• Genome-wide CRISPR/Cas9 library screening identified PHGDH as a critical driver for Sorafenib resistance in HCC

  Nature Communications, Published online: 15 October 2019; doi:10.1038/s41467-019-12606-7Resistance to the tyrosine kinase inhibitor Sorafenib, which is the standard treatment for advanced hepatocellular carcinoma, is a major clinical challenge. Here, the authors show that phosphoglycerate dehydrogenase, a key enzyme in the serine synthesis pathway, drives sorafenib resistance.

  Nature Communications - current - nature.com science feeds

  Mon Oct 14, 2019 17:00
• Scale-invariant magnetic textures in the strongly correlated oxide NdNiO₃

  Nature Communications, Published online: 15 October 2019; doi:10.1038/s41467-019-12502-0The many strongly interacting degrees of freedom in transition metal oxides make it difficult to capture and describe the nature of their metal-insulator transitions. Li et al. show that a resonant magnetic X-ray nanoprobe gives access to local critical behavior that is difficult to detect otherwise.

  Nature Communications - current - nature.com science feeds

  Mon Oct 14, 2019 17:00
• Statistical learning goes beyond the <i>d</i>-band model providing the thermochemistry of adsorbates on transition metals

  Nature Communications, Published online: 15 October 2019; doi:10.1038/s41467-019-12709-1Assessing catalytic mechanisms using DFT calculations greatly aids catalyst design, but is impractical for large molecules. Here the authors develop a statistical learning-based thermochemical model for estimating adsorption of organics onto metals, retaining DFT accuracy while reducing the number of calculations by a factor of 20.

  Nature Communications - current - nature.com science feeds

  Mon Oct 14, 2019 17:00
• Embryonic mesothelial-derived hepatic lineage of quiescent and heterogenous scar-orchestrating cells defined but suppressed by WT1

  Nature Communications, Published online: 15 October 2019; doi:10.1038/s41467-019-12701-9Activated hepatic stellate cells of putative mesodermal origin orchestrate scarring during injury. Here, the authors define a discrete morphologically plastic lineage of embryonic mesothelial-derived scar-orchestrating cells, through a distinct quiescent adult precursor, defined and paradoxically inhibited by WT1.

  Nature Communications - current - nature.com science feeds

  Mon Oct 14, 2019 17:00
• The TLR7/8 agonist R848 remodels tumor and host responses to promote survival in pancreatic cancer

  Nature Communications, Published online: 15 October 2019; doi:10.1038/s41467-019-12657-wIn the treatment of pancreatic ductal adenocarcinoma (PDAC), comorbidities such as cachexia limit quality of life and survival. Here, the authors show TLR7/8 agonist R848 remodels host and tumour immune responses, promoting survival and attenuating cachexia in murine models of PDAC.

  Nature Communications - current - nature.com science feeds

  Mon Oct 14, 2019 17:00
• Pathogenesis of hypertension in a mouse model for human <i>CLCN2</i> related hyperaldosteronism

  Nature Communications, Published online: 15 October 2019; doi:10.1038/s41467-019-12113-9Mutations in the chloride channel ClC-2 have been found in primary aldosteronism (PA). Here, Göppner et al. generate transgenic mice expressing a mutant form of ClC-2 that displays increased chloride currents like patient mutations, and find it recapitulates the key pathological features of PA.

  Nature Communications - current - nature.com science feeds

  Mon Oct 14, 2019 17:00
• Resonant catalysis of thermally activated chemical reactions with vibrational polaritons

  Nature Communications, Published online: 15 October 2019; doi:10.1038/s41467-019-12636-1Strong coupling of molecular vibrations to an optical cavity may catalyze thermally activated reactions, showcasing the potential of polariton chemistry. Here, the authors provide a theoretical framework explaining the chemical kinetics deriving from transit through polaritonic and dark states.

