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Κυριακή 6 Οκτωβρίου 2019


Allergy Antibiotics And Microbial Resistance
Condition:   Infection Intervention:   Procedure: penicillin allergy assessment pathway Sponsors:   University of Leeds;   University of Oxford Recruiting (Source: ClinicalTrials.gov)
MedWorm Allergy & Immunology Clinical Trials
Mon Sep 30, 2019 18:00
Effects of Low Dose Ozone on Airway Inflammatory Responses in Adults With Asthma - Sedentary Nasal Ozone (Asthma SNOZ)
Condition:   Asthma, Allergic Interventions:   Device: HET tracker;   Other: Ozone;   Other: FA Sponsors:   University of North Carolina, Chapel Hill;   Environmental Protection Agency (EPA);   North Carolina State University Not yet recruiting (Source: ClinicalTrials.gov)
MedWorm Allergy & Immunology Clinical Trials
Mon Sep 30, 2019 18:00
Impact of Poaterior Nasal Neurectomy on Recurrence Rate in Allergic Rhinosinusitis With Nasal Polyposis
Condition:   Nasal Polyps Intervention:   Procedure: Posterior neurectomy Sponsor:   Assiut University Not yet recruiting (Source: ClinicalTrials.gov)
MedWorm Allergy & Immunology Clinical Trials
Thu Sep 26, 2019 18:00
Comparison of Innate Immune Responses Induced by Allergy Immunotherapy (AIT) With Different Adjuvants
Condition:   Allergic Rhinitis Interventions:   Biological: Allergovit;   Biological: Polvac;   Biological: Pollinex Quattro Sponsors:   University of Zurich;   Zentrums für Rhinologie und Allergologie Wiesbaden Not yet recruiting (Source: ClinicalTrials.gov)
MedWorm Allergy & Immunology Clinical Trials
Thu Sep 26, 2019 18:00
How TKA Implants Affect Muscle Quality and Activity During Daily Living and Immunological Response
Conditions:   Osteoarthritis, Knee;   Inflammation Knees Interventions:   Device: Zimmer NexGen LPS-Flex;   Device: Smith & Nephew Journey II Sponsors:   Ottawa Hospital Research Institute;   University of Ottawa Recruiting (Source: ClinicalTrials.gov)
MedWorm Allergy & Immunology Clinical Trials
Thu Sep 26, 2019 18:00
Duke University could receive up to $400M to improve flu vaccine
Thanks to a historic grant package from the federal government, Duke University researchers are tasked with creating a long-lasting, non-seasonal flu shot. Stemming from the same White House effort that's benefiting Triangle companies, Duke University has received $29.6 million from the National Institute of Allergy and Infectious Diseases (NIAID). The sizable research allotment Is part of a multi-contract award potentially worth up to $400 million o ver the next seven years – meaning it could…...
MedWorm Allergy & Immunology News
04:34
Teal Pumpkins Offer Halloween Safe Zone For Kids With Food Allergies
Food allergies can sap some of the fun out of Halloween, as hidden and known allergens in candy spook kids and their parents. The Teal Pumpkin Project organizes an effort to offer children non-food items like glows sticks and bubbles, all while raising awareness of a growing public-health problem. (Source: Forbes.com Healthcare News)
MedWorm Allergy & Immunology News
Sat Oct 05, 2019 21:52
Tick bites can cause potentially fatal and permanent allergy to meat
NHS medics have revealed that five patients have developed serious allergic reactions to beef, pork and lamb after getting bitten by ticks, and the only 'cure' is to completely avoid the meats. (Source: the Mail online | Health)
MedWorm Allergy & Immunology News
Sun Oct 06, 2019 02:45
Respiratory Capacity and Swallowing Function in Spinal Disorders: A Pilot Study
Conditions:   Spinal Cord Injuries;   Deglutition Disorders Interventions:   Other: Starch-based thickened liquids;   Other: Xanthan-gum thickened liquids Sponsors:   University Health Network, Toronto;   National Institute on Deafness and Other Communication Disorders (NIDCD) Active, not recruiting (Source: ClinicalTrials.gov)
MedWorm Audiology Clinical Trials
Thu Oct 03, 2019 18:00
Physiological Flow of Liquids in Healthy Swallowing
Conditions:   Deglutition;   Healthy Swallowing;   Aging Interventions:   Other: Starch-thickened liquids;   Other: Xanthan-gum thickened liquids Sponsors:   University Health Network, Toronto;   National Institute on Deafness and Other Communication Disorders (NIDCD) Recruiting (Source: ClinicalTrials.gov)
MedWorm Audiology Clinical Trials
Thu Oct 03, 2019 18:00
Loss of Long-time Spouse Can Send Older Adult Into Decline
Photo credit Jeremy Wong Dear Carol: My 87-year-old dad died three months ago from cancer. He and Mom had been married more than 56 years and his loss was devastating to her. Dad had been Mom’s main caregiver for nearly 20 years because of her past cancer and ongoing vascular dementia. What upsets me is that Mom isn’t making any progress in coping with dad’s death. We talk a lot about how we miss him but she always follows the conversation by saying, “He’s not gone.” On better days she’ll say, “I...
MedWorm Cancer & Oncology Blogs
Sun Oct 06, 2019 00:00
Part 6 - Why Is Cancer Pain So Special?
by Drew Rosielle (@drosielle)A Series of Observations on Opioids By a Palliative Doc Who Prescribes A Lot of Opioids But Also Has Questions.This is the 5th post in a series about opioids, with a focus on how my thinking about opioids has changed over the years. See also:Part 1 – Introduction, General Disclaimers, Hand-Wringing, and a Hand-Crafted Graph.Part 2 – We Were Wrong 20 years Ago, Our Current Response to the Opioid Crisis is Wrong, But We Should Still Be Helping Most of our Long-Term Patients...
