• Experimental Physiology
• Influence of methazolamide on the human control of breathing: A comparison to acetazolamide

  Abstract Acetazolamide is used to prevent/treat acute mountain sickness and both central and obstructive sleep apnoea. Methazolamide, like acetazolamide reduces hypoxic pulmonary vasoconstriction, but has fewer side effects including less skeletal muscle function impairment. Since methazolamide's effects on respiratory control in humans are unknown, we (1) compared the effects of oral methazolamide and acetazolamide on ventilatory control, and (

  Experimental Physiology

  Wed Oct 09, 2019 01:44
• Latest Results for Inflammation
• 6-Bromoindirubin-3′-Oxime Suppresses LPS-Induced Inflammation via Inhibition of the TLR4/NF-κB and TLR4/MAPK Signaling Pathways

  Abstract We investigated the efficacy of the traditional herbal extract 6-bromoindirubin-3′-oxime (BIO) against lipopolysaccharide (LPS)-induced mastitis in mice and inflammatory signaling in mouse mammary epithelial cells (MMECs). In vivo, breast inflammation scores and enzyme-linked immunosorbent assay (ELISA) detection of pro-inflammatory factor expression were used to assess the effect of BIO against mas

  Latest Results for Inflammation

  Wed Oct 09, 2019 17:00
• Psychophysiology
• Neural gain induced by startling acoustic stimuli is additive to preparatory activation

  Abstract Loud acoustic stimuli presented during movement preparation can shorten reaction time and increase response forcefulness. We examined how efferent connectivity of an agonist muscle to reticulospinal and corticospinal pathways, and the level of prepared movement force, affect reaction time and movement execution when the motor response is triggered by an intense acoustic stimulus. In Experiment 1, participants executed ballistic wrist fl

  Psychophysiology

  Wed Oct 09, 2019 06:19
• N400/frontal negativity reveals the controlled processes of taxonomic and thematic relationships in semantic priming for artifacts

  Abstract Recent studies show that taxonomic and thematic relationships are functionally and neurologically dissociated; however, there remain some discrepancies due to inconsistencies in definitions, task properties, and concept domains. This issue was further explored via the semantic priming paradigm with a long SOA of 600 ms while controlling for perceptual or functional features of artifacts involved across taxonomic and thematic relationshi

  Psychophysiology

  Wed Oct 09, 2019 04:13
• The Journal of Physiology
• Prenatal alcohol exposure programs offspring disease: Insulin resistance in adult males in a rat model of acute exposure

  Abstract Alcohol consumption is highly prevalent amongst women of reproductive age. Given that approximately 50% of pregnancies are unplanned, alcohol has the potential to affect fetal development and program chronic disease in offspring. We examined the effect of an acute but moderate prenatal alcohol exposure (PAE) on glucose metabolism, lipid levels and dietary preference in adolescent and/or adult rat offspring. Pregnant Sprague‐Dawley rats

  The Journal of Physiology

  Tue Oct 08, 2019 06:08