  Nature Communications - current - nature.com science feeds

  Mon Oct 14, 2019 17:00
• Triplet-triplet annihilation effects in rubrene/C₆₀ OLEDs with electroluminescence turn-on breaking the thermodynamic limit

  Nature Communications, Published online: 15 October 2019; doi:10.1038/s41467-019-12597-5Triplet-triplet annihilation effects in rubrene/C60 OLEDs with electroluminescence turn-on breaking the thermodynamic limit

  Nature Communications - current - nature.com science feeds

  Mon Oct 14, 2019 17:00
• Genome-wide CRISPR/Cas9 library screening identified PHGDH as a critical driver for Sorafenib resistance in HCC

  Nature Communications - current - nature.com science feeds

  Mon Oct 14, 2019 17:00
• Scale-invariant magnetic textures in the strongly correlated oxide NdNiO₃

  Nature Communications - current - nature.com science feeds

  Mon Oct 14, 2019 17:00
• Statistical learning goes beyond the <i>d</i>-band model providing the thermochemistry of adsorbates on transition metals

  Nature Communications - current - nature.com science feeds

  Mon Oct 14, 2019 17:00
• Embryonic mesothelial-derived hepatic lineage of quiescent and heterogenous scar-orchestrating cells defined but suppressed by WT1

  Nature Communications - current - nature.com science feeds

  Mon Oct 14, 2019 17:00
• The TLR7/8 agonist R848 remodels tumor and host responses to promote survival in pancreatic cancer

  Nature Communications - current - nature.com science feeds

  Mon Oct 14, 2019 17:00
• Pathogenesis of hypertension in a mouse model for human <i>CLCN2</i> related hyperaldosteronism

  Nature Communications - current - nature.com science feeds

  Mon Oct 14, 2019 17:00
• Resonant catalysis of thermally activated chemical reactions with vibrational polaritons

  Nature Communications - current - nature.com science feeds

  Mon Oct 14, 2019 17:00
• Triplet-triplet annihilation effects in rubrene/C₆₀ OLEDs with electroluminescence turn-on breaking the thermodynamic limit

  Nature Communications - current - nature.com science feeds

  Mon Oct 14, 2019 17:00
• JoVE: Journal of Visualized Experiments
• Production of Dynein and Kinesin Motor Ensembles on DNA Origami Nanostructures for Single Molecule Observation

  The goal of this protocol is to form ensembles of molecular motors on DNA origami nanostructures and observe the ensemble motility using total internal reflection fluorescence microscopy.

  JoVE: Journal of Visualized Experiments

  Tue Oct 15, 2019 12:41
• Isolation and Differentiation of Primary Myoblasts from Mouse Skeletal Muscle Explants

  Myoblasts are proliferating precursor cells that differentiate to form polynucleated myotubes and eventually skeletal muscle myofibers. Here, we present a protocol for efficient isolation and culture of primary myoblasts from young adult mouse skeletal muscles. The method enables molecular, genetic, and metabolic studies of muscle cells in culture.

  JoVE: Journal of Visualized Experiments

  Tue Oct 15, 2019 12:00
• High Throughput Co-culture Assays for the Investigation of Microbial Interactions

  The co-culture interaction assays presented in this protocol are inexpensive, high throughput, and simple. These assays can be used to observe microbial interactions in co-culture, identify interaction patterns, and characterize the inhibitory potential of a microbial strain of interest against human and environmental pathogens.

  JoVE: Journal of Visualized Experiments

  Tue Oct 15, 2019 11:42
• Biomechanical Testing of Murine Tendons

  The protocol describes efficient and reproducible tensile biomechanical testing methods for murine tendons through the use of custom-fit 3D printed fixtures.

  JoVE: Journal of Visualized Experiments

  Tue Oct 15, 2019 11:42
• High-Resolution Complexome Profiling by Cryoslicing BN-MS Analysis

  A versatile cryoslicing BN-MS protocol using a microtome is presented for high-resolution complexome profiling.

  JoVE: Journal of Visualized Experiments

  Tue Oct 15, 2019 10:43
• Design, Synthesis, and Photochemical Properties of Clickable Caged Compounds

  A protocol for the synthesis and measurement of the photochemical properties of modular caged compounds with clickable moieties is presented.