MedWorm Cancer & Oncology Blogs
Sun Oct 06, 2019 15:00
Part 5 - Why Do We Lump the Non-Cancer Pain Syndromes Together?
by Drew Rosielle (@drosielle)A Series of Observations on Opioids By a Palliative Doc Who Prescribes A Lot of Opioids But Also Has Questions.This is the 5th post in a series about opioids, with a focus on how my thinking about opioids has changed over the years. See also:Part 1 – Introduction, General Disclaimers, Hand-Wringing, and a Hand-Crafted Graph.Part 2 – We Were Wrong 20 years Ago, Our Current Response to the Opioid Crisis is Wrong, But We Should Still Be Helping Most of our Long-Term Patients...
MedWorm Cancer & Oncology Blogs
Sun Oct 06, 2019 14:00
Strategies for job search
I have been reading on this forum some people giving out bad job search advice, and I want to use my own example to illustrate why they are bad advice: 1. You can wait until later in the year because there will be less competition. While you might think that your odds of landing a better job improves as your PGY5 years goes on because most of the graduates have signed contracts hence less competition, this was absolutely not true in my case. I was stupid enough to decline job offers in the......
MedWorm Cancer & Oncology Forums
00:55
Daily imaging poll
Just want to get a sense of what kind of patients people are doing daily CBCT for when doing IMRT. Head and neck seems standard, CNS, prostate patients. Do you guys standardly do for all lung patients? When you are doing daily CBCT, do you guys get any other 2d images on any of the fractions? (Source: Student Doctor Network)
MedWorm Cancer & Oncology Forums
Fri Oct 04, 2019 17:01
Here are the first four investments from Venture Investors' new $75M health VC fund
Invenra Inc., a Madison startup that developed a drug discovery platform to identify human multi-specific antibodies for immuno-oncology, is one of the four startups to receive an investment from Wisconsin's Venture Investors. The funding comes from the venture capital investment group's new $75 million fund dedicated to health startups, which will be managed from Madison, Ann Arbor, Michigan, and Milwaukee. The investment amounts were not disclosed, but Venture Investors says it makes initial…...
MedWorm Cancer & Oncology News
Sun Oct 06, 2019 15:00
Utility of Computed Tomography for the Diagnosis of Invasive Aspergillosis in Hematological Malignancy
Conference abstracts (Source: The Aspergillus Website - updates)
MedWorm Cancer & Oncology News
Sun Oct 06, 2019 14:39
Medical staffers are experts. But my hospital travails show why they can get it dangerously wrong.
How my repeated ER visits were part of my frustrating experience with a thyroid cancer odyssey. (Source: Washington Post: To Your Health)
MedWorm Cancer & Oncology News
Sun Oct 06, 2019 15:00
Breast Cancer Awareness BRAVE fighters strip down to show their beautiful bodies and scars
When Gina Dannatt was told she had as little as six months to live, her world imploded. Having already gone through a double mastectomy, chemotherapy and radiotherapy, the news that it had spread to both of her lungs was too much to bear. (Source: Daily Express - Health)
MedWorm Cancer & Oncology News
Sun Oct 06, 2019 12:00
Risk of Non-Melanoma Skin Cancer Following Hematopoietic Cell Transplantation and Voriconazole-Associated Risk
Conference abstracts (Source: The Aspergillus Website - updates)
MedWorm Cancer & Oncology News
Sat Oct 05, 2019 23:20
Dr Michael Mosley reveals the truth about processed meat and cancer
In an effort to clarify the issues surrounding, among other things, red and processed meat, the Mail on Sunday spoke to scientists who have devoted their careers to studying food and cancer. (Source: the Mail online | Health)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
MedWorm Cancer & Oncology News
Sun Oct 06, 2019 08:03
Australia to fund research on medicinal cannabis as demand grows
Australia will provide A$3 million ($2.03 million) for research on the use of cannabis to help cancer patients, its health minister said on Sunday, as the demand for medicinal cannabis products grows rapidly. (Source: Reuters: Health)
MedWorm Cancer & Oncology News
Sun Oct 06, 2019 06:51
DR MICHAEL MOSLEY: Could fasting 16 hours a day REALLY help you keep cancer at bay?
DR MICHAEL MOSLEY: Breast and bowel cancer are strongly linked to excess fat, so keeping to a healthy weight will reduce your risk. I believe one of the best ways to do this is by intermittent fasting. (Source: the Mail online | Health)
MedWorm Cancer & Oncology News
Sat Oct 05, 2019 23:22
Low-carb diets may help you shed weight but do they raise the risk of cancer?
The ketogenic diet is a low-carb, high-fat plan which even has its own hashtag #LCHF. But very low-carb diets often lack fibre - long proven to have a protective effect against bowel cancer. (Source: the Mail online | Health)
MedWorm Cancer & Oncology News
Sat Oct 05, 2019 23:22
Cancer, the foods you love and the truth about your Sunday roast beef
WHO data shows the risk of colorectal cancer is 1.18 times higher if you eat 50g of processed red meat per day. But the risk of any cancer is 40 times higher if you smoke - or 70 times higher if you drink as well. (Source: the Mail online | Health)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
MedWorm Cancer & Oncology News
Sat Oct 05, 2019 23:21
A label-free fluorescent enhancement nanosensor for ultrasensitive and highly selective detection of miRNA-378 through signal synergy amplification.
This study indicated that amplified fluorescence detection of microRNA-378 is a stable, low-cost, highly specific, and ultra-low as 1.07 fM detectability. The proposed approach of signal synergetic amplification facilitating the fluorescence detection microRNA shows great potential for potentially clinically diagnosis. PMID: 31585570 [PubMed - in process] (Source: Analytica Chimica Acta)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your...
