• Cancer Biology & Therapy: Table of Contents: Taylor and Francis
• Distinctive targetable genotypes of younger patients with lung adenocarcinoma: a cBioPortal for cancer genomics data base analysis

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  Cancer Biology & Therapy: Table of Contents: Taylor and Francis

  Wed Oct 09, 2019 01:32
• DLX6-AS1 promotes cell proliferation, migration and EMT of gastric cancer through FUS-regulated MAP4K1

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  Cancer Biology & Therapy: Table of Contents: Taylor and Francis

  Tue Oct 08, 2019 02:48
• Cancer Biotherapy & Radiopharmaceuticals - Table of Contents
• LncRNA LINC00974 Upregulates CDK6 to Promote Cell Cycle Progression in Gastric Carcinoma

  Cancer Biotherapy and Radiopharmaceuticals, Ahead of Print.

  Cancer Biotherapy & Radiopharmaceuticals - Table of Contents

  Wed Oct 09, 2019 00:00
• Cancer Immunology, Immunotherapy
• The prognostic significance of peritumoral tertiary lymphoid structures in breast cancer

  Abstract Tumors and their surrounding area represent spatially organized “ecosystems”, where tumor cells and the immune contextures of the different compartments are in a dynamic interplay, with potential clinical impact. Here, we aimed to investigate the prognostic significance of peritumoral tertiary lymphoid structures (TLS) either alone or jointly with the intratumoral densities and spatial distribution of CD8 + and CD163 +

  Cancer Immunology, Immunotherapy

  Tue Oct 08, 2019 17:00
• Cancer Science
• Experimental identification of cancer driver alterations in the era of pan‐cancer genomics

  Abstract Rapidly accumulating data from large‐scale cancer genomics studies have been generating important information about genes and their somatic alterations underlying cell transformation, cancer onset and tumor progression. However, these events are usually defined by using computational techniques, while the understanding of their actual functional roles and impact typically warrants validation by experimental means. Critical information h

  Cancer Science

  Tue Oct 08, 2019 04:33
• Cancers
• Cancers, Vol. 11, Pages 1519: Transcriptional Modulation by Idelalisib Synergizes with Bendamustine in Chronic Lymphocytic Leukemia

  Cancers, Vol. 11, Pages 1519: Transcriptional Modulation by Idelalisib Synergizes with Bendamustine in Chronic Lymphocytic Leukemia Cancers doi: 10.3390/cancers11101519 Authors: Kost Saleh Mejia Mostafizar Bouchard Banerji Marshall Gibson Johnston Katyal : The phosphatidyl-inositol 3 kinase (PI3K) δ inhibitor, idelalisib (IDE), is a potent inhibitor of the B-cell receptor pathway and a novel

  Cancers

  Tue Oct 08, 2019 17:00
• Cancers, Vol. 11, Pages 1520: Integrated Biobanking and Tumor Model Establishment of Human Colorectal Carcinoma Provides Excellent Tools for Preclinical Research

  Cancers, Vol. 11, Pages 1520: Integrated Biobanking and Tumor Model Establishment of Human Colorectal Carcinoma Provides Excellent Tools for Preclinical Research Cancers doi: 10.3390/cancers11101520 Authors: Mullins Micheel Matschos Leuchter Bürtin Krohn Hühns Klar Prall Linnebacher Over the time period from 2006 to 2017, consecutive patients operated on at the University Medical Center Rostock pa

  Cancers

  Tue Oct 08, 2019 17:00
• Cancers, Vol. 11, Pages 1517: Sorafenib-Regorafenib Sequential Therapy in Japanese Patients with Unresectable Hepatocellular Carcinoma—Relative Dose Intensity and Post-Regorafenib Therapies in Real World Practice

