examine different immunophenotypes of cancer-associated fibroblasts (CAFs) in tongue squamous cell carcinoma (TSCC) and to investigate how they related to clinical outcomes.MethodsSerial sections from 54 cases of TSCC were immunohistochemically staine
- AnnouncementsPublication date: October 2019Source: Journal of Cranio-Maxillofacial Surgery, Volume 47, Issue 10Author(s):
- Editorial BoardPublication date: October 2019Source: Journal of Cranio-Maxillofacial Surgery, Volume 47, Issue 10Author(s):
- EACMFS Prizes & AwardsPublication date: October 2019Source: Journal of Cranio-Maxillofacial Surgery, Volume 47, Issue 10Author(s):
Mediators of Inflammation
- IL-37 Plays a Beneficial Role in Patients with Acute Coronary SyndromeBackground. Interleukin-37 (IL-37) acts as an inhibitor of innate and adaptive immunity. However, the exact role of IL-37 in the patients with acute coronary syndrome (ACS) remains to be elucidated. Methods. Patients were classified into 4 groups: normal coronary artery (NCA), stable angina (SA), unstable angina (UA), and acute myocardial infarction (AMI). The circulating Treg, Th1, and Th17 frequencies were measured. The effect of IL-37 on stimu
- Cell-Type-Specific Transcription of Innate Immune Regulators in response to HMPV InfectionHuman metapneumovirus (HMPV) may cause severe respiratory disease. The early innate immune response to viruses like HMPV is characterized by induction of antiviral interferons (IFNs) and proinflammatory immune mediators that are essential in shaping adaptive immune responses. Although innate immune responses to HMPV have been comprehensively studied in mice and murine immune cells, there is less information on these responses in human cells, comp
- Nitrate Poisoning due to Ingestion of Cabbages (Brassica oleracea var. capitata L.) (Brassicaceae) in Kitui County, KenyaNitrate toxicosis associated with consumption of cabbages (Brassica oleracea var. capitata L.) (Brassicaceae) was diagnosed in a small herd comprising of ten goats in Matinyani ward, Kitui West sub-County of Kitui County in Kenya. The clinical signs were ataxia, ruminal tympany, bluish-brown mucous membranes, rapid and difficult breathing, incoordination, head pressing, aggressive movements, jugular distension, increased heart rates, tremors, and
Mark Allen Group: British Journal of Nursing: Table of Contents
- British Journal of Nursing, Volume 28, Issue 18, Page 1213-1213, October 2019.British Journal of Nursing, Volume 28, Issue 18, Page 1213-1213, October 2019.
- Reliability and minimum detectable change of measures of gait in children during walking and running on an instrumented treadmillPublication date: Available online 7 October 2019Source: Gait & PostureAuthor(s): Simon C. McSweeney, Lloyd F. Reed, Scott C. WearingAbstractBackgroundInstrumented treadmills that incorporate pressure platforms are increasingly used to characterize gait in children. Although footprint size is known to influence the measurement performance of pressure platforms, published evidence on the reliability of such systems for children’s gait is lacking.R
Respiration
- Rheumatoid Arthritis-Associated Interstitial Lung Disease: Clinical Characteristics and Predictors of MortalityIntroduction: Interstitial lung disease (ILD) is a serious extraarticular manifestation of rheumatoid arthritis (RA), but no evidence-based therapy exists. Ongoing studies investigate the role of antifibrotic therapies for progressive fibrosing ILD (PF-ILD), including RA-ILD. The aim of the present study was to investigate the frequency of PF-ILD and the clinical characteristics of RA-ILD in a well-characterised, population-based cohort. Methods:
- Interferon-Gamma and Tumor Necrosis Factor-Related Weak Inducer of Apoptosis Expression in Neoangiogenesis in Colorectal Polypoid LesionsBackground: Interferon gamma (IFNγ) and tumor necrosis factor-related weak inducer of apoptosis (TWEAK) molecules seem to have a potential effect on angiogenic factors such as vascular endothelial growth factor (VEGF). The aim of this study was to assess a possible interplay between IFNγ and TWEAK cytokines and VEGF machinery in the different steps of colorectal carcinogenesis. Methods: A total of 92 subjects with colonic adenoma or cancer who un
Parasite
- Sleeping sickness in the historical focus of forested Guinea: update using a geographically based methodAuthors: Fabrice Courtin, Oumou Camara, Mamadou Camara, Moïse Kagbadouno, Bruno Bucheton, Philippe Solano and Vincent Jamonneau.Parasite Vol. 26 , page 61Published online: 10/10/2019 Keywords: Sleeping sickness ; Trypanosoma brucei gambiense ; Guinea ; Geography ; Risk ; Elimination.<img src="http://feeds.feedburner.com/~r/edp_parasite/~4/mlXVDij4OdA" height="1" width="1" alt=""/>
- A Case of Non-Resolving MEK Inhibitor-Associated RetinopathyThe mitogen-activated kinase pathway plays an important role in cell survival, and its dysregulation is associated with cancers such as melanoma. Drugs designed to target this pathway have been associated with serous retinal detachments in a new entity termed MEK inhibitor-associated retinopathy (MEKAR). MEKAR has classically been described as self-limiting, with serous fluid often resolving without discontinuation of the drug. We present a case
Πέμπτη 10 Οκτωβρίου 2019
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