MedWorm Cancer & Oncology Research
05:28
7-O-geranylquercetin contributes to reverse P-gp-mediated adriamycin resistance in breast cancer
Publication date: Available online 5 October 2019Source: Life SciencesAuthor(s): Enxia Zhang, Jiasi Liu, Lei Shi, Xin Guo, Ze Liang, Jiaxin Zuo, Hong Xu, Huaxin Wang, Xiaohong Shu, Shanshan Huang, Shubiao Zhang, Xiaohui Kang, Yuhong ZhenAbstractAimsTo investigate the effect of 7-O-geranylquercetin (GQ), a derivative of quercetin (Q), on reversing drug resistance in breast cancer MCF-7/ADR cells and reveal the mechanisms related to P-glycoprotein (P-gp).Main methodsCell viability was determined by...
MedWorm Cancer & Oncology Research
03:41
Chemical modifications of polysaccharides and their anti-tumor activities
Publication date: Available online 5 October 2019Source: Carbohydrate PolymersAuthor(s): Liuming Xie, Mingyue Shen, Yuzhen Hong, Hedan Ye, Lixin Huang, Jianhua XieAbstractWith the rising trend of incidence of cancers, effective therapies are urgently needed to control human malignancies. However, the chemotherapy drugs currently on the market cause serious side effects. Polysaccharides belong to a class of biomacromolecules, which have drawn considerable research interest over the years as it possess...
MedWorm Cancer & Oncology Research
03:39
Improved durable responses regardless of age following cytoreduction and “no-tourniquet” hyperthermic isolated limb chemotherapy for in transit melanoma of the extremity.
ConclusionCombining cytoreduction with no-tourniquet HILP/HILI for in-transit metastatic melanoma of the extremity resulted in 100% survival regardless of age at 1 year and 68% 3-year survival in patients over 80 without any increase in adverse events. (Source: The American Journal of Surgery)
MedWorm Cancer & Oncology Research
01:16
Predictors of Ileus Following Colorectal Resections
ConclusionsEvaluation of factors such as male gender, older age, anastomosis formation, diagnosis of cancer and inflammatory bowel disease, can help facilitate earlier diagnosis of postoperative ileus and may require consideration of prophylactic therapy. (Source: The American Journal of Surgery)
MedWorm Cancer & Oncology Research
01:16
Therapeutic Options for Early Cancer of the Esophagogastric Junction
Publication date: Available online 6 October 2019Source: Cirugía Española (English Edition)Author(s): Félix Junquera, Sonia Fernández-Ananín, Carmen BalaguéAbstractEarly-stage (T1) esophagogastric junction cancer continues to represent 2%–3% of all cases. Adenocarcinoma is the most frequent and important type, the main risk factors for which are gastroesophageal reflux and Barrett's esophagus with dysplasia.Patients with mucosal (T1a) or submucosal (T1b) involvement initially require a thorough digestive...
MedWorm Cancer & Oncology Research
01:16
Corrigendum to “Thermal-ablation of vertebral metastases prevents adverse events in patients with differentiated thyroid carcinoma” [Eur. J. Radiol. 119 (2019) 108650]
Publication date: Available online 6 October 2019Source: European Journal of RadiologyAuthor(s): M. Barat, L. Tselikas, T. de Baère, G. Gravel, S. Yevich, A. Delpla, N. Magand, G. Louvel, J. Hadoux, A. Berdelou, M. Terroir, E. Baudin, M. Schlumberger, S. Leboulleux, F. Deschamps (Source: European Journal of Radiology)
MedWorm Cancer & Oncology Research
00:36
Breast metastases: A Rare Manifestation of Advanced Uterine Serous Carcinoma
Publication date: Available online 5 October 2019Source: Gynecologic Oncology ReportsAuthor(s): Jennifer McEachron, Rachel Mendoza, Yi-Chun Lee, Margaux J. KanisAbstractMetastasis of non-mammary tumors to the breast are uncommon, representing < 1% of all breast tumors. Breast metastasis are associated with advanced disease and poor prognosis regardless of the origin of the primary tumor. Uterine cancer metastasis to the breast is an extremely rare finding and has not been reported in the case...
MedWorm Cancer & Oncology Research
Sun Oct 06, 2019 23:14
Imaging Biomarkers of Adiposity and Sarcopenia as Potential Predictors for Overall Survival Among Patients with Endometrial Cancer Treated with Bevacizumab
ConclusionObesity has been associated with increased levels of vascular endothelial growth factor (VEGF), the main target for bevacizumab therapy. Imaging measurements of VFA may provide prognostic information for patients with EC but no adiposity marker was predictive of improved response to bevacizumab. (Source: Gynecologic Oncology Reports)
MedWorm Cancer & Oncology Research
Sun Oct 06, 2019 23:14
Our experience of a nurse-led oral and maxillofacial surgical clinic in a tertiary centre: two years on
We describe our two-year experience of a nurse led clinic (NLC) in a tertiary centre oral and maxillofacial surgical (OMFS) department. The clinic is run by a specialist nurse, in parallel with a consultant’s clinic and focuses on the management and review of non-malignant lesions. Increased clinical flexibility, reduced waiting times, and tailored educational resources have contributed to an improved experience for the patients. (Source: British Journal of Oral and Maxillofacial Surgery)
MedWorm Cancer & Oncology Research
Sun Oct 06, 2019 21:39
Squamous cell carcinoma of the head and neck – screening in patients who misuse alcohol and tobacco in Switzerland: a prospective pilot study
Publication date: Available online 6 October 2019Source: British Journal of Oral and Maxillofacial SurgeryAuthor(s): M. Mermod, A. Adam, C. Clair, M. Faouzi, C. Simon, J.-B. Daeppen, N. Bertholet, Y. MonnierAbstractSquamous cell carcinoma (SCC) of the head and neck is the sixth most common cancer worldwide. It is preceded by early asymptomatic lesions which, if identified early enough and removed, would prevent malignant transformation or avoid delaying diagnosis to advanced stages. Our aim was to...