  Cancers, Vol. 11, Pages 1517: Sorafenib-Regorafenib Sequential Therapy in Japanese Patients with Unresectable Hepatocellular Carcinoma—Relative Dose Intensity and Post-Regorafenib Therapies in Real World Practice Cancers doi: 10.3390/cancers11101517 Authors: Wang Tsuchiya Kurosaki Yasui Inada Kirino Yamashita Sekiguchi Hayakawa Osawa Okada Higuchi Takaura Maeyashiki Kaneko Tamaki

  Cancers

  Tue Oct 08, 2019 17:00
• Cancers, Vol. 11, Pages 1516: Epidemiology of Simultaneous Medullary and Papillary Thyroid Carcinomas (MTC/PTC): An Italian Multicenter Study

  Cancers, Vol. 11, Pages 1516: Epidemiology of Simultaneous Medullary and Papillary Thyroid Carcinomas (MTC/PTC): An Italian Multicenter Study Cancers doi: 10.3390/cancers11101516 Authors: Marialuisa Appetecchia Rosa Lauretta Agnese Barnabei Letizia Pieruzzi Irene Terrenato Elisabetta Cavedon Caterina Mian Maria Grazia Castagna Rossella Elisei Background: The concomitant presence of papillary thyroid cancer (PT

  Cancers

  Tue Oct 08, 2019 17:00
• Cancers, Vol. 11, Pages 1518: A Smo/Gli Multitarget Hedgehog Pathway Inhibitor Impairs Tumor Growth

  Cancers, Vol. 11, Pages 1518: A Smo/Gli Multitarget Hedgehog Pathway Inhibitor Impairs Tumor Growth Cancers doi: 10.3390/cancers11101518 Authors: Lospinoso Severini Quaglio Basili Ghirga Bufalieri Caimano Balducci Moretti Romeo Loricchio Maroder Botta Mori Infante Di Marcotullio : Pharmacological Hedgehog (Hh) pathway inhibition has emerged as a valuable anticancer strategy. A

  Cancers

  Tue Oct 08, 2019 17:00
• Cancers, Vol. 11, Pages 1514: KRAS Mutations Predict Response and Outcome in Advanced Lung Adenocarcinoma Patients Receiving First-Line Bevacizumab and Platinum-Based Chemotherapy

  Cancers, Vol. 11, Pages 1514: KRAS Mutations Predict Response and Outcome in Advanced Lung Adenocarcinoma Patients Receiving First-Line Bevacizumab and Platinum-Based Chemotherapy Cancers doi: 10.3390/cancers11101514 Authors: Ghimessy Gellert Schlegl Hegedus Raso Barbai Timar Ostoros Megyesfalvi Gieszer Moldvay Renyi-Vamos Lohinai Hoda Klikovits Klepetko Laszlo Dome

  Cancers

  Tue Oct 08, 2019 17:00
• Cancers, Vol. 11, Pages 1515: Gene-Specific Targeting of DNA Methylation in the Mammalian Genome

  Cancers, Vol. 11, Pages 1515: Gene-Specific Targeting of DNA Methylation in the Mammalian Genome Cancers doi: 10.3390/cancers11101515 Authors: Urbano Smith Weeks Chatterjee DNA methylation is the most widely-studied epigenetic modification, playing a critical role in the regulation of gene expression. Dysregulation of DNA methylation is implicated in the pathogenesis of numerous diseases. For example, aberrant DNA methyl

  Cancers

  Tue Oct 08, 2019 17:00
• Cancers, Vol. 11, Pages 1512: Tumor Drug Distribution after Local Drug Delivery by Hyperthermia, In Vivo

  Cancers, Vol. 11, Pages 1512: Tumor Drug Distribution after Local Drug Delivery by Hyperthermia, In Vivo Cancers doi: 10.3390/cancers11101512 Authors: Helena C. Besse Angelique D. Barten-van Rijbroek Kim M.G. van der Wurff-Jacobs Clemens Bos Chrit T.W. Moonen Roel Deckers Tumor drug distribution and concentration are important factors for effective tumor treatment. A promising method to enhance the distribution and the