  JoVE: Journal of Visualized Experiments

  Tue Oct 15, 2019 10:43
• Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing

  Described here is a simplified standard operating procedure for microbiome profiling using 16S rRNA metagenomic sequencing and analysis using freely available tools. This protocol will help researchers who are new to the microbiome field as well as those requiring updates on methods to achieve bacterial profiling at a higher resolution.

  JoVE: Journal of Visualized Experiments

  Tue Oct 15, 2019 09:44
• Journal of the American Chemical Society: Latest Articles (ACS Publications)
• [ASAP] Spotlights on Recent <italic toggle="yes">JACS</italic> Publications

  Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b11052

  Journal of the American Chemical Society: Latest Articles (ACS Publications)

  Mon Oct 14, 2019 21:00
• [ASAP] Molecularly Defined Manganese Catalyst for Low-Temperature Hydrogenation of Carbon Monoxide to Methanol

  Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b08990

  Journal of the American Chemical Society: Latest Articles (ACS Publications)

  Mon Oct 14, 2019 21:00
• [ASAP] How [FeFe]-Hydrogenase Facilitates Bidirectional Proton Transfer

  Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b09225

  Journal of the American Chemical Society: Latest Articles (ACS Publications)

  Mon Oct 14, 2019 21:00
• [ASAP] Controllable, Sequential, and Stereoselective C–H Allylic Alkylation of Alkenes

  Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b08801

  Journal of the American Chemical Society: Latest Articles (ACS Publications)

  Mon Oct 14, 2019 21:00
• [ASAP] Cationic Polyelectrolyte for Anionic Cyanines: An Efficient Way To Translate Molecular Properties into Material Properties

  Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b08877

  Journal of the American Chemical Society: Latest Articles (ACS Publications)

  Mon Oct 14, 2019 21:00
• [ASAP] Flow Rhodaelectro-Catalyzed Alkyne Annulations by Versatile C–H Activation: Mechanistic Support for Rhodium(III/IV)

  Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b07763

  Journal of the American Chemical Society: Latest Articles (ACS Publications)

  Mon Oct 14, 2019 21:00
• [ASAP] Three-Dimensional Phthalocyanine Metal-Catecholates for High Electrochemical Carbon Dioxide Reduction

  Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b09298

  Journal of the American Chemical Society: Latest Articles (ACS Publications)

  Mon Oct 14, 2019 21:00
• [ASAP] Transition-State Stabilization by n?p* Interactions Measured Using Molecular Rotors

  Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b08542

  Journal of the American Chemical Society: Latest Articles (ACS Publications)

  Mon Oct 14, 2019 21:00
• [ASAP] <italic toggle="yes">O</italic>-Methyltransferase-Mediated Incorporation of a ß-Amino Acid in Lanthipeptides

  Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b07396

  Journal of the American Chemical Society: Latest Articles (ACS Publications)

  Mon Oct 14, 2019 21:00
• [ASAP] Disodium Salts of Pseudoephedrine-Derived Myers Enolates: Stereoselectivity and Mechanism of Alkylation

  Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b08176

  Journal of the American Chemical Society: Latest Articles (ACS Publications)

  Mon Oct 14, 2019 21:00
• [ASAP] Programming DNA-Based Biomolecular Reaction Networks on Cancer Cell Membranes

  Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b05598

  Journal of the American Chemical Society: Latest Articles (ACS Publications)

  Mon Oct 14, 2019 21:00
• [ASAP] Interrogating Intracellular Zinc Chemistry with a Long Stokes Shift Zinc Probe ZincBY-4

  Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b06442

  Journal of the American Chemical Society: Latest Articles (ACS Publications)

  Mon Oct 14, 2019 21:00
• [ASAP] Wavelength-Dependent Energy and Charge Transfer in MOF: A Step toward Artificial Porous Light-Harvesting System

  Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b08078

  Journal of the American Chemical Society: Latest Articles (ACS Publications)

  Mon Oct 14, 2019 21:00
• [ASAP] Remote Functionalization of a,ß-Unsaturated Carbonyls by Multimetallic Sequential Catalysis

  Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b09373

  Journal of the American Chemical Society: Latest Articles (ACS Publications)

  Mon Oct 14, 2019 21:00