MedWorm Cancer & Oncology Research
Sun Oct 06, 2019 21:39
Epigenetic silencing of microRNA-335 contributes to nasopharyngeal carcinoma metastasis
ConclusionGene methylation contributes the expression of miR-335 in nasopharyngeal carcinoma. The expression of miR-335 methylation is correlated with the metastasis of nasopharyngeal carcinoma. (Source: American Journal of Otolaryngology)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
MedWorm Cancer & Oncology Research
Sun Oct 06, 2019 21:35
Prognostic value of lymph node density for major salivary gland carcinoma without clinical lymph node metastasis
ConclusionResults demonstrated that lymph node density functions as a predictor of outcomes for major salivary gland carcinoma without clinical lymph node metastasis. (Source: American Journal of Otolaryngology)
MedWorm Cancer & Oncology Research
Sun Oct 06, 2019 21:35

Evaluations of Biomarker Status Changes between Primary and Recurrent Tumor Tissue Samples in Breast Cancer Patients.
Conclusion: A substantial discordance in ER, PR, and HER2 status were observed between primary breast cancer tissues and recurrent lesions. Rebiopsy could bring new therapeutic opportunities in the management of patients with recurrent breast cancer. PMID: 31583246 [PubMed - in process] (Source: Biomed Res)
MedWorm Cancer & Oncology Research
Sun Oct 06, 2019 21:29
Selenium nanoparticles act as an intestinal p53 inhibitor mitigating chemotherapy-induced diarrhea in mice
Publication date: Available online 5 October 2019Source: Pharmacological ResearchAuthor(s): Feng Sun, Jiajia Wang, Ximing Wu, Chung S. Yang, Jinsong ZhangAbstractSelenium, at high-dose levels approaching its toxicity, protects tissues from dose-limiting toxicities of many cancer chemotherapeutics without compromising their therapeutic effects on tumors, there by allowing the delivery of higher chemotherapeutic doses to achieve increased cure rate. In this regard, selenium nanoparticles (SeNPs), which...
MedWorm Cancer & Oncology Research
Sun Oct 06, 2019 21:12
Terminating the renewal of tumor-associated macrophages: a sialic acid-based targeted delivery strategy for cancer immunotherapy
Publication date: Available online 5 October 2019Source: International Journal of PharmaceuticsAuthor(s): Junqiang Ding, Dan Zhao, Yawei Hu, Mingqi Liu, Xinrui Liao, Bowen Zhao, Xinrong Liu, Yihui Deng, Yanzhi SongAbstractMononuclear phagocytes are efficient drug delivery targets for cancers owing to their cancerous tissue-accumulating nature. As receptors of sialic acid, Siglecs (sialic acid-binding immunoglobulin-type lectins) are noticeably found on peripheral blood monocytes (PBMs) and tumor-associated...
MedWorm Cancer & Oncology Research
Sun Oct 06, 2019 21:12
Influence of the Method of Preparation on the Characteristics and Performance of Cholesterol-based Polymeric Nanoparticles for Redox-triggered Release of Doxorubicin in Tumor Cells
In this study the influence of the method of preparation on the characteristics and bio-responsiveness of doxorubicin-loaded redox-sensitive nanoparticles (DOX-SS-NPs), formed by a biocompatible cholesterol-based amphiphilic block copolymer (PC5MA-SS-PEO) was investigated. Two commonly used preparation techniques: 1) cosolvent removal and 2) an O/W emulsion method were compared and the in vitro and in vivo performance of promising formulations was assessed. Besides particle size distribution and...
MedWorm Cancer & Oncology Research
Sun Oct 06, 2019 21:12
PCC0208017, a novel small-molecule inhibitor of MARK3/MARK4, suppresses glioma progression in vitro and in vivo
Publication date: Available online 18 September 2019Source: Acta Pharmaceutica Sinica BAuthor(s): Fangfang Li, Zongliang Liu, Heyuan Sun, Chunmei Li, Wenyan Wang, Liang Ye, Chunhong Yan, Jingwei Tian, Hongbo WangAbstractGliomas are the most common primary intracranial neoplasms among all brain malignancies, and the microtubule affinity regulating kinases (MARKs) have become potential drug targets for glioma. Here, we report a novel dual small-molecule inhibitor of MARK3 and MARK4, designated as PCC0208017....
MedWorm Cancer & Oncology Research
Sun Oct 06, 2019 20:17
Cancers, Vol. 11, Pages 1497: Comprehensive Metabolomic Search for Biomarkers to Differentiate Early Stage Hepatocellular Carcinoma from Cirrhosis
This study aimed to develop a metabolite panel to differentiate early-stage HCC from cirrhosis. Cross-sectional metabolomic analyses of serum samples were performed for 53 and 47 patients with early HCC and cirrhosis, respectively, and 50 matched healthy controls. Results were validated in 82 and 80 patients with early HCC and cirrhosis, respectively. To retain a broad spectrum of metabolites, technically distinct analyses (global metabolomic profiling using gas chromatography time-of-flight mass...