  Cancers

  Tue Oct 08, 2019 17:00
• Cancers, Vol. 11, Pages 1511: Tumor Endothelial Heterogeneity in Cancer Progression

  Cancers, Vol. 11, Pages 1511: Tumor Endothelial Heterogeneity in Cancer Progression Cancers doi: 10.3390/cancers11101511 Authors: Nako Maishi Dorcas A. Annan Hiroshi Kikuchi Yasuhiro Hida Kyoko Hida Tumor blood vessels supply nutrients and oxygen to tumor cells for their growth and provide routes for them to enter circulation. Thus, angiogenesis, the formation of new blood vessels, is essential for tumor progression and m

  Cancers

  Tue Oct 08, 2019 17:00
• Cancers, Vol. 11, Pages 1513: Transcriptome Profiling Reveals Matrisome Alteration as a Key Feature of Ovarian Cancer Progression

  Cancers, Vol. 11, Pages 1513: Transcriptome Profiling Reveals Matrisome Alteration as a Key Feature of Ovarian Cancer Progression Cancers doi: 10.3390/cancers11101513 Authors: Sumegha Mitra Kartikeya Tiwari Ram Podicheti Taruni Pandhiri Douglas B. Rusch Andrea Bonetto Chi Zhang Anirban K. Mitra Background: Ovarian cancer is the most lethal gynecologic malignancy. There is a lack of comprehensive investigation of

  Cancers

  Tue Oct 08, 2019 17:00
• Clinical and translational oncology
• Prognostic factors associated with survival in a large cohort of gastric cancer patients resected over a decade at a single Italian center: the Cremona experience

  Abstract Background Incidence of gastric cancer (GC) shows different distribution in Italy, with higher incidence in the north and center. We retrospectively analyzed the clinical data of patients resected at the Hospital of Cremona between January 2007 and December 2016. Available clinical variables were linked with survival to identify possible prognostic factors.

  Clinical and translational oncology

  Wed Oct 09, 2019 17:00
• ECLIM-SEHOP, a new platform to set up and develop international academic clinical trials for childhood cancer and blood disorders in Spain

  Abstract Introduction Cancer and blood disorders in children are rare. The progressive improvement in survival over the last decades largely relies on the development of international academic clinical trials that gather the sufficient number of patients globally to elaborate solid conclusions and drive changes in clinical practice. The participation of Spain into large international a

  Clinical and translational oncology

  Tue Oct 08, 2019 17:00
• Updated guidelines for predictive biomarker testing in advanced non-small-cell lung cancer: a National Consensus of the Spanish Society of Pathology and the Spanish Society of Medical Oncology

  Abstract In 2011 the Spanish Society of Medical Oncology (SEOM) and the Spanish Society of Pathology (SEAP) started a joint project to establish guidelines on biomarker testing in patients with advanced non-small-cell lung cancer (NSCLC) based on current evidence. As this field is constantly evolving, these guidelines have been updated, previously in 2012 and 2015 and now in 2019. Current evidence suggests that the mandatory te

  Clinical and translational oncology

  Tue Oct 08, 2019 17:00
• Clinical Cancer Research Online First Articles
• A PI3K/AKT Scaffolding Protein, IQ motif-containing GTPase Associating Protein 1 (IQGAP1), Promotes Head and Neck Carcinogenesis

  Purpose: Head and neck cancer (HNC) is the sixth most common cancer worldwide with a 5-year survival rate of less than 50%. The PI3K/AKT/mTOR signaling pathway is frequently implicated in HNC. Recently, IQmotif-containing GTPase activating protein 1 (IQGAP1) was discovered to scaffold the PI3K/AKT signaling pathway. IQGAP1gene expression is increased in HNC, raising the hypothesis that IQGAP1 contributes to HNC. Experimental Design: We performed