MedWorm Cancer & Oncology Research
Sun Oct 06, 2019 00:00
Adipose Stem Cells and Cancer: Concise Review
Adipose stem cells (ASCs) play a critical role in the tumor microenvironment of many different tumors through complex signaling networks. Common pathways activated by ASCs in multiple tumor types are highlighted in this review. AbstractIt is well established that the tumor microenvironment plays an important role in cancer development and progression. The tumor microenvironment is composed of neoplastic cells, endothelial cells, pericytes, adipocytes, fibroblasts and other connective tissue cells,...
MedWorm Cancer & Oncology Research
Sun Oct 06, 2019 00:00
Metabolism and Gut Microbiota in Cancer Immunoediting, CD8/Treg Ratios, Immune Cell Homeostasis, and Cancer (Immuno)Therapy: Concise Review
Factors that can impact the outcome of combination therapy include dose, frequency and order of administration, affecting not only the tumor burden but also metabolic competition, microbiota and the balance between cytotoxic and regulatory immunity. AbstractThe concept of immunoediting, a process whereby the immune system eliminates immunogenic cancer cell clones, allowing the remaining cells to progress and form a tumor, has evolved with growing appreciation of the importance of cancer ecology on...
MedWorm Cancer & Oncology Research
Sun Oct 06, 2019 00:00
Microenvironmental Regulation of Long Noncoding RNA LINC01133 Promotes Cancer Stem Cell ‐Like Phenotypic Traits in Triple‐Negative Breast Cancers
LINC01133 responds to mesenchymal stem/stromal cell ‐regulated miR‐199a/214‐FOXP2 pathway and upregulates the expression of the pluripotency master regulator KLF4 to drive cancer‐stem‐cell‐like phenotypic traits. AbstractThe fibrotic tumor microenvironment is a critical player in the pathogenesis of triple ‐negative breast cancers (TNBCs), with the presence of fibroblastic infiltrates particularly correlating with tumors that are clinically advanced. On this front, we previously demonstrated that...
MedWorm Cancer & Oncology Research
Sun Oct 06, 2019 00:00
Curcumin Inhibits Cell Viability and Increases Apoptosis of SW620 Human Colon Adenocarcinoma Cells via the Caudal Type Homeobox-2 (CDX2)/Wnt/ β-Catenin Pathway.
CONCLUSIONS Curcumin reduced cell viability and increased apoptosis in SW620 human colonic adenocarcinoma cells by restoring CDX2, which inhibited the Wnt/ß-catenin signaling pathway. PMID: 31584928 [PubMed - in process] (Source: Medical Science Monitor)
MedWorm Cancer & Oncology Research
Sun Oct 06, 2019 18:43
GAS5, a FoxO1-actived long noncoding RNA, promotes propofol-induced oral squamous cell carcinoma apoptosis by regulating the miR-1297-GSK3 β axis.
GAS5, a FoxO1-actived long noncoding RNA, promotes propofol-induced oral squamous cell carcinoma apoptosis by regulating the miR-1297-GSK3β axis. Artif Cells Nanomed Biotechnol. 2019 Dec;47(1):3985-3993 Authors: Gao C, Ren C, Liu Z, Zhang L, Tang R, Li X Abstract Propofol, an intravenous anaesthetic agent, has been found to exhibit antitumour effects in various kinds of cancer cells. However, the potential roles and regulatory mechanisms of propofol in oral squamous cell...
MedWorm Cancer & Oncology Research
Sun Oct 06, 2019 18:42
A mechanistic and empirical review of antcins, a new class of phytosterols of formosan fungi origin
Publication date: Available online 5 October 2019Source: Journal of Food and Drug AnalysisAuthor(s): K.J. Senthil Kumar, M. Gokila Vani, Chieh-Yin Chen, Wen-Wei Hsiao, Jing Li, Zhan-xi Lin, Fang-Hua Chu, Gow-Chin Yen, Sheng-Yang WangAbstractAntcins are unique phytosterols isolated from A. cinnamomea and A. salmomea, which are the endemic fungus of Taiwan. A. cinnamomea has long been highly valued medicinal mushroom in Taiwan and traditionally used as a folk remedy for various human illness. Recent...
MedWorm Cancer & Oncology Research
Sun Oct 06, 2019 16:38
[Reactive Oxygen Species (ROS) Signaling: Regulatory Mechanisms and Pathophysiological Roles].
Authors: Hirata Y Abstract Reactive oxygen species (ROS) are highly reactive molecules generated during mitochondrial respiration and under various environmental stresses, and cause damage to DNA, proteins, and lipids, which is linked to a wide variety of pathologies. However, recent studies have revealed the physiological importance of ROS as signaling molecules, which play crucial roles in the maintenance of cellular functions and homeostasis. According to the extent and duration of ROS...
MedWorm Cancer & Oncology Research
Sun Oct 06, 2019 16:32
[Effects of Renal Function Evaluation with or without Serum Creatinine Adjustment on Cisplatin/Fluorouracil Therapy for Cervical Cancer].
Authors: Takagi M, Sagara A, Ishizawa A, Ito A, Miyazaki M, Senzaki K, Nagai T, Yamada K Abstract The dosage of cisplatin is adjusted according to creatinine clearance (Ccr) estimated by the Cockcroft-Gault formula, which is commonly used as a marker for renal function. It is known that different serum creatinine (Scr) levels are reported depending on the analytical methods utilized such as the Scr level by the enzyme method being lower than that by the Jaffe method. Although the enzyme...
MedWorm Cancer & Oncology Research
Sun Oct 06, 2019 16:32
[Systematic Review of Case Reports on the Adverse Events Due to Health Food Intake by Cancer Patients].
Authors: Kojima A, Sato Y, Nishijima C, Umegaki K, Chiba T Abstract Cancer patients use health foods (HFs) as complementary and alternative medicine, although the details of their adverse events (AEs) are unclear. We searched three databases [PubMed, "Igaku Chuo Zasshi", and Information System on Safety and Effectiveness for Health Foods website (https://hfnet.nibiohn.go.jp/)] for case reports on AEs related to HF intake in cancer patients published before October 2018. Of the matched reports,...