  Clinical Cancer Research Online First Articles

  Wed Oct 09, 2019 06:02
• Metformin abrogates age-associated ovarian fibrosis

  Purpose:The ovarian cancer risk factors of age and ovulation are curious since ovarian cancer incidence increases in postmenopausal women, long after ovulations have ceased. To determine how age and ovulation underlie ovarian cancer risk, we assessed the effects of these risk factors on the ovarian microenvironment. Experimental Design:Aged C57/lcrfa mice (0-33 months old) were generated to assess the aged ovarian microenvironment. To expand our

  Clinical Cancer Research Online First Articles

  Wed Oct 09, 2019 06:02
• Randomized phase 0/I trial of the mitochondrial inhibitor ME-344 or placebo added to bevacizumab in early HER2-negative breast cancer

  Background: We previously demonstrated that mitochondrial inhibitors efficacy was restricted to a metabolic context in which mitochondrial respiration was the predominant energy source, a situation achievable by inducing vascular normalization/hypoxia correction with antiangiogenics. Vascular normalization can be tracked with FDG-PET. We tested the efficacy of the mitochondrial inhibitor ME-344 or placebo added to bevacizumab in early breast canc

  Clinical Cancer Research Online First Articles

  Wed Oct 09, 2019 06:02
• European Journal of Cancer
• Deep and sustained radiological response after MEK-RAF inhibition in <em>HRAS</em> mutant apocrine carcinoma of the scalp

  Publication date: November 2019Source: European Journal of Cancer, Volume 122Author(s): Mariana Scaranti, Daniel Nava Rodrigues, Udai Banerji

  European Journal of Cancer

  Wed Oct 09, 2019 07:40
• Future Oncology
• Healthcare resource utilization and costs of adverse events among patients with metastatic urothelial cancer in USA

  Future Oncology, Ahead of Print.

  Future Oncology

  Tue Oct 08, 2019 20:10
• CT-guided transthoracic needle biopsy: advantages in histopathological and molecular tests

  Future Oncology, Ahead of Print.

  Future Oncology

  Tue Oct 08, 2019 18:45
• Genes, Chromosomes and Cancer
• Novel SS18‐NEDD4 gene fusion in a primary renal synovial sarcoma

  ABSTRACT We report a primary renal synovial sarcoma with a novel gene fusion and unusual morphology. The patient was a 35‐year‐old female who was found to have a 5 cm hypocellular, myxoid spindle cell renal neoplasm that subtly permeated amongst native renal tubules. The tumor cells showed elongated hyperchromatic nuclei with ill‐defined pale cytoplasm, lacking significant mitotic activity or necrosis. Based on its deceptively bland morphology,

  Genes, Chromosomes and Cancer

  Tue Oct 08, 2019 05:19
• International Journal of Cancer
• Breast cancer by migrant background in Belgium: lower risk, but worse survival in women of non‐European origin

  Foreign and native populations differ in terms of breast cancer outcomes. Studies rarely distinguish between pre‐ and postmenopausal breast cancer, although the risk profile is different; nor between migrants of the first and second generation, which is crucial to examine genetic and environmental influences on breast cancer. This research fills these gaps by investigating patterns in breast cancer incidence and survival in different migrant grou

  International Journal of Cancer

  Wed Oct 09, 2019 04:44
• International trends in hepatocellular carcinoma incidence, 1978‐2012

  Primary liver cancer, the major histology of which is hepatocellular carcinoma (HCC), is the second leading cause of cancer death worldwide. We comprehensively examine recent international trends of primary liver cancer and HCC incidence using population‐based cancer registry data. Incidence for all primary liver cancer and for HCC by calendar time and birth cohort was examined for selected countries between 1978 and 2012. For each successive 5‐y

  International Journal of Cancer

  Wed Oct 09, 2019 04:38
• Fraser extracellular matrix complex subunit 1 promotes liver metastasis of gastric cancer

  Liver metastasis is often fatal in patients with gastric cancer, therefore, we aimed to identify genes associated with the mechanisms of liver metastasis of gastric cancer (GC) and to investigate their potential to predict recurrence and to serve as targets of therapy. Recurrence pattern‐specific transcriptome analysis was performed to identify liver metastasis‐associated genes. A stable knockout cell line was generated to investigate metabolic p

  International Journal of Cancer

  Wed Oct 09, 2019 04:34
• Continuing increased risk of second cancer in long‐term testicular cancer survivors after treatment in the cisplatin era

  Using complete information on total treatment burden, this population‐based study aimed to investigate second cancer (SC) risk in testicular cancer survivors (TCS) treated in the cisplatin era. The Cancer Registry of Norway identified 5 625 1‐year TCS diagnosed 1980‐2009. Standardized incidence ratios (SIRs) were calculated to evaluate the total and site‐specific incidence of SC compared with the general population. Cox regression analyses evalua

  International Journal of Cancer

  Wed Oct 09, 2019 04:28
• Journal of Cancer Education
• Twenty-five-Year Follow-up of Short-term Cancer Research Trainees at the University of Alabama at Birmingham: a Brief Report

  Abstract Long-term follow-up is needed to evaluate the impact of short-term cancer research programs on the career trajectories of medical and graduate students. Participation in these programs may be crucial in fostering the next generation of cancer research scientists. This report presents the career outcomes and research productivity of 77 medical and public health students with 25 years of tracking data following their p

  Journal of Cancer Education

  Mon Sep 30, 2019 17:00
• HPV Vaccination Communication Messages, Messengers, and Messaging Strategies

  Abstract Human papillomavirus (HPV) causes over 39,000 cancers annually in the US. The HPV vaccine is safe and effective but underutilized to prevent cancer. In the US, only 37% of adolescents ages 13–17 have received the full vaccine series. Ineffective messages and misinformation about the vaccine have negatively impacted its uptake in the US. It was initially only approved for girls and early marketing focused on cervical

  Journal of Cancer Education

  Mon Sep 30, 2019 17:00
• Describing a Process for Creating a Patient Visible Quality Educational Display to Increase Patient Engagement in Radiation Oncology Throughout the Canadian Maritimes Provinces

  Abstract Here, we report the process for creating a patient visible quality educational display to highlight the collaborative quality working practices of Radiation Oncology clinicians and staff in the main Radiotherapy Centers throughout three Canadian provinces. These processes are often not visible to patients yet they speak directly to the standards of care delivered at these centers. The Canadian Partnership for Quality

  Journal of Cancer Education

  Mon Sep 30, 2019 17:00
• Journal of Cancer Research and Clinical Oncology
• Microwave ablation as local consolidative therapy for patients with extracranial oligometastatic EGFR-mutant non-small cell lung cancer without progression after first-line EGFR-TKIs treatment

  Abstract Objectives Evidence from multiple clinical trials showed that local consolidative therapy (LCT) improved survival in oligometastatic non-small cell lung cancer (NSCLC) patients. In the present study, we aim to explore the potential role of microwave ablation (MWA) as LCT for epidermal growth factor receptor (EGFR)-mutant advanced NSCLC patients with extracranial oligometastasi

  Journal of Cancer Research and Clinical Oncology

  Wed Oct 09, 2019 17:00
• Malignant ascites-derived organoid (MADO) cultures for gastric cancer in vitro modelling and drug screening

  Abstract Purpose Malignant ascites (MA) is a common manifestation in advanced gastric cancer with peritoneal carcinomatosis and usually indicates a poor prognosis. However, lack of in vitro models that can faithfully recapitulate the characteristics of tumour cells in ascites hinders related researches. Tumour organoids have emerged as a robust in vitro model for tumour research and dr

  Journal of Cancer Research and Clinical Oncology

  Tue Oct 08, 2019 17:00
• Molecular Cancer Therapeutics Online First Articles
• Precision Chemo-Radiotherapy for HER2 Tumors Using Antibody Conjugates of an Auristatin Derivative with Reduced Cell Permeability