MedWorm Cancer & Oncology Research
Sun Oct 06, 2019 16:32
Organ/Tissue-Specific Vascular Endothelial Cell Heterogeneity in Health and Disease.
Authors: Minami T, Muramatsu M, Kume T Abstract The vascular system forms the largest surface in our body, serving as a critical interface between blood circulation and our diverse organ/tissue environments. Thus, the vascular system performs a gatekeeper function for organ/tissue homeostasis and the body's adjustment to pathological challenges. The endothelium, as the most inner layer of the vasculature, regulates the tissue microenvironment, which is critical for development, hemostatic...
MedWorm Cancer & Oncology Research
Sun Oct 06, 2019 16:19
Leucine-Rich Alpha-2-Glycoprotein 1 in Serum Is a Possible Biomarker to Predict Response to Preoperative Chemoradiotherapy for Esophageal Cancer.
Authors: Nambu M, Masuda T, Ito S, Kato K, Kojima T, Daiko H, Ito Y, Honda K, Ohtsuki S Abstract The purpose of the present study was to identify a biomarker that can predict the response to preoperative chemoradiotherapy (PCRT) in esophageal cancer patients. Twenty-five serum samples collected from patents with esophageal cancer before PCRT (responder = 13, non-responder = 12) were analyzed by quantitative proteomics, and 248 proteins were identified. Among them, the serum levels of leucine-rich...
MedWorm Cancer & Oncology Research
Sun Oct 06, 2019 16:19
The effect of surgical margin positivity on survival in laryngeal cancer surgery.
CONCLUSION: The absence of a tumor at the surgical margin is one of the most basic rules in oncologic surgery. KEY WORDS: Laryngeal carcinoma, Oncologic surgery, Survival, Surgical Margin. PMID: 31586379 [PubMed - as supplied by publisher] (Source: Annali Italiani di Chirurgia)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
MedWorm Cancer & Oncology Research
Sun Oct 06, 2019 15:49
Biosynthesis of Novel Shikonin Glucosides by Enzymatic Glycosylation.
Authors: Li B, Zhu M, Ma H, Ma T, Dai Y, Li H, Li Y, Wu CZ Abstract Shikonin, a natural naphthoquinone, has attracted much attention due to its various biological activities. Two shikonin glucosides, shikonin-1',8-di-O-β-D-glucopyranoside (1) and shikonin-1'-O-β-D-glucopyranoside (2), were biosynthesized through in vitro enzymatic glycosylation and their structures were elucidated using spectroscopic techniques. The water-solubility and stability of compounds 1 and 2 were significantly...
MedWorm Cancer & Oncology Research
Sun Oct 06, 2019 15:09
Ceftazidime plasma concentration in a patient with cystic fibrosis treated with ceftazidime/avibactam plus trimethoprim/sulfametoxazole for Bulkholderia cepacia reacutization.
Authors: Saffioti C, Barco S, Cangemi G, Mesini A, Casciaro R, Cresta F, Castellani C, Bandettini R, Morelli P, Castagnola E PMID: 31583970 [PubMed - as supplied by publisher] (Source: Journal of Chemotherapy)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
MedWorm Cancer & Oncology Research
Sun Oct 06, 2019 13:42

Cellular signaling and epigenetic regulation of gene expression in leukemia
Publication date: Available online 5 October 2019Source: Advances in Biological RegulationAuthor(s): Chandrika Gowda, Chunhua Song, Yali Ding, Soumya Iyer, Pavan Dhanyamraju, Mary McGrath, Yevgeniya Bamme, Mario Soliman, Shriya Kane, Jonathon L. Payne, Sinisa DovatAbstractAlterations in normal regulation of gene expression is one of the key features of hematopoietic malignancies. In order to gain insight into the mechanisms that regulate gene expression in these diseases, we dissected the role of...
MedWorm Cancer & Oncology Research
Sun Oct 06, 2019 13:38
Molecules, Vol. 24, Pages 3595: Chemical Profile and Multicomponent Quantitative Analysis for the Quality Evaluation of Toad Venom from Different Origins
This study demonstrated that integrating HPLC-ESI-Q-TOF-MS/MS, HPLC fingerprints, and multicomponent quantitative analysis coupled with chemometrics was a comprehensive and reliable strategy for evaluation of Chansu in both qualitative and quantitative aspects. In addition, our study represented the most comprehensive characterization on the chemical compositions of Chansu, which could provide important reference information for the discovery of potential bioactive compounds. (Source: Molecules)
MedWorm Cancer & Oncology Research
Sun Oct 06, 2019 00:00
Molecules, Vol. 24, Pages 3593: Broccoli or Sulforaphane: Is It the Source or Dose That Matters?
Authors: Yoko Yagishita Jed W. Fahey Albena T. Dinkova-Kostova Thomas W. Kensler There is robust epidemiological evidence for the beneficial effects of broccoli consumption on health, many of them clearly mediated by the isothiocyanate sulforaphane. Present in the plant as its precursor, glucoraphanin, sulforaphane is formed through the actions of myrosinase, a β-thioglucosidase present in either the plant tissue or the mammalian microbiome. Since first isolated from broccoli and...
MedWorm Cancer & Oncology Research
Sun Oct 06, 2019 00:00
EAU-EANM-ESTRO-ESUR-SIOG Prostate Cancer Guideline Panel Consensus Statements for Deferred Treatment with Curative Intent for Localised Prostate Cancer from an International Collaborative Study (DETECTIVE Study)
ConclusionsConsensus statements and the findings are expected to guide and inform routine clinical practice and research, until higher levels of evidence emerge through prospective comparative studies and clinical trials.Patient summaryWe undertook a project aimed at standardising the elements of practice in active surveillance programmes for early localised prostate cancer because currently there is great variation and uncertainty regarding how best to conduct them. The project involved large numbers...