  The most successful therapeutic strategies for locally advanced cancers continue to combine decades old classical radiosensitizing chemotherapies with radiotherapy. Molecular targeted radiosensitizers offer the potential to improve the therapeutic ratio by increasing tumor specific kill while minimizing drug delivery and toxicity to surrounding normal tissue. Auristatins are a potent class of anti-tubulins that sensitize cells to ionizing radiati

  Molecular Cancer Therapeutics Online First Articles

  Wed Oct 09, 2019 06:58
• Synergism between ATM and PARP1 inhibition involves DNA damage and abrogating the G2 DNA damage checkpoint

  PARP inhibitors have emerged as effective chemotherapeutic agents for BRCA1/BRCA2-deficient cancers. Another DNA damage response protein ATM is also increasingly being recognized as a target for synthetic lethality with PARP inhibitors. As ATM functions in both cell cycle arrest and DNA repair after DNA damage, how cells respond to inhibition of ATM and PARP1 is yet to be defined precisely. We found that loss of ATM function, either in an ATM-def

  Molecular Cancer Therapeutics Online First Articles

  Wed Oct 09, 2019 06:58
• Synergy between EphA2-ILs-DTXp, a novel EphA2 targeted nanoliposomal taxane, and PD-1 inhibitors in preclinical tumor models

  Combinations of chemotherapy with immunotherapy have seen recent clinical success, including two approvals of anti-PD-1/L1 agents in combination with taxane based chemotherapy in non-small cell lung cancer and triple-negative breast cancer. Here we present a study on the combination activity and mechanistic rationale of a novel EphA2-targeted liposomal taxane (EphA2-ILs-DTXp) and anti-PD-1. This combination was highly active in mouse syngeneic

  Molecular Cancer Therapeutics Online First Articles

  Wed Oct 09, 2019 06:58
• Role of dimerized C16orf74 in aggressive pancreatic cancer: A novel therapeutic target

  The therapeutic outcome for pancreatic ductal adenocarcinoma (PDAC), over the past 30 years remains stagnant due to the lack of effective treatments. We performed a genome-wide analysis to identify novel therapeutic targets for PDAC. Our analysis showed that Homo sapiens chromosome 16 open reading frame 74 (C16orf74) was upregulated in most of PDAC patients and associated with poor prognosis. Previously, we demonstrated that C16orf74 interacts wi

  Molecular Cancer Therapeutics Online First Articles

  Wed Oct 09, 2019 06:58
• Molecular Carcinogenesis
• Issue Information ‐ Ed Board

  Molecular Carcinogenesis

  Thu Oct 10, 2019 00:40
• Pathology & Oncology Research
• Berberine Promotes Osteogenic Differentiation of Human Dental Pulp Stem Cells Through Activating EGFR-MAPK-Runx2 Pathways

  Abstract Similar to the mesenchymal stem cells (MSCs), dental pulp stem cells (DPSCs) also have pluripotent differentiation characteristic and may be more ideal for tissue regeneration, especially in tooth regeneration engineering. However, bacterial infection may be a powerful obstacle. Berberine (BBR), known with antibacterial effects, was recently found to play functions in bone formation through promoting osteogenic differe

  Pathology & Oncology Research

  Tue Oct 08, 2019 17:00
• ScienceDirect Publication: Cancer Epidemiology (open access)
• Analysis of racial disparities in the treatment and outcomes of colorectal cancer in young adults

  Publication date: December 2019Source: Cancer Epidemiology, Volume 63Author(s): Olatunji B. Alese, Renjian Jiang, Katerina M. Zakka, Christina Wu, Walid Shaib, Mehmet Akce, Madhusmita Behera, Bassel F. El-RayesAbstractBackgroundThe incidence of colorectal cancer (CRC) in young adults is increasing. Minority populations with CRC are known to have worse survival outcomes. The aim of this study is to evaluate adults under age 50 years with CRC by ra

  ScienceDirect Publication: Cancer Epidemiology (open access)

  Wed Oct 09, 2019 05:04