MedWorm Cancer & Oncology Research
Sun Oct 06, 2019 11:41
The Balancing Act: Assessing Treatment Burden Versus Treatment Benefit with Evolving Metastatic Hormone-sensitive Prostate Cancer Data
Publication date: Available online 5 October 2019Source: European UrologyAuthor(s): Christopher J. Sweeney, Himisha Beltran (Source: European Urology)
MedWorm Cancer & Oncology Research
Sun Oct 06, 2019 11:41
Clinical experience and results with a Rhombic Plate for transoral endoscopically-assisted osteosynthesis of fractures of the condylar neck
We present the clinical and functional results in 81 patients with 98 fractures of the condylar neck who we have treated with this technique. Of these six required surgical revision, and ultimately all but two had satisfactory occlusion and mandibular function. Our complication rate of 6/81 (7.4%) compares favourably with those reported elsewhere, and confirms that open reduction and internal fixation of condylar fractures using the Rhombic plate through an intra-oral approach provides good outcomes....
MedWorm ENT & OMF Research
Sun Oct 06, 2019 21:39
Use of an acrylic jig to aid orbital reconstruction after resection of a sphenoid intraosseous meningioma: a technical note
Publication date: Available online 6 October 2019Source: British Journal of Oral and Maxillofacial SurgeryAuthor(s): J.V. Williams, J.D. Parmar, L.M. Carter, P. Woodhead, R. Corns (Source: British Journal of Oral and Maxillofacial Surgery)
MedWorm ENT & OMF Research
Sun Oct 06, 2019 21:39
Comparison of the piezoelectric cutter with a conventional cutting technique in orthognathic surgery
Publication date: Available online 5 October 2019Source: British Journal of Oral and Maxillofacial SurgeryAuthor(s): G.W. Jenkins, R.J. LangfordAbstractThe use of a piezoelectric cutter has been reported to improve outcomes in orthognathic surgery, particularly with regards to neurosensory disturbance of the inferior alveolar nerve. The aims of this retrospective longitudinal cohort study were to compare outcomes regarding neurosensory disturbance, and operating time. During two 15-month periods...
MedWorm ENT & OMF Research
Sun Oct 06, 2019 21:39
Pregnancy and childbirth after an iliac crest free flap
We report two successful pregnancies and vaginal deliveries by patients who had previously had deep circumflex iliac artery free flaps that had been harvested for reconstruction in the head and neck. (Source: British Journal of Oral and Maxillofacial Surgery)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
MedWorm ENT & OMF Research
Sun Oct 06, 2019 21:39
Should Excess Topical Decongestant Use Raise a Red Flag? Rhinitis Medicamentosa and Opioid Use Disorder.
CONCLUSIONS: RM is associated with increased odds of having an OUD. PMID: 31581795 [PubMed - as supplied by publisher] (Source: The Annals of Otology, Rhinology, and Laryngology)
MedWorm ENT & OMF Research
Fri Oct 04, 2019 00:00
A Foreign Body in the Ostium of the Maxillary Sinus.
Authors: Lee JH PMID: 31581835 [PubMed - as supplied by publisher] (Source: Ear, Nose and Throat Journal)
MedWorm ENT & OMF Research
Thu Oct 03, 2019 00:00
Huge Cholesterol Granuloma in Nasoseptal Region.
Authors: Yücel Ekici N PMID: 31581831 [PubMed - as supplied by publisher] (Source: Ear, Nose and Throat Journal)
MedWorm ENT & OMF Research
Thu Oct 03, 2019 00:00
Can MDCT Scan of the Temporal Bone Looking at Pneumatization Predict Surgical Vulnerability of the Facial Nerve?
CONCLUSION: Cochleariform process is an important landmark to localize the tympanic segment of the facial canal. In sclerosed mastoids, scutum-CP and scutum-promontorium distances decreased. There was no relationship between FCD rates and mastoid pneumatization levels. It may be due to the development of FCD that occurs during the intrauterine period. In endoscopic and classic ear surgeries, mastoid pneumatization must be evaluated preoperatively to avoid facial nerve injuries. PMID: 31581825...
MedWorm ENT & OMF Research
Thu Oct 03, 2019 00:00
Differential Diagnosis Under the Microscope: Crystalloid Granuloma of the Parotid Gland.
Authors: O'Malley QF, Sims JR, Spaulding SL, Sandler ML, Everest S, Khorsandi AS, Brandwein-Weber M, Urken ML PMID: 31581833 [PubMed - as supplied by publisher] (Source: Ear, Nose and Throat Journal)
MedWorm ENT & OMF Research
Thu Oct 03, 2019 00:00
Evaluation of the Presence of Sensorineural Hearing Loss and the Relationship With Intraoperative Findings in Cholesteatoma.
Authors: Gulustan F, Yazici ZM, Sayin I, Abakay MA, Gunes S, Akidil AO Abstract We investigated whether cholesteatoma is associated with sensorineural hearing loss (SNHL) and the effects of a lateral semicircular canal (LSCC) fistula, destruction of stapes, localization of cholesteatoma, and air-bone gap (ABG) size on SNHL. The charts of 159 patients who had received surgery for unilateral cholesteatoma were examined retrospectively. In all patients, air conduction and bone conduction (BC)...
MedWorm ENT & OMF Research
Thu Oct 03, 2019 00:00
Overstay and Readmission in Ear, Nose, and Throat Day Surgery-Factors Affecting Postanesthesia Course.
CONCLUSIONS: Day surgery could be done safely using local anesthesia, as the number of study outcomes was no greater than in general anesthesia. Sex, type of procedure, and age affected the rate of study outcomes, but ASA class and anesthesia form did not. Our overstay, contact, and readmission rates are on the same level, or lower, than in international studies. PMID: 31581823 [PubMed - as supplied by publisher] (Source: Ear, Nose and Throat Journal)
MedWorm ENT & OMF Research
Thu Oct 03, 2019 00:00
Implication and Management of Incidental Oropharyngeal Papillomas-A Retrospective Case Series Review.
CONCLUSION: Oropharyngeal papillomas, when present, can be found incidentally during examination of the oropharynx for other symptoms. Office-based biopsy and KTP laser is a safe and efficient means of identifying and removing most oropharyngeal papillomas. PMID: 31581834 [PubMed - as supplied by publisher] (Source: Ear, Nose and Throat Journal)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
MedWorm ENT & OMF Research
Thu Oct 03, 2019 00:00
Moth in the Left Ear.
Authors: Chiu CC, She YY PMID: 31581832 [PubMed - as supplied by publisher] (Source: Ear, Nose and Throat Journal)
MedWorm ENT & OMF Research
Thu Oct 03, 2019 00:00

Mastoid Reconstruction With Platelet-Rich Plasma and Bone Pate After Canal Wall Down Mastoidectomy: A Preliminary Report.
CONCLUSION: Autologous materials (PRP and bone pate pate) after canal wall down mastoidectomy appear to be a reliable and effective choice for mastoid reconstruction. PMID: 31581830 [PubMed - as supplied by publisher] (Source: Ear, Nose and Throat Journal)
MedWorm ENT & OMF Research
Thu Oct 03, 2019 00:00
The Relationship of Vestibulo-Ocular Reflex With Self-Reported Dizziness Handicap in Patients With Vestibular Deafferentation.
In this study, to contribute to this issue, the vestibulo-ocular reflex features and their relationship with balance perception at long-term follow-up in vestibular neurectomy (VN) and total labyrentectomy patients were evaluated. Prospectively, 19 VN and 18 labyrinthectomy patients were enrolled in this study. Patients underwent video head impulse test (VHIT) as objective vestibular test and dizziness handicap inventory (DHI) as subjective vestibular test when they attended to their control visit...
MedWorm ENT & OMF Research
Thu Oct 03, 2019 00:00
Investigation of Oxidative Stress in Antrochoanal Polyp Etiology.
Authors: Islamoglu Y, Kesici GG, Canan Y, Kale H, Kara Ö, Erel O, Babademez MA Abstract Antrochoanal polyps (ACPs) are benign lesions of the paranasal sinuses. Similarities between ACPs and nasal polyps have been previously investigated. However, oxidative stress has been implicated but not investigated in terms of the etiology of ACPs. Thus, the aim of this study was to investigate oxidative stress in the etiology of ACPs. The study population comprised 93 patients divided into 3 groups....
MedWorm ENT & OMF Research
Thu Oct 03, 2019 00:00
The Role of the Parotid-Mastoid Fascia in Identification of the Facial Nerve Trunk During Parotidectomy.
CONCLUSION: The parotid fascia, particularly the parotid-mastoid segment overlying the facial nerve trunk, can be utilized as an additional landmark of depth to help identify the facial nerve trunk during a parotidectomy in conjunction with other commonly used standard anatomic landmarks. The parotid fascia sling spans from the mastoid and tragal pointer to the parotid gland and can be easily palpated intraoperatively. Once the fascia is removed, the facial nerve trunk is identified. PMID: 31581824...
MedWorm ENT & OMF Research
Thu Oct 03, 2019 00:00
Benign Paroxysmal Positional Vertigo: Comparison of Idiopathic BPPV and BPPV Secondary to Vestibular Neuritis.
Authors: Türk B, Akpinar M, Kaya KS, Korkut AY, Turgut S Abstract The aim of this study was to reveal clinical features of benign paroxysmal positional vertigo (BPPV) through comparing idiopathic BPPV and BPPV secondary to vestibular neuritis (VN). The clinical data of the 189 BPPV patients admitted to our tertiary care hospital including otolaryngological, audiological, vestibular, neurological, and radiological evaluations were reviewed. Patients diagnosed with idiopathic BPPV (n = 145)...
MedWorm ENT & OMF Research
Thu Oct 03, 2019 00:00
A case of necrotizing sialometaplasia.
Authors: León X, Szafranska J, Méndez JE PMID: 31582173 [PubMed - as supplied by publisher] (Source: Acta Otorrinolaringologica Espanola)
MedWorm ENT & OMF Research
Mon Sep 30, 2019 00:00
The Utility of Stuttering Support Organization Conventions for Young People Who Stutter
ConclusionSSOs may be beneficial in reducing the negative impact of stuttering and should be considered a potentially valuable addition to traditional therapy for stuttering. (Source: Journal of Fluency Disorders)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
MedWorm Speech Therapy Research
02:35
A prosodic account of wh-formation in Jordanian Arabic
Publication date: Available online 5 October 2019Source: LinguaAuthor(s): Ekab Al-Shawashreh, Marwan Jarrah, Moh’d Al-Omari, Mutasim Al-DeaibesAbstractThis paper shows that wh-formation in Jordanian Arabic (JA) is prosodically ruled. Wh-words should move either to the left or to the right periphery of the phonological phrase that contains the relevant wh-word. What appears as an in-situ instance of a wh-question in JA, as reported by several studies, is in fact a true instance of a moved wh-word...
MedWorm Speech Therapy Research
Sun Oct 06, 2019 12:14

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